keyword
https://read.qxmd.com/read/38530580/assessment-of-pheniramine-in-alternative-biological-matrices-by-liquid-chromatography-tandem-mass-spectrometry
#1
JOURNAL ARTICLE
Humera Shafi Makhdoom, Ali Imran Abid, Majida Mujahid, Saira Afzal, Kishwar Sultana, Nisar Hussain, Kashif Barkat
Pheniramine is an over-the-counter antihistamine drug. Its accessibility and low cost made it more popular among drug abusers in Pakistan. In this study, pheniramine was quantified in both conventional and alternative specimens of twenty chronic drug abusers, aged 16-50 years, who were positive for pheniramine in comprehensive toxicological screening for drugs by gas chromatography with mass spectral detection in positive electron impact mode. Pheniramine was extracted from biological specimens using solid phase extraction and liquid chromatography tandem mass spectrometry was employed for quantification...
March 26, 2024: Forensic Science, Medicine, and Pathology
https://read.qxmd.com/read/38527894/comparative-evaluation-of-spe-methods-for-biotoxicity-assessment-of-water-and-wastewater-linkage-between-chemical-extracting-efficiency-and-biotoxicity-outcome
#2
JOURNAL ARTICLE
Jiawei Zhou, Shihao Wang, Xiwei He, Hongqiang Ren, Xu-Xiang Zhang
Biotoxicity assessment results of environmental waters largely depend on the sample extraction protocols that enrich pollutants to meet the effect-trigger thresholds of bioassays. However, more chemical mixture does not necessarily translate to higher combined biotoxicity. Thus, there is a need to establish the link between chemical extracting efficiency and biotoxicity outcome to standardize extraction methods for biotoxicity assessment of environmental waters. This study compares the performance of five different extraction phases in solid phase extraction (SPE), namely HLB, HLB+Coconut, C18 cartridge, C18 disk and Strata-X, and evaluated their chemical extracting efficiencies and biotoxicity outcomes...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38526815/analysis-and-identification-of-phenolic-compounds-with-antiproliferative-activity-from-chinese-olive-canarium-album-l-fruit-extract-by-hplc-dad-spe-tt-nmr
#3
JOURNAL ARTICLE
Yu-Te Yeh, Chien-Kuang Chen, Yi-Chun Liao, Shoei-Sheng Lee, Shu-Chen Hsieh
Chinese olives (Canarium album L.) are rich in phenolic compounds, exhibiting a broad spectrum of potential clinical applications. This study is the first report on the isolation and elucidation of bioactive compounds with high antiproliferative activity from the ethyl acetate fraction of a Chinese olive fruit methanolic extract (CO-EtOAc). We used the WST-1 assay to determine which subfractions of CO-EtOAc had significant antiproliferative activity using the murine colon cancer cell line CT26. Subsequently, the functional compounds were characterized by the hyphenated technique and high-performance liquid chromatography-diode array detector-solid phase extraction-transfer tube-nuclear magnetic resonance (HPLC-DAD-SPE-TT-NMR)...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38524584/simultaneous-determination-of-28-illegal-drugs-in-sewage-by-high-throughput-online-spe-istd-uhplc-ms-ms
#4
JOURNAL ARTICLE
Shunqin Chen, Han Yang, Shan Zhang, Faze Zhu, Shan Liu, Huan Gao, Qing Diao, Wenbo Ding, Yuemeng Chen, Peng Luo, Yubo Liu
This study developed an online solid-phase extraction ultra-high performance liquid chromatography-tandem mass spectrometry (Online-SPE-UHPLC-MS/MS) method for the analysis of 28 illegal drugs in sewage. To achieve this, 28 isotope internal standards (ISTDs) were added to 3 mL sewage samples, the pH was adjusted to 7-8 using hydrochloric acid or 20% ammonia water, followed by centrifugation, filtration, and analysis using UHPLC-MS/MS. The results indicated an excellent linearity of 1-300 ng L-1 , and cotinine in the concentration range of 20-6000 ng L-1 , linear correlation coefficient R2  > 0...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524455/development-and-validation-of-uflc-ms-ms-analytical-method-for-the-simultaneous-quantification-of-antibiotic-residues-in-surface-water-groundwater-and-pharmaceutical-waste-water-samples-from-south-india
#5
JOURNAL ARTICLE
Sravani Kamatham, Manoharan Seeralan, Uma Sekar, Sujatha Kuppusamy
Antibiotic residues in pharmaceutical wastewater pose a significant environmental concern due to their potential role in fostering antimicrobial resistance. South Indian pharmaceutical companies produce a wide range of antibiotics. As a result, the industries that discharge water may include antibiotic residues, which could be harmful to the environment. In this study, a novel, quick, accurate, and sensitive approach for the simultaneous detection of 11 antibiotics was established, and triple quadrupole mass spectrometry, ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS), and selective solid-phase extraction (SPE) were used for validation...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38522407/a-solid-liquid-microextraction-approach-from-a-spot-in-an-adsorbent-layer-of-a-chromatographic-plate
#6
JOURNAL ARTICLE
Rafał Gajos, Anna Klimek-Turek, Tadeusz H Dzido
A new approach to extracting substances from a spot on a chromatographic plate for subsequent liquid chromatography-mass spectrometry analysis is described. This method involves extraction in a solid phase (an adsorbent layer of a chromatographic plate) - a liquid system using a simple device. For a single extraction of six selected coccidiostats from the adsorbent layer on the chromatographic plate with silica gel, 50 µL of methanol was used for 5 min. The data from the extraction experiments and liquid chromatography-mass spectrometry measurements demonstrated a good correlation between the ratio of the peak areas of the coccidiostats to the internal standard and the concentration of the substances in the range of two orders of magnitude...
