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A M Heeren, J Rotman, A G M Stam, N Pocorni, A A Gassama, S Samuels, M C G Bleeker, C H Mom, H J M A A Zijlmans, G G Kenter, E S Jordanova, T D de Gruijl
BACKGROUND: Cervical cancer (CxCa) is mainly a locally invading disease that metastasizes to loco-regional lymph node basins before involving distant organs in more advanced stages. Local immune potentiation of tumor-draining lymph nodes (TDLN) may thus protect against tumor progression. METHODS: To identify therapeutic targets for local immune modulation, multi-parameter flow cytometric T-cell profiling of primary cervical tumors (PT) and TDLN (n = 37) was performed...
February 12, 2019: Journal for Immunotherapy of Cancer
Amitis Ramezani, Arezoo Aghakhani, Sepehr Soleymani, Anahita Bavand, Azam Bolhassani
BACKGROUND: Among different types of human papillomavirus (HPV), types 16 and 18 were known to be high-risk agents causing mainly cervical cancer. Up to now, the potential of HPV E7 protein has been proved as a diagnostic marker of cervical cancer. Moreover, the levels of anti-heat shock protein (Hsp) and anti-high mobility group box-1 (HMGB1) antibodies in cancer patients have been useful in tumor diagnosis. The goal of the present study was to determine the efficiency of the potential serologic markers including HPV E7, Hsp20, Hsp27 proteins and Hp91 peptide in Iranian HPV-exposed women, for the first time...
February 12, 2019: BMC Infectious Diseases
Yang Yang, He-Xiao Wang, Lan Zhang, Wei Huo, Xiao-Dong Li, Rui-Qun Qi, Xiao-Yu Song, Shi Wei, Xing-Hua Gao, Shuai Han, Liu Cao
Hyperthermia has been clinically utilized as an adjuvant therapy in the treatment of cervical carcinoma. However, thermotolerance induced by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperthermic therapy, for which the exact mechanism remains unknown. In the present study, we found that heat treatment induced HO-1 expression and decreased copy number of HPV16 in cervical cancer cells and tissues from cervical cancer and precursor lesions. Knockdown of HO-1 stimulated autophagy accompanied by downregulation of X-linked inhibitor of apoptosis protein...
2019: International Journal of Biological Sciences
Yanmei Ge, Shanliang Zhong, Meng Ren, Yanping Ge, Yuan Mao, Peng Cao
BACKGROUND: The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China. METHODS: A total of 65,613 women aged 16-85 years were recruited from Nanjing Kingmed Diagnostics, including 45,736 outpatients and 19,877 healthy women. The cervico-vaginal cells were collected and then HPV types were detected using the Tellgenplex™ HPV DNA Test...
February 11, 2019: BMC Public Health
Chuqing Zhang, Yunjing Luo, Rugang Zhong, Priscilla T Y Law, Siaw Shi Boon, Zigui Chen, Chi-Hang Wong, Paul K S Chan
BACKGROUND: Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one of these co-factors. Epidemiologic studies have associated high PAH exposure with increased risk for cancer development. To date, many studies focus on benzo[a]pyrene, however, the role of other PAHs should not be neglected. This study aimed to compare the potential of different PAHs as a co-factor in HPV-mediated carcinogenesis, and to investigate the possible mechanisms involved...
February 11, 2019: BMC Cancer
Yang Yang, Yuxin Che, Yan Zhao, Xuelian Wang
No licensed therapeutic human papillomavirus (HPV) vaccine is currently available, so it remains a high priority to develop a therapeutic HPV vaccine or prophylactic/therapeutic HPV vaccine for cervical cancer. In this current study, we designed an HPV vaccine including CpG oligodeoxynucleotides 1826 as an adjuvant and HPV16 E7 43-77 peptide as antigen, which contains a CD8 T cell epitope (E7 49-57), and two CD4 T cell epitopes (E7 43-77 and E7 50-62). The prophylactic and therapeutic effect on cervical cancer induced by a single administration of vaccine, were comprehensively evaluated by examining the tumor size and the percentage of tumor-free/bearing mice...
February 8, 2019: International Immunopharmacology
Giorgio Bogani, Antonino Ditto, Stefano Ferla, Biagio Paolini, Claudia Lombardo, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: We have investigated outcomes of women presenting with recurrent high-grade vaginal intra-epithelial neoplasia. METHODS: Data of consecutive women diagnosed with recurrent high-grade vaginal intra-epithelial neoplasia after primary treatment(s) were retrieved. Risk of developing new recurrence over the time was assessed using Kaplan-Meier and Cox models. RESULTS: Data of 117 women were available for the analysis. At primary diagnosis, 41 (35%), 4 (3...
