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Coiled Coil

M Bizkarguenaga, L Gomez-Santos, J F Madrid, F J Sáez, E Alonso
BACKGROUND: Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) is a Golgi protein that plays a role in vesicular transport and intracellular protein trafficking and degradation. Mice deficient in GOPC protein have globozoospermia and are infertile. The germ cell nuclear factor (GCNF) is a member of the nuclear receptor superfamily which is expressed in male germ cells, from spermatocytes and spermatids, both in the nucleus and the acrosomal region. It is not known if its expression could be altered in Gopc-/- mice with defective acrosomes...
February 20, 2019: Andrology
Hao-Chen Ding, Xue-Peng Li, Rui-Zhi Li, Shu-Min Yi, Yong-Xia Xu, Hong-Bo Mi, Jian-Rong Li
This study examined the changes of water state and gel characteristics of Hairtail surimi during thermal processing including two steps. The results showed that there were four content of water in Hairtail surimi gels. Water holding capacity (WHC) and T23 relaxation time of water and gel strength increased from 47.01% to 78.97% and from 64.23 ms to 51.52 ms, respectively, and whiteness decreased from 63.87 to 55.22 during the entire thermal processing. Meanwhile, the texture properties including hardness, gumminess, and chewiness declined from 402...
February 20, 2019: Journal of Texture Studies
Qiongyu Li, Da Wo, Yue Huang, Na Yu, Jianwei Zeng, Hongwei Chen, Huai Wang, Liya Bao, Shan Lin, JianFeng Chu, Jun Peng
The protective role of alkaloids from Nelumbinis Plumula (AFNP) on the aorta during hypertension is not yet fully understood. We hypothesize that AFNP exerts protective effects against Ang II-induced hypertension by mediating RhoA/ROCK pathway and phenotypic switching during hypertension. In the present study, we evaluated the effect of AFNP on angiotensin II (Ang II)-induced actin cytoskeleton reorganization and aorta remodeling, as well as the involvement of RhoA/Rho-associated coiled kinase (ROCK) pathway in protecting against hypertension...
February 20, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
P Chellapandi, R Prathiviraj, A Prisilla
Malaria is a life-threatening mosquito-borne blood disease caused by infection with Plasmodium parasites. Anti-malarial drug resistance is a global threat to control and eliminate malaria and therefore, it is very important to discover and evaluate new drug targets. The 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) homolog is a second in vivo target for fosmidomycin within isoprenoid biosynthesis in malarial parasites. In the present study, we have deciphered the sequence-structure-function integrity of IspD homologs based on their evolutionary imprints...
February 19, 2019: Journal of Computer-aided Molecular Design
Toru Yamada, Yasuaki Motomura, Eiji Hiraoka, Aki Miyagaki, Juichi Sato
BACKGROUND Intramural hematoma of the esophagus (IHE), a rare manifestation of acute mucosal injuries of the esophagus, can be caused by trauma such as endoscopic surgeries. Coagulation disorders increase the risk of IHE. The most common location of IHE is in the distal esophagus. The characteristic clinical triad of manifestations comprises acute retrosternal pain, odynophagia or dysphagia, and hematemesis. It is important to distinguish IHE from other acute conditions such as acute coronary syndrome, aortic dissection, and pulmonary embolism...
February 20, 2019: American Journal of Case Reports
Anja Golob-Urbanc, Uroš Rajčević, Žiga Strmšek, Roman Jerala
Several antibody-targeting cancer immunotherapies have been developed based on T cell activation at the target cells. One of the most potent activators of T cells are bacterial superantigens, which bind to MHC class II on antigen presenting cells and activate T cells through T cell receptor. Strong T cell activation is also one of the main weaknesses of this strategy as it may lead to systemic T cell activation. To overcome the limitation of conventional antibody-superantigen fusion proteins, we have split a superantigen into two fragments, individually inactive, until both fragments came into close proximity and reassemble into a biologically active form capable of activating T cell response...
February 19, 2019: Journal of Biological Chemistry
Kari Kopra, Natalia Tong-Ochoa, Mari Laine, Ville Eskonen, Päivi J Koskinen, Harri Härmä
We have developed a rapid and sensitive universal peptide-based time-resolved luminescence assay for detection of enzymatic post-translational modifications (PTMs). PTMs play essential roles in intracellular signaling and cell regulation, thus providing functional protein diversity in cell. Due this, impaired PTM patterns have been linked to multiple disease states. Clear link between PTMs and pathological conditions have also driven assay development further, but still today most of the methodologies are based on single-specificity or group-specific PTM-recognition...
