Sidharth P Mishra, Shalini Jain, Bo Wang, Shaohua Wang, Brandi C Miller, Jea Y Lee, Cesar V Borlongan, Lin Jiang, Julie Pollak, Subhash Taraphder, Brian T Layden, Sushil G Rane, Hariom Yadav
Aging-related abnormalities in gut microbiota are associated with cognitive decline, depression, and anxiety, but underlying mechanisms remain unstudied. Here, our study demonstrated that transplanting old gut microbiota to young mice induced inflammation in the gut and brain coupled with cognitive decline, depression, and anxiety. We observed diminished mucin formation and increased gut permeability ("leaky gut") with a reduction in beneficial metabolites like butyrate because of decline in butyrate-producing bacteria in the aged gut microbiota...
February 8, 2024: JCI Insight