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Feyissa Efa, Yared Alemu, Getenet Beyene, Esayas Kebede Gudina, Wakjira Kebede
Objectives: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are often difficult to manage due to its resistance to multiple antibiotics. This study aimed to determine the nasal carriage of MRSA and its antimicrobial susceptibility patterns among medical students at the Jimma University medical center (JUMC), Southwest Ethiopia. Methods: An institution based cross-sectional study was conducted at the JUMC from May to August; 2016. A total of 371 participants were systematically selected...
January 2019: Heliyon
Aníbal García-Sempere, Isabel Hurtado, Daniel Bejarano-Quisoboni, Clara Rodríguez-Bernal, Yared Santa-Ana, Salvador Peiró, Gabriel Sanfélix-Gimeno
BACKGROUND: Worldwide, there is growing evidence that quality of international normalized ratio (INR) control in atrial fibrillation patients treated with Vitamin K Antagonists (VKA) is suboptimal. However, sex disparities in population-based real-world settings have been scarcely studied, as well as patterns of switching to second-line Non-VKA oral anticoagulants (NOAC). We aimed to assess the quality of INR control in atrial fibrillation patients treated with VKA in the region of Valencia, Spain, for the whole population and differencing by sex, and to identify factors associated with poor control...
2019: PloS One
Chloé Saadé, Ghassan Sleilaty, Marie-Hélène Gannagé-Yared
BACKGROUND: Few studies looked at the prevalence of dyslipidemia in pediatric Middle-Eastern countries. In addition, worldwide longitudinal changes of lipid profile is not well documented. The purpose of this study is to look at the longitudinal changes of lipid parameters in Lebanese school-age children. MATERIALS AND METHODS: A total of 97 subjects (41 girls and 56 boys) aged between 11 and 21 years were included in this study. The subjects were selected among 339 school-age children with a previous abnormal lipid profile who were recruited from 10 schools of varying socio-economic levels (SEL)...
February 11, 2019: Lipids in Health and Disease
Nicole L Prokopishyn, Brent R Logan, Deidre M Kiefer, Jennifer A Sees, Pintip Chitphakdithai, Ibrahim A Ahmed, Paolo N Anderlini, Amer M Beitinjaneh, Christopher Bredeson, Jan Cerny, Saurabh Chhabra, Andrew Daly, Miguel Angel Diaz, Nosha Farhadfar, Haydar A Frangoul, Siddhartha Ganguly, Dennis A Gastineau, Usama Gergis, Gregory A Hale, Peiman Hematti, Rammurti T Kamble, Kimberly A Kasow, Hillard M Lazarus, Jane L Liesveld, Hemant S Murthy, Maxim Norkin, Richard F Olsson, Mona Papari, Bipin N Savani, Jeffrey Szer, Edmund K Waller, Baldeep Wirk, Jean A Yared, Michael A Pulsipher, Nirali N Shah, Galen E Switzer, Paul V O'Donnell, Dennis L Confer, Bronwen E Shaw
Bone Marrow (BM) is an essential hematopoietic stem cell (HSC) source for many allogeneic hematopoietic cell transplant (HCT) recipients, including adult patients (for specific diseases and transplant strategies) and the majority of pediatric transplants. However, since the advent of Granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC), there has been a significant decrease in utilization of BM in transplant patients, predominantly thought to be due to the increased logistical challenges around BM harvesting compared to PBSC, and generally no significant survival advantage of BM or PBSC...
February 1, 2019: Biology of Blood and Marrow Transplantation
Hiwot Degu, Abigiya Wondimagegnehu, Yared Mamushet Yifru, Ayele Belachew
BACKGROUND: Polyneuropathy is one of the commonest complications of long-standing diabetes. Progressive sensory loss can predispose patients to foot ulcer and the neuropathy oftentimes causes pain. The pain can significantly affect the quality of life of patients. OBJECTIVES: To describes the health-related quality of life of patients with type II diabetes mellitus suffering from painful diabetic peripheral neuropathy at two referral hospitals in Addis Ababa, Ethiopia, 2017...
