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Urinary biomarkers

Changkai Deng, Qiang Peng, Xianliang Hu, Li Gao, Juan Xu, Jing Su, Xue Xia, Feng Liu, Maoxian Li
PURPOSE: Based on previously two meta-analyses, urinary nerve growth factor (NGF) has emerged as one potentially noninvasive biomarker for overactive bladder (OAB) in adults. We performed this systematic review to explore if NGF is a biomarker for OAB in children. METHODS: A literature search was conducted in PubMed, Embase, Web of science and Cochrane Library. Copies of all relevant articles were retrieved for quality assessment and data abstraction by two reviewers...
February 19, 2019: Pediatric Surgery International
Yuan-Yuei Chen, Tung-Wei Kao, Chung-Ching Wang, Ying-Jen Chen, Chen-Jung Wu, Ching-Huang Lai, Wei-Liang Chen
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants. Exposure to PAHs is associated with several adverse health outcomes. However, no previous study has examined the relationship between PAH exposure and functional dependence in an elderly population. Our aim was to examine whether PAH exposure was associated with functional dependence including total disability, activities of daily living (ADL), instrumental activities of daily living (IADL), leisure and social activities (LSA), lower extremity mobility (LEM), and general physical activities (GPA) in an elderly population...
February 18, 2019: Environmental Science and Pollution Research International
Pierbruno Ricci, Pedro Magalhães, Magdalena Krochmal, Martin Pejchinovski, Erica Daina, Maria Rosa Caruso, Laura Goea, Iwona Belczacka, Giuseppe Remuzzi, Muriel Umbhauer, Jens Drube, Lars Pape, Harald Mischak, Stéphane Decramer, Franz Schaefer, Joost P Schanstra, Silvia Cereghini, Petra Zürbig
Renal Cysts and Diabetes Syndrome (RCAD) is an autosomal dominant disorder caused by mutations in the HNF1B gene encoding for the transcriptional factor hepatocyte nuclear factor-1B. RCAD is characterized as a multi-organ disease, with a broad spectrum of symptoms including kidney abnormalities (renal cysts, renal hypodysplasia, single kidney, horseshoe kidneys, hydronephrosis), early-onset diabetes mellitus, abnormal liver function, pancreatic hypoplasia and genital tract malformations. In the present study, using capillary electrophoresis coupled to mass spectrometry (CE-MS), we investigated the urinary proteome of a pediatric cohort of RCAD patients and different controls to identify peptide biomarkers and obtain further insights into the pathophysiology of this disorder...
February 18, 2019: Scientific Reports
Fang Zhao, Danny Vesprini, Richard S C Liu, Ekaterina Olkhov-Mitsel, Laurence H Klotz, Andrew Loblaw, Stanley K Liu, Bharati Bapat
PURPOSE: Prostate cancer (CaP) patients with low-grade tumors are enrolled in active surveillance (AS) programs and monitored with digital rectal exams (DREs), prostate-specific antigen (PSA) tests, and periodic invasive biopsies. Patients are "reclassified" with higher-risk disease if they show signs of disease progression. However, AS patients who will reclassify cannot be easily identified upfront and suffer morbidities associated with biopsy. Biomarkers derived from noninvasively obtained specimens such as serum or urine samples are promising alternatives to monitor patients with clinically insignificant cancer...
February 15, 2019: Urologic Oncology
Nathan Kuppermann, Peter S Dayan, Deborah A Levine, Melissa Vitale, Leah Tzimenatos, Michael G Tunik, Mary Saunders, Richard M Ruddy, Genie Roosevelt, Alexander J Rogers, Elizabeth C Powell, Lise E Nigrovic, Jared Muenzer, James G Linakis, Kathleen Grisanti, David M Jaffe, John D Hoyle, Richard Greenberg, Rajender Gattu, Andrea T Cruz, Ellen F Crain, Daniel M Cohen, Anne Brayer, Dominic Borgialli, Bema Bonsu, Lorin Browne, Stephen Blumberg, Jonathan E Bennett, Shireen M Atabaki, Jennifer Anders, Elizabeth R Alpern, Benjamin Miller, T Charles Casper, J Michael Dean, Octavio Ramilo, Prashant Mahajan
Importance: In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and meningitis, may lead to dangerous complications. However, lumbar punctures and hospitalizations involve risks and costs. Clinical prediction rules using biomarkers beyond the white blood cell count (WBC) may accurately identify febrile infants at low risk for SBIs. Objective: To derive and validate a prediction rule to identify febrile infants 60 days and younger at low risk for SBIs...
February 18, 2019: JAMA Pediatrics
Margarida Correia-Neves, Gabrielle Fröberg, Liudmyla Korshun, Sofia Viegas, Paula Vaz, Nehaben Ramanlal, Judith Bruchfeld, Beston Hamasur, Patrick Brennan, Gunilla Källenius
Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests...
