Hypoxic ischemic encephalopathy in newborn

Hailu Tazebew Amare, Ashenafi Tazebew Amare
Background: Neonatal seizures are the most common neurological dysfunction in the neonatal period. Neonatal seizure patterns and short-term neurologic outcomes, particularly in the Ethiopian context, have not been adequately studied. Objective: The main aim of this study is to assess the pattern, probable etiology, short-term outcomes, and determinants of neonatal seizures in the neonatal intensive care unit of Gondar University Specialized Comprehensive Hospital...
2019: Pediatric Health, Medicine and Therapeutics
Lindsay A Wilson, Deshayne B Fell, Steven Hawken, Coralie A Wong, Malia S Q Murphy, Julian Little, Beth K Potter, Mark Walker, Thierry Lacaze-Masmonteil, Sandra Juul, Pranesh Chakraborty, Kumanan Wilson
Hypoxic ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. Our study sought to examine whether patterns of newborn screening analytes differed between infants with and without neonatal HIE in order to identify opportunities for potential use of these analytes for diagnosis in routine clinical practice. We linked a population-based newborn screening registry with health databases to identify cases of HIE among term infants (≥37 weeks' gestation) in Ontario from 2010-2015. Correlations between HIE and screening analytes were examined using multivariable logistic regression models containing clinical factors and individual screening analytes (acyl-carnitines, amino acids, fetal-to-adult hemoglobin ratio, endocrine markers, and enzymes)...
October 31, 2019: Scientific Reports
Naveed Ur Rehman Durrani, Jameel AlGhamdi, Niels Rochow, Salhab El Helou, Michael Lefebvre Marrin
Hypoglycemia may lead to neurological impairment; therefore, high-risk newborns are screened postnatally. However, hypoglycemia monitoring protocols often do not include cord blood acidosis as a risk factor. The study aimed to find an association between asymptomatic cord blood acidosis and hypoglycemia. All healthy term infants born at McMaster Children Hospital, Hamilton, Canada, between October 2013 and September 2014, who had umbilical cord blood pH <7.0 or base excess <12 mmol/L were studied. Infants with evidence of hypoxic-ischemic encephalopathy, birth weights outside of 10th to 95th percentiles for gestation, mothers with preeclampsia, diabetes or taking a -blockers at the time of the birth were excluded...
November 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Helen Petousis-Harris, Yannan Jiang, Lennex Yu, Donna Watson, Tony Walls, Nikki Turner, Anna S Howe, Jennifer B Griffin
We aimed to evaluate the safety of maternal Tdap; thus, we assessed health events by examining the difference in birth and hospital-related outcomes of infants with and without fetal exposure to Tdap. This was a retrospective cohort study using linked administrative datasets. The study population were all live-born infants in New Zealand (NZ) weighing at least 400 g at delivery and born to women who were eligible for the government funded, national-level vaccination program in 2013. Infants were followed from birth up to one year of age...
October 11, 2019: Vaccines
Rakesh Rao, Kyong-Soon Lee, Isabella Zaniletti, Toby D Yanowitz, Robert DiGeronimo, Maria L V Dizon, Shannon E Hamrick, Girija Natarajan, Eric S Peeples, Karna Murthy, Amit M Mathur, An Massaro
OBJECTIVE(S): Quantify antimicrobial therapy (AMT) use in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia (HIE/TH). STUDY DESIGN: Newborns with HIE/TH were identified from the Children's Hospital Neonatal Database (CHND). Early infection (onset ≤7 days of life) was defined as "confirmed" (culture proven) or "suspected infection" (culture negative but treated) and compared with a "no infection" group...
October 14, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
Gülsüm Kadıoğlu Şimşek, H Gözde Kanmaz Kutman, Fuat Emre Canpolat, Mehmet Büyüktiryaki, Yaprak Engin Üstün
OBJECTIVE: The objective of this study was to establish the local incidence of hearing screening failure rate in newborns with all three stages of hypoxic ischemic encephalopathy (HIE). METHODS: This retrospective cohort study was undertaken in a tertiary neonatal intensive care unit. Medical records and hearing secreening test results were collected for two years. RESULTS: One hundred and ninety seven infants diagnosed with HIE, 20 of them died, 177 screened...
