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"Advanced Glycation End Products"

Beatriz Paradela-Dobarro, Susana B Bravo, Adriana Rozados-Luís, Mercedes González-Peteiro, Alfonso Varela-Román, José Ramón González-Juanatey, Javier García-Seara, Ezequiel Alvarez
OBJECTIVES: Characterization of the type of glycation found in circulating proteins from cardiovascular patients in comparison with healthy control subjects and to explore the pathophysiological molecular effects of these glycomodified proteins on human umbilical vein endothelial cells (HUVEC) in culture. METHODS: Human serum albumin pools from 10 subjects each, of patients with heart failure (HF) presenting high or low glycation levels, and from healthy subjects were isolated and purified...
March 12, 2019: Biomedicine & Pharmacotherapy
Si-Yi Wang, Jie-Yao Li, Ji-Hao Xu, Zhong-Sheng Xia, Di Cheng, Wa Zhong, Yu Lai, Tao Yu, Qi-Kui Chen
Butyrate is widely accepted as a proliferation inhibitor in colon cancer but less thoroughly characterized in the colonic epithelium of objects with type 2 diabetes mellitus. The present study investigated the regulatory effect of butyrate on proliferation, the related molecule high-mobility group box 1 (HMGB1) and the receptor for advanced glycation end products (RAGE) in the colon of db/db type 2 diabetic model mice and non-cancerous NCM460 colon cells. Proliferation and the expression of HMGB1 and RAGE were increased and could be partially reversed by butyrate treatment in the colon of db/db mice, which were consistent in NCM460 cells under a high glucose state...
August 31, 2018: Journal of Pharmacological Sciences
Lívia Fontes da Silva, Erika Cavalheiro Skupien, Tássia Kirchmann Lazzari, Sizuane Rieger Holler, Ellis Gabriela Correa de Almeida, Luísa Rebechi Zampieri, Sandra Eugênia Coutinho, Michael Andrades, Denise Rossato Silva
INTRODUCTION: The receptor for advanced glycation end products (RAGE) is expressed in normal lungs and is upregulated during infection. AGEs and RAGE cause oxidative stress and apoptosis in lung cells. The objective of this study is to evaluate levels of AGEs and its soluble receptor (sRAGE), and to investigate their relationship with food intake and nutritional status, in a university-affiliated hospital in Brazil. METHODS: Case-control study, from June 2017 to June 2018...
2019: PloS One
Jiao Qin, Zhangzhe Peng, QiongJing Yuan, Qian Li, Yu Peng, Rui Wen, Zhaolan Hu, Jun Liu, Xiongfang Xia, Hong Deng, Xuan Xiong, Jinyue Hu, Lijian Tao
Diabetic nephropathy (DN) is a major complication of diabetes. Currently, drugs are not available to effectively control the disease. Fluorofenidone (AKF-PD) is a recently developed drug; it possesses activities in reducing DN progression in preclinical research. Nonetheless, its renal protection and the underlying mechanisms have not been thoroughly investigated. We report here that AKF-PD significantly alleviatesrenal oxidative stress (OS) in db/dbmice through downregulation of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase and upregulation of glutathione peroxidase and superoxide dismutase, thereby protecting kidney from DN pathogenesis...
March 13, 2019: Scientific Reports
Alice Barros Câmara, Igor Augusto Brandãob
BACKGROUND: Vitamin D (VD) deficiency affects individuals of different ages in many countries. VD deficiency may be related to several diseases, including cancer. OBJECTIVE: This study aimed to review the relationship between VD deficiency and cancer. METHOD: We describe the proteins involved in cancer pathogenesis and how those proteins can be influenced by VD deficiency. We also investigated a relationship between cancer death rate and solar radiation...
March 12, 2019: Anti-cancer Agents in Medicinal Chemistry
Marine Serveaux-Dancer, Matthieu Jabaudon, Isabelle Creveaux, Corinne Belville, Raïko Blondonnet, Christelle Gross, Jean-Michel Constantin, Loïc Blanchon, Vincent Sapin
The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NF κ B, Akt, p38, and MAP kinases) that initiate and perpetuate an unfavorable proinflammatory state. Due to these numerous functional activities, RAGE is implicated in multiple diseases. AGER is a highly polymorphic gene, with polymorphisms or SNP (single-nucleotide polymorphism) that could be responsible or co-responsible for disease development...
2019: Disease Markers
Hwai-Jeng Lin, Zhi-Pei Jiang, Horng-Ren Lo, Chun-Lung Feng, Chih-Jung Chen, Chia-Yu Yang, Mei-Zi Huang, Hui-Yu Wu, Yu-An Chen, Yu Chen, Cheng-Hsun Chiu, Chih-Ho Lai
The receptor for advanced glycation end products (RAGE) interacts with various molecules in the cell membrane to induce an inflammatory response. The cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Amongst, CdtA and CdtC interact with membrane lipid rafts, by which CdtB enters the nucleus to induce pathogenesis. In this study, we first explored the relationships between RAGE, lipid rafts, and inflammation in gastrointestinal epithelial cells exposed to CDT...
