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JOURNAL ARTICLE
Nicolas Vallet, Sophie Le Grand, Louise Bondeelle, Benedicte Hoareau, Aurelien Corneau, Delphine Bouteiller, Simon Tournier, Lucille Lew-Derivry, Armelle Bohineust, Marie Tourret, Delphine Gibert, Ethan Mayeur, Raphaël A Itzykson, Kim Pacchiardi, Brian Ingram, Stephane Cassonnet, Patricia Lepage, Régis Peffault de Latour, Gérard Socie, Anne Bergeron, David Michonneau
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better understand the mechanisms underlying relapse, the first cause of mortality after transplantation. We used multi-omics on patients' samples to decipher immune alterations associated with azithromycin intake and post-transplant relapsed malignancies...
August 19, 2022: Blood
#22
REVIEW
Tiantian Su, Qiuyun Guan, Huijuan Cheng, Zhenduo Zhu, Chunru Jiang, Paipai Guo, Yu Tai, Hanfei Sun, Manman Wang, Wei Wei, Qingtong Wang
Human G protein-coupled receptor 56 (GPR56) is encoded by gene ADGRG1 from chromosome 16q21 and is homologously encoded in mice, at chromosome 8. Both 687 and 693 splice forms are present in humans and mice. GPR56 has a 381 amino acid-long N-terminal extracellular segment and a GPCR proteolysis site upstream from the first transmembrane domain. GPR56 is mainly expressed in heart, brain, thyroid, platelets and peripheral blood mononuclear cells. Accumulating evidence indicates that GPR56 promotes the formation of myelin sheaths and the development of oligodendrocytes in the cerebral cortex of the central nervous system...
August 11, 2022: Acta Physiologica
#23
JOURNAL ARTICLE
Vashe Chandrakanthan, Prunella Rorimpandey, Fabio Zanini, Diego Chacon, Jake Olivier, Swapna Joshi, Young Chan Kang, Kathy Knezevic, Yizhou Huang, Qiao Qiao, Rema A Oliver, Ashwin Unnikrishnan, Daniel R Carter, Brendan Lee, Chris Brownlee, Carl Power, Robert Brink, Simon Mendez-Ferrer, Grigori Enikolopov, William Walsh, Berthold Göttgens, Samir Taoudi, Dominik Beck, John E Pimanda
Mouse haematopoietic stem cells (HSCs) first emerge at embryonic day 10.5 (E10.5), on the ventral surface of the dorsal aorta, by endothelial-to-haematopoietic transition. We investigated whether mesenchymal stem cells, which provide an essential niche for long-term HSCs (LT-HSCs) in the bone marrow, reside in the aorta-gonad-mesonephros and contribute to the development of the dorsal aorta and endothelial-to-haematopoietic transition. Here we show that mesoderm-derived PDGFRA+ stromal cells (Mesp1der PSCs) contribute to the haemogenic endothelium of the dorsal aorta and populate the E10...
July 28, 2022: Nature Cell Biology
#24
JOURNAL ARTICLE
Sharareh Siamakpour-Reihani, Felicia Cao, Jing Lyu, Yi Ren, Andrew B Nixon, Jichun Xie, Amy T Bush, Mark D Starr, James R Bain, Michael J Muehlbauer, Olga Ilkayeva, Virginia Byers Kraus, Janet L Huebner, Nelson J Chao, Anthony D Sung
Although hematopoietic stem cell transplantation (HCT) is the only curative treatment for acute myeloid leukemia (AML), it is associated with significant treatment related morbidity and mortality. There is great need for predictive biomarkers associated with overall survival (OS) and clinical outcomes. We hypothesized that circulating metabolic, inflammatory, and immune molecules have potential as predictive biomarkers for AML patients who receive HCT treatment. This retrospective study was designed with an exploratory approach to comprehensively characterize immune, inflammatory, and metabolomic biomarkers...
2022: PloS One
#25
JOURNAL ARTICLE
Lei Zhang, Lin Han, Ziyan Liu, Jiaru Jing, Jingyu Wang, Wei Zhang, Ai Gao
Benzene poisoning is a common adverse blood outcome in occupational workers, manifested by hematopoietic dysfunction. However, the specific phenotype and its mechanisms of early hematopoietic toxicity caused by benzene remain unclear. After 15 days of exposure, the WBC levels were not significantly altered in benzene-exposed mice. However, the level of red blood cells (RBC) showed a significant decrease, and it was significantly and negatively correlated with urinary S-phenylmercapturic acid (SPMA). Notably, 5 mg/kg benzene exposure significantly inhibited the renewal capacity and the number of colony formation of hematopoietic stem progenitor cells in mice, especially erythrocyte differentiation...
