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Hypoxic ischemic encephalopathy in newborn

Adrienne Bingham, Fusun Gundogan, Katherine Rand, Abbot R Laptook
OBJECTIVE: To determine if pre-specified placental abnormalities among newborns with hypoxic-ischemic encephalopathy (HIE) differ compared to newborns admitted to a NICU without encephalopathy. STUDY DESIGN: Retrospective case-control study of newborns with HIE (2006-2014) and controls matched for birth year, gestational age, weight, and gender. One pathologist reviewed archived placental sections using pre-specified criteria. RESULTS: Sixty-seven newborns had HIE, 46 had available placentas and were matched with 92 controls...
February 15, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
P Sg, A Kadam, S Kadam, U Vaidya, P Kumar, I Bhagat, A Pandit, N Chouthai
BACKGROUND: Perinatal asphyxia is a prominent cause of neonatal mortality in the developing world. Growth in head circumference is associated with improved neurodevelopment. Previous studies found a positive correlation between additional dietary supplementation and growth in head circumference among newborns with perinatal brain injury. This study aims to evaluate the association between anthropometric parameters and developmental outcomes in newborns with hypoxic ischemic encephalopathy (HIE)...
February 4, 2019: Journal of Neonatal-perinatal Medicine
Zeynep Gokce-Samar, Karine Ostrowsky-Coste, Dominique Gauthier-Morel, Pascale Keo-Kosal, Julitta De Regnauld De Bellescize, Alexandra Montavont, Eleni Panagiotakaki, Olivier Claris, Alexis Arzimanoglou
OBJECTIVES: To evaluate the predictive factors for status epilepticus (SE) in neonates and prognostic factors for patient outcomes in newborns suffering either isolated seizures or SE. METHODS: A retrospective single-center study from January 2010 to December 2014, included 91 newborns who had neonatal seizures. Among them, 50 newborns experienced SE and 41 newborns presented isolated seizures only. SE was defined as a single seizure lasting more than 15 min or repeated seizures without return to preictal neurological baseline for more than 15 min...
January 29, 2019: European Journal of Paediatric Neurology: EJPN
Bushra Afzal, Praveen Chandrasekharan, Daniel J Tancredi, James Russell, Robin H Steinhorn, Satyan Lakshminrusimha
OBJECTIVES: Therapeutic hypothermia is standard of care in management of moderate/severe hypoxic-ischemic encephalopathy. Persistent pulmonary hypertension of the newborn is associated with hypoxic-ischemic encephalopathy and is exacerbated by hypoxemia and hypercarbia. Gas exchange is assessed by arterial blood gas analysis (with/without correction for body temperature), pulse oximetry, and end-tidal CO2. DESIGN: A retrospective chart review. SETTINGS: Regional perinatal center in Western New York...
February 2019: Pediatric Critical Care Medicine
Lei Zhu, Boxiang Qi, Daorong Hou
BACKGROUND: To explore the roles of HIF1α- and HIF2α-regulated BNIP3 in hypoxia-induced injury of neurons. METHODS: The sera of neonates with hypoxic-ischemic encephalopathy (HIE) within 24 h after birth and full-term healthy newborns (n = 40) were collected. The BNIP3 levels were detected by ELISA. AGE1.HN cells were cultured in 1% O2 at 37 °C. The apoptosis of cells treated with 1, 5 and 10 ng/ml BNIP3 for 48 h was detected by flow cytometry. The proliferation of cells transfected with siBNIP3 was detected by CCK-8 assay...
January 18, 2019: Pathology, Research and Practice
Vinzenz Boos, Anna Tietze, Felix Berger, Christoph Bührer
OBJECTIVES: Patients with severe congenital heart disease and cardiac anomalies such as restrictive foramen ovale, intact atrial septum, or narrowing of ductus arteriosus are at risk for perinatal asphyxia, leading to hypoxic-ischemic encephalopathy. We hypothesize that therapeutic hypothermia can be applied to these patients and seek to investigate feasibility and safety of this method. DESIGN: A retrospective observational study. SETTING: The Department of Neonatology of Charité, University Hospital, Berlin, Germany...
January 22, 2019: Pediatric Critical Care Medicine
María Arriaga-Redondo, Juan Arnaez, Isabel Benavente-Fernández, Simón Lubián-López, Montesclaros Hortigüela, Cristina Vega-Del-Val, Alfredo Garcia-Alix
Cerebral oximetry using near-infrared spectroscopy (NIRS) provides continuous, noninvasive assessment of the degree of hemoglobin saturation of the brain tissue. Previous studies suggest that high values of regional cerebral tissue oxygen saturation (rScO2 ) during the first days in neonates with significant hypoxic-ischemic encephalopathy (HIE) are correlated with an adverse neurological outcome. However, the results are not consistent among the studies. To examine the correlation of rScO2 values and their variability over time with HIE severity, amplitude integrated electroencephalography (aEEG) background and seizure activity, neuron-specific enolase levels in cerebrospinal fluid, magnetic resonance imaging (MRI) findings, and neurological outcome...
