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Pei-Hsun Wu, Yi-Ching Cheng, Haon-Yao Chen, Ti-Wen Chueh, Hui-Chen Chen, Li-Hsun Huang, Zhong-Xian Wu, Tsung-Min Hsieh, Chao-Chin Chang, Ping-Yi Yang, Cheng-Fang Lin, Chang-Ping Yu
Control of organic matter, nutrients and disinfection byproduct formation is a major challenge for the drinking water treatment plants on Matsu Islands, Taiwan, receiving source water from the eutrophic reservoirs. A pilot entrapped biomass reactor (EBR) system was installed as the pretreatment process to reduce organic and nitrogen contents into the drinking water treatment plant. The effects of hydraulic retention time (HRT) and combination of preceding physical treatment (ultraviolet and ultrasound) on the treatment performance were further evaluated...
February 4, 2019: Environmental Pollution
K Steinerová, P Jindra, D Lysák, M Karas
BACKGROUND: Allogeneic hematopoietic stem cell transplantation is one of the therapeutic options for patients with relapsed or refractory classic Hodgkins lymphoma (cHL). In the case of dis-ease relapse after transplant, other treatment options are still limited (for example donor lymphocyte infusion, and chemother-apy with brentuximab, bendamustine, or other agents) with uncertain outcomes in terms of patient tolerance and long-term dis-ease remission. One way to achieve remission is administration of the PD-1 inhibitor nivolumab, a PD-1 checkpoint inhibitor...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Nitika Paudel, Derek Schulze, Ryan D Gentzler, Andrew M Evens, Irene Helenowski, Gary Dillehay, Olga Frankfurt, Jayesh Mehta, Eric D Donnelly, Leo I Gordon, Jane N Winter, Bharat B Mittal
PURPOSE: The patterns of failure and long-term outcomes of patients with relapsed or refractory classical Hodgkin lymphoma (cHL) treated with total lymphoid irradiation (TLI) and high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (aSCT) is reported. METHODS AND MATERIALS: Patients with biopsy-proven primary refractory/relapsed cHL who received salvage chemotherapy and accelerated hyperfractionated TLI prior to HDCT and aSCT were included...
February 11, 2019: International Journal of Radiation Oncology, Biology, Physics
Mirza Hasanuzzaman, Md Mahabub Alam, Kamrun Nahar, Sayed Mohammad Mohsin, M H M Borhannuddin Bhuyan, Khursheda Parvin, Barbara Hawrylak-Nowak, Masayuki Fujita
Nickel (Ni), an essential nutrient of plant but very toxic to plant at supra-optimal concentration that causes inhibition of seed germination emergence and growth of plants as a consequence of physiological disorders. Hence, the present study investigates the possible mechanisms of Ni tolerance in rice seedlings by exogenous application of silicon (Si). Thirteen-day-old hydroponically grown rice (Oryza sativa L. cv. BRRI dhan54) were treated with Ni (NiSO4 .7H2 O, 0.25 and 0.5 mM) sole or in combination with 0...
February 13, 2019: Ecotoxicology
Youlin Peng, Ting Zou, Lamei Li, Shiwen Tang, Qiao Li, Jie Zhang, Yongjun Chen, Xuechun Wang, Guotao Yang, Yungao Hu
Light is one of the most important environmental factors that affect many aspects of plant growth, including chlorophyll (Chl) synthesis and flowering time. Here, we identified a rice mutant, yellow leaf and early flowering ( ye1 ), and characterized the gene YE1 by using a map-based cloning method. YE1 encodes a heme oxygenase, which is localized to the chloroplasts. YE1 is expressed in various green tissues, especially in leaves, with a diurnal-rhythmic expression pattern, and its transcripts is also induced by light during leaf-greening...
February 11, 2019: International Journal of Molecular Sciences
Hao Wu, Huan Wang, Feng Xu, Jiepeng Chen, Lili Duan, Fengjiao Zhang
Cardiovascular diseases (CVDs) are the leading cause of death in the world; however, current agents for CVDs prevention are still limited. Owing to the serious bleeding risk of Aspirin, FDA recently recommended against it from preventing first heart attacks. Nattokinase (NK), a serine protease possessing many key beneficial effects on cardiovascular system, is being pursued as a promising alternative agent. In light of this, the safety profile of NK, in particular its potential genotoxicity, need to be characterized...
February 8, 2019: Regulatory Toxicology and Pharmacology: RTP
Patrick L Brezonik, R William Bouchard, Jacques C Finlay, Claire G Griffin, Leif G Olmanson, Jesse P Anderson, William A Arnold, Raymond Hozalski
Two other optically related water quality variables also directly affect SD: non-algal suspended solids (SSNA ) and colored dissolved organic matter (CDOM, expressed as the absorption coefficient at 440 nm, a440 ). Using a database of ~ 1460 samples from ~ 625 inland lake basins in Minnesota and two other Upper Midwest states, Wisconsin and Michigan, we analyzed relationships among these variables, with special focus on CDOM levels that influence SD values and the Minnesota SD standards used to assess eutrophication impairment of lakes...
