keyword
https://read.qxmd.com/read/37503468/a-clinicoepidemiological-study-of-cutaneous-and-systemic-comorbidities-of-seborrheic-dermatitis-in-adolescent-and-adult-females
#21
JOURNAL ARTICLE
Rajashekar T S, Savana Waikhom, Suresh Kumar K, Meghana E Reddy
Background Seborrheic dermatitis is the most common, chronic inflammatory skin condition which is confined to the scalp, nasolabial folds, and regions rich in sebaceous glands for which no definitive cause has been found. Although the disease is more common, the comorbidities associated with it have not been studied in detail. This study aims to assess the prevalence of seborrheic dermatitis and its associated cutaneous and systemic comorbidities in adolescent and adult patients. Methodology This cross-sectional study was performed among 451 adolescent and adult female patients who visited the Department of Dermatology, Venereology, and Leprosy of R...
June 2023: Curēus
https://read.qxmd.com/read/37424516/intermittent-fasting-modulates-immune-response-by-generating-tregs-via-tgf-%C3%AE-dependent-mechanisms-in-obese-mice-with-allergic-contact-dermatitis
#22
JOURNAL ARTICLE
Sang-Chul Han, Jung-Il Kang, Youn Kyung Choi, Hye-Jin Boo, Weon-Jong Yoon, Hee-Kyoung Kang, Eun-Sook Yoo
People with obesity maintain low levels of inflammation; therefore, their exposure to foreign antigens can trigger an excessive immune response. In people with obesity or allergic contact dermatitis (ACD), symptoms are exacerbated by a reduction in the number of regulatory T cells (Tregs) and IL-10/TGF-β-modified macrophages (M2 macrophages) at the inflammatory site. Benefits of intermittent fasting (IF) have been demonstrated for many diseases; however, the immune responses regulated by macrophages and CD4+T cells in obese ACD animal models are poorly understood...
July 10, 2023: Biomolecules & Therapeutics
https://read.qxmd.com/read/37373616/clinical-epidemiological-characteristics-of-hidradenitis-suppurativa-a-retrospective-cohort-study-from-a-tertiary-care-centre-in-northern-israel
#23
JOURNAL ARTICLE
Anan Hammud, Emily Avitan-Hersh, Ziad Khamaysi
BACKGROUND: Hidradenitis suppurativa (HS) is characterised by inflamed lesions that typically appear in apocrine-rich flexural areas. Although studies have reported clinical and epidemiological data from western countries, data from the Middle East are scarce. The aim of this study is to characterise the differences in the clinical characteristics of patients with HS of Arab and Jewish ancestry and review the clinical characteristics, the course of the disease, the comorbidities, and the response to treatment...
June 8, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37371748/role-of-epicardial-adipose-tissue-secretome-on-cardiovascular-diseases
#24
REVIEW
Sara Leo, Elena Tremoli, Letizia Ferroni, Barbara Zavan
Obesity and insulin resistance are associated with the inflamed and defective adipose tissue (AT) phenotype, and are established risk factors for cardiovascular diseases (CVDs). Extracellular vesicles (EVs) are a heterogeneous group of cell-derived lipid membrane vesicles involved in the onset and development of many pathologies, including insulin resistance, diabetes, and CVDs. The inflammation associated with overweight and obesity triggers the transition of the AT secretome from healthy to pathological, with a consequent increased expression of pro-inflammatory mediators...
June 7, 2023: Biomedicines
https://read.qxmd.com/read/37289080/inflamed-adipose-tissue-therapeutic-targets-for-obesity-related-endothelial-injury
#25
REVIEW
Wanlin Dai, Ziqi Liu, Shaojie Yang, Jing Kong
Cardiovascular disease (CVD) is the leading cause of death worldwide and is primarily associated with obesity, visceral adiposity, and unhealthy perivascular adipose tissue (PVAT). The inflammatory polarization of immune cells residing in adipose tissue and abnormal levels of adipose-related cytokines are crucial factors contributing to the pathogenesis of metabolic disorders. We reviewed the most relevant papers in the English literature regarding PVAT and obesity-related inflammation and CVD, aiming to explore potential therapeutic targets for metabolic alterations related to CV health...