2019: PloS One
Maheen Z Abidi, Parameswaran Hari, Min Chen, Soyoung Kim, Minoo Battiwala, Parastoo Bahrami Dahi, Miguel Angel Diaz, Robert Peter Gale, Siddhartha Ganguly, Usama Gergis, Jaime Green, Gerhard Hildebrandt, Joshua A Hill, Krishna Komanduri, Hillard Lazarus, David Marks, Taiga Nishihori, Richard Olsson, Sachiko Seo, Celalettin Ustun, Jean Yared, Dwight Yin, John Wingard, Baldeep Mona Wirk, Jeffrey Auletta, Caroline Lindemans, Marcie Riches
Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. CNS viruses predominantly included human herpes virus 6 (HHV-6) (73%), followed by Epstein-Barr Virus (10%), cytomegalovirus (3%), varicella zoster virus (3%), herpes simplex virus (3%) and Adenovirus (3%)...
January 29, 2019: Bone Marrow Transplantation
Carly Dunn, Harrison P Nguyen, Viraat Patel, Heather S Barker, A Hafeez Diwan, Marwan Yared, Tarek Elghetany, Alejandro Restrepo, Harry Dao
Post-transplant lymphoproliferative disorder (PTLD) is an uncommon complication after solid organ transplants and hematopoietic stem cell transplants. Isolated involvement of the skin without systemic involvement in PTLD is extremely rare. Primary cutaneous PTLD is generally categorized as either cutaneous T-cell lymphomas or cutaneous B-cell lymphomas, with variable Epstein-Barr virus (EBV) positivity. Herein, we describe an exceedingly uncommon case of a primary cutaneous Hodgkin-like polymorphic PTLD. A man in his 60s, with a history of kidney transplant, presented with a 5-week history of 2 indurated plaques...
January 22, 2019: Journal of Cutaneous Pathology
Nada Younes, Marie-Ange El Hajj, Aren Joe Bizdikian, Marie-Hélène Gannagé-Yared
The purpose of this study is to establish the prevalence and determinants of fractures among 974 Lebanese schoolchildren aged 8-18. Fractures might be less common in the Lebanese pediatric population compared to western populations. Male gender and high SES are independent risk factors for fractures, while 25(OH)D and BMI have no impact. PURPOSE: To establish the prevalence of fractures among Lebanese schoolchildren and its relationship with age, gender, BMI, 25 hydroxyvitamin D (25(OH)D) levels, and socioeconomic status (SES)...
January 15, 2019: Archives of Osteoporosis
Hani Tohme, Joseph Makzoume, Paul Boulos, Jihad Fakhoury, Carole Yared, Ziad Salameh, Maha Daou
PURPOSE: The aim of this study was to compare and evaluate the retention of two new attachment systems used for implant-supported overdentures subjected to insertion-removal cycles. MATERIALS AND METHODS: Twenty custom-manufactured polyvinyl chloride models mimicking implant-retained over-dentureresin blocks were fabricated and divided into two groups (n = 10): group 1 ('Kerator' attachment) and group 2 ('EMI' attachment). Each model received two parallel implants (JD evolution®) 20 mm apart and was subjected to cyclic retention forces of 10, 100, 1000, 5000, 10000 and 14600 cycles using a universal testing machine in a 0...
November 1, 2018: Journal of Contemporary Dental Practice
Max Bowman, Lael Reinstatler, Jason Pettus, Joseph E Yared, Erik Pattison
No abstract text is available yet for this article.
March 2019: Urology Case Reports
Clara L Rodríguez-Bernal, Aníbal García-Sempere, Isabel Hurtado, Yared Santa-Ana, Salvador Peiró, Gabriel Sanfélix-Gimeno
INTRODUCTION: Atrial fibrillation (AF) is one of the leading causes of cerebrovascular mortality and morbidity. Oral anticoagulants (OACs) have been shown to reduce the incidence of cardioembolic stroke in patients with AF, adherence to treatment being an essential element for their effectiveness. Since the release of the first non-vitamin K antagonist oral anticoagulant, several observational studies have been carried out to estimate OAC adherence in the real world using pharmacy claim databases or AF registers...