November 8, 2018: Journal of Gynecologic Oncology
Gary M Clifford, Vanessa Tenet, Damien Georges, Laia Alemany, Miquel Angel Pavón, Zigui Chen, Meredith Yeager, Michael Cullen, Joseph F Boland, Sara Bass, Mia Steinberg, Tina Raine-Bennett, Thomas Lorey, Nicolas Wentzensen, Joan Walker, Rosemary Zuna, Mark Schiffman, Lisa Mirabello
BACKGROUND: Human papillomavirus (HPV)16 can be separated into genetic sub-lineages (A1-4, B1-4, C1-4, D1-4) which may have differential cervical cancer risk. METHODS: A next-generation sequencing assay was used to whole-genome sequence 7116 HPV16-positive cervical samples from well-characterised international epidemiological studies, including 2076 controls, 1878 squamous cell carcinoma (SCC) and 186 adenocarcinoma/adenosquamous cell carcinoma (ADC), and to assign HPV16 sub-lineage...
February 6, 2019: Papillomavirus Research
Jing Wang, Dandan Tang, Jialu Wang, Zhaoxia Zhang, Yanxia Chen, Kai Wang, Xueliang Zhang, Cailing Ma
BACKGROUND: Genotype distribution and prevalence of human papillomavirus (HPV) among women vary from different regions and crowds, prophylactic HPV vaccin could prevent some diseases related to HPV, which include cervical precancerous lesions and cancer. Baseline surveys prior to mass HPV vaccination are critical to determine vaccine efficacy and detect changes in HPV type after vaccination. OBJECTIVE: The aim of this study is to study the HPV type-specific prevalence in 698 women with cytological abnormalities, aging from 18 to 77 years old...
February 8, 2019: Human Vaccines & Immunotherapeutics
Marta Checchi, David Mesher, Hamish Mohammed, Kate Soldan
OBJECTIVES: In 2008, a national human papillomavirus (HPV) vaccination programme for females was introduced in England using the bivalent vaccine (HPV16 and 18 only). In 2012, the programme changed to offer the quadrivalent vaccine that includes protection against the two HPV types that cause the majority of anogenital warts (AGW; HPV6 and 11). We present data reporting AGW diagnoses in sexual health clinics (SHCs) in England to the end of 2017, including diagnoses among birth cohorts offered the quadrivalent vaccine...
February 5, 2019: Sexually Transmitted Infections
Xiaoning Luo, Erich M Sturgis, Zheng Yang, Yan Sun, Peng Wei, Zhensheng Liu, Qingyi Wei, Guojun Li
Since lymphocyte telomere length (LTL) plays critical roles in the maintenance of genomic stability and integrity, LTL thus may influence the etiology and prognosis of squamous cell carcinoma of the oropharynx (SCCOP). However, given the association between LTL and risk of HPV-associated SCCOP and between LTL and tumor HPV status of SCCOP, we hypothesized that LTL is associated with SCCOP prognosis, particularly in HPV-positive patients after definitive radiotherapy. LTL and tumor HPV type 16 (HPV16) status were determined in 564 incident SCCOP patients before radiotherapy or chemoradiation...
February 5, 2019: Carcinogenesis
Penelope Gray, Tapio Luostarinen, Simopekka Vänskä, Tiina Eriksson, Camilla Lagheden, Irene Man, Johanna Palmroth, Ville N Pimenoff, Anna Söderlund-Strand, Joakim Dillner, Matti Lehtinen
Oncogenic non-vaccine human papillomavirus (HPV) types may conceivably fill the vacated ecological niche of the vaccine types. The likelihood of this may differ by the risk of acquiring HPV infections. We examined occurrence of HPV types among vaccinated and unvaccinated subgroups of 1992-1994 birth cohorts with differing acquisition risks up to 9 years post-implementation of HPV vaccination in 33 Finnish communities randomized to: Arm A (gender-neutral HPV16/18 vaccination), Arm B (girls-only HPV16/18 vaccination and hepatitis B-virus (HBV) vaccination of boys), and Arm C (gender-neutral HBV vaccination)...
February 5, 2019: International Journal of Cancer. Journal International du Cancer
Lucia Sommerova, Milan Anton, Pavla Bouchalova, Hedvika Frankova, Vladimír Rak, Eva Jandakova, Iveta Selingerova, Martin Bartosik, Borivoj Vojtesek, Roman Hrstka
Cervical cancer is one of the most common malignancies in women. MicroRNAs (miRNAs) are involved in a variety of fundamental cellular processes, including carcinogenesis. The potential utilization of aberrantly expressed miRNAs as novel biomarkers in cervical cancer diagnostics is growing. We investigated miRNA expression profiles during the progression of dysplasia in cervical epithelium to identify aberrantly expressed miRNAs. High-throughput miRNA profiling of high grade precancerous lesions identified 79 miRNAs showing significant difference in expression values compared to normal cervical epithelium...
January 31, 2019: Antiviral Research
Satoshi Kawai, Yutaka Torii, Iwao Kukimoto, Takuma Fujii
We herein present a case of primary signet-ring cell carcinoma of the cervix. Pelvic magnetic resonance imaging revealed a 38-mm cervical tumor, and computed tomography revealed no findings suggestive of distal metastasis or other tumor origins. Gastrointestinal endoscopy showed no abnormal findings. Histopathology revealed signet-ring cell-type mucinous adenocarcinoma. By immunohistochemistry, tumor cells were negative for the mammary neoplasm marker, gross cystic disease fluid protein 15 and gastrointestinal neoplasm markers, MUC2, MUC6, and CDX2, but positive for p16...