June 6, 2023: Endocrinology
https://read.qxmd.com/read/37212552/different-sensitivity-to-diet-induced-hyperinsulinemia-and-hyperglycemia-between-mice-with-global-or-bone-marrow-specific-apoe-receptor-2-deficiency
#26
JOURNAL ARTICLE
Patrick R Wolfkiel, April M Haller, Jillian Kirby, Anja Jaeschke, David Y Hui
This study explored the role of apoE receptor-2 (apoER2), a unique member of the LDL receptor family proteins with a restricted tissue expression profile, in modulating diet-induced obesity and diabetes. Unlike wild type mice and humans in which chronic feeding of a high fat Western type diet leads to obesity and the pre-diabetic state of hyperinsulinemia prior to hyperglycemia onset, the Lrp8 -/- mice with global apoER2 deficiency displayed lower body weight and adiposity, slower development of hyperinsulinemia, but accelerated onset of hyperglycemia...
May 22, 2023: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/37177808/endometrioma-within-the-anterior-abdominal-wall-causing-cyclic-abdominal-pain
#27
JOURNAL ARTICLE
Donald M Davis, Sowsan H Rasheid, Zachary H Boucher, Diana A Burgueno-Vega, Manuel A Molina
Lesions from endometriosis contain endometrial glands and stroma outside the uterine cavity. The lesions occur in the pelvis but are also found in the bowel, diaphragm, and pleural cavity. Endometriosis within the extraperitoneal abdominal wall is rare, though, and usually within c-section scars (incidence is .03%-.5%). The typical triad includes: mass in the abdominal wall, cyclical pain, and history of previous abdominal surgery. We present the case of a 28-year-old female with a past history of cesarean section and obesity (BMI = 31) who presented with approximately 3 years of abdominal pain which was "waxing and waning" in severity depending on her menstrual cycle...
May 13, 2023: American Surgeon
https://read.qxmd.com/read/37104853/human-ipsc-derived-proinflammatory-macrophages-cause-insulin-resistance-in-an-isogenic-white-adipose-tissue-microphysiological-system
#28
JOURNAL ARTICLE
Lin Qi, Koji Matsuo, Ashley Pereira, Yue Tung Lee, Fenmiao Zhong, Yuchen He, Peter-James H Zushin, Marko Gröger, Aditi Sharma, Holger Willenbring, Edward C Hsiao, Andreas Stahl
Chronic white adipose tissue (WAT) inflammation has been recognized as a critical early event in the pathogenesis of obesity-related disorders. This process is characterized by the increased residency of proinflammatory M1 macrophages in WAT. However, the lack of an isogenic human macrophage-adipocyte model has limited biological studies and drug discovery efforts, highlighting the need for human stem cell-based approaches. Here, human induced pluripotent stem cell (iPSC) derived macrophages (iMACs) and adipocytes (iADIPOs) are cocultured in a microphysiological system (MPS)...
April 27, 2023: Small
https://read.qxmd.com/read/36952341/saturated-fatty-acids-dampen-the-immunogenicity-of-cancer-by-suppressing-sting
#29
JOURNAL ARTICLE
Blake R Heath, Wang Gong, Hülya F Taner, Luke Broses, Kohei Okuyama, Wanqing Cheng, Max Jin, Zackary R Fitzsimonds, Andriana Manousidaki, Yuesong Wu, Shaoping Zhang, Haitao Wen, Steven B Chinn, Eric Bartee, Yuying Xie, James J Moon, Yu Leo Lei
Oncogenes destabilize STING in epithelial cell-derived cancer cells, such as head and neck squamous cell carcinomas (HNSCCs), to promote immune escape. Despite the abundance of tumor-infiltrating myeloid cells, HNSCC presents notable resistance to STING stimulation. Here, we show how saturated fatty acids in the microenvironment dampen tumor response to STING stimulation. Using single-cell analysis, we found that obesity creates an IFN-I-deprived tumor microenvironment with a massive expansion of suppressive myeloid cell clusters and contraction of effector T cells...
March 22, 2023: Cell Reports
https://read.qxmd.com/read/36893854/role-of-immune-responses-for-development-of-nafld-associated-liver-cancer-and-prospects-for-therapeutic-modulation
#30
REVIEW
Neda Yahoo, Michael Dudek, Percy Knolle, Mathias Heikenwälder
The liver is the central metabolic organ of the body regulating energy and lipid metabolism and at the same time has potent immunological functions. Overwhelming the metabolic capacity of the liver by obesity and sedentary lifestyle leads to hepatic lipid accumulation, chronic necro-inflammation, enhanced mitochondrial/ER-stress and development of non-alcoholic fatty liver disease (NAFLD), with its pathologic form nonalcoholic steatohepatitis (NASH). Based on knowledge on pathophysiological mechanisms, specifically targeting metabolic diseases to prevent or slow down progression of NAFLD to liver cancer will become possible...
