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Yolanda Y Huang, Guohua Li, Lena S Sun
BACKGROUND: Simple febrile seizure (SFS) affects 2% to 4% of children under 6 years of age. The purpose of this study is to examine the epidemiologic patterns and resource utilization of SFS-associated hospitalizations in children aged younger than 6 years of age in the United States. MATERIALS AND METHODS: This study is a serial, retrospective analysis of the Healthcare Cost and Utilization Project Kids' Inpatient Databases for the years 2003, 2006, 2009, and 2012...
January 2019: Journal of Neurosurgical Anesthesiology
Carlo Diaferia, Eliana Gianolio, Antonella Accardo
Magnetic resonance imaging (MRI) is one of the most important clinic diagnostic tool used to obtain high-quality body images. The administration of low-molecular-weight Gd complex-based MRI contrast agents (CAs) permits to increase the 1 H relaxation rate of nearby water molecules, thus modulating signal intensity and contrast enhancement. Even if highly accurate, MRI modality suffers from its low sensitivity. Moreover, low-molecular-weight CAs rapidly equilibrate between the intravascular and extravascular spaces after their administration...
February 15, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
Brandon B Carlson, Todd J Albert
INTRODUCTION: Intervertebral disc herniation (IDH) can cause back pain and/or radiculopathy and accounts for a significant portion of patients having spinal surgery in the USA. One of the most impactful and well-executed randomized trials to study diagnosis, treatments, and outcomes in patients with three commonly treated spinal conditions was the Spine Patient Outcomes Research Trial (SPORT). This study and the subsequent data analyses have resulted in numerous publications related to IDH...
February 15, 2019: International Orthopaedics
Y J Dakkak, D M Boeters, A C Boer, M Reijnierse, A H M van der Helm-van Mil
BACKGROUND: MRI-detected subclinical joint inflammation in the hand joints of patients with undifferentiated arthritis (UA) predicts progression to rheumatoid arthritis (RA). It is unknown if adding MRI of the foot increases predictive accuracy compared to the hand alone. METHODS: 1.5-T contrast-enhanced MRI of the unilateral foot (MTP-1-5) and hand (MCP-2-5 and wrist) was performed in 123 patients presenting with UA (not fulfilling the 2010 RA criteria) and scored for bone marrow edema (BME), synovitis and tenosynovitis...
February 14, 2019: Arthritis Research & Therapy
Sarah Ohrndorf, Aleid C Boer, Debbie M Boeters, Robin M Ten Brinck, Gerd-R Burmester, Marion C Kortekaas, Annette H M van der Helm-van Mil
OBJECTIVE: Ultrasound (US) and magnetic resonance imaging (MRI) are recommended in the diagnostic process of rheumatoid arthritis. Research on its comparability in early disease phases is scarce. Therefore, we compared synovitis and tenosynovitis detected by US and MRI on joint/tendon level. METHODS: Eight hundred forty joints and 700 tendons of 70 consecutive patients, presenting with inflammatory arthritis or clinically suspect arthralgia, underwent US and MRI of MCP (2-5), wrist and MTP (1-5) joints at the same day...
February 14, 2019: Arthritis Research & Therapy
Rohit Srivastava, Anna Jablonska, Chengyan Chu, Lydia Gregg, Jeff Bulte, Raymond C Koehler, Piotr Walczak, Miroslaw Janowski
White matter damage persists in hypoxic-ischemic newborns even when treated with hypothermia. We have previously shown that intra-ventricular delivery of human glial progenitors (GPs) at the neonatal stage is capable of replacing abnormal host glia and rescuing the lifespan of dysmyelinated mice. However, such transplantation in the human brain poses significant challenges as related to high-volume ventricles and long cell migration distances. These challenges can only be studied in large animal model systems...
February 14, 2019: Stem Cells and Development
S A Begum, T Mahmud, T Rahman, J Zannat, F Khatun, K Nahar, M Towhida, M Joarder, A Harun, F Sharmin
In Bangladesh incidence rate of breast cancer was about 22.5 per 100000 females. Breast cancer has been reported as the highest prevalence rate (19.3 per 100,000) among Bangladeshi women between 15 and 44 years of age. For this prevailing situation a cross-sectional study was designed to assess the knowledge, attitude and practices of community-dwelling women in Bangladesh towards breast cancer at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2013 to June 2014. All female participants attending at outpatient department of BSMMU having age more than 20 years and education at least JSC, purposively selected until the sample size achieved 500...