January 24, 2019: Therapeutic Hypothermia and Temperature Management
Brigitte Lemyre, Vann Chau
Therapeutic hypothermia is a standard of care for infants ≥36 weeks gestational age (GA) with moderate-to-severe hypoxic-ischemic encephalopathy. Because some studies included infants born at 35 weeks GA, hypothermia should be considered if they meet other criteria. Cooling for infants <35 weeks GA is not recommended. Passive cooling should be started promptly in community centres, in consultation with a tertiary care centre neonatologist, while closely monitoring the infant's temperature. Best evidence suggests that maintaining core body temperature between 33°C and 34°C for 72 hours, followed by a period of rewarming of 6 to 12 hours, is optimal...
July 2018: Paediatrics & Child Health
Andrea Laudi, Eric Peeples
PURPOSE: Neonatal hypoxic-ischemic encephalopathy (HIE) is a type of brain injury resulting from insufficient oxygen and blood supply. The standard treatment for HIE is therapeutic hypothermia, which involves a 72-hour period of hypothermia, during which time the infant is isolated from his/her parents. The primary objective of this study was to assess the effects of the diagnosis of neonatal encephalopathy and subsequent separation on rates of maternal postpartum depression (PPD) as compared to other hospitalized infants...
January 16, 2019: Journal of Maternal-fetal & Neonatal Medicine
Qi Xu, Vann Chau, Chinnuwat Sanguansermsri, Katherine E Muir, Emily W Y Tam, Steven P Miller, Darren S T Wong, Hao Chen, Peter K H Wong, Jill G Zwicker, Kenneth J Poskitt, Alan Hill, Elke H Roland
OBJECTIVE: To determine if patterns of hypoxic-ischemic brain injury on magnetic resonance imaging (MRI) in term newborns predict subsequent childhood epilepsy. Methods: This retrospective cohort study includes term newborns with encephalopathy (n = 181) born between 2004-2012 and admitted to British Columbia Children's Hospital. MRI was performed between 3 and 5 days of age. The predominant patterns of hypoxic-ischemic injury were classified as Normal, Watershed, Basal Nuclei, Total, and Focal-Multifocal...
January 15, 2019: Journal of Child Neurology
Miho Nonomura, Sayaka Harada, Yuki Asada, Hisako Matsumura, Hiroko Iwami, Yuko Tanaka, Hiroyuki Ichiba
BACKGROUND: Although therapeutic hypothermia improves the outcome of neonatal hypoxic-ischemic encephalopathy (HIE), its efficacy is still limited. This preliminary study evaluates the safety and feasibility of the combination therapy with erythropoietin (Epo), magnesium sulfate and hypothermia in neonates with HIE. METHODS: A combination therapy with Epo (300 U/kg every other day for 2 weeks), magnesium sulfate (250 mg/kg for 3 days) and hypothermia was started within 6 h of birth in neonates who met the institutional criteria for hypothermia therapy...
January 8, 2019: BMC Pediatrics
Michelle Welsford, Chika Nishiyama, Colleen Shortt, Tetsuya Isayama, Jennifer Anne Dawson, Gary Weiner, Charles Christoph Roehr, Myra H Wyckoff, Yacov Rabi
: media-1vid110.1542/5839981898001PEDS-VA_2018-1825 Video Abstract CONTEXT: The International Liaison Committee on Resuscitation prioritized to rigorously review the initial fraction of inspired oxygen (Fio2 ) during resuscitation of newborns. OBJECTIVE: This systematic review and meta-analysis provides the scientific summary of initial Fio2 in term and late preterm newborns (≥35 weeks' gestation) who receive respiratory support at birth. DATA SOURCES: Medline, Embase, Evidence Based Medicine Reviews, and Cumulative Index to Nursing and Allied Health Literature were searched between January 1, 1980 and August 10, 2018...
January 2019: Pediatrics
Y Moral, N J Robertson, F Goni-de-Cerio, D Alonso-Alconada
INTRODUCTION: Perinatal asphyxia remains a major cause of both mortality and neurological morbidity. Neonatal encephalopathy affects to 1-3/1,000 newborns, leading to significant brain damage and childhood disability. The only standard therapy is moderate hypothermia, whose efficacy, despite proved, is limited, being partially effective. DEVELOPMENT: The capacity of hypothermia in promoting cell proliferation in the neurogenic niches of the central nervous system remains subject of investigation...