September 19, 2019: International Journal of Pediatric Otorhinolaryngology
I Nour, R Elmaghraby, R Shehata, A El-Refaey, H Aldomiaty, A Mosbah, B Shouman, N Nasef
BACKGROUND: The reno-protective effect of therapeutic hypothermia in infants with hypoxic ischemic encephalopathy (HIE) is still debatable. We aimed to study the effect of therapeutic hypothermia on the development and progress of acute kidney injury (AKI) in neonates with HIE. METHODS: Thirty full term infants with HIE were equally distributed between cooling group (selective head cooling) or non-cooling group (late presentation after 6 hours of birth). Serum creatinine, urine output (UOP), serum neutrophil gelatinase-associated lipocalin (NGAL), and serum cystatin C were measured at baseline, day 4 and day 10 of life...
September 18, 2019: Journal of Neonatal-perinatal Medicine
Yaëlle Garner
Hypothermia therapy is a protocol put in place to treat neonatal hypoxic ischemic encephalopathy in the first six hours after birth in order to prevent irreversible brain damage. The parents are therefore immediately separated from the newborn and endure an interminable 72-hour wait before being able to really meet their baby. Psychological support is therefore necessary to be able to think the unthinkable.
September 2019: Soins. Pédiatrie, Puériculture
Esedra Krüger, Alta Kritzinger, Lidia Pottas
Purpose: To identify symptoms of oropharyngeal dysphagia (OPD) in breastfeeding neonates with hypoxic-ischemic encephalopathy (HIE) on therapeutic hypothermia (TH). Early identification of feeding problems in neonates with HIE by speech-language therapists (SLTs) may prevent secondary complications of OPD such as aspiration pneumonia and death. Materials and Methods: Twenty-eight full-term neonates with HIE (mean chronological age = 4.5 days) and 30 healthy term controls were prospectively recruited for this case-control study...
September 18, 2019: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Qiang Liu, Hui Yang, Xuemei Sun, Guimei Li
Objective: The objective of this study was to find out the maternal risk factors and perinatal complications in small for gestational age (SGA) newborns. Methods: A total of 181 SGA cases and 1299 cases of appropriate for gestational age (AGA) with the same gestational age between January 2015 and December 2016 were enrolled in Linyi People's Hospital, China. The risk factors were analyzed and the frequencies of perinatal complications were compared between the two groups...
September 2019: Pakistan Journal of Medical Sciences Quarterly
Mohab M Salah, M A Abdelmawla, Sally R Eid, Rasha M Hasanin, Eman A Mostafa, M W Abdelhameed
BACKGROUND: Neonatal encephalopathy is a heterogeneous syndrome characterised by signs of central nervous system dysfunction in the newborn. Matrix metalloproteinase-9(MMP-9) increases the blood-brain barrier permeability, and their inhibitors can reduce its damage. MMP-9 has been implicated specifically in cerebral ischemia. AIM: To measure serum MMP-9 in neonatal hypoxic-ischemic encephalopathy and evaluate its correlation to the severity of early prediction and treatment...
July 15, 2019: Open Access Macedonian Journal of Medical Sciences
R B Govindan, An Massaro, Gilbert Vezina, Taeun Chang, Adre du Plessis
BACKGROUND AND OBJECTIVE: To identify the optimal epoch length for power spectral analysis of cardiac beat-to-beat intervals (BBi) in critically ill newborns. MATERIALS AND METHOD: BBi of 49 term newborns undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy with well-defined outcomes (good outcome (n = 28): no or mild brain injury and adverse outcome (n = 21): moderate or severe brain injury or death) served as test population. A power spectrum of BBi was calculated with an autoregressive model in three different epoch lengths: 2 min, 5 min, and 10 min...
August 16, 2019: Computers in Biology and Medicine
Ewa Matylda Gulczynska, Janusz Gadzinowski, Marcin Kesiak, Barbara Sobolewska, Joanna Caputa, Anna Maczko, Wojciech Walas, Wioletta Cedrowska-Adamus, Tomasz Talar
OBJECTIVES: Therapeutic hypothermia TH became broadly used in the management of the asphyxiated newborns. Although two cooling methods are used, so far the superiority of none of them has been established. The purpose of the study is to compare two cooling methods: selective head cooling (SHC) and whole body cooling (WBC) MATERIAL AND METHODS: We conducted a prospective observational study in newborns with HIE. The patients received one of methods: SHC or WBC. The eligibility criteria were similar to previous studies...