December 19, 2018: BMJ Open
Isabel Hurtado-Navarro, Aníbal García-Sempere, Clara Rodríguez-Bernal, Yared Santa-Ana-Tellez, Salvador Peiró, Gabriel Sanfélix-Gimeno
Objective: To estimate drug exposure, Proportion of Days Covered (PDC) and percentage of patients with PDC ≥ 80% from a cohort of atrial fibrillation patients initiating oral anticoagulant (OAC) treatment. We employed three different approaches to estimate PDC, using either data from prescription and dispensing (PD cohort) or two common designs based on dispensing information only, requiring at least one (D1) or at least two (D2) refills for inclusion in the cohorts. Finally, we assessed the impact of adherence on health outcomes according to each method...
2018: Frontiers in Pharmacology
Charity Warigon, Wondimagegnehu Alemu, Fiona Braka, Hallah Tashikalmah, Yared Yehushualet, Kulchumi Hammanyero, Samuel Bawa, David Oviaesu, Sisay Tegegne, Mustapha Umar Maiiyali, Anne Eudes Jean Baptiste, Peter Nsubuga, Collins Boakye Agyemang
BACKGROUND: The mandate and unique experience of the World Health Organization (WHO) globally, enables over 190 countries, Nigeria inclusive, to depend on the technical support provided by the organization to define and mitigate the threats to public health. With other emerging health actors competing for scarce donors' resources, the demand for visibility has invariably equaled expectations on WHO's expertise and technical support. However, the inability to systematically document activities conducted by WHO personnel before 2013 overshadowed most of its invaluable contributions due to poor publicity...
December 13, 2018: BMC Public Health
Kulchumi Isa Hammanyero, Samuel Bawa, Fiona Braka, Bassey Enya Bassey, Akinola Fatiregun, Charity Warigon, Yared G Yehualashet, Sisay Gashu Tegene, Richard Banda, Charles Korir, Tesfaye Bedada Erbeto, Martin Chukwuji, Pascal Mkanda, Usman Saidu Adamu, Peter Nsubuga
BACKGROUND: The year 2014 was a turning point for polio eradication in Nigeria. Confronted with the challenges of increased numbers of polio cases detected in rural, hard-to-reach (HTR), and security-compromised areas of northern Nigeria, the Nigeria polio program introduced the HTR project in four northern states to provide immunization and maternal and child health services in these communities. The project was set up to improve population immunity, increase oral polio vaccine (OPV) and other immunization uptake, and to support Nigeria's efforts to interrupt polio transmission by 2015...
December 13, 2018: BMC Public Health
Sisay G Tegegne, Faisal Shuaib, Fiona Braka, Pascal Mkanda, Tesfaye B Erbeto, Aron Aregay, Oyaole D Rasheed, Akpan G Ubong, Njie Alpha, Ahmed Khedr, Mirghani A Isameldin, Yared G Yehushualet, Charity Warigon, Usman Adamu, Eunice Damisa, Bassey Okposen, Peter Nsubuga, Rui G Vaz, Wondimagegnehu Alemu
BACKGROUND: Supportive supervision is one of the interventions that fosters program improvement by way of imparting knowledge and skills to health workers. The basic challenge in supportive supervision is the availability of data in real time for timely and effective feedback. Thus, the main objective of this study was to determine the contribution of real-time data collection during supportive supervision for timely feedback and generation of evidence for health intervention planning...
December 13, 2018: BMC Public Health
Samuel Bawa, Faisal Shuaib, Mahmoud Saidu, Adamu Ningi, Suleiman Abdullahi, Bashir Abba, Audu Idowu, Jibrin Alkasim, Kulchumi Hammanyero, Charity Warigon, Sisay G Tegegne, Richard Banda, Charles Korir, Yared G Yehualashet, Tesfaye Bedada, Chukwuji Martin, Peter Nsubuga, Usman S Adamu, Bassey Okposen, Fiona Braka, Alemu Wondimagegnehu, Rui G Vaz
BACKGROUND: The Global Vaccine Action Plan (GVAP) seeks to achieve the total realization of its vision through equitable access to immunization as well as utilizing the immunization systems for delivery of other primary healthcare programs. The inequities in accessing hard-to-reach areas have very serious implications for the prevention and control of vaccine-preventable diseases, especially the polio eradication initiative. The Government of Nigeria implemented vaccination in hard-to-reach communities with support from the World Health Organization (WHO) to address the issues of health inequities in the hard-to-reach communities...