September 2022: Chemosphere
#26
JOURNAL ARTICLE
Sabrina Zippel, Nadine Dilger, Chandralekha Chatterjee, Annamarija Raic, Gerald Brenner-Weiß, Patrik Schadzek, Bastian E Rapp, Cornelia Lee-Thedieck
Leukemia patients undergo chemotherapy to combat the leukemic cells (LCs) in the bone marrow. During therapy not only the LCs, but also the blood-producing hematopoietic stem and progenitor cells (HSPCs) may be destroyed. Chemotherapeutics targeting only the LCs are urgently needed to overcome this problem and minimize life-threatening side-effects. Predictive in vitro drug testing systems allowing simultaneous comparison of various experimental settings would enhance the efficiency of drug development. Here, we present a three-dimensional (3D) human leukemic bone marrow model perfused using a magnetic, parallelized culture system to ensure media exchange...
May 17, 2022: Biofabrication
#27
JOURNAL ARTICLE
Oscar Daniel Rangel-Huerta, María José de la Torre-Aguilar, María Dolores Mesa, Katherine Flores-Rojas, Juan Luis Pérez-Navero, María Auxiliadora Baena-Gómez, Angel Gil, Mercedes Gil-Campos
Hematopoietic stem cell transplantation (HSCT) involves the infusion of either bone marrow or blood cells preceded by toxic chemotherapy. However, there is little knowledge about the clinical benefits of parenteral nutrition (PN) in patients receiving high-dose chemotherapy during HSCT. We investigated the lipidomic profile of plasma and the targeted fatty acid profiles of plasma and erythrocytes in children after HSCT using PN with either a fish oil-based lipid emulsion or a classic soybean oil emulsion. An untargeted liquid chromatography high-resolution mass spectrometry platform connected with a novel in silico annotation algorithm was utilized to determine the most relevant chemical subclasses affected...
March 27, 2022: International Journal of Molecular Sciences
#28
JOURNAL ARTICLE
Greta Simionato, Antonia Rabe, Joan Sebastián Gallego-Murillo, Carmen van der Zwaan, Arie Johan Hoogendijk, Maartje van den Biggelaar, Giampaolo Minetti, Anna Bogdanova, Heimo Mairbäurl, Christian Wagner, Lars Kaestner, Emile van den Akker
Hypoxia is associated with increased erythropoietin (EPO) release to drive erythropoiesis. At high altitude, EPO levels first increase and then decrease, although erythropoiesis remains elevated at a stable level. The roles of hypoxia and related EPO adjustments are not fully understood, which has contributed to the formulation of the theory of neocytolysis. We aimed to evaluate the role of oxygen exclusively on erythropoiesis, comparing in vitro erythroid differentiation performed at atmospheric oxygen, a lower oxygen concentration (three percent oxygen) and with cultures of erythroid precursors isolated from peripheral blood after a 19-day sojourn at high altitude (3450 m)...
March 23, 2022: Cells
#29
JOURNAL ARTICLE
Margaret M Smith, Anthony J Hayes, James Melrose
This review highlights the attributes of pentosan polysulphate (PPS) in the promotion of intervertebral disc (IVD) repair processes. PPS has been classified as a disease modifying osteoarthritic drug (DMOAD) and many studies have demonstrated its positive attributes in the countering of degenerative changes occurring in cartilaginous tissues during the development of osteoarthritis (OA). Degenerative changes in the IVD also involve inflammatory cytokines, degradative proteases and cell signalling pathways similar to those operative in the development of OA in articular cartilage...
