Qiang Xue, Silue Zeng, Yaguang Ren, Yingying Pan, Jianhai Chen, Ningbo Chen, Kenneth K Y Wong, Liang Song, Chihua Fang, Jinhan Guo, Jinfeng Xu, Chengbo Liu, Jie Zeng, Litao Sun, Hai Zhang, Jingqin Chen
Hypoxia is a critical tumor microenvironment (TME) component. It significantly impacts tumor growth and metastasis and is known to be a major obstacle for cancer therapy. Integrating hypoxia modulation with imaging-based monitoring represents a promising strategy that holds the potential for enhancing tumor theranostics. Herein, a kind of nanoenzyme Prussian blue (PB) is synthesized as a metal-organic framework (MOF) to load the second near-infrared (NIR-II) small molecule dye IR1061, which could catalyze hydrogen peroxide to produce oxygen and provide a photothermal conversion element for photoacoustic imaging (PAI) and photothermal therapy (PTT)...
January 1, 2024: Biomedical Optics Express