December 13, 2018: BMC Public Health
Hadiza Aliyu Iyal, Faisal Shuaib, Madubu Dauda, Abdullahi Suleiman, Fiona Braka, Sisay G Tegegne, Peter Nsubuga, Terna Nomhwange, Yared G Yehualashet, Sambo Ishaku, Charity Warigon, Furera Zakari, Gregory Umeh, Lami Samaila, Basirat Abdullahi, Kulchumi Hammanyero, Paul Dogo, Dawud Adamu, Rui G Vaz, Wondimagegnehu Alemu
BACKGROUND: Despite concerted global efforts being made to eradicate poliomyelitis, the wild poliovirus still circulates in three countries, including Nigeria. In addition, Nigeria experiences occasional outbreaks of the circulating vaccine-derived poliovirus type 2 (cVDPV2). Vaccine rejection by caregivers persists in some parts of northern Nigeria, which compromises the quality of supplemental immunization activities (SIAs). In 2013, the Expert Review Committee (ERC) on polio recommended innovative interventions in all high-risk northern states to improve the quality of SIA rounds through innovative interventions...
December 13, 2018: BMC Public Health
Loveday Nkwogu, Faisal Shuaib, Fiona Braka, Pascal Mkanda, Richard Banda, Charles Korir, Samuel Bawa, Sule Mele, Mahmud Saidu, Hyelni Mshelia, Aliyu Shettima, Sisay G Tegegne, Yared G Yehualashet, Usman Adamu, Peter Nsubuga, Rui G Vaz, Alemu Wondimagegnehu
BACKGROUND: Nigeria was polio free for almost 2 years but, with the recent liberation of areas under the captivity of insurgents, there has been a resurgence of polio cases. For several years, these inaccessible areas did not have access to vaccination due to activities of Bokoharam, resulting in a concentration of a cohort of unvaccinated children that served as a polio sanctuary. This article describes the processes of engagement of security personnel to access security-compromised areas and the impact on immunization outcomes...
December 13, 2018: BMC Public Health
Charles Korir, Faisal Shuaib, Usman Adamu, Samuel Bawa, Audu Musa, Abba Bashir, Ayodeji Isiaka, Adamu Ningi, Charity Warigon, Banda Richard, Braka Fiona, Mkanda Pascal, Nkwogu Loveday, Sisay G Tegegne, Mohammed Abdul-Aziz, Abdullahi Suleiman, Kabiru Mohammed, Melisa Corkum, Chima Onoka, Peter Nsubuga, Yared G Yehualashet, Rui G Vaz, Wondimagegnehu Alemu
BACKGROUND: The declaration of poliomyelitis eradication as a programmatic emergency for global public health by the 65th World Health Assembly in 2012 necessitated innovations and strategies to achieve results. Review of the confirmed polio cases in 2013 showed that most of the cases were from non-compliant households, where parents connived with vaccinators to finger mark the children without actually vaccinating the children with oral polio vaccine or children were absent from home at the time of the visit of vaccinators...
December 13, 2018: BMC Public Health
Yoshihiro Inamoto, Igor Petriček, Linda Burns, Saurabh Chhabra, Zack DeFilipp, Peiman Hematti, Alicia Rovó, Raquel Schears, Ami Shah, Vaibhav Agrawal, Aisha Ahmed, Ibrahim Ahmed, Asim Ali, Mahmoud Aljurf, Hassan Alkhateeb, Amer Beitinjaneh, Neel Bhatt, Dave Buchbinder, Michael Byrne, Natalie Callander, Kristina Fahnehjelm, Nosha Farhadfar, Robert Peter Gale, Siddhartha Ganguly, Gerhard C Hildebrandt, Erich Horn, Ann Jakubowski, Rammurti T Kamble, Jason Law, Catherine Lee, Sunita Nathan, Olaf Penack, Ravi Pingali, Pinki Prasad, Drazen Pulanic, Seth Rotz, Aditya Shreenivas, Amir Steinberg, Khalid Tabbara, André Tichelli, Baldeep Wirk, Jean Yared, Grzegorz W Basak, Minoo Battiwalla, Rafael Duarte, Bipin N Savani, Mary E D Flowers, Bronwen E Shaw, Nuria Valdés-Sanz
Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation...
December 7, 2018: Bone Marrow Transplantation
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