February 1, 2022: Stem Cells and Development
#30
JOURNAL ARTICLE
Bernhard Gentner, Francesca Tucci, Stefania Galimberti, Francesca Fumagalli, Maurizio De Pellegrin, Paolo Silvani, Chiara Camesasca, Silvia Pontesilli, Silvia Darin, Francesca Ciotti, Marina Sarzana, Giulia Consiglieri, Chiara Filisetti, Giulia Forni, Laura Passerini, Daniela Tomasoni, Daniela Cesana, Andrea Calabria, Giulio Spinozzi, Maria-Pia Cicalese, Valeria Calbi, Maddalena Migliavacca, Federica Barzaghi, Francesca Ferrua, Vera Gallo, Simona Miglietta, Erika Zonari, Patali S Cheruku, Claudia Forni, Marcella Facchini, Ambra Corti, Michela Gabaldo, Stefano Zancan, Serena Gasperini, Attilio Rovelli, Jaap-Jan Boelens, Simon A Jones, Robert Wynn, Cristina Baldoli, Eugenio Montini, Silvia Gregori, Fabio Ciceri, Maria G Valsecchi, Giancarlo la Marca, Rossella Parini, Luigi Naldini, Alessandro Aiuti, Maria-Ester Bernardo
BACKGROUND: Allogeneic hematopoietic stem-cell transplantation is the standard of care for Hurler syndrome (mucopolysaccharidosis type I, Hurler variant [MPSIH]). However, this treatment is only partially curative and is associated with complications. METHODS: We are conducting an ongoing study involving eight children with MPSIH. At enrollment, the children lacked a suitable allogeneic donor and had a Developmental Quotient or Intelligence Quotient score above 70 (i...
November 18, 2021: New England Journal of Medicine
#31
JOURNAL ARTICLE
Michelle Maartens, Maria Jacoba Kruger, Mari van de Vyver
Diabetes is a complex multifactorial disorder associated with hyperglycemia, oxidative stress, and inflammation. The pathological microenvironment impairs mesenchymal stem cell (MSC) viability and dysregulates their proregenerative and immune-modulatory function causing maladaptive tissue damage. Targeting stem cells to protect them against impairment could thus delay the onset of complications and enhance the quality of life in diabetes mellitus patients. The aim of this study was to investigate the efficacy of N-acetylcysteine (NAC) and ascorbic-acid-2-phosphate (AAP) oral supplementation as preventative measure against MSC impairment...
December 1, 2021: Stem Cells and Development
#32
REVIEW
Toshiyuki Yoneda, Masahiro Hiasa, Tatsuo Okui, Kenji Hata
Bone is one of the preferential target organs of cancer metastasis. Bone metastasis is associated with various complications, of which bone pain is most common and debilitating. The cancer-associated bone pain (CABP) is induced as a consequence of increased neurogenesis, reprogramming and axonogenesis of sensory nerves (SNs) in harmony with sensitization and excitation of SNs in response to the tumor microenvironment created in bone. Importantly, CABP is associated with increased mortality, of which precise cellular and molecular mechanism remains poorly understood...
October 2021: Journal of Bone Oncology
#33
JOURNAL ARTICLE
Yandan Chen, Shuyi Fang, Qingwei Ding, Rongzhen Jiang, Jiefeng He, Qin Wang, Yuting Jin, Xinxin Huang, Sheng Liu, Maegan L Capitano, Thao Trinh, Yincheng Teng, Qingyou Meng, Jun Wan, Hal E Broxmeyer, Bin Guo
The heterogeneity of human hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) under stress conditions such as ex vivo expansion is poorly understood. Here, we report that the frequencies of SCID-repopulating cells were greatly decreased in cord blood (CB) CD34+ HSCs and HPCs upon ex vivo culturing. Transcriptomic analysis and metabolic profiling demonstrated that mitochondrial oxidative stress of human CB HSCs and HPCs notably increased, along with loss of stemness. Limiting dilution analysis revealed that functional human HSCs were enriched in cell populations with low levels of mitochondrial ROS (mitoROS) during ex vivo culturing...
October 15, 2021: Journal of Clinical Investigation
#34
JOURNAL ARTICLE
Rui Sun, Lixiazi He, Hyeyoon Lee, Andrey Glinka, Carolin Andresen, Daniel Hübschmann, Irmela Jeremias, Karin Müller-Decker, Caroline Pabst, Christof Niehrs
Acute myeloid leukemia (AML) is a rapidly progressing cancer, for which chemotherapy remains standard treatment and additional therapeutic targets are requisite. Here, we show that AML cells secrete the stem cell growth factor R-spondin 2 (RSPO2) to promote their self-renewal and prevent cell differentiation. Although RSPO2 is a well-known WNT agonist, we reveal that it maintains AML self-renewal WNT independently, by inhibiting BMP receptor signaling. Autocrine RSPO2 signaling is also required to prevent differentiation and to promote self-renewal in normal hematopoietic stem cells as well as primary AML cells...
