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https://read.qxmd.com/read/30747694/same-day-versus-conventional-different-day-endoscopic-retrograde-cholangiopancreatography-and-laparoscopic-cholecystectomy-a-multi-center-retrospective-study
#1
Mohammed H Al-Temimi, Charles Trujillo, Mital Shah, Sriram Rangarajan, Edwin Kim, Bindupryia Chandrasekaran, David Handman, Samir Johna
Same-day endoscopic retrograde cholangiopancreatography (ERCP) and cholecystectomy (LC) could potentially reduce hospital length of stay (HLOS). Patients undergoing same-day procedures (N = 164) between 2012 and 2014 were compared with different-day procedures performed in the second half of 2014 (N = 276), in the Kaiser Permanente Southern California database. Both groups had comparable baseline characteristics. ERCP success rate (97.5% vs 93.5%), overall postoperative morbidity (3.66% vs 3.99%), and retained stones (2...
October 1, 2018: American Surgeon
https://read.qxmd.com/read/30584591/pediatric-outcomes-in-transplant-personalising-immunosuppression-to-improve-efficacy-positive-study-the-collaboration-and-design-of-a-national-transplant-precision-medicine-program
#2
Tanya Papaz, Upton Allen, Tom Blydt-Hansen, Patricia E Birk, Sandar Min, Lorraine Hamiwka, Veronique Phan, Tal Schechter, Donna A Wall, Simon Urschel, Bethany J Foster, Seema Mital
Background: Despite age-related differences in biology, physiology, and behavior, transplant immunosuppression is not tailored by age. This likely contributes to high graft failure and posttransplant complications. We present the aims, design, and methods of the Pediatric Outcomes in Transplant: PersOnaliSing Immunosuppression To ImproVe Efficacy Study aimed at personalizing posttransplant immunosuppression in children and young adults. Methods: In this prospective observational cohort study, we recruited pediatric and young adult solid organ transplant, pediatric allogeneic hematopoietic stem cell transplant recipients, and matched living and deceased organ donors from 14 transplant centers across Canada...
December 2018: Transplantation Direct
https://read.qxmd.com/read/30582328/oligopeptides-generated-by-neprilysin-degradation-of-%C3%AE-amyloid-have-the-highest-cu-ii-affinity-in-the-whole-a%C3%AE-family
#3
Karolina Bossak-Ahmad, Mariusz Mital, Dawid Płonka, Simon C Drew, Wojciech Bal
The catabolism of β-amyloid (Aβ) is carried out by numerous endopeptidases including neprilysin, which hydrolyzes peptide bonds preceding positions 4, 10, and 12 to yield Aβ4-9 and a minor Aβ12- x species. Alternative processing of the amyloid precursor protein by β-secretase also generates the Aβ11- x species. All these peptides contain a Xxx-Yyy-His sequence, also known as an ATCUN or NTS motif, making them strong chelators of Cu(II) ions. We synthesized the corresponding peptides, Phe-Arg-His-Asp-Ser-Gly-OH (Aβ4-9 ), Glu-Val-His-His-Gln-Lys-am (Aβ11-16 ), Val-His-His-Gln-Lys-am (Aβ12-16 ), and pGlu-Val-His-His-Gln-Lys-am (pAβ11-16 ), and investigated their Cu(II) binding properties using potentiometry, and UV-vis, circular dichroism, and electron paramagnetic resonance spectroscopies...
December 24, 2018: Inorganic Chemistry
https://read.qxmd.com/read/30571578/genetic-basis-for-congenital-heart-disease-revisited-a-scientific-statement-from-the-american-heart-association
#4
Mary Ella Pierpont, Martina Brueckner, Wendy K Chung, Vidu Garg, Ronald V Lacro, Amy L McGuire, Seema Mital, James R Priest, William T Pu, Amy Roberts, Stephanie M Ware, Bruce D Gelb, Mark W Russell
This review provides an updated summary of the state of our knowledge of the genetic contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial American Heart Association scientific statement on the genetic basis of congenital heart disease was published, new genomic techniques have become widely available that have dramatically changed our understanding of the causes of congenital heart disease and, clinically, have allowed more accurate definition of the pathogeneses of congenital heart disease in patients of all ages and even prenatally...
November 20, 2018: Circulation
https://read.qxmd.com/read/30548283/abnormal-fetal-cerebral-and-vascular-development-in-hypoplastic-left-heart-syndrome
#5
Caroline Kinnear, Maruti Haranal, Patrick Shannon, Edgar Jaeggi, David Chitayat, Seema Mital
OBJECTIVE: To assess the cerebral and vascular development in fetuses with hypoplastic left heart syndrome (HLHS). METHODS: Pregnant women carrying fetuses diagnosed with HLHS who decided to interrupt their pregnancies were included in our study. Aortic size and blood flow were assessed based from fetal echocardiography. Immunohistochemical staining was performed in brain sections obtained from pathology in fetuses with HLHS and control fetuses without heart disease...
