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Ocular surface neoplasia

Harrison-Williams C M Lloyd, Simon Arunga, Amos Twinamasiko, Meier A Frederick, John Onyango
AIM: The aim of the study was to assess the predictors of ocular surface squamous neoplasia (OSSN) and conjunctival squamous cell carcinoma (SCC) among Ugandan patients. MATERIALS AND METHODS: Patients presenting for removal of ocular surface lesions received human immunodeficiency virus (HIV) testing, completed questionnaires about demographic, behavioral, and historical potential risk factors for conjunctival neoplasia, and had lesions examined for interpalpebral versus other locations, rough versus smooth texture, and number of feeder vessels...
July 2018: Middle East African Journal of Ophthalmology
Yan Zhang, Sander Dubovy, Carol L Karp
No abstract text is available yet for this article.
February 14, 2019: JAMA Ophthalmology
Curtis E Margo, Norberto Mancera
No abstract text is available yet for this article.
December 2018: Annals of Translational Medicine
Pia R Mendoza, Caroline M Craven, Matthew H Ip, Matthew W Wilson, Minas T Coroneo, Hans E Grossniklaus
Aim: To describe 4 cases of conjunctival squamous cell carcinoma (SCC) with corneal stromal invasion. Methods: Retrospective, clinicopathologic case series. Results: All patients had prior resections of presumed pterygia. The degree of corneal involvement dictated the extent of surgical management. One eye with localized invasion was treated with lamellar keratoplasty and plaque brachytherapy. Another case with widespread invasion warranted penetrating keratoplasty and eventual enucleation...
June 2018: Ocular Oncology and Pathology
Natalie Wolkow, Frederick A Jakobiec, Amir H Afrogheh, Ralph C Eagle, Sara I Pai, William C Faquin
PURPOSE: Novel cancer immunotherapies, called immune checkpoint inhibitors, have demonstrated clinical efficacy in the treatment of squamous cell carcinomas of the head and neck. Tissue expression of programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2) has been shown to predict tumor response to these drugs. We examine the expression of prognostic immune biomarkers, PD-L1 and PD-L2, in invasive ocular surface squamous neoplasia. DESIGN: Retrospective case series...
January 8, 2019: American Journal of Ophthalmology
Tina Shrestha, Won Choi, Ga Eon Kim, Jee Myung Yang, Kyung Chul Yoon
The aim of this study was to identify the association between human papilloma virus (HPV) infection and ocular surface squamous neoplasia (OSSN) using p16 immunohistochemistry (IHC) and deoxyribonucleic acid (DNA) chip test.Thirty-eight patients who underwent surgical excision of OSSN were retrospectively studied using tissue samples. The IHC was performed to assess the expression of p16 and DNA chip test was used to detect 24 HPV serotypes.Among the 38 OSSN samples, 32 cases (84.2%) were histopathologically categorized as pre-invasive type and 6 cases (15...
January 2019: Medicine (Baltimore)
Christine A Kiire, Rosalind M K Stewart, Sathish Srinivasan, Heinrich Heimann, Stephen B Kaye, Baljean Dhillon
PURPOSE: To describe the incidence, associations and outcomes of ocular surface squamous neoplasia (OSSN) in the United Kingdom. METHODS: Prospective, observational study of every new case of OSSN reported via the British Ophthalmological Surveillance Unit reporting scheme over a 12-month period. Cases were followed up for 12 months. RESULTS: The reported incidence of OSSN was 0.53 cases/million/year (conjunctival intraepithelial neoplasia: 0...
December 28, 2018: Eye
Rama Rajagopal, Pratik V Kataria, Sudharshan Sridharan, Krishna Kumar, Kuzhanthai Lily Therese, Poongulali Selvamuthu
No abstract text is available yet for this article.
January 2019: Indian Journal of Ophthalmology
Alexandra Santoni, Juliette Thariat, Célia Maschi, Joel Herault, Stéphanie Baillif, Sandra Lassalle, Marie Laure Peyrichon, Julia Salleron, Jean-Pierre Caujolle
PURPOSE: Ocular Surface Squamous Neoplasia includes a spectrum of diseases from dysplasia to invasive squamous cell carcinoma of the conjunctiva. Whether the degree of invasion influences outcomes is debated. We evaluated the outcomes and management of conjunctival carcinomas defined as ≤0.2mm invasion of the chorion (miSCC) or over (SCC). DESIGN: this is a retrospective case series. METHODS: Clinical, tumor and therapeutic characteristics and outcomes were collected for consecutive patients with histology-proven invasive conjunctival miSCC/SCC treated between 2002 and 2017...
December 12, 2018: American Journal of Ophthalmology
E M Messmer
BACKGROUND: Neurotrophic keratopathy is characterized by corneal surface alterations, persistent corneal epithelial defects and/or corneal ulcerations associated with corneal sensory abnormalities. Due to the variable clinical picture neurotrophic keratopathy is often overlooked or diagnosed too late in the course of the disease. OBJECTIVE: Discussion of the clinical picture of neurotrophic keratopathy and recommendations for correct diagnosis. MATERIAL AND METHODS: Analysis of the existing literature and discussion of basic recent publications...