February 2019: ERJ Open Research
Jan Biegus, Robert Zymliński, Mateusz Sokolski, John Todd, Gad Cotter, Marco Metra, Ewa A Jankowska, Waldemar Banasiak, Piotr Ponikowski
AIMS: The clinical significance of the measurement of urine sodium concentration (UNa+ ) in response to loop diuretic administration in patients with acute heart failure (AHF) is still unsettled. We studied the association of serial measurements of spot UNa+ during the first 48 h of AHF treatment with the indices of decongestion, renal function, and prognosis. METHODS AND RESULTS: We enrolled 111 AHF patients, all of whom received intravenous furosemide on admission...
February 17, 2019: European Journal of Heart Failure
Christoph Schmidtkunz, Wolfgang Gries, Till Weber, Gabriele Leng, Marike Kolossa-Gehring
Di(2-propylheptyl) phthalate (DPHP) is used as a substitute for high molecular weight phthalates like di(2-ethylhexyl) phthalate (DEHP) which were subjected to authorization under REACh in 2015. An earlier study on the time trend of exposure in human 24-h urine samples from the German Environmental Specimen Bank has revealed that metabolites of DPHP emerged in 2009 and 2012 (Schütze et al., 2015). In order to better assess a potential trend and the present state of exposure to DPHP, we now measured 180 urine samples from the German Environmental Specimen Bank, 60 per year, collected in 2011, 2014 and 2017, randomized and blinded before analysis...
February 13, 2019: International Journal of Hygiene and Environmental Health
Ruth Montalbo, Juan J Lozano, Laura Izquierdo, Mercedes Ingelmo-Torres, Carmen BaÑos, Joan Palou, Antoine G Van der Heijden, Rafael Medina, Joerg Schmidbauer, Aleix Prat, Maria J Ribal, Antonio Alcaraz, Lourdes Mengual
This study aimed to improve our previous urine gene expression classifiers focusing on the detection of non-high-risk non-muscle-invasive bladder cancer (NMIBC), and develop a new classifier able to decrease the frequency of cystoscopies during bladder cancer (BC) patients' surveillance. A total of 597 urines from BC patients, controls and patients in follow-up for BC (PFBC) were included. The study has 3 phases. In the urinary biomarker discovery phase, 84 urines from BC and control patients were retrospectively included and analyzed by RNA sequencing...
February 7, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
Fayth L Miles, Jan Irene C Lloren, Ella Haddad, Karen Jaceldo-Siegl, Synnove Knutsen, Joan Sabate, Gary E Fraser
BACKGROUND: Differences in food composition, nutrient intake, and various health outcomes have been reported for vegetarians and non-vegetarians in the Adventist Health Study-2 (AHS-2) cohort. OBJECTIVE: We sought to determine whether biomarkers of dietary intake also differed between individuals classified as vegetarian (vegan, lacto-ovo-vegetarian, pesco-vegetarian, semi-vegetarian) and non-vegetarians based on patterns of consumption of meat, dairy, and eggs...
February 15, 2019: Journal of Nutrition
Fedja Farowski, Philipp Solbach, Anastasia Tsakmaklis, Susanne Brodesser, M Rebeca Cruz Aguilar, Oliver A Cornely, Katja Dettmer, Paul G Higgins, Sebastian Suerbaum, Nathalie Jazmati, Peter J Oefner, Maria J G T Vehreschild
BACKGROUND & AIMS: Faecal microbiota transplantation (FMT) has proven high clinical efficacy in the management of recurrent Clostridioides difficile infection (rCDI) with cure rates of over 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain elusive. The aim of the present study was to investigate different potential predictors of response to FMT. METHODS: Faecal specimens of sixteen patients undergoing FMT for rCDI, as well as samples from the respective donors were collected and analyzed by 16S rRNA gene profiling, bile acid-inducible (baiCD) gene specific qPCR, and liquid chromatography tandem-mass spectrometry (LC-MS/MS) to quantify the concentrations of primary and secondary bile acids...
January 26, 2019: Digestive and Liver Disease
Eline Oeyen, Lucien Hoekx, Stefan De Wachter, Marcella Baldewijns, Filip Ameye, Inge Mertens
Diagnostic methods currently used for bladder cancer are cystoscopy and urine cytology. Cystoscopy is an invasive tool and has low sensitivity for carcinoma in situ. Urine cytology is non-invasive, is a low-cost method, and has a high specificity but low sensitivity for low-grade urothelial tumors. Despite the search for urinary biomarkers for the early and non-invasive detection of bladder cancer, no biomarkers are used at the present in daily clinical practice. Extracellular vesicles (EVs) have been recently studied as a promising source of biomarkers because of their role in intercellular communication and tumor progression...
February 14, 2019: International Journal of Molecular Sciences
Ryoko Kawakami, Ikuko Kashino, Hiroshi Kasai, Kazuaki Kawai, Yun-Shan Li, Akiko Nanri, Mitsuru Higuchi, Tetsuya Mizoue
BACKGROUND: It remains unclear whether daily physical activity is associated with DNA damage. This cross-sectional study examined the association between leisure-time physical activity and urinary 8-hydroxydeoxyguanosine (8-OH-dG), a biomarker of oxidative DNA damage, or urinary 7-methylguanine (m7Gua), a biomarker of methylating DNA damage. METHODS: Participants included 501 workers (294 men and 207 women), aged 20-65 years, from municipal offices in Japan. Urinary 8-OH-dG and m7Gua were measured using column-switching HPLC...
