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High Blood Pressure Classification

Stefan van Duijvenboden, Ben Hanson, Nick Child, Pier D Lambiase, Christopher A Rinaldi, Gill Jaswinder, Peter Taggart, Michele Orini
Mechanical alternans (MA) is a powerful predictor of adverse prognosis in patients with heart failure and cardiomyopathy, but its use remains limited due to the need of invasive continuous arterial pressure recordings. This study aims to assess novel cardiovascular correlates of MA in the intact human heart to facilitate affordable and non-invasive detection of MA and advance our understanding of the underlying pathophysiology. Arterial pressure, respiration, and ECG were recorded in 12 subjects with healthy ventricles during voluntarily controlled breathing at different respiratory rate, before and after administration of beta-blockers...
February 12, 2019: Annals of Biomedical Engineering
Annina S Vischer, Thenral Socrates, Clemens Winterhalder, Jens Eckstein, Michael Mayr, Thilo Burkard
OBJECTIVES: Recently, ACC/AHA and ESC/ESH guidelines defined different office blood pressure measurement (OBPM) procedures and ranges. We aimed to describe the effect of the different methods to calculate OBPM on BP classification. METHODS AND RESULTS: Four standardised OBPM were performed in 802 patients within a single visit. BP values were calculated (EUR-/US-BPM) and categorised (EUR-/US-Ranges) according to ACC/AHA and ESC/ESH guidelines. Comparing the BPM procedures, the mean absolute difference of systolic and diastolic BP was 4 (SD ± 5) and 3 (SD ± 3) and a difference ≥ 5 mmHg was found in 35% and 16%, respectively...
February 6, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
R Ma, J-M Ren, P Li, Y-J Zhou, M-K Zhou, Z Hu, X-Y Xiao
OBJECTIVE: Yes-associated protein (YAP) is a critical factor of Hippo pathway. It can control organ size, regulate proliferation, differentiation, and apoptosis of cells, and mediate epithelial-mesenchymal transition and cell contact inhibition. It has gradually become a hot spot in the field of diabetic nephropathy (DN). Tea domain (TEAD) is a factor with a deoxyribose nucleic acid (DNA) binding domain, which combines with activated YAP to control the expression of their important target factor - connective tissue growth factor (CTGF)...
January 2019: European Review for Medical and Pharmacological Sciences
Carlos Cristi-Montero, Palma Chillón, Idoia Labayen, José A Casajus, Marcela Gonzalez-Gross, Jérémy Vanhelst, Yannis Manios, Luis A Moreno, Francisco B Ortega, Jonatan R Ruiz
Purpose: This study aims to compare adolescents' cardiometabolic risk score through an integrative classification of physical activity (PA), which involves the combination of moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB). Methods: A cross-sectional study derived from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study database (2006-2008) was conducted in adolescents ( n  = 548; boys, 47.3%; 14.7 ± 1...
January 2019: Journal of Sport and Health Science
Qin Liu, Yaping Hou, Liu Yang, Min Zhao, Shengxu Li, Bo Xi
In contrast to the percentile-based definitions of elevated blood pressure (BP) and hypertension for children and adolescents of all ages in the 2004 fourth report, the 2017 American Academy of Pediatrics (AAP) BP guideline recommends a change to single BP cut-offs for clinical diagnosis (120/< 80-129/< 80 mmHg for elevated BP and ≥ 130/80 mmHg for hypertension) in adolescents aged 13 years and older, and it also recommends researchers using the percentile-based definitions for more precise BP classification...
February 1, 2019: Pediatric Cardiology
Haisheng Zhang, Mingsheng Chen, Gui Jin, Jia Xu, Mingxin Qin
Hematoma enlargement often occurs in patients with spontaneous intracerebral hemorrhage (ICH), so it is necessary to monitor the amount of intracranial hemorrhage in patients after admission. At present, the commonly used intracranial pressure (ICP) method has the disadvantages of trauma and infection, and the Computer Tomography (CT) method cannot achieve continuous monitoring. So it is urgent to develop a non-contact and non-invasive method for continuous monitoring of cerebral hemorrhage. The dielectric properties of blood are different from those of brain tissue, so the hematoma will affect the amplitude and phase of the electromagnetic waves passing through the head...
