keyword
https://read.qxmd.com/read/38537235/relation-between-neutrophil-to-lymphocyte-ratio-with-epidural-analgesia-timing-and-thoracotomy-pain
#1
JOURNAL ARTICLE
Taha Semerci, Ersagun Tugcugil, Ahmet Besir
OBJECTIVE: This study investigated the relationship of the pre-operative neutrophil/lymphocyte ratio (NLR) to the timing of epidural analgesia administration and post-operative acute and chronic pain in thoracotomy. MATERIALS AND METHODS: The study was conducted on 60 patients, with NLR ≥ 2 (Group A) and NLR < 2 (Group B). Each group was divided into subgroups pre-emptive analgesia (Group P) and control group (Group C). Epidural analgesic solution was administered as a bolus before the surgical incision in Group P and at the end of the operation in Group C...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537053/characterizing-the-opioidergic-mechanisms-of-repetitive-transcranial-magnetic-stimulation-induced-analgesia-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Ying Liu, Junfeng Sun, Chaomin Wu, Jinxuan Ren, Yanni He, Na Sun, Hao Huang, QunShan Chen, Dan Liu, Yangyuxin Huang, Feng Xu, Lina Yu, Bernadette M Fitzgibbon, Robin F H Cash, Paul B Fitzgerald, Min Yan, Xianwei Che
Repetitive transcranial magnetic stimulation (rTMS) is a promising technology to reduce chronic pain. Investigating the mechanisms of rTMS analgesia holds the potential to improve treatment efficacy. Using a double-blind and placebo-controlled design at both stimulation and pharmacologic ends, this study investigated the opioidergic mechanisms of rTMS analgesia by abolishing and recovering analgesia in 2 separate stages across brain regions and TMS doses. A group of 45 healthy participants were equally randomized to the primary motor cortex (M1), the dorsolateral prefrontal cortex (DLPFC), and the Sham group...
March 26, 2024: Pain
https://read.qxmd.com/read/38537025/effects-of-an-early-intensive-blood-pressure-lowering-strategy-using-remifentanil-and-dexmedetomidine-in-patients-with-spontaneous-intracerebral-hemorrhage-a-multicenter-prospective-superiority-randomized-controlled-trial
#3
JOURNAL ARTICLE
Rui Dong, Fen Li, Bin Li, Qiming Chen, Xianjian Huang, Jiehua Zhang, Qibing Huang, Zeli Zhang, Yunxing Cao, Mingbiao Yang, Jianwei Li, Zhanfu Li, Cuiyu Li, Guohua Liu, Shu Zhong, Guang Feng, Ming Zhang, Yumei Xiao, Kangyue Lin, Yunlong Shen, Huanzhang Shao, Yuan Shi, Xiangyou Yu, Xiaopeng Li, Lan Yao, Xinyu Du, Ying Xu, Pei Kang, Guoyi Gao, Bin Ouyang, Wenjin Chen, Zhenhua Zeng, Pingyan Chen, Chunbo Chen, Hong Yang
BACKGROUND: Although it has been established that elevated blood pressure and its variability worsen outcomes in spontaneous intracerebral hemorrhage, antihypertensives use during the acute phase still lacks robust evidence. A blood pressure-lowering regimen using remifentanil and dexmedetomidine might be a reasonable therapeutic option given their analgesic and anti-sympathetic effects. The objective of this superiority trial was to validate the efficacy and safety of this blood pressure-lowering strategy that uses remifentanil and dexmedetomidine in patients with acute intracerebral hemorrhage...
March 27, 2024: Anesthesiology
https://read.qxmd.com/read/38536739/a-scoping-review-of-the-mechanisms-underlying-developmental-anesthetic-neurotoxicity
#4
JOURNAL ARTICLE
Matthew Thomas Borzage, Bradley S Peterson
Although anesthesia makes painful or uncomfortable diagnostic and interventional health care procedures tolerable, it may also disrupt key cellular processes in neurons and glia, harm the developing brain, and thereby impair cognition and behavior in children. Many years of studies using in vitro, animal behavioral, retrospective database studies in humans, and several prospective clinical trials in humans have been invaluable in discerning the potential toxicity of anesthetics. The objective of this scoping review was to synthetize the evidence from preclinical studies for various mechanisms of toxicity across diverse experimental designs and relate their findings to those of recent clinical trials in real-world settings...