2019: Ginekologia Polska
Liang Liu, Zhichen Zhao, Qimeng Yin, Xiaolu Zhang
Neonatal hypoxic/ischemic encephalopathy (NHIE) is a severe condition that leads to death or neurological disability in newborns. The underlying pathological mechanisms are unclear, and developing the target neuroprotective strategies are urgent. 2,7,2'-trihydroxy-4,4'7'-trimethoxy-1,1'-biphenanthrene (TTB) is a natural product isolated from Cremastra appendiculata (D. Don) Makino and Liparis nervosa (Thunb.) Lindl. TTB has demonstrated potent cytotoxic activity against stomach (HGC-27) and colon (HT-29) cancer cell lines...
2019: Frontiers in Pharmacology
Elena V Wachtel, Sourabh Verma, Pradeep V Mally
Hypoxic-ischemic encephalopathy is a subtype of neonatal encephalopathy and a major contributor to global neonatal morbidity and mortality. Despite advances in obstetric and neonatal care there are still challenges in accurate determination of etiology of neonatal encephalopathy. Thus, identification of intrapartum risk factors and comprehensive evaluation of the neonate is important to determine the etiology and severity of neonatal encephalopathy. In developed countries, therapeutic hypothermia as a standard of care therapy for neonates with hypoxic-ischemic encephalopathy has proven to decrease incidence of death and neurodevelopmental disabilities, including cerebral palsy in surviving children...
July 29, 2019: Current Problems in Pediatric and Adolescent Health Care
Gabriel Altit, Philip T Levy
No abstract text is available yet for this article.
July 31, 2019: American Journal of Respiratory and Critical Care Medicine
Ajay Goenka, Elissa Yozawitz, William A Gomes, Suhas M Nafday
OBJECTIVE:  To compare the utility of electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) to detect brain dysfunction and injury across a cohort of newborn infants treated with selective head cooling (SHC) or whole body cooling (WBC). STUDY DESIGN:  Therapeutic hypothermia (TH) is a standard neuroprotection tool for hypoxic-ischemic encephalopathy (HIE) in neonates. Sixty-six newborns, SHC ( n  = 22) and WBC ( n  = 44), were studied utilizing standardized scoring systems for interpretation of EEG and MRI based on the severity of the findings...
July 25, 2019: American Journal of Perinatology
T Khetsuriani-Millischer, A Nabi
The article reports a rare case of umbilical cord twisted five times around the fetus`s neck. Our case referred to a 37 year old bedridden woman with diabetes and low amniotic fluid. As a result of performed caesarian section the newborn survived and is in a good state now. The umbilical cord wrapping around the fetus`s neck during conservative labor give rise to various complications in the fetus and is the cause of hypoxic-ischemic encephalopathy; the umbilical cord wrapping around the fetus`s neck tightly for several times causes intrauterine hypoxia; we consider ultrasonographic visualization of the umbilical cord to be included in the guidelines; cesarean intervention reduces complications during the labor and the postnatal period by 50%...
May 2019: Georgian Medical News
Patrick D Thornton, Richard T Campbell, Mulubrhan F Mogos, Carrie S Klima, Johanna Parsson, Minna Strid
BACKGROUND: Meconium aspiration syndrome (MAS) is a leading cause of morbidity and mortality among term, otherwise healthy newborns, yet population studies are rare. Definitions, outcomes and International Classification of Diseases (ICD) codes are heterogenous, complicating estimates of incidence, outcomes and risks. AIMS: To measure population incidence, risks and outcomes of MAS by ICD codes. STUDY DESIGN: Retrospective population study...
September 2019: Early Human Development
Yvonne W Wu, Amy M Goodman, Taeun Chang, Sarah B Mulkey, Fernando F Gonzalez, Dennis E Mayock, Sandra E Juul, Amit M Mathur, Krisa Van Meurs, Robert C McKinstry, Raymond W Redline
BACKGROUND: Newborns with hypoxic-ischemic encephalopathy (HIE) may exhibit abnormalities on placental histology. In this phase II clinical trial ancillary study, we hypothesized that placental abnormalities correlate with MRI brain injury and with response to treatment. METHODS: Fifty newborns with moderate/severe encephalopathy who received hypothermia were enrolled in a double-blind, placebo-controlled trial of erythropoietin for HIE. A study pathologist reviewed all available clinical pathology reports to determine the presence of chronic abnormalities and acute chorioamnionitis...
July 1, 2019: Pediatric Research
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