March 18, 2024: Journal of Chromatography. A
https://read.qxmd.com/read/38522298/in-tube-solid-phase-extraction-with-graphitic-based-polyurethane-sponge-as-a-superhydrophobic-sorbent-and-determination-of-drug-residues-in-foodstuffs-using-high-performance-liquid-chromatography
#7
JOURNAL ARTICLE
Sidra Iram, Zahra Nazar, Muhammad Sajid, Thomas William Chamberlain, Muhammad Furqan Nawaz, Muhammad Mahboob Ahmed, Muhammad Kashif
Veterinary drugs used in animal husbandry raise public health concerns due to their residues in the bodies of animals. This study employs a simple and quick sample preparation technique, in-tube solid phase extraction, to extract drug residues from foodstuffs, including eggs, honey, and water. This technique utilizes the synergy of graphitic-based materials and polyurethane sponges (PU) combined through dip coating method to make reusable sorbents for extracting drugs, including amoxicillin, paracetamol, ciprofloxacin, and cefixime...
March 20, 2024: Food Chemistry
https://read.qxmd.com/read/38522130/a-high-throughput-method-for-the-determination-of-14-uv-filters-in-human-plasma-by-lc-ms-ms-minimize-interferences-from-proteins-and-phospholipids-in-the-matrix
#8
JOURNAL ARTICLE
Wucheng Yang, Jianglu Feng, Wenyao Liang, Mingxia Nie, Jianhua Tan, Ruifang Fan
Accurate monitoring of UV-filters exposure levels in human plasma is a challenge because of the significant differences in the physicochemical properties of UV-filters, as well as the matrix effect caused by abundant proteins and phospholipids in plasma. Therefore, an effective and rapid method for simultaneous determination of 14 UV-filters in human plasma using protein precipitation-solid phase extraction (SPE) coupled with liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed. Acetonitrile with 0...
March 20, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38520897/analysis-of-vitamin-d-and-its-metabolites-in-biological-samples-part-ii-optimization-of-a-sample-preparation-method-for-liver-tissue
#9
JOURNAL ARTICLE
Veronika Pilařová, Bárbara Socas-Rodríguez, Lucie Nováková, Cecilia Holm, Margareta Sandahl, Charlotta Turner
Extraction of vitamin D, including its hydroxylated and esterified metabolites, from soft tissues such as the liver is challenging due to the lipophilic character of matrix and analytes that are expected in very low concentration levels. In this study, we aimed at the optimization of two-step extraction using solid-liquid extraction as the first step, followed by solid-phase extraction. Various solvents, including ethanol, acetonitrile, methanol, acetone, heptane, and heptane with isopropanol, were investigated to isolate vitamin D compounds from liver tissue in the first step...
March 11, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38520247/use-of-the-dummy-approach-for-the-synthesis-of-ion-imprinted-polymers-with-ni-ii-or-zn-ii-as-template-ion-for-the-solid-phase-extraction-of-cu-ii
#10
JOURNAL ARTICLE
Pengchao Cao, Valérie Pichon, Catherine Dreanno, Kada Boukerma, Nathalie Delaunay
There is a strong interest in monitoring copper in environmental waters, but its direct analysis suffers from strong matrix interferences. This is why, a sample pretreatment based on solid-phase extraction (SPE) is often used but conventional sorbents usually lack specificity. It is overcome with ion-imprinted polymers (IIPs). This work evaluates for the first time the use of the dummy approach for the synthesis of Cu(II)-targeting IIPs. Two analog ions Ni(II) and Zn(II) were tested as templates and the resulting IIPs were packed in SPE cartridges...