March 27, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38536664/pharmacokinetics-of-subcutaneous-ketamine-administration-via-the-omnipod%C3%A2-system-in-dogs
#5
JOURNAL ARTICLE
Claudia Colón, Peter Early, Karen Muñana, Natasha Olby, Christopher Mariani, Shelby Mancini, Gilad Fefer, Zhong Li, Jessica Briley, Kate Bailey, Duncan Lascelles, Kristen Messenger
Ketamine is an injectable anesthetic agent with analgesic and antidepressant effects that can prevent maladaptive pain. Ketamine is metabolized by the liver into norketamine, an active metabolite. Prior rodent studies have suggested that norketamine is thought to contribute up to 30% of ketamine's analgesic effect. Ketamine is usually administered as an intravenous (IV) bolus injection or continuous rate infusion (CRI) but can be administered subcutaneously (SC) and intramuscularly (IM). The Omnipod® is a wireless, subcutaneous insulin delivery device that adheres to the skin and delivers insulin as an SC CRI...
March 27, 2024: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/38535972/a-year-in-review-in-minerva-anestesiologica-2023-anesthesia-analgesia-and-perioperative-medicine
#6
JOURNAL ARTICLE
Franco Cavaliere, Massimo Allegri, Alparslan Apan, Luca Brazzi, Massimiliano Carassiti, Edmond Cohen, Pierangelo DI Marco, Olivier Langeron, Marco Rossi, Peter Spieth, David Turnbull, Frank Weber
No abstract text is available yet for this article.
March 2024: Minerva Anestesiologica
https://read.qxmd.com/read/38535859/intraoperative-isoflurane-end-tidal-concentration-during-infusion-of-fentanyl-tramadol-or-fentanyl-tramadol-combination-in-cats
#7
JOURNAL ARTICLE
Claudia Interlandi, Fabio Bruno, Marco Tabbì, Francesco Macrì, Simona Di Pietro, Elisabetta Giudice, Patrizia Licata, Daniele Macrì, Viola Zappone, Giovanna Lucrezia Costa
The aim of this study was to evaluate the end-tidal concentration of isoflurane required, clinical parameters, intraoperative antinociceptive effect, and postoperative analgesia in cats undergoing ovariohysterectomy, receiving fentanyl, tramadol, or fentanyl/tramadol. Sixty-six cats in three groups, were premedicated with dexmedetomidine and infused with one of the following treatments: fentanyl, tramadol, or fentanyl/tramadol combination. Anesthesia was induced with alfaxolone and maintained with isoflurane, titrated to keep heart rate, respiratory rate and systolic arterial pressure within target values recorded at endotracheal intubation...
March 11, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535499/modulation-of-the-mas-related-g-protein-coupled-receptor-x2-mrgprx2-by-xenobiotic-compounds-and-its-relevance-to-human-diseases
#8
REVIEW
Alicja Dziadowiec, Iwona Popiolek, Mateusz Kwitniewski, Grzegorz Porebski
Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis. In this paper, we review natural products and herbal medicines that may potentially interact with MRGPRX2...
March 13, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535420/functional-recovery-and-regenerative-effects-of-direct-transcutaneous-electrical-nerve-stimulation-in-treatment-of-post-covid-19-guillain-barr%C3%A3-and-acute-transverse-myelitis-overlap-syndrome-a-clinical-case
#9
Mustafa Al-Zamil, Natalia G Kulikova, Inessa A Minenko, Numman Mansur, Denis M Zalozhnev, Marat B Uzdenov, Alina A Dzhanibekova, Alikhan A Gochiyayev, Natalia A Shnayder
Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain-Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome...
February 26, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535273/anti-inflammatory-antipyretic-and-analgesic-potential-of-chitin-and-chitosan-derived-from-cockroaches-periplaneta-americana-and-termites
#10
JOURNAL ARTICLE
Khushbakht Asad, Sumaira Shams, Eliana Ibáñez-Arancibia, Patricio R De Los Ríos-Escalante, Farhad Badshah, Farooq Ahmad, Muhammad Salman Khan, Asar Khan
The chitin and chitosan biopolymers are extremely valuable because of their numerous industrial and pharmacological uses. Chitin and chitosan were extracted from the exoskeleton of Periplaneta americana (cockroaches) and termites using various acid and alkali techniques. The extraction process involves an initial demineralization step, during which integument dry powder was subjected to 500 mL (2.07 mol/L) of concentrated HCl at 100 degrees Celsius for 30 min, followed by meticulous rinsing with distilled water to restore the pH to its baseline...
