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REVIEW
Vincent A Eiselt, Stefan Bereswill, Markus M Heimesaat
Prosthetic joint infections (PJIs) are dreaded arthroplasty complications often caused by Staphylococcus aureus. Due to methicillin-resistant S. aureus (MRSA) strains or biofilm formation, successful treatment remains difficult. Currently, two-stage revision surgery constitutes the gold standard therapy of PJIs, sometimes replaced or supplemented by debridement, antibiotics, and implant retention (DAIR). Given the dire consequences of therapeutic failure, bacteriophage therapy might be another treatment option...
March 4, 2024: European Journal of Microbiology & Immunology
#22
JOURNAL ARTICLE
Valery J Kogler, Jeffrey Miles, Tahsin Ozpolat, S Lawrence Bailey, Daire Ann Byrne, Morgan Bawcom-Randall, Yi Wang, Hannah Larsen, Franklin Reed, Xiaoyun Fu, Moritz Stolla
Platelets are stored at room temperature for 5-7 days (RSP). Due to frequent and severe shortages, the FDA recently approved up to 14-day cold-stored platelets in plasma (CSP). However, the post-transfusion function of CSP is unknown and it is unclear which donors are best suited to provide either RSP or CSP. In this study, we sought to evaluate the post-transfusion platelet function and its predictors for platelets stored for the maximum approved storage times (7-day RSP, 14-day CSP) in healthy volunteers on acetylsalicylic acid (ASA)...
March 1, 2024: Blood
#23
JOURNAL ARTICLE
Carlos A Higuera-Rueda, Nicolas S Piuzzi, Nathalie B Milbrandt, Yu Hsin Tsai, Alison K Klika, Anna Cristina S Samia, Anabelle Visperas
BACKGROUND: Chronic periprosthetic joint infection (PJI) is a major complication of total joint arthroplasty. The underlying pathogenesis often involves the formation of bacterial biofilm that protects the pathogen from both host immune responses and antibiotics. The gold standard treatment requires implant removal, a procedure that carries associated morbidity and mortality risks. Strategies to preserve the implant while treating PJI are desperately needed. Our group has developed an anti-biofilm treatment, PhotothermAA gel, that has shown complete eradication of two-week-old mature biofilm in vitro...
February 22, 2024: Journal of Arthroplasty
#24
JOURNAL ARTICLE
Anaïk Previdi, Christèle Dubourg, Valérie Cormier Daire, Mélanie Fradin, Corinne Collet
Low-density lipoprotein receptor-related protein 6 (LRP6) is a co-receptor of the Wnt signaling pathway, which plays an essential role in various biological activities during embryonic and postnatal development. LRP6 is exceptionally associated with rare diseases and always with autosomal dominant inheritance. Here we report a familial phenotype of high bone mass associated with skeletal anomalies and oligodontia but also persistent left superior vena cava, inguinal hernia, hepatic cysts, abnormal posterior fossa and genital malformations...
February 22, 2024: Clinical Genetics
#25
JOURNAL ARTICLE
Clare C Sullivan, Daire M O'Leary, Fiona M Boland, Claire M Condron, Claire M Mulhall, Walter J Eppich
BACKGROUND: Simulation-based education (SBE) affords learners opportunities to develop communication skills, including those related to pediatrics. Feedback is an integral part of SBE, and while much research into feedback from multiple sources exists, the findings are mixed. The aim of this comparative study was to replicate some of this work in a novel area, pediatric medical education, to better understand how multisource feedback (self, educator, and simulated parent) may inform learning and curriculum design...
February 17, 2024: Advances in Simulation
#26
JOURNAL ARTICLE
Vineet Desai, Alexander R Farid, Adriana P Liimakka, Jaime Lora-Tamayo, Marjan Wouthuyzen-Bakker, Jesse W P Kuiper, Nemandra Sandiford, Antonia F Chen
BACKGROUND: Rheumatoid arthritis (RA) is a risk factor for periprosthetic joint infection (PJI) after total joint arthroplasty (TJA). The purpose of this study was to perform a systematic review comparing the failure rates of debridement, antibiotics, and implant retention (DAIR), one-stage exchange arthroplasty/revision (OSR), and 2-stage exchange arthroplasty/revision (TSR) for RA patients with PJI and identify risk factors in the RA population associated with increased treatment failure rate...
