Raluca M Boteanu, Viorel I Suica, Luminita Ivan, Florentina Safciuc, Elena Uyy, Emanuel Dragan, Sorin M Croitoru, Valentina Grumezescu, Marioara Chiritoiu, Livia E Sima, Constantin Vlagioiu, Gabriel Socol, Felicia Antohe
Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing becomes a clinical problem and affects the patient's quality of life. We aimed to design a new bioactive surface of titanium implants with a synergetic PEG biopolymer-based composition for gradual delivery of growth factors (FGF2, VEGF, and BMP4) during bone healing. The optimal architecture of non-cytotoxic polymeric coatings deposited by dip coating under controlled parameters was assessed both in cultured cells and in a rat tibial defect model (100% viability)...
October 28, 2020: Scientific Reports