March 2024: Journal of Separation Science
https://read.qxmd.com/read/38519512/volatile-profile-of-bee-bread
#11
JOURNAL ARTICLE
Katarzyna Pokajewicz, Darya Lamaka, Nataliia Hudz, Leonora Adamchuk, Piotr Paweł Wieczorek
Bee bread is one of the least studied bee products. In this study, ten bee bread samples were characterized using palynology and HS-SPME-GC-MS (headspace solid-phase microextraction gas chromatography-mass spectrometry). In total, over one hundred different volatile components were identified, belonging to different chemical groups. Only ten common components were detected in all the samples. These volatiles were ethanol, ethylene chloride, ethyl acetate, acetic acid, α-pinene, furfural, nonane, nonanal, n-hexane and isovaleric acid...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38519156/pressurized-liquid-extraction-assisted-by-high-intensity-ultrasound-to-obtain-hesperidin-from-lime-waste-integration-of-in-line-purification-and-on-line-chromatographic-analysis
#12
JOURNAL ARTICLE
Vitor L Sanches, Monique Martins Strieder, Marcia Cristina Breitkreitz, Rosângela Maria Neves Bezerra, Jaísa O Chaves, Isadora Lopes de Oliveira, Leonardo M de Souza Mesquita, Juliane Viganó, Letícia Sanches Contieri, Rodrigo Stein Pizani, Maurício A Rostagno
Hesperidin is a phenolic compound usually found in citrus fruits, which is known for its anti-inflammatory and antioxidant properties. This bioactive compound has already been used to formulate medications to treat chronic venous insufficiency. In this work, through a system which allows the in-line coupling of the pressurized liquid extraction (PLE) and high-intensity ultrasound (HIUS) with solid phase extraction (SPE), and analysis by high-performance liquid chromatography with UV-Vis detector (HPLC-UV) in on-line mode, a method was developed to obtain, separate, and quantify hesperidin from the industrial waste of lime...
April 2024: Food Research International
https://read.qxmd.com/read/38516858/sensitive-detection-of-herbicide-residues-using-field-amplified-sample-injection-coupled-with-electrokinetic-supercharging-in-flow-gated-capillary-electrophoresis
#13
JOURNAL ARTICLE
Ying Gong, Maojun Gong
Residues of glyphosate (GlyP) and its major degradation product, aminomethylphosphonic acid (AMPA), widely exist in the water system and plant products and thus are also present in the bodies of animals and humans. Although no solid evidence has been obtained, the concern about the cancer risk of GlyP is persistent. The measurement of GlyP and AMPA in trace levels is often needed but lacks readily available analytical approaches with detection sensitivity, accuracy and speed. This study aims to develop a simple and robust technique for the sensitive detection of GlyP and AMPA residues in a surface water system with flow-gated capillary electrophoresis (CE)...
March 22, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38516662/organ-level-distribution-tandem-mass-spectrometry-analysis-of-three-structural-types-of-brassinosteroids-in-rapeseed
#14
JOURNAL ARTICLE
Jianhua Tong, Wenkui Zhao, Keming Wang, Danyi Deng, Langtao Xiao
BACKGROUND: Brassinosteroids (BRs) are a class of naturally occurring steroidal phytohormones mediating a wide range of pivotal developmental and physiological functions throughout the plant's life cycle. Therefore, it is of great significance to determine the content and the distribution of BRs in plants.Regretfully, although a large number of quantitative methods for BRs by liquid chromatography-tandem mass spectrometry (LC-MS/MS) have been reported, the in planta distribution of BRs is still unclear because of their lower contents in plant tissues and the lack of effective ionizable groups in their chemical structures...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38516194/anion-exchange-hplc-monitoring-of-mrna-in-vitro-transcription-reactions-to-support-mrna-manufacturing-process-development
#15
JOURNAL ARTICLE
Emma N Welbourne, Kate A Loveday, Adithya Nair, Ehsan Nourafkan, Jixin Qu, Ken Cook, Zoltán Kis, Mark J Dickman
mRNA technology has recently demonstrated the ability to significantly change the timeline for developing and delivering a new vaccine from years to months. The potential of mRNA technology for rapid vaccine development has recently been highlighted by the successful development and approval of two mRNA vaccines for COVID-19. Importantly, this RNA-based approach holds promise for treatments beyond vaccines and infectious diseases, e.g., treatments for cancer, metabolic disorders, cardiovascular conditions, and autoimmune diseases...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38515656/determination-of-nitrofuran-metabolites-and-nifurpirinol-in-animal-tissues-and-eggs-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-validated-according-to-regulation-eu-2021-808