February 10, 2019: Ecological Applications: a Publication of the Ecological Society of America
A Amraee, M R Evazi, M Shakeri, N Roozbeh, M Ghazanfarpour, M Ghorbani, J Ansari, L Darvish
AIMS: The primary standard treatment for classic Hodgkin's lymphoma (cHL) is chemotherapy and radiation therapy. However, some patients get relapsed, or their diseases become resistant. PD1 blocking antibodies have been used to increase the response of treatment in solid tumors, and led to potentially stable responses that are acceptable. Our purpose in this study is to investigate the effect of nivolumab as a PD1 blocking antibody on the survival rate of patients with Hodgkin's cancer...
February 9, 2019: Clinical & Translational Oncology
Sher Bahadar Khan, Mumtaz Ali Khan, Irshad Ahmad, Tayyab Ur Rehman, Shahid Ullah, Rahim Dad, Asad Sultan, Atta Muhammad Memon
For detection and isolation of Salmonella enterica, 650 meat and tissue samples were processed using Rappaport-Vassiliadis Enrichment broth and Salmonella Chromogenic agar followed by confirmation through specific antisera and polymerase chain reaction (PCR) targeting their Specific Serovar Genomic Regions (SSGRS). Isolates were tested for 15 antibiotics (CRO, AMX, GEN, STR, TET, CHL, CLR, LVX, OFX, GAT, CIP, SXT, AMP, LIN and AZM) according to the disc diffusion method and antimicrobial resistant genes (tet(A), tet(B), tet(C), strA/strB, aadA, aac(3)IV), aadB, sul1, sul2 and sul3, blaCMY-2, blaTEM and blaSHV) using PCR...
February 6, 2019: Microbial Pathogenesis
Wenda Wang, Long-Jiang Yu, Caizhe Xu, Takashi Tomizaki, Songhao Zhao, Yasufumi Umena, Xiaobo Chen, Xiaochun Qin, Yueyong Xin, Michihiro Suga, Guangye Han, Tingyun Kuang, Jian-Ren Shen
Diatoms are abundant photosynthetic organisms in aquatic environments and contribute 40% of its primary productivity. An important factor that contributes to the success of diatoms is their fucoxanthin chlorophyll a/c-binding proteins (FCPs), which have exceptional light-harvesting and photoprotection capabilities. Here, we report the crystal structure of an FCP from the marine diatom Phaeodactylum tricornutum , which reveals the binding of seven chlorophylls (Chls) a, two Chls c, seven fucoxanthins (Fxs), and probably one diadinoxanthin within the protein scaffold...
February 8, 2019: Science
Maxim S Svetlov, Elena Plessa, Chih-Wei Chen, Anthony Bougas, Marios G Krokidis, George P Dinos, Yury Polikanov
The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics, chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate sites on the bacterial ribosome: the catalytic peptidyl transferase center (PTC) and the nascent polypeptide exit tunnel (NPET), respectively. The previously reported competitive binding of CHL and ERY might be due either to a direct collision of the two drugs on the ribosome or due to a drug-induced allosteric effect. Because of the resolution limitations, the available structures of these antibiotics in complex with bacterial ribosomes do not allow us to discriminate between these two possible mechanisms...
February 7, 2019: RNA
Aina Venkatasamy, Daphné Le Foll, Carine Eyermann, Hella Vuong, Dominique Rohmer, Anne Charpiot, Francis Veillon
OBJECTIVES: Lateral semicircular canal (LSCC) malformations  are one of the most common inner ear malformations. The purpose of this study is to analyze the prevalence and type of hearing losses associated with LSCC malformations, compared to a control group. MATERIALS AND METHODS: We retrospectively included 109 patients (166 ears) presenting with a CT-confirmed LSCC malformation, compared to a control group (24 patients). The bony island surface and the width of the inner portion of the LSCC were measured to confirm the malformation...
February 6, 2019: European Archives of Oto-rhino-laryngology
Eric D Hsi, Hongli Li, Andrew B Nixon, Heiko Schöder, Nancy L Bartlett, Michael LeBlanc, Sonali Smith, Brad S Kahl, John P Leonard, Andrew M Evens, David W Scott, Lisa M Rimsza, Jonathan W Friedberg
Serum soluble chemokines/cytokines produced by Hodgkin-cells and the tumor microenvironment might be of value as biomarkers in classic Hodgkin lymphoma (cHL). We assessed serum TARC, MDC, IL10, and soluble CD163 (sCD163) levels at baseline, time of interim fluorodeoxyglucose positron emission tomography (FDG-PET), and post-therapy in cHL patients treated on S0816, an intergroup phase 2 response-adapted study evaluating escalated therapy for interim PET(PET2)-positive patients ( Identifier: NCT00822120)...