August 17, 2021: Cell Reports
#35
JOURNAL ARTICLE
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2 expression is controlled by the Tie2 promoter. Tie2CRE/+ ;Bmp2tg/tg mice develop aortic valve dysfunction postnatally, accompanied by pre-calcific lesion formation in valve leaflets. Remarkably, Tie2CRE/+ ;Bmp2tg/tg mice develop extensive soft tissue bone formation typical of acquired forms of heterotopic ossification (HO) and genetic bone disorders, such as Fibrodysplasia Ossificans Progressiva (FOP)...
July 22, 2021: Cell Death & Disease
#36
JOURNAL ARTICLE
Weidong Zhang, Niu Wang, Tongtong Zhang, Meng Wang, Wei Ge, Xin Wang
Emerging studies show that melatonin promotes cashmere development through hypodermic implantation. However, the impact and underlying mechanisms are currently unknown. In vitro study has previously demonstrated that melatonin induces cashmere growth by regulating the proliferation of goat secondary hair follicle stem cells (gsHFSCs), but there is limited information concerning the effects of melatonin on cell pluripotency. It is also known that Wnt signaling may actively participate in regulating cell proliferation and stem cell pluripotency...
2021: Frontiers in Cell and Developmental Biology
#37
JOURNAL ARTICLE
Chun Xia Zhang, Feng Liu
The blood system provides the body with oxygen and nutrients, maintains the homeostasis of the internal environment through material exchange, and keeps the body with immune defense and protection. Hematopoietic stem cells (HSCs), which are pluripotent adult stem cells with self-renewal and differentiation potential, are the origin of mature blood cells in the body. The production, development and maturation processes of HSCs and their derivatives are the so-called 'hematopoiesis', which begins in the early embryonic development and throughout the life course; any abnormality during these processes can cause the occurrence of hematological diseases...
April 20, 2021: Yi Chuan, Hereditas
#38
JOURNAL ARTICLE
Laura Rodriguez, Pascale Duchez, Nicolas Touya, Christelle Debeissat, Amélie V Guitart, Jean-Max Pasquet, Marija Vlaski-Lafarge, Philippe Brunet de la Grange, Zoran Ivanovic
Alpha tocopherol acetate (αTOA) is an analogue of alpha tocopherol (αTOC) that exists in the form of an injectable drug. In the context of the metabolic hypothesis of stem cells, we studied the impact of αTOA on the metabolic energetic profile and functional properties of hematopoietic stem and progenitor cells. In ex vivo experiments performed on cord blood CD34+ cells, we found that αTOA effectively attenuates oxidative phosphorylation without affecting the glycolysis rate. This effect concerns complex I and complex II of the mitochondrial respiratory chain and is related to the relatively late increase (3 days) in ROS (Reactive Oxygen Species)...
April 10, 2021: Biomolecules
#39
JOURNAL ARTICLE
Wiebke Lückstädt, Simon Bub, Tomas Koudelka, Egor Pavlenko, Florian Peters, Prasath Somasundaram, Christoph Becker-Pauly, Ralph Lucius, Friederike Zunke, Philipp Arnold
Cluster of differentiation 109 (CD109) is a glycosylphosphatidylinositol (GPI)-anchored protein expressed on primitive hematopoietic stem cells, activated platelets, CD4+ and CD8+ T cells, and keratinocytes. In recent years, CD109 was also associated with different tumor entities and identified as a possible future diagnostic marker linked to reduced patient survival. Also, different cell signaling pathways were proposed as targets for CD109 interference including the TGFβ, JAK-STAT3, YAP/TAZ, and EGFR/AKT/mTOR pathways...
2021: Frontiers in Cell and Developmental Biology
#40
JOURNAL ARTICLE
Jiajing Qiu, Jana Gjini, Tasleem Arif, Kateri Moore, Miao Lin, Saghi Ghaffari
Hematopoietic cell transplantation is a critical curative approach for many blood disorders. However, obtaining grafts with sufficient numbers of hematopoietic stem cells (HSCs) that maintain long-term engraftment remains challenging; this is due partly to metabolic modulations that restrict the potency of HSCs outside of their native environment. To address this, we focused on mitochondria. We found that human HSCs are heterogeneous in their mitochondrial activity as measured by mitochondrial membrane potential (MMP) even within the highly purified CD34+CD38-CD45RA-CD90+CD49f+ HSC population...
March 23, 2021: Blood Advances
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