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Jonathan Kuten, Nicola J Mabjeesh, Hedva Lerman, Charles Levine, Sophie Barnes, Einat Even-Sapir
BACKGROUND: Ga-prostate-specific membrane antigen positron emission tomography/computerized tomography (Ga-PSMA PET/CT) is part of the initial workup of patients with intermediate and high-risk prostate cancer provided by the Israeli national health services. OBJECTIVES: To assess the incidence of metastatic spread in consecutive patients with newly diagnosed cancer, and the potential added value of Ga-PSMA PET/CT to the staging imaging algorithm. METHODS: Patients with newly diagnosed intermediate- and high-risk prostate cancer were referred for initial staging by Ga-PSMA PET/CT between May 2016 and April 2017...
February 2019: Israel Medical Association Journal: IMAJ
Sol Jaworowski, Jean-Louis Golmard, Morag Engelberg, Sarah Prijs, Lital Twizer, Cornelius Gropp, Joseph Mergui
BACKGROUND: A history of childhood sexual abuse (CSA) has been linked to a variety of physical and psychiatric illnesses, including ischemic heart disease and post-traumatic stress disorder (PTSD). OBJECTIVES: To determine the prevalence of past CSA and re-traumatization among hospital psychiatric consultations and to determine whether a CSA group in a hospital setting shared characteristics with community samples described in the literature. METHODS: We divided 228 consecutive psychiatric consultations into two groups...
February 2019: Israel Medical Association Journal: IMAJ
Arend M Hamming, Marianne A A van Walderveen, Inge A Mulder, Irene C van der Schaaf, L Jaap Kappelle, Birgitta K Velthuis, Michel D Ferrari, Gisela M Terwindt, Marieke C Visser, Wouter Schonewille, Ale Algra, Marieke J H Wermer
OBJECTIVES: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine. MATERIALS AND METHODS: Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria...
February 16, 2019: Brain and Behavior
Louise Lindholdt, Thomas Lund, Johan Hviid Andersen, Claus D Hansen, Merete Labriola
PURPOSE: The Future Occupation of Children and Adolescents cohort (the FOCA cohort) is a large population-based cohort study that was established as a resource for research in order to study adolescence factors and future educational and vocational trajectories in a life-course perspective. The cohort covers a broad array of themes within public health, including diseases and health behaviours. Through linkage to register data on the participants' parents, the cohort allows investigation of parental effects over time on adolescents' behaviours and interactions across generations...
February 15, 2019: BMJ Open
Kousalya Prabahar, Teja Katikam, Saranya Punniyakotti, Praveen Devanandan
To evaluate the anti-hypertensive drugs used in pregnancy induced hypertension and to determine the safety of the anti-hypertensive drugs administered in gestational hypertensive patients. Pregnancy induced hypertension are very common in women and if unnoticed may lead to severe complications. The appropriate therapy is very much essential for the welfare of both the mother and the child. Hence this study was undertaken to identify the commonly used and safe drugs in pregnancy induced hypertension. This retrospective study was carried out in the Medical Records Department of a specialized gynecological hospital...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Dawn T Bounds, Laurel D Edinburgh, Louis F Fogg, Elizabeth M Saeywc
BACKGROUND: Adolescent victims of sexual assault and exploitation suffer significant mental health distress including PTSD, self-harm, suicidal ideation, and attempts. OBJECTIVE: This longitudinal observational study investigated the Runaway Intervention Program's influence on trauma responses at 3, 6, and 12 months for adolescents who have run away at least once and have been sexually assaulted or exploited. PARTICIPANTS: Runaways (n = 362) received nurse practitioner (NP) home and community visits, intensive case management, and optional empowerment groups...
February 14, 2019: Child Abuse & Neglect
Marisa E Marraccini, Leslie A Brick, Lisa L Weyandt, Alyssa Francis, Christine Clarkin, Yumeng Fang
BACKGROUND: College students are at increased risk for self-injurious thoughts and behaviors (SITB) and sexual risk behaviors (SRB). Although students with a history of SITB appear to be more prone to SRB, the mechanisms linking these risk behaviors remain largely unexplored. Previous research points to emotional control (EC), defined as one's awareness and adaptability of emotions, as a potential mechanism explaining the relationship between SITB and SRB.1 METHODS: Data included 722 college students attending two different universities in the northeast and southeast regions of the United States...
