Liu-Chun Wang, Pei-Yu Chiou, Ya-Ping Hsu, Chin-Lai Lee, Chih-Hsuan Hung, Yi-Hsuan Wu, Wen-Jyun Wang, Gia-Ling Hsieh, Ying-Chi Chen, Li-Chan Chang, Wen-Pin Su, Divinah Manoharan, Min-Chiao Liao, Suresh Thangudu, Wei-Peng Li, Chia-Hao Su, Hong-Kang Tian, Chen-Sheng Yeh
Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2 O2 → ‧OH for tumoral therapy. Unfortunately, H2 O2 is often taken from the limited endogenous supply of H2 O2 in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H2 O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe3+ -N ≡ C-Fe2+ composition through the proposed proton-induced metal replacement reactions...
August 5, 2023: Nature Communications