February 1, 2024: JBJS Reviews
#27
JOURNAL ARTICLE
A M Sallam, A A Faheim, Z A El-Elshafiey, M M Abdel Azeem, M G El Feky, M Y Hanfi
This work is mainly concerned with the effect of anthropogenic activities and natural radioactivity due to the presence of highly radioactive black sand spots, factory construction, and shipping, in addition to other activities like agriculture on human beings. Forty samples were collected along Baltim-El Burullus coastal plain to detect the effect of these problems and determine the suggested solutions. The black sand of the Baltim-El Burullus coastal plain exhibits a considerable amount of economically heavy minerals, their ratio relative to the bulk composition in the investigated samples ranges from 3...
February 15, 2024: Scientific Reports
#28
JOURNAL ARTICLE
Billy I Kim, Andrew M Schwartz, Colleen M Wixted, Isabel P Prado, Breanna A Polascik, Jessica L Seidelman, Thorsten M Seyler
BACKGROUND: Pseudomonas species are a less common but devastating pathogen family in prosthetic joint infections (PJIs). Despite advancements in management, Pseudomonas PJIs remain particularly difficult to treat because of limited antibiotic options and robust biofilm formation. This study aimed to evaluate Pseudomonas PJI outcomes at a single institution and review outcomes reported in the current literature. METHODS: All hip or knee PJIs at a single institution with positive Pseudomonas culture were evaluated...
February 13, 2024: Journal of the American Academy of Orthopaedic Surgeons
#29
JOURNAL ARTICLE
David Gallagher, Daire J Hurley, Brian O'Tuama, Emily Hughes, Tim Fulcher
SIGNIFICANCE: We evaluate the relationship between tear film osmolarity measurements and quality of vision in patients presenting for routine eye clinic appointments. We found that the hyperosmolar group (>316 mOsm/L) had a worse quality-of-vision score than the normal osmolarity group, with glare being the most problematic symptom. PURPOSE: Quality of vision is a perception and measure of real-world vision, which is not measured routinely in a clinical setting...
January 1, 2024: Optometry and Vision Science: Official Publication of the American Academy of Optometry
#30
JOURNAL ARTICLE
Sarah Kate Eustace, John Hynes, Aisling O Byrne, Daire Hurley, Orla Murray, Stephen Eustace
OBJECTIVES: To describe the percutaneous image-guided treatment of mucoid degeneration of the ACL causing deep knee pain on flexion in patients with advanced knee osteoarthritis. METHODS: Five patients with mucoid degeneration of the ACL complicating knee osteoarthritis underwent percutaneous image-guided steroid bupivacaine ACL sleeve injections over a 3-year period. RESULTS: There were four males and one female of mean age 54 (range 48-59 years)...
February 13, 2024: Irish Journal of Medical Science
#31
JOURNAL ARTICLE
Daniel L J Morris, Katherine Walstow, Lisa Pitt, Marie Morgan, Amol A Tambe, D I Clark, Timothy Cresswell, Marius P Espag
BACKGROUND: The Discovery Elbow System (DES) utilizes a polyethylene bearing within the ulnar component. An exchange bearing requires preoperative freezing and implantation within 2 minutes of freezer removal to allow insertion. We report our outcomes and experience using this technique. METHODS: This was an analysis of a two-surgeon consecutive series of DES bearing exchange. Inclusion criteria included patients in which exchange was attempted with a minimum 1-year follow-up...
January 26, 2024: Clinics in shoulder and elbow
#32
Alexei Buruian, Susana Angelo, Emanuel Seiça, Fábio Fernandes, António Mendes
A 57-year-old male, with chronic bilateral knee pain and a history of poorly controlled hyperuricemia leading to gouty attacks, underwent orthopedic assessment. Radiographic and MRI findings confirmed chronic gouty arthropathy with erosive bony defects, the most significant on the right proximal tibia. Total knee arthroplasty (TKA) was performed without any complications, addressing the bony defect with cement and a semi-constrained prosthesis. However, a gouty attack led to prolonged wound discharge and periprosthetic infection postoperatively, prompting revision surgery with debridement, antibiotics, and implant retention (DAIR)...