March 7, 2023: Journal of Hepatology
https://read.qxmd.com/read/36811824/age-of-first-overweight-and-obesity-covid-19-and-long-covid-in-two-british-birth-cohorts
#31
JOURNAL ARTICLE
Charis Bridger Staatz, David Bann, George B Ploubidis, Alissa Goodman, Richard J Silverwood
Longer exposure to obesity, and thus a longer period in an inflamed state, may increase susceptibility to infectious diseases and worsen severity. Previous cross-sectional work finds higher BMI is related to worse COVID-19 outcomes, but less is known about associations with BMI across adulthood. To examine this, we used body mass index (BMI) collected through adulthood in the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS70). Participants were grouped by the age they were first overweight (> 25 kg/m2 ) and obese (> 30 kg/m2 )...
February 22, 2023: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/36768438/dihomo-%C3%AE-linolenic-acid-20-3n-6-metabolism-derivatives-and-potential-significance-in-chronic-inflammation
#32
REVIEW
Anne-Mari Mustonen, Petteri Nieminen
Dihomo- γ -linolenic acid (DGLA) has emerged as a significant molecule differentiating healthy and inflamed tissues. Its position at a pivotal point of metabolic pathways leading to anti-inflammatory derivatives or via arachidonic acid (ARA) to pro-inflammatory lipid mediators makes this n-6 polyunsaturated fatty acid (PUFA) an intriguing research subject. The balance of ARA to DGLA is probably a critical factor affecting inflammatory processes in the body. The aim of this narrative review was to examine the potential roles of DGLA and related n-6 PUFAs in inflammatory conditions, such as obesity-associated disorders, rheumatoid arthritis, atopic dermatitis, asthma, cancers, and diseases of the gastrointestinal tract...
January 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36731652/gps2-mediated-regulation-of-the-adipocyte-secretome-modulates-adipose-tissue-remodeling-at-the-onset-of-diet-induced-obesity
#33
JOURNAL ARTICLE
Justin English, Joseph Orofino, Carly Cederquist, Indranil Paul, Hao Li, Johan Auwerx, Andrew Emili, Anna Belkina, Dafne Cardamone, Valentina Perissi
OBJECTIVE: Dysfunctional, unhealthy expansion of white adipose tissue due to excess dietary intake is a process at the root of obesity and Type 2 Diabetes development. The objective of this study is to contribute to a better understanding of the underlying mechanism(s) regulating the early stages of adipose tissue expansion and adaptation to dietary stress due to an acute, high-fat diet (HFD) challenge, with a focus on the communication between adipocytes and other stromal cells. METHODS: We profiled the early response to high-fat diet exposure in wildtype and adipocyte-specific GPS2-KO (GPS2-AKO) mice at cellular, tissue and organismal level...
January 30, 2023: Molecular Metabolism
https://read.qxmd.com/read/36631993/multiple-roles-of-sirtuin-6-in-adipose-tissue-inflammation
#34
JOURNAL ARTICLE
Eun Ju Bae, Byung-Hyun Park
Adipose tissue (AT) inflammation is strongly associated with obesity-induced insulin resistance. When subjected to metabolic stress, adipocytes become inflamed and secrete a plethora of cytokines and chemokines, which recruit circulating immune cells to AT. Although sirtuin 6 (Sirt6) is known to control genomic stabilization, aging, and cellular metabolism, it is now understood to also play a pivotal role in the regulation of AT inflammation. Sirt6 protein levels are reduced in the AT of obese humans and animals and increased by weight loss...
January 12, 2023: Diabetes & Metabolism Journal
https://read.qxmd.com/read/36596964/exosomes-from-inflamed-macrophages-promote-the-progression-of-parkinson-s-disease-by-inducing-neuroinflammation
#35
JOURNAL ARTICLE
Yan Jin, Runze Wu, Li Li, Lihua Shen, Yunjuan Gu, Cheng Sun
Inflammation is a common feature both for Parkinson's disease (PD) and obesity-associated metabolic syndromes. Inflammation mediated by inflamed macrophages in white adipose tissue plays a pivotal role for the pathogenesis of metabolic syndromes. Exosomes are important carriers connecting peripheral tissues and the central nervous system (CNS). Therefore, we speculate that exosomes derived from inflamed macrophages may be involved in the pathological progression of PD. Here, we prepared exosomes from lipopolysaccharide (LPS) or interferon gamma (IFNγ) treated macrophages (inflamed macrophages) and examined their potential roles in PD...