January 2019: Mymensingh Medical Journal: MMJ
Ann L Brown, Jordana Phillips, Tejas S Mehta, Alexander Brook, Richard E Sharpe, Priscilla J Slanetz, Vandana Dialani
The purpose of this study was to evaluate providers' ordering practices and perceptions of breast magnetic resonance imaging (MRI) in an academic network in order to better understand and educate a referral base. An online survey was distributed to primary care providers (PCPs) and specialists in our hospital and community practices. Questions included provider demographics, current ordering practices, challenges to ordering, and perceptions about breast MRI. Of 525 ordering providers, 134 responded (26% response rate)...
February 12, 2019: Breast Journal
Ye Tian, Jason Mendes, Apoorva Pedgaonkar, Mark Ibrahim, Leif Jensen, Joyce D Schroeder, Brent Wilson, Edward V R DiBella, Ganesh Adluru
PURPOSE: Dynamic contrast enhanced MRI of the heart typically acquires 2-4 short-axis (SA) slices to detect and characterize coronary artery disease. This acquisition scheme is limited by incomplete coverage of the left ventricle. We studied the feasibility of using radial simultaneous multi-slice (SMS) technique to achieve SA, 2-chamber and/or 4-chamber long-axis (2CH LA and/or 4CH LA) coverage with and without electrocardiography (ECG) gating using a motion-robust reconstruction framework...
2019: PloS One
Allison S Glass, Marc A Dall'Era
OBJECTIVES: To review the role of multi-parametric magnetic resonance imaging (mpMRI) for active surveillance of prostate cancer. MATERIALS AND METHODS: We performed a comprehensive search of Medline and Embase databases for relevant articles. Search terms included prostate cancer, active surveillance or monitoring, expectant management, and MRI in the English language. We also reviewed practice guidelines from recognized international associations or societies involved in prostate cancer care...
February 11, 2019: BJU International
Obada Hasan, Muhammad Atif, Mir Muzamil Jessar, Pervaiz Hashmi
Application of three-dimensional (3D) printing facilities in orthopaedic surgery is getting popular in resourceconstrained countries. It is cost- and resource-efficient to assist in planning and increasing orthopaedic procedures efficienc y. Furthermore, it improves educational training and provides cheaper prosthesis and creation of customised implants for special cases. Moreover, 3D models of computed tomography (CT) and magnetic resonance imaging (MRI) data play a helpful rule for a more hands-on approach for the surgeon...
February 2019: JPMA. the Journal of the Pakistan Medical Association
Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso
BACKGROUND/OBJECTIVES: Data estimating the prevalence of significant findings during the investigation of patients with Chronic Asymptomatic Pancreatic Hyperenzymemia (CAPH) are scanty and heterogeneous, and the diagnostic approach is therefore uncertain. The aim of this study was to meta-analyze pancreatic abnormalities detected at second-level imaging in patients with CAPH. METHODS: Pubmed database was searched until September 2018 for articles evaluating CAPH patients through MRI-Cholangio-Pancreatography with/without secretin (MRCP or s-MRCP) or Endoscopic Ultrasound (EUS)...
January 31, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Elissa Port, Ferdynand Hebal, Catherine J Hunter, Fizan Abdullah, Bryan Malas, Marleta Reynolds
BACKGROUND: Objective preoperative assessment of pectus excavatum (PE) deformity in patients is limited to preoperative measurement of severity using computed tomography (CT) or magnetic resonance imaging (MRI). Postoperative assessment is currently subjective as postoperative CT scans are not recommended in light of radiation exposure and high cost to families. White Light Scanning (WLS) is a novel 3D imaging modality that offers an alternative that is a quick, nonionizing, inexpensive, and safe strategy for measurement both pre- and postsurgery...
January 23, 2019: Journal of Pediatric Surgery
Ivana Stojanovic, John E Schneider, Jacie Cooper
AIMS: The purpose of this study is to assess the economic cost differences and the associated treatment resource changes between the developing coronary artery disease (CAD) diagnostic tool fast strain-encoded cardiac imaging (Fast-SENC) and the current commonly used stress test single-photon emission computed tomography (SPECT). MATERIALS AND METHODS: We first created a 'payer perspective' model consisting of long-term and short-term components that used a hypothetical cohort of patients of average age (60...