March 21, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534647/synthesis-and-characterization-of-new-n-acyl-hydrazone-derivatives-of-carprofen-as-potential-tuberculostatic-agents
#11
JOURNAL ARTICLE
Ilinca Margareta Vlad, Diana Camelia Nuță, Miron Theodor Căproiu, Florea Dumitrașcu, Eleonóra Kapronczai, Georgiana Ramona Mük, Speranta Avram, Adelina Gabriela Niculescu, Irina Zarafu, Vanesa Alexandra Ciorobescu, Ana Maria Brezeanu, Carmen Limban
N-acyl hydrazone (NAH) is recognized as a promising framework in drug design due to its versatility, straightforward synthesis, and attractive range of biological activities, including antimicrobial, antitumoral, analgesic, and anti-inflammatory properties. In the global context of increasing resistance of pathogenic bacteria to antibiotics, NAHs represent potential solutions for developing improved treatment alternatives. Therefore, this research introduces six novel derivatives of ( EZ )-N'-benzylidene-2-(6-chloro-9 H -carbazol-2-yl)propanehydrazide, synthesized using a microwave-assisted method...
February 23, 2024: Antibiotics
https://read.qxmd.com/read/38534328/modification-of-mesenchymal-stem-stromal-cell-derived-small-extracellular-vesicles-by-calcitonin-gene-related-peptide-cgrp-antagonist-potential-implications-for-inflammation-and-pain-reversal
#12
JOURNAL ARTICLE
Kevin Liebmann, Mario A Castillo, Stanislava Jergova, Thomas M Best, Jacqueline Sagen, Dimitrios Kouroupis
During the progression of knee osteoarthritis (OA), the synovium and infrapatellar fat pad (IFP) can serve as source for Substance P (SP) and calcitonin gene-related peptide (CGRP), two important pain-transmitting, immune, and inflammation modulating neuropeptides. Our previous studies showed that infrapatellar fat pad-derived mesenchymal stem/stromal cells (MSC) acquire a potent immunomodulatory phenotype and actively degrade Substance P via CD10 both in vitro and in vivo. On this basis, our hypothesis is that CD10-bound IFP-MSC sEVs can be engineered to target CGRP while retaining their anti-inflammatory phenotype...
March 10, 2024: Cells
https://read.qxmd.com/read/38534290/pediatric-sedation-in-dutch-dental-clinics-the-influence-of-guideline-modifications-on-adverse-events
#13
JOURNAL ARTICLE
Jonah M Hill, Daphne Y S Vogel, Bea Spek, Catharine J de Jong, Janneke B Krikken, Jaap S J Veerkamp
Background : Dental fear and uncooperative behavior can hinder dental treatment quality. Pediatric Procedural Sedation and Analgesia (PPSA) is used to facilitate treatment when the coping capacity is exceeded. Out-of-hospital PPSA has been associated with more adverse outcomes compared to when it is used in hospital-based settings. The updated Dutch PPSA guidelines have increased costs and raised concerns about the accessibility of specialized high-quality dental care for children in the Netherlands. This study aimed to investigate the impact of the updated 2017 guidelines on the occurrence rate of adverse events during PPSA in twelve Dutch dental clinics...
March 5, 2024: Dentistry Journal
https://read.qxmd.com/read/38534034/management-of-interdental-papillary-defects-using-subperiosteal-hyaluronic-acid-injection-overlay-technique-a-prospective-longitudinal-clinical-study
#14
JOURNAL ARTICLE
Wiam Hamadeh, Rola Alhabashneh, Reem Abdelhafez, Yousef Khader
OBJECTIVE: Currently, there is no established treatment protocol to treat interdental papillary loss. This research aimed to evaluate the outcomes of interdental papillary reconstruction using minimally invasive surgery, with injectable hyaluronic acid gel. METHOD AND MATERIALS: Seventeen patients were included, each with five sites of class 1 papillary recession (40 sites in the maxilla and 45 sites in the mandible). Subperiosteal tunneling was performed through a horizontal incision made apical to the base of the papilla without penetrating it...