January 2024: Curēus
#33
JOURNAL ARTICLE
Lorena Casareto, Natasha M Appelman-Dijkstra, Maria Luisa Brandi, Roland Chapurlat, Valérie Cormier-Daire, Neveen A T Hamdy, Karen E Heath, Joachim Horn, Giovanna Mantovani, Klaus Mohnike, Sérgio Bernardo Sousa, André Travessa, Lena Lande Wekre, M Carola Zillikens, Luca Sangiorgi
There is no universally accepted definition for rare diseases: in Europe a disease is considered to be rare when affecting fewer than 1 in 2000 people. European Reference Networks (ERNs) have been the concrete response to address the unmet needs of rare disease patients and many pan-European issues in the field, reducing inequities, and significantly increasing accessibility to high-quality healthcare across Europe. ERNs are virtual networks, involving centres and patient representatives with the general scope to facilitate discussion on complex cases requiring highly specialised competences and trained expertise...
January 29, 2024: European Journal of Medical Genetics
#34
JOURNAL ARTICLE
Elke Thijs, Daire Hurley, Brendan Cummings, Dirk Elewaut, Nick Verougstraete, Ilse Claerhout, Conor C Murphy, William Power, Dimitri Roels
PURPOSE: The aim of this study was to report 2 cases of levamisole-adulterated cocaine-induced mucous membrane pemphigoid. METHODS: This study is a review of case reports and literature. RESULTS: Two patients presented with bilateral severe purulent conjunctivitis, corneal ulceration, and rapidly progressive forniceal shortening. Both patients were active cocaine users. A complete blood analysis showed a positive antineutrophil cytoplasmic antibody immunofluorescence with a mixed perinuclear antineutrophil cytoplasmic antibody and cytoplasmic-staining antineutrophil cytoplasmic antibody pattern...
January 31, 2024: Cornea
#35
JOURNAL ARTICLE
Mohamed Amine Haouari, Caroline Touloupas, Isabelle Boulay-Coletta, Nadia Fathallah, Lucas Spindler, Vincent de Parades, Marc Zins
PLACE DE L'IRM POUR EXPLORER LES PATHOLOGIES ANORECTALES. L'imagerie par résonance magnétique (IRM) est l'un des examens d'imagerie les plus utiles à l'exploration des pathologies ano rectales. Elle est complémentaire de l'examen clinique et de l'endo scopie. Elle permet de fournir des données indispensables à une prise en charge optimale du patient par le proctologue, le chirurgien ou l'oncologue en fonction de la nature de l'atteinte anale ou rectale. Il est nécessaire de respecter les différentes indications de cet examen, qui ont été bien définies pour chaque pathologie par les différentes sociétés savantes...
December 2023: La Revue du Praticien
#36
JOURNAL ARTICLE
Lessons from two series by physicians and caregivers' self-reported data in DDX3X-related disorders.
Valentin Ruault, Pauline Burger, Johanna Gradels-Hauguel, Nathalie Ruiz, Rami Abou Jamra, Alexandra Afenjar, Yves Alembik, Jean-Luc Alessandri, Stéphanie Arpin, Giulia Barcia, Šárka Bendová, Ange-Line Bruel, Perrine Charles, Nicolas Chatron, Maya Chopra, Solène Conrad, Valérie Cormier Daire, Auriane Cospain, Christine Coubes, Juliette Coursimault, Andrée Delahaye-Duriez, Martine Doco, William Dufour, Benjamin Durand, Camille Engel, Laurence Faivre, Fanny Ferroul, Mélanie Fradin, Hélène Frenkiel, Carlo Fusco, Livia Garavelli, Aurore Garde, Bénédicte Gerard, David Germanaud, Louise Goujon, Aurélie Gouronc, Emmanuelle Ginglinger, Alice Goldenberg, Miroslava Hancarova, Markéta Havlovicová, Delphine Heron, Bertrand Isidor, Nolwenn Jean Marçais, Boris Keren, Margarete Koch-Hogrebe, Paul Kuentz, Victoria Lamure, Anne-Sophie Lebre, François Lecoquierre, Natacha Lehman, Gaetan Lesca, Stanislas Lyonnet, Delphine Martin, Cyril Mignot, Teresa M Neuhann, Gaël Nicolas, Mathilde Nizon, Florence Petit, Christophe Philippe, Amélie Piton, Marzia Pollazzon, Darina Prchalová, Audrey Putoux, Marlène Rio, Sophie Rondeau, Massimiliano Rossi, Quentin Sabbagh, Pascale Saugier-Veber, Ariane Schmetz, Julie Steffann, Christel Thauvin-Robinet, Annick Toutain, Frederic Tran Mau Them, Gabriele Trimarchi, Marie Vincent, Markéta Vlčková, Dagmar Wieczorek, Marjolaine Willems, Kevin Yauy, Michaela Zelinová, Alban Ziegler, Boris Chaumette, Bekim Sadikovic, Jean-Louis Mandel, David Geneviève
INTRODUCTION AND METHODS: We report two series of individuals with DDX3X variations, one (48 individuals) from physicians and one (44 individuals) from caregivers. RESULTS: These two series include several symptoms in common, with fairly similar distribution, which suggests that caregivers' data are close to physicians' data. For example, both series identified early childhood symptoms that were not previously described: feeding difficulties, mean walking age, and age at first words...