2019: Frontiers in Immunology
Weixiang Sun, Yuyan Gao, Yushi Ding, Ying Cao, Jing Chen, Gaohong Lv, Jinfu Lu, Bin Yu, Meilin Peng, Huiqin Xu, Yun Sun
Catalpol (Cat.) is an iridoid glucoside extracted from the root of Rehmannia glutinosa Libosch. In this study, we investigated whether Cat. could protect the mouse glomerular endothelial cells against the deleterious effect induced by advanced glycation end products (AGEs) and explored potential mechanisms. We found that 10 μM Cat. showed a protective effect on dead cells stimulated by AGEs. Cat. significantly decreased the expression of p-NF-κBp65 and inducible nitric oxide synthase (iNOS) and increased the expression of phosphorylated-endothelial nitric oxide synthase (p-eNOS; Ser1177), PI3K, p-Akt (Thr308), and total-Akt...
March 12, 2019: IUBMB Life
Lisa Strohbuecker, Hans Koenen, Esther van Rijssen, Bram van Cranenbroek, Esther Fasse, Irma Joosten, Andreas Körber, Christoph Bergmann
Purpose: Psoriasis vulgaris (PV) is an autoimmune-related chronic inflammatory disease of the skin, with both vascular and metabolic effects. Aggravating factors have been identified that initiate and maintain inflammation, including expression of Th1-, Th17-, and Th22-cell derived cytokines. Recently, we showed that the evolutionarily ancient and highly conserved damage-associated molecular pattern molecule "high mobility group box 1 (HMGB1)" is significantly increased in the serum of PV patients with disease progression and is decreased under standard therapies...
2019: Psoriasis: Targets and Therapy
Richard Kehm, Jana Rückriemen, Daniela Weber, Stefanie Deubel, Tilman Grune, Annika Höhn
Diet-induced hyperglycemia is described as one major contributor to the formation of advanced glycation end products (AGEs) under inflammatory conditions, crucial in type 2 diabetes progression. Previous studies have indicated high postprandial plasma AGE-levels in diabetic patients and after long-term carbohydrate feeding in animal models. Pancreatic islets play a key role in glucose metabolism; thus, their susceptibility to glycation reactions due to high amounts of dietary carbohydrates is of special interest...
March 11, 2019: Nutrition & Diabetes
Nanees Fouad El-Malkey, Nourelhuda A Mohammed, Amal Al-Shahat Ibrahim, Doaa M Abdullah
The effect of vitamin D on cardiac dysfunction after menopause is still under investigation. Therefore, we investigated the effect of vitamin D3 on cardiac apoptotic and structural changes in ovariectomized rats. Forty adult female albino rats were divided into 4 equal groups: sham rats, sham rats treated with vitamin D3, ovariectomized rats and ovariectomized rats treated with vitamin D3 (500 IU/kg/day/6 weeks, orally). Body weight, blood pressure, heart rate and whole heart weight (WHW) were measured. Serum soluble receptors of advanced glycation end products (sRAGE), C-reactive protein (CRP), malondialdehyde and total antioxidant capacity (TAC) were estimated...
March 11, 2019: Canadian Journal of Physiology and Pharmacology
Elaheh Foroumandi, Mohammad Alizadeh, Sorayya Kheirouri, Mohammad Asghari Jafarabadi
This study aimed to identify any association of serum nitric oxide (NO) and advanced glycation end products (AGEs) with body mass index (BMI) in apparently healthy subjects. In this cross-sectional study, participants were 90 apparently healthy subjects, categorized into three BMI groups as follows: BMI≤19.5 (n = 21), 19.6≤BMI≤24.9 (n = 35), and BMI≥25 (n = 34). Serum levels of NO were measured by griess reaction method. Determination of serum pentosidine and carboxymethyllysine (CML) was done using ELISA...
2019: PloS One
Sho-Ichi Yamagishi, Ami Sotokawauchi, Takanori Matsui
Accumulating evidence has shown that incidence of atrial fibrillation (AF) is higher in patients with diabetes, especially those with poor glycemic control or long disease duration. Non-enzymatic glycation of amino acids of proteins, lipids, and nucleic acids has progressed under normal aging process and/or diabetic condition, which could lead to the formation and accumulation of advanced glycation end products (AGEs). AGEs not only alter the tertiary structure and physiological function of macromolecules, but also evoke inflammatory and fibrotic reactions through the interaction of cell surface receptor for AGEs (RAGE), thereby being involved in aging-related disorders...
March 11, 2019: Mini Reviews in Medicinal Chemistry
Song-Tao Tang, Hai-Qin Tang, Huan Su, Yi Wang, Qing Zhou, Qiu Zhang, Yuan Wang, Hua-Qing Zhu
OBJECTIVE: Glucagon-like peptide-1 (GLP-1) showed protective effects on endothelium-dependent dilatation. Since endothelial barrier dysfunction also plays a pivotal role in atherosclerosis, this study was designed to investigate the effects of GLP-1 on endothelial barrier function in diabetic aortic endothelium and explore the underlying mechanism. METHODS: For in vivo studies, diabetic rats were established and subjected to 12- and 24-week treatment of exenatide...