February 7, 2019: Journal of Affective Disorders
Zhiling Bai, Zhuoping Duan, Lijing Wen, Zhenyu Zhang, Zhuocheng Ou, Fenglei Huang
To facilitate the pre-estimation and optimization of the prescription design of a multi-component polymer bonded explosive (PBX), a multicomponent mesoscopic reaction rate model (MC-DZK model) is developed to predicate preferably the influence of both the explosive components and the particle size of on the shock initiation. All the parameters in the model are determined directly by the parameters in the DZK model for each explosive component. Furthermore, for the multicomponent insensitive explosive PBXC10 (70% TATB, 25% HMX, and 5% Kel-F800 by weight) with different explosive particle sizes, both shock initiation experiments and corresponding numerical simulations are performed, and there is satisfactory agreement between the numerical results and the available experimental data...
February 10, 2019: Journal of Hazardous Materials
Ali A Asadi-Pooya, Zahra Bahrami, Maryam Homayoun
PURPOSE: The purpose of this study was to investigate the long-term outcome of patients with psychogenic nonepileptic seizures (PNES), who never visited a psychologist and never received a proper therapy for their condition (due to lack of resources). We also aimed to investigate factors potentially associated with the outcome in these patients. METHODS: We studied all patients with PNES, who were admitted to the epilepsy monitoring unit at the Shiraz Comprehensive Epilepsy Center, from 2008 until 2013...
February 11, 2019: Seizure: the Journal of the British Epilepsy Association
Ali Karayağmurlu, İsmail Aytaç, Secaattin Gülşen
OBJEVTIVES: Otorhinologic trauma is an important condition at the ear, nose and throat (ENT) outpatient clinic in children. Attention deficit hyperactivity disorder (ADHD) has been identified as a potential risk factor that may contribute to the incidence of traumatic injuries. The aim of the study was to investigate whether there is an association between otorhinologic trauma and ADHD symptoms in children. METHODS: A prospective study was conducted between September 2017 and March 2018...
February 8, 2019: International Journal of Pediatric Otorhinolaryngology
Quinn Orb, Aida Rezaie, Sheldon Furst, Jeremy D Meier, Albert H Park
INTRODUCTION: There is increasing concern regarding the risks associated with the use of general anesthesia in pediatric patients. Many otolaryngologic procedures performed under general anesthesia can also be performed in clinic. We hypothesize that anxiolytics can aid in performing common procedures in clinic thus avoiding the need to undergo general anesthesia in the OR. METHODS: We performed a retrospective review of patients undergoing inoffice procedures with anxiolytics in our pediatric otolaryngology outpatient clinic between February 2013 and January 2017...
February 5, 2019: International Journal of Pediatric Otorhinolaryngology
Christopher A Groh, Madelaine Faulkner, Shiffen Getabecha, Victoria Taffe, Gregory Nah, Kathi Sigona, Debbe McCall, Mellanie True Hills, Kathleen Sciarappa, Mark J Pletcher, Jeffrey E Olgin, Gregory M Marcus
BACKGROUND: Triggers for discrete atrial fibrillation (AF) events remain poorly studied and incompletely characterized. OBJECTIVE: The present study describes common triggers for AF and their relationships with patient characteristics. METHODS: We invited symptomatic, paroxysmal AF patients enrolled in the Health eHeart Study and through the patient-centered advocacy organization to complete a questionnaire regarding their AF triggers and cardiovascular risk factors...
January 30, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Andre Monteiro, Guilherme Jose Agnoletto, Manuel F Granja, Ester N Bit-Ivan, Eric Sauvageau
BACKGROUND: Intracranial vascular infections of fungal etiology are extremely rare. The vast majority of cases occur in immunocompromised patients with invasive fungal disease, most commonly originating in the paranasal sinuses or the lungs. An extremely rare type in this part of the world, called Granulomatous Invasive Rhinosinusitis, has been reported to affect immunocompetent patients in most cases, and its causative strain has potential to invade the intracranial arteries. CASE DESCRIPTION: We present a rare case of basilar artery rupture and infarction secondary to granulomatous invasive rhinosinusitis in a 50 year old male who presented with ischemic symptoms and 6 month history of headache, dizziness and falls in Florida, USA...
February 14, 2019: World Neurosurgery
Bocar Baya, Chad J Achenbach, Bourahima Kone, Yacouba Toloba, Djeneba K Dabitao, Bassirou Diarra, Drissa Goita, Seydou Diabaté, Mamoudou Maiga, Dianguina Soumare, Khadidia Ouattara, Tenin Kanoute, Gaoussou Berthe, Youssouf M Kamia, Yeya Dit Sadio Sarro, Moumine Sanogo, Antieme C G Togo, Bindongo P P Dembele, Nadie Coulibaly, Amadou Kone, Maxwell Akanbi, Michael Belson, Sounkalo Dao, Susan Orsega, Sophia Siddiqui, Seydou Doumbia, Robert L Murphy, Souleymane Diallo
BACKGROUND: MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF® has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. In this stud, we aimed to determine the clinical factors associated with MDR-TB in Bamako, Mali. METHODS: We performed a cross-sectional study of 214 patients with presumed MDR-TB admitted to University of Bamako Teaching Hospital, Point-G between 2007 and 2016...