January 1, 2019: Revista de Neurologia
Valerio Vitale, Eugenio Rossi, Marco Di Serafino, Rocco Minelli, Ciro Acampora, Francesca Iacobellis, Chiara D'Errico, Aniello Esposito, Francesco Esposito, Gianfranco Vallone, Massimo Zeccolini
Nowadays, cranial ultrasonography (US) of the newborn represents the first imaging method in brain damage study and its possible outcomes. This exam is performed using the natural fontanelles, especially the anterior one. It is fast, non-invasive and does not produce any side effect. Ultrasonographic examination is usually performed in cases of prematurity, especially in children with birth weight less than 1500 g, because important informations about the possible presence of pathologies such as cerebral hemorrhage and hypoxic-ischemic encephalopathy are given...
December 14, 2018: Journal of Ultrasound
Inna Skarga-Bandurova, Tetiana Biloborodova, Maksym Nesterov
The topic of neonatal hypoxia is of paramount importance to anyone who cares during pregnancy and childbirth. Modern medicine associates this pathology with severe problems in the prenatal period. Underlying diseases of the mother during pregnancy, her anamnesis of life are the leading causes of complications in the newborn. Nevertheless, patterns of fetal hypoxia and neonatal hypoxia, as well as mechanisms of hypoxic-ischemic encephalopathy in newborns, remains poorly known and require further research. This study is focused on finding risk factors related to the chronic fetal hypoxia and defining a group of signs for diagnosing neonatal hypoxia...
December 1, 2018: Journal of Medical Systems
Kaylan M Brady, Jonathan A Blau, Spencer J Serras, Jeremy T Neuman, Richard Sidlow
Multilevel cervical disconnection syndrome (MCDS) is a rare malformation of the cervical spine previously documented in two toddlers. We present a case of a newborn first thought to have hypoxic-ischemic encephalopathy who was subsequently diagnosed with MCDS. The possibility of in utero presentation of the syndrome in this patient and the categorization of this syndrome in the spectrum of basilar skull/upper cervical malformation syndromes is discussed.
2018: Case Reports in Neurological Medicine
Lorena Barata, Luis Arruza, Maria-José Rodríguez, Esther Aleo, Eva Vierge, Enrique Criado, Elena Sobrino, Carlos Vargas, María Ceprián, Ana Gutiérrez-Rodríguez, William Hind, José Martínez-Orgado
OBJECTIVE: Hypothermia, the gold standard after a hypoxic-ischemic insult, is not beneficial in all treated newborns. Cannabidiol is neuroprotective in animal models of newborn hypoxic-ischemic encephalopathy. This study compared the relative efficacies of cannabidiol and hypothermia in newborn hypoxic-ischemic piglets and assessed whether addition of cannabidiol augments hypothermic neuroprotection. METHODS: One day-old HI (carotid clamp and FiO2 10% for 20 min) piglets were randomized to vehicle or cannabidiol 1 mg/kg i...
November 20, 2018: Neuropharmacology
Marta Campanile, Pietro D'Alessandro, Luigi Della Corte, Gabriele Saccone, Salvatore Tagliaferri, Bruno Arduino, Giuseppina Esposito, Francesca Giovanna Esposito, Antonio Raffone, Maria Gabriella Signorini, Giovanni Magenes, Mariarosaria Di Tommaso, Serena Xodo, Fulvio Zullo, Vincenzo Berghella
OBJECTIVE: To evaluate whether intrapartum cardiotocography with computer analysis decreases the incidence of newborn metabolic acidosis or obstetric intervention when compared with visual analysis through a systematic review with meta-analysis of randomized controlled trials. METHODS: The research was conducted using Medline, Embase, Web of Science, Scopus,, Ovid and Cochrane Library as electronic databases from the inception of each database to May 2018...
November 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Elizabeth A Schump
It is well-documented in the literature that infants who suffer from hypoxic ischemic encephalopathy are at high risk for neurologic sequelae or even death. With the addition of therapeutic hypothermia into the treatment regimen for neonatal hypoxic ischemic encephalopathy, newborns afflicted with hypoxic ischemic encephalopathy were given the opportunity for a better outcome. Questions linger as to the most optimal treatment strategy of therapeutic hypothermia for these newborns. The goal of this article is to discuss current management strategies, as well as future trends, for infants with hypoxic ischemic encephalopathy...
December 2018: Critical Care Nursing Clinics of North America
Lars Walløe, Nils Lid Hjort, Marianne Thoresen
No abstract text is available yet for this article.
November 11, 2018: Acta Paediatrica
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