March 27, 2024: Quintessence International
https://read.qxmd.com/read/38533719/tianeptine-as-an-opiate-replacement-in-a-patient-on-methadone-treatment-a-case-report
#15
JOURNAL ARTICLE
Vivek Velagapudi, Jordan Calabrese, Roopa Sethi
Tianeptine, an antidepressant and full µ-opioid receptor agonist, has increased in popularity and has been used as an over-the-counter supplement over the past decade. Due to its well-documented euphoric effects, there exists elevated risk for potential abuse. Buprenorphine-naloxone has been successfully utilized to treat opioid use disorder (OUD) in patients concurrently using tianeptine, limiting withdrawal symptoms and abstinence. However, there is limited evidence on the management of tianeptine use disorder, specifically methadone or naltrexone...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533718/patient-genetic-heterogeneities-acting-as-indicators-of-post-operative-pain-and-opioid-requirement-in-orthopedic-surgery-a-systematic-review
#16
JOURNAL ARTICLE
Ahmad Hasan, Adam Pearl, Mohammad Daher, Khaled J Saleh
INTRODUCTION: Orthopedic surgical procedures are expected to increase annually, making it imperative to understand the correlations between patient genetic makeup and post-operative pain levels. METHODS: We performed a systematic literature review using PubMed and Cochrane databases in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of 299 articles were initially selected, 20 articles remained after title and abstract review, and nine articles were selected for inclusion upon full text review...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533717/examining-the-relationship-between-head-trauma-and-opioid-use-disorder-a-systematic-review
#17
JOURNAL ARTICLE
Ali Abid, Maria Paracha, Iva Çepele, Awais Paracha, Joseph Rueve, Akbar Fidahussain, Humza Rehman, McKimmon Engelhardt, Noor Alyasiry, Zohair Siddiqui, Satvik Vasireddy, Bishal Kadariya, Nikith Rao, Rohan Das, Wilson Rodriguez, Dixie Meyer
OBJECTIVE: To examine recent literature and determine common clinical risk factors between antecedent traumatic brain injury (TBI) and the following development of opioid misuse and provide a framework for clinical identification of at-risk subjects and evaluate potential treatment implications within this association. DESIGN: A comprehensive systematic literature search of PubMed was conducted for articles between 2000 and December 2022. Studies were included if the human participant had any head trauma exposure and any chronic opioid use or dependence...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533716/role-of-opioid-use-in-gastrointestinal-obstruction-and-perforation-a-retrospective-review
#18
JOURNAL ARTICLE
Divya Bishnoi, Priyanka Sharma, Anant Kumar Rathi
INTRODUCTION: Pain is one of the most common complaints that brings a patient to a hospital. For this, usually, the patient might have already consumed various types of pain killer combinations, either prescribed or over-the-counter. In some of these cases, a patient consumes these medicines unmonitored for a long time and then comes with complications, among which gastrointestinal tract obstruction and perforation are the most life threatening. MATERIALS AND METHODS: Case files from the Department of Surgery were retrieved and studied...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533715/chronic-opioid-pain-treatment-converted-to-buprenorphine-a-case-series-using-a-3-step-low-dose-incremental-dosing-guideline
#19
JOURNAL ARTICLE
Gregory Acampora, Yi Zhang
We report a 30-case series from the Pain Management Center at the Massachusetts General Hospital where we have applied a guideline to convert chronic treatment for pain from full agonist opioids (FAO) to buprenorphine (BUP). Of the patients, 24 (80 percent) elected to continue BUP over FAO. Five conversions were stopped for side effects (fatigue) and/or lack of sufficient pain reduction. One patient elected not to participate on the day that the conversion was to begin. There were no major adverse events. We conclude that conversion to BUP should be considered as an alternative to treat patients on chronic opioids for pain...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533714/short-term-healthcare-resource-utilization-associated-with-receipt-of-cdc-informed-opioid-thresholds-among-commercially-insured-new-chronic-opioid-users
#20
JOURNAL ARTICLE
Martin J Calabrese, Fadia T Shaya, Francis Palumbo, Mary Lynn McPherson, Ester Villalonga-Olives, Zafar Zafari, Ryan Mutter
OBJECTIVE: To evaluate the impact of recent changes to the Centers for Disease Control and Prevention (CDC) morphine milligram equivalent (MME)/day threshold recommendations on healthcare utilization. DESIGN: A retrospective cohort study of new chronic opioid users (NCOUs). SETTING: Commercially insured plans across the United States using IQVIA PharMetrics® Plus for Academics database with new use between January 2014 and March 2015...
2024: Journal of Opioid Management
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