January 28, 2019: Computer Assisted Surgery (Abingdon, England)
Toh Peng Yeow, Evelyn Su-Yin Aun, Chee Peng Hor, Shueh Lin Lim, Chong Hui Khaw, Nor Azizah Aziz
It remains widely perceived that early-onset Type 2 Diabetes (T2D) in children and adolescents is rare and clinically distinct from Type 1 Diabetes (T1D). We studied the challenges of classifying subtypes of early-onset diabetes using clinical features and biomarkers, and management of these patients. We reviewed retrospectively the record of patients < 25 years old who attended the diabetes clinic in Penang General Hospital, Malaysia between 1st December 2012 and 30th June 2015. We examined their clinical features, C-peptide and pancreatic autoantibodies...
2019: PloS One
Partini Pudjiastuti Trihono, Lia Rhodia, Mulya Rahma Karyanti
BACKGROUND: Each kidney injury may develop into chronic kidney disease (CKD) and end stage renal disease (ESRD) that associates with high mortality and socio-economic burden. There is limited data about clinical characteristics of children having CKD in developing countries, espesially in Indonesia. OBJECTIVE: To describe clinical profiles and characteristics of kidney diseases in adolescents aged 15-18 years. METHODS: This study was a cross-sectional study which used data from National Basic Health Survey (Riskesdas) 2013...
October 2018: Acta Medica Indonesiana
Edward Buitenwerf, Mats F Boekel, Marieke I van der Velde, Magiel F Voogd, Michiel N Kerstens, Götz J K G Wietasch, Thomas W L Scheeren
BACKGROUND: There is no consensus on how to define haemodynamic instability during general anaesthesia. Patients are often classified as stable or unstable based solely on blood pressure thresholds, disregarding the degree of instability. Vasoactive agents and volume therapy can directly influence classification but are usually not considered. OBJECTIVE: To develop and validate a scoring tool to quantify the overall degree of haemodynamic instability. DESIGN: Retrospective observational study...
January 7, 2019: European Journal of Anaesthesiology
Emily-Ann Butler, Murray Baron, Agnes B Fogo, Tracy Frech, Cybele Ghossein, Eric Hachulla, Sabrina Hoa, Sindhu R Johnson, Dinesh Khanna, Luc Mouthon, Mandana Nikpour, Susanna Proudman, Virginia Steen, Edward Stern, John Varga, Christopher Denton, Marie Hudson
BACKGROUND: This project was undertaken to generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology. METHODS: An international, multidisciplinary panel of experts was invited to participate in a 3-round Delphi exercise developed using a survey based on items identified by a scoping review. In Round 1, participants were asked to identify omissions and clarify ambiguities regarding the items in the survey...
January 7, 2019: Arthritis & Rheumatology
Maciej Kostrubiec, Magdalena Pływaczewska, David Jiménez, Mareike Lankeit, Michał Ciurzynski, Stavros Konstantinides, Piotr Pruszczyk
BACKGROUND:  Haemodynamic alterations caused by acute pulmonary embolism (PE) may affect multi-organ function including kidneys. This multi-centre, multinational cohort study aimed to validate the prognostic significance of estimated glomerular filtration rate (eGFR) and its potential additive value to the current PE risk assessment algorithms. METHODS:  The post hoc analysis of pooled prospective cohort studies: 2,845 consecutive patients (1,424 M/1,421 F, 66 ± 17 years) with confirmed acute PE and followed up for 180 days...
January 2019: Thrombosis and Haemostasis
Thanh-Huyen T Vu, Lihui Zhao, Lei Liu, Cuiping Schiman, Donald M Lloyd-Jones, Martha L Daviglus, Kiang Liu, Daniel B Garside, Jeremiah Stamler, James F Fries, Ya-Chen Tina Shih, Norrina B Allen
Background Data are sparse on the association of cardiovascular health ( CVH ) in younger/middle age with the incidence of dementia later in life. Methods and Results We linked the CHA (Chicago Heart Association Detection Project in Industry) study data, assessed in 1967 to 1973, with 1991 to 2010 Medicare and National Death Index data. Favorable CVH was defined as untreated systolic blood pressure/diastolic blood pressure ≤120/≤80 mm Hg, untreated serum total cholesterol <5.18 mmol/L, not smoking, bone mass index <25 kg/m2 , and no diabetes mellitus...
January 8, 2019: Journal of the American Heart Association
Anatole Harrois, Benjamin Soyer, Tobias Gauss, Sophie Hamada, Mathieu Raux, Jacques Duranteau
BACKGROUND: Organ failure, including acute kidney injury (AKI), is the third leading cause of death after bleeding and brain injury in trauma patients. We sought to assess the prevalence, the risk factors and the impact of AKI on outcome after trauma. METHODS: We performed a retrospective analysis of prospectively collected data from a multicenter trauma registry. AKI was defined according to the risk, injury, failure, loss of kidney function and end-stage kidney disease (RIFLE) classification from serum creatinine only...