May 9, 2019: Analytica Chimica Acta
Fangfang Tang, Jiahao Hao, Fabio Freschi, Chaoqun Niu, Maurizio Repetto, Feng Liu, Stuart Crozier
Insertable head gradient coils offer significant advantages such as high gradient strength and fast gradient switching speed owing to close distance to the target region of interest than whole-body cylindrical coils. To produce superior gradient performance, the local head coil is typically designed with an asymmetric configuration to accommodate both the shoulders and head of a patient, leading to tough dimensional constraints and practical limits to the coil implementation. In this paper, we proposed a new cone-shaped model to improve the performance of the asymmetric head coils and also to mitigate patient claustrophobia...
February 19, 2019: Physics in Medicine and Biology
Venkata Veerendranadh Chebrolu, Peter D Kollasch, Vibhas Deshpande, John Grinstead, Benjamin M Howe, Matthew A Frick, Andrew J Fagan, Thomas Benner, Robin M Heidemann, Joel P Felmlee, Kimberly K Amrami
BACKGROUND: MR image intensity nonuniformity is often observed at 7T. Reference scans from the body coil used for uniformity correction at lower field strengths are typically not available at 7T. PURPOSE: To evaluate the efficacy of a novel algorithm, Uniform Combined Reconstruction (UNICORN), to correct receive coil-induced nonuniformity in musculoskeletal 7T MRI without the use of a reference scan. STUDY TYPE: Retrospective image analysis study...
February 19, 2019: Journal of Magnetic Resonance Imaging: JMRI
Palmira Villa-Valverde, Ignacio Rodríguez, Daniel Padró, Marina Benito, Carlos Ernesto Garrido-Salmon, Jesús Ruiz-Cabello
OBJECTIVE: Given the growing interest in fluorine, it is necessary to develop new multi-tuned RF coils. Therefore, our objective is to design a simple and versatile double-tuned RF coil that can be used as a transmitter and receiver double-tuned coil (1 H and 19 F) or as transmitter-only double-tuned coil. MATERIALS AND METHODS: A high-pass eight-element birdcage coil was built for 1 H and 19 F for a 7 T scanner. PIN diodes and cable traps to block unwanted common mode currents in cables were introduced to confer more flexibility to the coil...
February 16, 2019: Magma
Helena Posch, Katharina Erb-Eigner
Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Additionally, the role of MRI in the acute clinical setting and in trauma are discussed...
February 18, 2019: Klinische Monatsblätter Für Augenheilkunde
Xiaofei Wang, Chao Han, Deguang Xing, Chengwei Wang, Xuan Ding
OBJECTIVE: This study aimed to investigate the efficacy of early management for poor-grade aneurysmal subarachnoid hemorrhage (aSAH; WFNS grade IV and V), and analyze the prognostic factors. PATIENTS AND METHODS: A total of 104 consecutive patients with poor-grade aSAH from the Department of Neurosurgery, the Second Hospital of Shandong University were enrolled between January 2010 and December 2017. All these patients underwent early microsurgical clipping or endovascular coiling within three days after onset...
February 5, 2019: Clinical Neurology and Neurosurgery
Jihong Wang, Jingxiu Zhang, Xiangguo Sun, Chengjun Liu, Xingli Li, Lei Chen
The respiratory syncytial virus fusion (RSV-F) protein is a primary target for vaccine and drug development against respiratory infection and pediatric pneumonia. The RSV-F core forms a trimer-of-hairpins (TOH) motif in post-fusion conformation, which is characterized by a six-helix bundle (6HB) where the three N-terminal HRn helices define a central coiled-coil, while three C-terminal HRc helices pack on the coiled-coil surface in an antiparallel manner. Here, one tightly packed HRn-HRc helix-helix interaction is stripped from the 6HB, which represents the minimum unit of RSV-F TOH motif...
