Kefu Liu, Ailikemu Aierken, Mengyao Liu, Nazakat Parhat, Wei Kong, Xingyu Yin, Gang Liu, Ding Yu, Jie Hong, Junjun Ni, Zhenzhen Quan, Xiaoyun Liu, Simei Ji, Jian Mao, Weijun Peng, Chao Chen, Yan Yan, Hong Qing
Alzheimer's disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level...
March 15, 2024: IScience