2019: PloS One
Yoojin M Kim, David J Polzin, Aaron Rendahl, Jennifer L Granick
BACKGROUND: Active kidney injury may play a role in chronic kidney disease (CKD) progression in dogs. Neutrophil gelatinase-associated lipocalin (NGAL), a novel tubular kidney injury biomarker, may help differentiate progressive CKD from stable CKD in dogs. OBJECTIVES: To determine if urinary NGAL : creatinine ratio (UNCR) differentiates stable and progressive CKD in dogs. We hypothesized that UNCR would be higher in dogs with progressive CKD versus stable CKD...
February 14, 2019: Journal of Veterinary Internal Medicine
Carmen Campos-Silva, Henar Suárez, Ricardo Jara-Acevedo, Estefanía Linares-Espinós, Luis Martinez-Piñeiro, María Yáñez-Mó, Mar Valés-Gómez
Extracellular vesicles (EVs) provide an invaluable tool to analyse physiological processes because they transport, in biological fluids, biomolecules secreted from diverse tissues of an individual. EV biomarker detection requires highly sensitive techniques able to identify individual molecules. However, the lack of widespread, affordable methodologies for high-throughput EV analyses means that studies on biomarkers have not been done in large patient cohorts. To develop tools for EV analysis in biological samples, we evaluated here the critical parameters to optimise an assay based on immunocapture of EVs followed by flow cytometry...
February 14, 2019: Scientific Reports
Janneke Evelyne Stalenhoef, Cees van Nieuwkoop, Darius Cameron Wilson, Willize Elizabeth van der Starre, Tanny J K van der Reijden, Nathalie Manon Delfos, Eliane Madeleine Sophie Leyten, Ted Koster, Hans Christiaan Ablij, Johannes Jan Willem van 't Wout, Jaap Tamino van Dissel
BACKGROUND: A reduction in duration of antibiotic therapy is crucial in minimizing the development of antimicrobial resistance, drug-related side effects and health care costs. The minimal effective duration of antimicrobial therapy for febrile urinary tract infections (fUTI) remains a topic of uncertainty, especially in male patients, those of older age or with comorbidities. Biomarkers have the potential to objectively identify the optimal moment for cessation of therapy. METHODS: A secondary analysis of a randomized placebo-controlled trial among 35 primary care centers and 7 emergency departments of regional hospitals in the Netherlands...
February 14, 2019: BMC Infectious Diseases
Salisu M Abubakar, Moses T Ukeyima, Jeremy P E Spencer, Julie A Lovegrove
BACKGROUND/OBJECTIVES: The acute impact of Hibiscus sabdariffa calyces (HSC) extract on postprandial vascular function and other cardiometabolic risk factors have not been studied previously. This study investigated the acute impact of HSC extract consumption on blood pressure (BP), vascular function and other cardiometabolic risk markers. SUBJECTS/METHODS: Twenty-five men with 1% to 10% cardiovascular disease (CVD) risk (determined by QRISK® 2) were randomised to consume either 250 mL of the aqueous extract of HSC or water with breakfast in a randomised, controlled, single-blinded, 2-meal cross-over study (ClinicalTrials...
February 5, 2019: Nutrients
E G Baksheeva, N N Tsybikov
In recent years, researchers have become increasingly interested in urinary microvesicles. They contain disease-specific biomarkers and can be used for predicting and diagnosing various diseases of the urinary system without resorting to invasive procedures. This review presents data on domestic and international research investigating the importance and potential application of urinary microvesicles for the diagnosis and prediction of diseases of the urinary system.
October 2018: Urologii︠a︡
Ahmed A Albayar, Abigail Roche, Przemyslaw Swiatkowski, Sarah Antar, Nouran Ouda, Eman Emara, Douglas H Smith, Ali K Ozturk, Basem I Awad
Spinal Cord Injury (SCI) is a major challenge in Neurotrauma research. Complex pathophysiological processes take place immediately after the injury and later on as the chronic injury develops. Moreover, SCI is usually accompanied by traumatic injuries because the most common modality of injury is road traffic accidents and falls. Patients develop significant permanent neurological deficits that depend on the extent and the location of the injury itself and in time they develop further neurological and body changes that may risk their mere survival...
2019: Frontiers in Neurology
Jian Chen, Hongwei Hou, Huan Chen, Yanbo Luo, Lirong Zhang, Yunfei Zhang, Hansong Liu, Fangfang Zhang, Yong Liu, An Wang, Qingyuan Hu
The incidence of laryngeal cancer (LYC) is second only to lung cancer, which is also the second most common cancer in head and neck cancer. Risk assessment metabolomics biomarkers to diagnose LYC have not been found by now. To profile the metabolites in healthy controls (HCs) and LYC patients (LYCs), urine metabonomics study was performed based on reversed phase liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (RPLC-QTOF/MS). Six urine differentially expressed metabolites (Variable Importance in Projection >1, p <  0...
January 30, 2019: Journal of Pharmaceutical and Biomedical Analysis
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