January 2019: Indian Journal of Pathology & Microbiology
Elham Beyranvand Nejad, Robert B Ratts, Eleni Panagioti, Christine Meyer, Jennifer D Oduro, Luka Cicin-Sain, Klaus Früh, Sjoerd H van der Burg, Ramon Arens
BACKGROUND: The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell responses, and the ability to engineer the genome of this DNA virus positions CMV-based vaccine vectors highly suitable as a cancer vaccine platform. Defined immune thresholds for tumor protection and the factors affecting such thresholds have not well been investigated in cancer immunotherapy. We here determined using CMV as a vaccine platform whether critical thresholds of vaccine-specific T cell responses can be established that relate to tumor protection, and which factors control such thresholds...
January 31, 2019: Journal for Immunotherapy of Cancer
Eduardo Lazcano-Ponce, Martha Carnalla-Cortés, Tonatiuh Barrientos-Gutiérrez, Leticia Torres-Ibarra, Aurelio Cruz-Valdez, Jorge Salmerón, Mauricio Hernández-Ávila
OBJECTIVE: To asses the non-inferiority between two differ- ent vaccination schedules one month after the administration of the third dose. MATERIALS AND METHODS: We evaluated the anti-HPV 16/18 antibody titers induced by quadrivalent HPV vaccine administered using two different schedules in girls 9 to 10-year-old girls: a traditional (0-2-6) and an alterna- tive (0-6-50). Blood samples were collected at month 7, 21 and 51. RESULTS: The antibody geometric mean titer ratios one month after the application of the third dose -month 51 for the alternative and month 7 for the traditional- were 1...
November 2018: Salud Pública de México
Hector Posso, Leith León-Maldonado, Betania Allen-Leigh, Jorge Salmerón, Manuel Quiterio, Anna R Giuliano, Staci L Sudenga, Alan G Nyitray, B Nelson Torres, Martha Abrahamsen, Eduardo Lazcano-Ponce
OBJECTIVE: Describe the natural history of anal HPV among men. MATERIALS AND METHODS: Prospective study among men 18-70 years (n=665), from Cuernavaca, Mexico who completed questionnaires and provided specimens (HPV genotyped) at enrollment and 1+ follow-up visit. HPV prevalence and incidence were estimated. Prevalence ratios were calculated with Poisson regression using robust variance estimation. Person-time for incident HPV infection was estimated using number of events modeled as Poisson variable for total person-months...
November 2018: Salud Pública de México
Eduardo Lazcano-Ponce, Staci L Sudenga, B Nelson Torres, Mark Stoler, Leith León-Maldonado, Betania Allen-Leigh, Héctor Posso, Manuel Quiterio, María Del Pilar Hernández-Nevarez, Jorge Salmerón, Anna R Giuliano
OBJECTIVE: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs. MATERIALS AND METHODS: Participants (healthy males 18- 74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months;including excision biopsy on suspicious EGL with histological confirmation.Linear array assay PCR characterized 37 high/low-risk HPV-DNA types...
November 2018: Salud Pública de México
Junfen Xu, Habin Liu, Yanqin Yang, Xiaohong Wang, Poching Liu, Yang Li, Craig Meyers, Nilam Sanjib Banerjee, Hsu-Kun Wang, Maggie Cam, Weiguo Lu, Louise T Chow, Xing Xie, Jun Zhu, Zhi-Ming Zheng
RNA-binding proteins (RBPs) control mRNA processing, stability, transport, editing, and translation. We recently conducted transcriptome analyses comparing normal (i.e., healthy) cervical tissue samples with human papillomavirus (HPV)-positive cervical cancer tissue samples and identified 614 differentially expressed protein-coding transcripts which are enriched in cancer-related pathways and consist of 95 known RBPs. We verified the altered expression of 26 genes with a cohort of 72 cervical samples, including 24 normal cervical samples, 25 cervical intraepithelial neoplasia grade 2 (CIN2) and CIN3 samples, and 23 cervical cancer tissue samples...
January 29, 2019: MBio
Y H Zhao, Y P Bai, M L Mao, H Zhang, X L Zhao, D M Yang, H F Wan, H G Liu
Objective: To observe the clinicopathologic features of oropharyngeal squamous cell carcinoma associated with human papilloma virus (OPSCC-HPV) and discuss the role and value of different in situ hybridization (ISH) detection methods for HPV in pathologic diagnosis. Methods: Fifteen cases of OPSCC-HPV were collected from Department of Pathology, Beijing Tongren Hospital, Capital Medical University from January 2016 to August 2018. These cases were diagnosed in accordance with the WHO classification of head and neck tumors...
February 8, 2019: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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