Carlos Elias Conti Filho, Lairane Bridi Loss, Clairton Marcolongo-Pereira, Joamyr Victor Rossoni Junior, Rafael Mazioli Barcelos, Orlando Chiarelli-Neto, Bruno Spalenza da Silva, Roberta Passamani Ambrosio, Fernanda Cristina de Abreu Quintela Castro, Sarah Fernandes Teixeira, Nathana Jamille Mezzomo
Alzheimer's disease (AD) is the most common type of dementia in the elderly. Several hypotheses emerged from AD pathophysiological mechanisms. However, no neuronal protective or regenerative drug is available nowadays. Researchers still work in drug development and are finding new molecular targets to treat AD. Therefore, this study aimed to summarize main advances in AD pharmacological therapy. Clinical trials registered in the National Library of Medicine database were selected and analyzed accordingly to molecular targets, therapeutic effects, and safety profile...
2023: Frontiers in Pharmacology