February 18, 2019: Chemical Biology & Drug Design
Matthias Gawlitza, Sébastien Soize, Pierre-François Manceau, Laurent Pierot
Intrasaccular flow disruption is an innovative technique for the endovascular treatment of intracranial aneurysms. Among flow disrupting devices, the Woven EndoBridge (WEB) is currently the only flow disrupter on the market and has seen an extensive scientific evaluation. It was shown that the device provides a safe and effective treatment particularly for wide-neck aneurysms of proximal bifurcations. Areas covered: We describe the principal concept and the technical evolution of intrasaccular flow disruption and discuss all devices that have to date been presented, with a special focus on the WEB...
February 18, 2019: Expert Review of Medical Devices
Vaisakh Mohan, Nilimesh Das, Aritra Das, Vipin Mishra, Pratik Sen
In this contribution, the structural and dynamical changes occurring to papain molecules in ethanol-water binary solvent mixture have been investigated and compared with its denatured state induced by guanidine hydrochloride. Steady-state fluorescence, solvation dynamics, time-resolved rotational anisotropy, circular dichroism and single molecular level fluorescence correlation spectroscopic studies were carried out for this purpose. In ethanol-water mixture with XEtOH = 0.6, DACIA-tagged papain was found to undergo a blue shift of 12 nm, while in presence of 5 M GnHCl, a red shift of 5 nm was observed...
February 18, 2019: Journal of Physical Chemistry. B
Scott M Herting, Yonghong Ding, Anthony J Boyle, Daying Dai, Landon D Nash, Solmaz Asnafi, Daniel R Jakaitis, Collin R Johnson, Lance M Graul, Chung Yeh, David F Kallmes, Ramanathan Kadirvel, Duncan J Maitland
Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs)...
February 18, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Mareike Gastl, Alexander Gotschy, Jochen von Spiczak, Malgorzata Polacin, Florian Bönner, Christiane Gruner, Malte Kelm, Frank Ruschitzka, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
Purpose: Hypertrophic cardiomyopathy (HCM) is characterized by a heterogeneous morphology and variable prognosis. A mismatch between left ventricular mass (LVM) and microvascular circulation with corresponding relative ischemia has been implicated to cause myocardial replacement fibrosis that deteriorates prognosis. Besides parametric T1 mapping, Cardiovascular Magnetic Resonance (CMR) T2* mapping is able to identify ischemia as well as fibrosis in cardiac and extracardiac diseases. Therefore, we aimed to investigate the value of T2* mapping to characterize structural alterations in patients with HCM...
2019: European Journal of Radiology Open
Tania S Vergara Gomez, Marc Dubois, Stanislav Glybovski, Benoit Larrat, Julien de Rosny, Carsten Rockstuhl, Monique Bernard, Redha Abdeddaim, Stefan Enoch, Frank Kober
Earlier work on RF metasurfaces for preclinical MRI has targeted applications such as whole-body imaging and dual-frequency coils. In these studies, a nonresonant loop was used to induce currents into a metasurface that was operated as a passive inductively powered resonator. However, as we show in this study, the strategy of using a resonant metasurface reduces the impact of the loop on the global performance of the assembled coil. To mitigate this deficiency, we developed a new approach that relies on the combination of a commercial surface coil and a coupled-wire structure operated away from its resonance...
February 17, 2019: NMR in Biomedicine
Tomoyuki Fujita, Hirohi Amanao
We report a case of a 75-year-old woman with residual shunt of patent ductus arteriosus after initial surgical repair. She was successfully treated by thoracic aortic stent graft and residual shunt disappeared. Re-surgical repair for residual shunt of patent ductus arteriosus is very invasive and challenging procedure. Also endo-vascular repair using coil or an occluding device can be problematic because of anatomical change due to initial surgical repair. Thoracic aortic stent graft, as a re-intervention procedure for patent ductus arteriosus, is simple, safe, and useful in elderly patients...
February 2019: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Yasuyuki Kobayashi, Koji Nakanishi, Mikizo Nakai
A 32-year-old man leaping down from the 3rd floor of his house got injured and was transferred to our center. Pseudoaneurysm at the aortic isthmus as well as pelvic and lower limb fractures were observed by computed tomography (CT) scan. Thoracic endovascular aortic repair(TEVAR)of the thoracic aorta was performed from zone 2, followed by external skeletal fixation. Postoperative chest X-ray revealed right hemothorax, and CT scan showed active bleeding from the right subclavian artery in addition to splenic artery pseudoaneurysm...
February 2019: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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