February 14, 2019: International Journal of Infectious Diseases: IJID
Marie-Claude Pelland-Marcotte, Catherine Tucker, Alicia Klaassen, Maria Laura Avila, Ali Amid, Nour Amiri, Suzan Williams, Jacqueline Halton, Leonardo R Brandão
BACKGROUND: Little is known about severe pulmonary embolism in children. We aimed to report pulmonary embolism outcomes, identify risk factors for unfavourable outcomes, and evaluate the discriminative ability of two clinical-severity indices in children. METHODS: In this retrospective cohort study, we included consecutive patients aged 18 years or younger with acute pulmonary embolism, objectively diagnosed radiologically or pathologically, between Jan 1, 2000, and Dec 31, 2016, from two Canadian paediatric hospitals (The Hospital for Sick Children, Toronto, ON, and the Children's Hospital of Eastern Ontario, Ottawa, ON)...
February 13, 2019: Lancet Haematology
José L Yáñez-Ortega, Esther Arrieta-Cerdán, José E Lozano-Alonso, Milagros Gil Costa, Ana M Gutiérrez-Araus, José A Cordero-Guevara, Tomás Vega Alonso
INTRODUCTION: Several studies warn that overweight and obesity have become an epidemic with severe consequences in the population's health. The objetive of the present study is to estimate the prevalence of overweight and obesity in Castile and Leon in a sample of children at 6, 11 and 14 years of age, to describe its evolution and its association with life habits and antecedents. MATERIAL AND METHODS: Observational study, retrospective cohort, performed by the pediatricians of the Health Sentinel Network...
February 13, 2019: Endocrinología, Diabetes y Nutrición
Ilyse S Kornblau, Jaafar F El-Annan
We reviewed literature on adverse reactions to intravenous fluorescein angiography (IVFA) using PubMed and found 78 articles in English from 1961-2017. The reported rates of adverse reactions were overall 0.083-21.69%, separated into mild (1.24-17.65%), moderate (0.2-6%), and severe (0.04-0.59%). There were 1:100,000 to 1:220,000 deaths. Fluorescein concentration, volume injected, speed of injection, temperature, and contaminates were not correlated with the incidence of reactions. Patient characteristics including other comorbid diseases, allergy history, age, race, and gender showed only an increased rate of reaction in patients with a history of reaction to fluorescein...
February 14, 2019: Survey of Ophthalmology
Peter H Adler, Hiroyuki Takaoka, Mohd Sofian-Azirun, Chee Dhang Chen, I Wayan Suana
A recently described species of black fly, Simulium wayani Takaoka and Chen, from the island of Timor was chromosomally mapped to provide insights into its evolutionary and biogeographic history. The morphologically based species status of S. wayani is supported by a suite of fixed chromosomal rearrangements and unique sex chromosomes derived primarily from a large pool of polymorphisms in the S. ornatipes complex in Australia. The banding patterns of its polytene chromosomes indicate that S. wayani is closely related to a pair of homosequential cryptic species (S...
February 14, 2019: Acta Tropica
Tara D Mangal, Ana Roberta Pati Pascom, Juan F Vesga, Mariana Veloso Meireles, Adele Schwartz Benzaken, Timothy B Hallett
Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil's integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), reporting rates and ART initiation rates. An age-structured deterministic model with a flexible spline was used to describe the natural history of HIV along with reporting and treatment rates. Individual-level surveillance data for 1,077,295 cases (HIV/AIDS diagnoses, ART dispensations, CD4 counts and HIV/AIDS-related deaths) were used to calibrate the model using Bayesian inference...
February 7, 2019: Epidemics
Helena M Gardiner
The aim of foetal cardiac therapy is to treat an abnormality at the developmental stage so that the process of cardiac growth, which is complex and relies on the volume and direction of circulating blood as well as genetic determinants, can continue. In reality, most cardiac interventions are palliative; hence, major abnormalities are still present at birth. Nevertheless, tangible benefits following successful foetal intervention include improved haemodynamics and reduction in secondary damage leading to better postnatal outcomes...
January 17, 2019: Best Practice & Research. Clinical Obstetrics & Gynaecology
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