March 7, 2019: Biomedicine & Pharmacotherapy
Hitoshi Takamatsu, Ken-Ichi Yamamoto, Nahoko Tomonobu, Hitoshi Murata, Yusuke Inoue, Akira Yamauchi, I Wayan Sumardika, Chen Youyi, Rie Kinoshita, Masahiro Yamamura, Hideyo Fujiwara, Yosuke Mitsui, Kota Araki, Junichiro Futami, Ken Saito, Hidekazu Iioka, I Made Winarsa Ruma, Endy Widya Putranto, Masahiro Nishibori, Eisaku Kondo, Yasuhiko Yamamoto, Shinichi Toyooka, Masakiyo Sakaguchi
The fertile stroma in pancreatic ductal adenocarcinomas (PDACs) has been suspected to greatly contribute to PDAC progression. Since the main cell constituents of the stroma are fibroblasts, there is cross-talking(s) between PDAC cells and surrounding fibroblasts in the stroma, which induces a fibroblast proliferation burst. We have reported that several malignant cancer cells including PDAC cells secrete a pronounced level of S100A11, which in turn stimulates proliferation of cancer cells via the receptor for advanced glycation end products (RAGE) in an autocrine manner...
March 8, 2019: Oncology Research
Naonori Masuda, Hiroki Tsujinaka, Hiromasa Hirai, Mariko Yamashita, Tetsuo Ueda, Nahoko Ogata
BACKGROUND: Amyloid beta (Aβ) is a constituent of drusen that is a common sign of age-related macular degeneration (AMD). The purpose of this study was to investigate the effect of Aβ on human retinal pigment epithelial (RPE) cells in culture. METHODS: Cells from a human RPE cell line (ARPE-19) were exposed to 0 to 25 μM of Aβ 1-40 for 48 h, and the number of living cells was determined by WST-8 cleavage. Replicative DNA synthesis was measured by the incorporation of 5'-bromo-2'-deoxyuridine...
March 8, 2019: BMC Ophthalmology
Xiaojing Yan, Yue Zhuo, Xiqing Bian, Jianmin Li, Yida Zhang, Lidong Ma, Guanghua Lu, Ming-Quan Guo, Jian-Lin Wu, Na Li
Toosendanin (TSN), a compound from Melia toosendan, exerts severe hepatotoxicity, which restricts its clinical application. However, the mechanism is not clear. Our previous research found that covalent modification of TSN for proteins might be a possible reason using human liver microsome, and the glycolytic enzymes, triosephosphate isomerase 1 (TPIS) and α-enolase (ENOA), were responsible for the hepatotoxicity. In this study, we tried to prove them in cell and animal models by integration of proteomics, metabolomics and biological methods...
March 8, 2019: Chemical Research in Toxicology
Chia-Liang Wang, Kuan-Pin Lin, Guoo-Shyng W Hsu, Kai-Li Liu, Chih-Hung Guo
Patients undergoing long-term hemodialysis (HD) are known to have abnormal blood concentrations of antioxidant minerals; concurrent oxidative stress can contribute to increased vascular calcification. This study aims to evaluate the associations between circulating antioxidant minerals and clinical biomarkers of vascular calcification in HD patients. Blood biochemical parameters, antioxidant minerals (selenium (Se), zinc (Zn), copper (Cu), and magnesium (Mg)), and several promoters and inhibitors of calcification (matrix Gla protein (MGP), fibroblast growth factor-23 (FGF-23), matrix metalloproteinases (MMP-2 and -9), and tissue inhibitors of metalloproteinase (TIMP-1 and -2)) were determined in HD patients (n = 62) and age- and sex-matched healthy individuals (n = 30)...
March 7, 2019: Biological Trace Element Research
Annabel Biruete, Kathleen M Hill Gallant, Stephen R Lindemann, Gretchen N Wiese, Neal X Chen, Sharon M Moe
Phosphate binders are commonly prescribed in patients with end-stage kidney disease to prevent and treat hyperphosphatemia. These binders are usually associated with gastrointestinal distress, may bind molecules other than phosphate, and may alter the gut microbiota, altogether having systemic effects unrelated to phosphate control. Sevelamer is the most studied of the available binders for nonphosphate-related effects including binding to bile acids, endotoxins, gut microbiota-derived metabolites, and advanced glycation end products...
March 4, 2019: Journal of Renal Nutrition
Anu Kajal, Randhir Singh
Inthe present study, we have demonstrated the phytochemical composition of petroleum ether extract of C. sativum (CPE) seeds by using chromatographic, spectroscopic as well spectrometric analysis. CPE was evaluated for its possible role in mitigation of diabetic nephropathy (DN) in Streptozotocin (STZ)-nicotinamide (NAD) induced type 2 diabetes model. Administration of CPE at doses of 100, 200, and 400 mg/kg for 45 days has produced significant attenuation of elevated biochemical parameters including serum glucose, lipid and creatinine levels...
2019: PloS One
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