February 7, 2019: Journal of Medical Economics
H Michael Gach
PURPOSE: To identify an inexpensive, low-dielectric liquid for large MRI phantoms that can be used at multiple magnetic field strengths. METHODS: The T1 and T2 of four candidate phantom liquids (pure mineral oil, food-grade white mineral oil, silicone oil, and glycerol) with low dielectric constants were measured at three field strengths (0.35, 1.5, and 3 T) and extrapolated for 7 T. The complex permittivities of the liquids were measured for frequencies from 13 MHz to 600 MHz...
February 5, 2019: Medical Physics
Sheena K Sikora, Stephen K Tham, Jason N Harvey, Marc Garcia-Elias, Tony Goldring, Andrew H Rotstein, Eugene T Ek
Background  Scapholunate instability (SLI) is the most common form of carpal instability. Early detection of SLI is imperative as early reconstructive procedures can potentially prevent the natural history of progressive degenerative arthritis. After wrist arthroscopy, magnetic resonance imaging (MRI) remains the next best noninvasive diagnostic option; however, access still remains costly and is often limited in many health care systems worldwide. In this article, we describe a novel device that allows for dynamic X-rays to be taken, accentuating the scapholunate (SL) widening...
February 2019: Journal of Wrist Surgery
David Marlevi, Bram Ruijsink, Maximilian Balmus, Desmond Dillon-Murphy, Daniel Fovargue, Kuberan Pushparajah, Cristóbal Bertoglio, Massimiliano Colarieti-Tosti, Matilda Larsson, Pablo Lamata, C Alberto Figueroa, Reza Razavi, David A Nordsletten
Many cardiovascular diseases lead to local increases in relative pressure, reflecting the higher costs of driving blood flow. The utility of this biomarker for stratifying the severity of disease has thus driven the development of methods to measure these relative pressures. While intravascular catheterisation remains the most direct measure, its invasiveness limits clinical application in many instances. Non-invasive Doppler ultrasound estimates have partially addressed this gap; however only provide relative pressure estimates for a range of constricted cardiovascular conditions...
February 4, 2019: Scientific Reports
Cian M Scannell, Adriana D M Villa, Jack Lee, Marcel Breeuwer, Amedeo Chiribiri
Kinetic parameter values, such as myocardial perfusion, can be quantified from dynamic contrast enhanced (DCE-) magnetic resonance imaging (MRI) data using tracer-kinetic modelling. However, respiratory motion affects the accuracy of this process. Motion compensation of the image series is difficult due to the rapid local signal enhancement caused by the passing of the gadolinium-based contrast agent. This contrast enhancement invalidates the assumptions of the (global) cost functions traditionally used in intensity-based registrations...
February 1, 2019: IEEE Transactions on Medical Imaging
Gustav J Strijkers, Ericky C A Araujo, Noura Azzabou, David Bendahan, Andrew Blamire, Jedrek Burakiewicz, Pierre G Carlier, Bruce Damon, Xeni Deligianni, Martijn Froeling, Arend Heerschap, Kieren G Hollingsworth, Melissa T Hooijmans, Dimitrios C Karampinos, George Loudos, Guillaume Madelin, Benjamin Marty, Armin M Nagel, Aart J Nederveen, Jules L Nelissen, Francesco Santini, Olivier Scheidegger, Fritz Schick, Christopher Sinclair, Ralph Sinkus, Paulo L de Sousa, Volker Straub, Glenn Walter, Hermien E Kan
Neuromuscular diseases are characterized by progressive muscle degeneration and muscle weakness resulting in functional disabilities. While each of these diseases is individually rare, they are common as a group, and a large majority lacks effective treatment with fully market approved drugs. Magnetic resonance imaging and spectroscopy techniques (MRI and MRS) are showing increasing promise as an outcome measure in clinical trials for these diseases. In 2013, the European Union funded the COST (co-operation in science and technology) action BM1304 called MYO-MRI (www...
2019: Journal of Neuromuscular Diseases
Timothy S Crall
Recent literature tells us that knee arthroscopy in the setting of osteoarthritis is no better than placebo, but arthroscopy for isolated, nondegenerative meniscus tears is both helpful to patients and cost-effective. Since most patients with osteoarthritis have meniscus pathology, we need an accurate way to rule out degenerative disease in patients who are otherwise good candidates for arthroscopic partial meniscectomy. Magnetic resonance imaging can be misleading. Needle arthroscopy is a new tool that can potentially help dig us out of this diagnostic dilemma...
February 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
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