December 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
Konrad Pieszko, Jarosław Hiczkiewicz, Paweł Budzianowski, Janusz Rzeźniczak, Jan Budzianowski, Jerzy Błaszczyński, Roman Słowiński, Paweł Burchardt
BACKGROUND: Increased systemic and local inflammation play a vital role in the pathophysiology of acute coronary syndrome. This study aimed to assess the usefulness of selected machine learning methods and hematological markers of inflammation in predicting short-term outcomes of acute coronary syndrome (ACS). METHODS: We analyzed the predictive importance of laboratory and clinical features in 6769 hospitalizations of patients with ACS. Two binary classifications were considered: significant coronary lesion (SCL) or lack of SCL, and in-hospital death or survival...
December 3, 2018: Journal of Translational Medicine
Cesare Cuspidi, Carla Sala, Marijana Tadic, Guido Grassi
An increasing attention has been devoted in the last two decades to masked hypertension (MH), a condition characterized by the fact that classification of a normal blood pressure (BP) status by office measurements is not confirmed by home and/or ambulatory BP monitoring (ABPM).MH definition (i.e. normal office BP, but high out-of-office BP) should be restricted to untreated subjects (true MH) whereas masked uncontrolled hypertension (MUCH) reserved to treated patients previously classified as hypertensives, presenting normal office BP and high ABPM or home values...
December 3, 2018: American Journal of Hypertension
Jorinde Aw Polderman, Violet Farhang-Razi, Susan Van Dieren, Peter Kranke, J Hans DeVries, Markus W Hollmann, Benedikt Preckel, Jeroen Hermanides
BACKGROUND: In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However, whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied...
November 23, 2018: Cochrane Database of Systematic Reviews
Ian Howard, Bernard Pillay, Nicholas Castle, Loua Al Shaikh, Robert Owen, David Williams
BACKGROUND: Emergency Care has previously been identified as an area of significant concern regarding the prevalence of Adverse Events (AEs). However, the majority of this focus has been on the in-hospital setting, with little understanding of the identification and incidence of AEs in the prehospital environment. METHOD: The early development and testing of Emergency Medical Services (EMS) specific triggers for the identification of AEs and Harm has been previously described...
November 26, 2018: BMC Emergency Medicine
Rosanna Coppo
The search of personalized treatment for a subject with immunoglobulin A nephropathy (IgAN) is appealing since the individual long-term outcome is highly variable in spite of common mild clinical signs such as microscopic haematuria, moderate proteinuria and slightly reduced glomerular filtration rate (GFR). The only risk factor considered by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to target corticosteroid/immunosuppressive treatment in IgAN is proteinuria persistently >1 g/day despite 3-6 months of optimized supportive care...
November 26, 2018: Nephrology, Dialysis, Transplantation
Pei Xiao, Tao Huang, Yinkun Yan, Xiaoyuan Zhao, Haibo Li, Jie Mi
BACKGROUND AND AIMS: Considerable attention is given nowadays to the presence of cardiovascular diseases risk factors in children. The current blood lipid classification system for Chinese children was based on the United States National Cholesterol Education Program (NCEP) cutpoints, which did not take the age, gender and race differences into consideration. This study aimed to develop gender- and age-specific lipid cutpoints for dyslipidemia screening in Chinese children and compare the ability of new cutpoints and NCEP pediatric cutpoints to predict obesity and unfavorable blood pressure (BP) levels...
November 10, 2018: Atherosclerosis
Yuki Miyake, Eri Eguchi, Hiroshi Ito, Kazufumi Nakamura, Tatsuo Ito, Kenjiro Nagaoka, Noriyoshi Ogino, Keiki Ogino
The purpose of this study was to investigate the relationship between occupational dysfunction and metabolic syndrome (MetS) and its component factors in community-dwelling Japanese adults (N = 1,514). Self-reported lifestyle behaviors, Classification and Assessment of Occupational Dysfunction (CAOD) scores, and metabolic traits were measured. CAOD levels were divided into tertiles (low, moderate, and high), and their associations with MetS and its components were evaluated through logistic regression analysis...
November 17, 2018: International Journal of Environmental Research and Public Health
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