February 5, 2019: Blood
Stephanie Dutkiewicz, Anna E Hickman, Oliver Jahn, Stephanie Henson, Claudie Beaulieu, Erwan Monier
Monitoring changes in marine phytoplankton is important as they form the foundation of the marine food web and are crucial in the carbon cycle. Often Chlorophyll-a (Chl-a) is used to track changes in phytoplankton, since there are global, regular satellite-derived estimates. However, satellite sensors do not measure Chl-a directly. Instead, Chl-a is estimated from remote sensing reflectance (RRS ): the ratio of upwelling radiance to the downwelling irradiance at the ocean's surface. Using a model, we show that RRS in the blue-green spectrum is likely to have a stronger and earlier climate-change-driven signal than Chl-a...
February 4, 2019: Nature Communications
Yike He, Yaodong He, Biswarup Sen, Hao Li, Jiaqian Li, Yongfeng Zhang, Jianle Zhang, Sunny C Jiang, Guangyi Wang
With the escalating coastal development and loss of vegetated landscape, the volume of storm runoff increases significantly in Chinese coastal cities. To protect human health and valuable recreational resources, it is necessary to develop a quantitative understanding of coastal pollution. Here we studied the influence of storm runoff on the nutrients and microbial pathogens at two popular bathing beaches in northern China. Dongshan Beach, located near the mouth of an urban river, is influenced by non-point source pollution while Tiger-Rock Beach, a coastal beach, is primarily influenced by a point source from a storm drain outfall...
January 29, 2019: Science of the Total Environment
Marta Mendel, Wojciech Karlik, Magdalena Chłopecka
Regardless of the efforts put into preventing or reducing fungal growth, extensive mycotoxin contamination has been reported in animal feeds. In the case of pigs, one of the mycotoxins of major concern is deoxynivalenol (DON). The use of adsorbents as feed additives represents one of the strategies to control mycotoxins' contamination in feedstuff. Therefore, the aim of the study was to verify the ability of chlorophyllin (CHL) to reduce the absorption rate of DON in swine mucosa explants. Intestine was obtained from routinely slaughtered adult pigs...
February 2, 2019: Mycotoxin Research
Vasily Kurashov, Ming-Yang Ho, Gaozhong Shen, Karla Piedl, Tatiana N Laremore, Donald A Bryant, John H Golbeck
Certain cyanobacteria can thrive in environments enriched in far-red light (700-800 nm) due to an acclimation process known as far-red light photoacclimation (FaRLiP). During FaRLiP, about 8% of the Chl a molecules in the photosystems are replaced by Chl f and a very small amount of Chl d. We investigated the spectroscopic properties of Photosystem I (PSI) complexes isolated from wild-type (WT) Synechococcus sp. PCC 7335 and a chlF mutant strain (lacking Chl f synthase) grown in white and far-red light (WL-PSI and FRL-PSI, respectively)...
February 1, 2019: Photosynthesis Research
Xiaoqing Jin, Tao Liu, Jiaojiao Xu, Zixing Gao, Xiaohui Hu
BACKGROUND: Salinity-alkalinity stress is one of the major abiotic stresses affecting plant growth and development. γ-Aminobutyrate (GABA) is a non-protein amino acid that functions in stress tolerance. However, the interactions between cellular redox signaling and chlorophyll (Chl) metabolism involved in GABA-induced salinity-alkalinity stress tolerance in plants remains largely unknown. Here, we investigated the role of GABA in perceiving and regulating chlorophyll biosynthesis and oxidative stress induced by salinity-alkalinity stress in muskmelon leaves...
February 1, 2019: BMC Plant Biology
Yuki Takegawa, Makoto Nakamura, Shin Nakamura, Takumi Noguchi, Julien Sellés, A William Rutherford, Alain Boussac, Miwa Sugiura
The monomeric chlorophyll, ChlD1 , which is located between the PD1 PD2 chlorophyll pair and the pheophytin, PheoD1, is the longest wavelength chlorophyll in the heart of Photosystem II and is thought to be the primary electron donor. Its central Mg2+ is liganded to a water molecule that is H-bonded to D1/T179. Here, two site-directed mutants, D1/T179H and D1/T179V, were made in the thermophilic cyanobacterium, Thermosynechococcus elongatus, and characterized by a range of biophysical techniques. The Mn4 CaO5 cluster in the water-splitting site is fully active in both mutants...
January 28, 2019: Biochimica et biophysica acta. Bioenergetics
Linda von Hoff, Eva Kärgel, Vedran Franke, Erik McShane, Kathrin W Schulz-Beiss, Giannino Patone, Nikolai Schleussner, Marina Kolesnichenko, Norbert Hübner, Oliver Daumke, Matthias Selbach, Altuna Akalin, Stephan Mathas, Claus Scheidereit
Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors and tumor-microenvironment interactions contribute to this activation. Here, in an unbiased approach to identify the cHL cell-secreted key factors for NF-κB activation, we have dissected the secretome of cultured cHL cells by chromatography and subsequent mass spectrometry. We identified lymphotoxin-α (LTA) as the causative factor for autocrine and paracrine activation of canonical and non-canonical NF-κB in cHL cell lines...
January 29, 2019: Blood
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