#16
JOURNAL ARTICLE
Francisco Moragues, Pablo Miralles, Carmen Igualada, Clara Coscollà
In this work, an analytical method for the determination of eight non-allowed nitrofurans, including nifurpirinol and the metabolites of furazolidone, furaltadone, nitrofurantoin, nitrofurazone, nifursol, nitrovin, and nifuroxazide in animal tissues, including muscle (poultry, bovine, ovine, porcine, rabbit, and fish), kidney (bovine, ovine, porcine), and eggs, has been developed and validated according to Regulation (EU) 2021/808. The method was based on derivatization with 2-nitrobenzaldehyde in acid medium, followed by vortex-assisted liquid-liquid extraction and solid phase extraction for sample purification prior to ultra-high performance liquid chromatography-tandem mass spectrometry...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38513888/sex-bmi-and-apoe4-increase-plasma-pl-epa-response-during-an-omega-3-fatty-acids-supplementation-a-secondary-analysis
#17
JOURNAL ARTICLE
Insaf Loukil, Ester Cisneros Aguilera, Annick Vachon, Pauline Léveillé, Mélanie Plourde
UNLABELLED: The brain is concentrated in omega-3 fatty acids (ω3 FAs) and these FAs must come from the plasma pool. The two main ω3 FAs, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), must be non esterified (NEFA) or esterified in phospholipid (PL) to reach the brain. We hypothesized that the plasma levels of these ω3 FAs can be modulated by sex, body mass index (BMI), age, and the presence of the apolipoprotein E epsilon 4 allele (APOE4) in response to the supplementation...
March 19, 2024: Journal of Nutrition
https://read.qxmd.com/read/38513494/rapidly-enrichment-and-detection-of-per-and-polyfluoroalkyl-substances-in-foods-using-a-novel-bifunctional-covalent-organic-framework
#18
JOURNAL ARTICLE
Jing Gong, Xingyuan Zhang, Rongyao Liang, Juanqiong Ma, Na Yang, Kaiwei Cai, Jinyun Wu, Zhiyong Xie, Shusheng Zhang, Yanlong Chen, Qiongfeng Liao
Per- and polyfluoroalkyl substances (PFASs) are extensively found in foods, posing potential toxicity to humans. Therefore, rapid analysis and monitoring of PFASs in foods are crucial for public health and also a challenge. To detect trace PFASs in foods, construction of sorbents with multiple interactions could be an effective approach. Herein, a cationic-fluorinated covalent organic framework (CF-COF) was prepared by post-modification and used as a magnetic solid-phase extraction adsorbent for adsorption of PFASs...
March 16, 2024: Food Chemistry
https://read.qxmd.com/read/38513429/simultaneous-determination-of-twelve-neonicotinoids-and-six-metabolites-in-human-urine-with-isotope-dilution-uplc-q-orbitrap-hrms
#19
JOURNAL ARTICLE
Boya Zhang, Zheng Wang, Jiming Zhang, Yiming Dai, Jiayun Ding, Jianqiu Guo, Yuhang Chen, Dasheng Lu, Chunhua Wu, Zhijun Zhou
The extensive global use of neonicotinoid insecticides (NNIs) has led to widespread human exposure, necessitating the development of effective methods for large-scale biomonitoring. However, current methods are inadequate in simultaneously and accurately detecting various NNIs or their metabolites (m-NNIs). In this study, we aimed to establish a robust method using solid-phase extraction (SPE)-ultra high performance liquid chromatography tandem Q-Orbitrap high resolution mass spectrometry (UPLC-Q-Orbitrap HRMS) for the simultaneous determination of 12 NNIs and 6 m-NNIs in human urine...
March 14, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38512591/validation-of-a-size-exclusion-method-for-concomitant-purification-and-formulation-of-peptide-radiopharmaceuticals
#20
JOURNAL ARTICLE
Sebastian Martin, Lennard Wendlinger, Alexandra Litvinenko, Radmila Faizova, Margret Schottelius
BACKGROUND: Both in clinical routine and in preclinical research, the established standard procedure for the final purification of radiometal-labeled peptide radiopharmaceuticals is cartridge-based reversed-phase (RP) solid phase extraction (SPE). It allows the rapid and quantitative separation of the radiolabeled peptide from hydrophilic impurities and easy integration into automated synthesis procedures. However, product elution from RP cartridges necessitates the use of organic solvents and product recovery is sometimes limited...
March 21, 2024: EJNMMI Radiopharmacy and Chemistry
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