December 7, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Steven S Bae, Clara C Chan
INTRODUCTION: To evaluate the indications and outcomes of manual blade superficial keratectomy STUDY DESIGN: Retrospective, nonrandomized, consecutive case series METHODS: Database search of patients from 2012-2017 who underwent superficial keratectomy was conducted at a tertiary care hospital cornea clinic. Charts of 121 patients (156 eyes) were reviewed who had at least 4 weeks of follow-up and both preoperative and postoperative measurements of best-corrected visual acuity or corneal cylinder...
December 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Nandini Venkateswaran, Carolina Mercado, Anat Galor, Carol L Karp
PURPOSE: To compare the efficacy of topical 5-fluorouracil 1% (5FU) and interferon alfa-2b 1 MIU/mL (IFN) eye drops as primary treatment modalities for ocular surface squamous neoplasia (OSSN). DESIGN: Retrospective, comparative, interventional case series. METHODS: Fifty-four patients who received 5FU and 48 patients who received IFN as primary therapy for OSSN were included. Primary outcome measures were the frequency of clinical resolution and time to OSSN recurrence by treatment modality...
November 21, 2018: American Journal of Ophthalmology
J M Pérez Dieste, M Castroviejo Bolíbar, M E Abad Collazo, C Sánchez Servate
No abstract text is available yet for this article.
November 16, 2018: Archivos de la Sociedad Española de Oftalmología
Purvasha Narang, Vikas Mittal, Vikas Menon, Anirban Bhaduri, Bhaskar Roy Chaudhuri, Santosh G Honavar
Purpose: To determine the role of primary limbal stem cell transplantation (LSCT) in managing extensive ocular surface squamous neoplasia (OSSN) with more than 3 quadrants of limbal involvement to prevent manifestations of limbal stem cell deficiency. Methods: A multi-center, comparative, and interventional clinical study of cases and historical controls was done. Patients with a limbal mass suggestive of OSSN involving more than 3 quadrants of limbus (> 9 clock hours) and no local, regional or systemic metastasis, who underwent primary surgical excision with or without adjuvant chemotherapy and had a minimum follow-up of 12 months were included in this study...
November 2018: Indian Journal of Ophthalmology
Hershel Patel, Lauren J Jeang, Ankit Shah, Edgar M Espana, Curtis E Margo
Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone. Cases: Two patients with 360 degrees of limbal involvement. Results: Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease...
September 2018: Ocular Oncology and Pathology
Alison D Early, Sarah Adelson, Craig J Miller, Thomas F Mauger
Objective: To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia. Materials and methods: This is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t -test...
2018: Clinical Ophthalmology
I-Hsin Ma, Fung-Rong Hu, I-Jong Wang, Wei-Li Chen, Ya-Jui Hsu, Hsiao-Sang Chu, Chang-Tsu Yuan, Yu-Chih Hou
BACKGROUND/PURPOSE: To describe the clinical and histologic characteristics of ocular surface squamous neoplasia (OSSN) and evaluate factors significant in recurrence at a university hospital in North Taiwan. METHODS: Patient charts, clinical features, and pathology records were retrospectively reviewed in patients with pathology-proved OSSN from January, 1994 to December, 2014. Clinicopathologic correlation was analyzed. RESULTS: Thirty-six patients were recruited...
September 25, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Q F Liang, J J Huang, K Cao, G Y Su, Z Q Wang, Y Zhang, B Li
Objective: To study the histopathology manifestation and imaging characteristics of in vivo confocal microscopy (IVCM) for diagnosis of ocular surface squamous neoplasia (OSSN) and analyze the reliability of IVCM in differential diagnosis from OSSN cases. Methods: A prospective study. Twenty-three patients (23 eyes) with OSSN were collected from September 2015 to November 2017 in Beijing Tongren Eye center. They were underwent the examinations sequentially as follows: visual examination; slit-lamp microscope examination and ocular surface photography; color fundus image; anterior segment optical coherence tomography examination; IVCM examination and histopathology examination after surgery...
September 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Carolina L Mercado, Cameron Pole, James Wong, Juan F Batlle, Fabiola Roque, Noah Shaikh, Juan C Murillo, Anat Galor, Carol L Karp
PURPOSE: To characterize vision-related and psychosocial quality of life (QoL) parameters in medically and surgically treated patients with OSSN. METHODS: Forty-one patients with OSSN treated with medical therapy consisting of interferon alpha 2b drops 1 MIU/ml (n = 22) or who underwent surgical excision (n = 19) were contacted. All subjects answered a quality of life assessment with an original questionnaire in which they were asked about a range of parameters...
September 11, 2018: Ocular Surface
Sonali V Kumar, D Joshi
No abstract text is available yet for this article.
July 2018: Medical Journal, Armed Forces India
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