January 2024: Molecular Genetics & Genomic Medicine
#37
JOURNAL ARTICLE
Quentin Hennocq, Marjolaine Willems, Jeanne Amiel, Stéphanie Arpin, Tania Attie-Bitach, Thomas Bongibault, Thomas Bouygues, Valérie Cormier-Daire, Pierre Corre, Klaus Dieterich, Maxime Douillet, Jean Feydy, Eva Galliani, Fabienne Giuliano, Stanislas Lyonnet, Arnaud Picard, Thantrira Porntaveetus, Marlène Rio, Flavien Rouxel, Vorasuk Shotelersuk, Annick Toutain, Kevin Yauy, David Geneviève, Roman H Khonsari, Nicolas Garcelon
The field of dysmorphology has been changed by the use Artificial Intelligence (AI) and the development of Next Generation Phenotyping (NGP). The aim of this study was to propose a new NGP model for predicting KS (Kabuki Syndrome) on 2D facial photographs and distinguish KS1 (KS type 1, KMT2D-related) from KS2 (KS type 2, KDM6A-related). We included retrospectively and prospectively, from 1998 to 2023, all frontal and lateral pictures of patients with a molecular confirmation of KS. After automatic preprocessing, we extracted geometric and textural features...
January 28, 2024: Scientific Reports
#38
JOURNAL ARTICLE
Daire Buckley, Ali S Khashan, Fergus P McCarthy, Karen O'Connor, Gillian M Maher
OBJECTIVE: To examine the association between threatened miscarriage, and neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in offspring by age 14 years. METHODS: We used data from the Millennium Cohort Study, a nationally representative longitudinal study of children born in the UK. Data on threatened miscarriage and potential confounders were maternal-reported and collected at 9 months postpartum...
January 28, 2024: Journal of Autism and Developmental Disorders
#39
JOURNAL ARTICLE
Dominik Szymski, Nike Walter, Katja Hierl, Markus Rupp, Volker Alt
BACKGROUND: The rise of periprosthetic joint infections (PJIs) due to aging populations is steadily increasing the number of arthroplasties and treatment costs. This study analyzed the direct health care costs of PJI for total hip arthroplasty and total knee arthroplasty (TKA) in Europe. METHODS: The databases PubMed, Scopus, Embase, Cochrane, and Google Scholar were systematically screened for direct costs of PJI in Europe. Publications that defined the joint site and the procedure performed were further analyzed...
January 23, 2024: Journal of Arthroplasty
#40
JOURNAL ARTICLE
Joyee Tseng, Victoria Oladipo, Siddhartha Dandamudi, Conor M Jones, Brett R Levine
INTRODUCTION: Periprosthetic joint infection (PJI) remains a serious complication after total knee arthroplasty (TKA). While debridement, antibiotics, and implant retention (DAIR) are considered for acute PJI, success rates vary. This study aims to assess a new scoring system's accuracy in predicting DAIR success. METHODS: 119 TKA patients (2008-2019) diagnosed with PJI who underwent DAIR were included for analysis. Data were collected on demographics, laboratory values, and clinical outcomes...
January 4, 2024: Antibiotics
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