January 3, 2023: Molecular Neurobiology
https://read.qxmd.com/read/36595817/perineal-burn-injury-with-hidradenitis-suppurativa-a-case-report
#36
JOURNAL ARTICLE
Linyue Wang, Wenyue Qi, Jihua Gao, Maosheng Tian, Hongyuan Sun, Wencong Xu
RATIONALE: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease which usually presents with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas. Severe HS has interconnecting sinus tracts and when it occurs in the perianal region, perianal fistulas can form. Obesity and smoking are 2 risk factors for the development of HS. PATIENT CONCERNS: We report a case of a 33-year-old male diagnosed with perianal HS and perianal fistula following a burn injury to the area that occurred during childhood...
December 23, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/36483560/inflamed-adipose-tissue-a-culprit-underlying-obesity-and-heart-failure-with-preserved-ejection-fraction
#37
REVIEW
Chenyu Li, Donglu Qin, Jiarui Hu, Yang Yang, Die Hu, Bilian Yu
The incidence of heart failure with preserved ejection fraction is increasing in patients with obesity, diabetes, hypertension, and in the aging population. However, there is a lack of adequate clinical treatment. Patients with obesity-related heart failure with preserved ejection fraction display unique pathophysiological and phenotypic characteristics, suggesting that obesity could be one of its specific phenotypes. There has been an increasing recognition that overnutrition in obesity causes adipose tissue expansion and local and systemic inflammation, which consequently exacerbates cardiac remodeling and leads to the development of obese heart failure with preserved ejection fraction...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36428692/obesity-influences-the-expression-of-key-immunomodulators-in-normal-human-breast-tissue-basal-like-breast-cancer-patients-and-cell-lines
#38
JOURNAL ARTICLE
DeQuarius King, Muhammad G Khodary, Temesgen Samuel, Clayton Yates, Deepa Bedi
Among the different components of the breast cancer microenvironment are adipocytes, which are mainly composed of differentiated adipocytes and adipose progenitors. The role of obesity in tumor progression has become a key topic in clinical studies, but the mechanics of this are still misunderstood. There is significant evidence of serum amyloid (SAA1), an acute-phase protein, being heavily expressed in inflamed, septic conditions. VTCN1 and VSIR, members of the immunoglobulin family, are key players in T-cell regulation...
November 15, 2022: Cancers
https://read.qxmd.com/read/36364929/anti-inflammatory-protein-isolated-from-tamarind-promotes-better-histological-aspects-in-the-intestine-regardless-of-the-improvement-of-intestinal-permeability-in-a-preclinical-study-of-diet-induced-obesity
#39
JOURNAL ARTICLE
Mayara S R Lima, Catarina Gonçalves, Mafalda D Neto, Maria Helena Macedo, Jaluza L C de Queiroz, Valéria C da Silva, Izael de S Costa, Christina da S Camillo, Pedro Paulo de A Santos, Aldo A M Lima, Lorenzo Pastrana, Bruna L L Maciel, Ana Heloneida A Morais
Obesity is associated with metabolic and physiological effects in the gut. In this study, we evaluated the anti-inflammatory effect of trypsin inhibitor isolated from tamarind seeds (TTI) in vitro (interaction with lipopolysaccharide (LPS) and inhibitory activity against human neutrophil elastase (HNE)), and using intestinal co-cultures of Caco-2:HT29-MTX cell lines inflamed with TNF-α (50 ng/mL) and a Wistar rat model of diet-induced obesity (n = 15). TTI was administered to animals by gavage (10 days), and the treated group (25 mg/kg/day) was compared to animals without treatment or treated with a nutritionally adequate diet...
November 4, 2022: Nutrients
https://read.qxmd.com/read/36276810/phillyrin-restores-metabolic-disorders-in-mice-fed-with-high-fat-diet-through-inhibition-of-interleukin-6-mediated-basal-lipolysis
#40
JOURNAL ARTICLE
Zhizheng Fang, Lu Wei, Yanping Lv, Tongsheng Wang, Hamizah Shahirah Hamezah, Rongchun Han, Xiaohui Tong
The function of white adipose tissue as an energy reservoir is impaired in obesity, leading to lipid spillover and ectopic lipid deposition. Adipose tissue inflammation can reduce the efficacy of lipid storage in adipocytes by augmenting basal lipolysis through producing interleukin-6 (IL-6). Therefore, pharmacological compounds targeting adipose tissue inflammation or IL-6 signaling might have the potential to combat obesity. This study aims to investigate the impact of Phillyrin, which is frequently used for treating respiratory infections in clinics in China, on obesity-related metabolic dysfunctions...
2022: Frontiers in Nutrition
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