December 12, 2018: Prenatal Diagnosis
https://read.qxmd.com/read/30469856/automated-logic-synthesis-for-electro-optic-logic-based-integrated-optical-computing
#6
Zhoufeng Ying, Zheng Zhao, Chenghao Feng, Rohan Mital, Shounak Dhar, David Z Pan, Richard Soref, Ray T Chen
Integrated optical computing attracts increasing interest recently as Moore's law approaches the physical limitation. Among all the approaches of integrated optical computing, directed logic that takes the full advantage of integrated photonics and electronics has received lots of investigation since its first introduction in 2007. Meanwhile, as integrated photonics matures, it has become critical to develop automated methods for synthesizing optical devices for large-scale optical designs. In this paper, we propose a general electro-optic (EO) logic in a higher level to explore its potential in integrated computing...
October 15, 2018: Optics Express
https://read.qxmd.com/read/30455415/robo4-variants-predispose-individuals-to-bicuspid-aortic-valve-and-thoracic-aortic-aneurysm
#7
Russell A Gould, Hamza Aziz, Courtney E Woods, Manuel Alejandro Seman-Senderos, Elizabeth Sparks, Christoph Preuss, Florian Wünnemann, Djahida Bedja, Cassandra R Moats, Sarah A McClymont, Rebecca Rose, Nara Sobreira, Hua Ling, Gretchen MacCarrick, Ajay Anand Kumar, Ilse Luyckx, Elyssa Cannaerts, Aline Verstraeten, Hanna M Björk, Ann-Cathrin Lehsau, Vinod Jaskula-Ranga, Henrik Lauridsen, Asad A Shah, Christopher L Bennett, Patrick T Ellinor, Honghuang Lin, Eric M Isselbacher, Christian Lacks Lino Cardenas, Jonathan T Butcher, G Chad Hughes, Mark E Lindsay, Luc Mertens, Anders Franco-Cereceda, Judith M A Verhagen, Marja Wessels, Salah A Mohamed, Per Eriksson, Seema Mital, Lut Van Laer, Bart L Loeys, Gregor Andelfinger, Andrew S McCallion, Harry C Dietz
Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1-2%)1-3 that frequently presents with ascending aortic aneurysm (AscAA)4 . BAV/AscAA shows autosomal dominant inheritance with incomplete penetrance and male predominance. Causative gene mutations (for example, NOTCH1, SMAD6) are known for ≤1% of nonsyndromic BAV cases with and without AscAA5-8 , impeding mechanistic insight and development of therapeutic strategies. Here, we report the identification of variants in ROBO4 (which encodes a factor known to contribute to endothelial performance) that segregate with disease in two families...
January 2019: Nature Genetics
https://read.qxmd.com/read/30447318/examining-the-epidemiology-of-coincident-psoriasis-and-sarcoidosis-an-observational-cross-sectional-study
#8
Elizabeth B Wallace, Hasan Khosravi, Cara J Joyce, Frank R Vleugels, Mital Patel
No abstract text is available yet for this article.
November 14, 2018: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30178515/a-randomized-clinical-trial-of-age-and-genotype-guided-tacrolimus-dosing-after-pediatric-solid-organ-transplantation
#9
RANDOMIZED CONTROLLED TRIAL
Sandar Min, Tanya Papaz, Myriam Lafreniere-Roula, Nadya Nalli, Hartmut Grasemann, Steven M Schwartz, Binita M Kamath, Vicky Ng, Rulan S Parekh, Cedric Manlhiot, Seema Mital
BACKGROUND: Tacrolimus pharmacokinetics are influenced by age and CYP3A5 genotype with CYP3A5 expressors (CYP3A5*1/*1 or *1/*3) being fast metabolizers. However, the benefit of genotype-guided dosing in pediatric solid organ transplantation has been understudied. OBJECTIVE: To determine whether age and CYP3A5 genotype-guided starting dose of tacrolimus result in earlier attainment of therapeutic drug concentrations. SETTING: Single hospital-based transplant center...
November 2018: Pediatric Transplantation
https://read.qxmd.com/read/30138813/nontargeted-metabolomics-approach-to-determine-metabolites-profile-and-antioxidant-study-of-tropical-almond-terminalia-catappa-l-fruit-peels-using-gc-qtof-ms-and-lc-qtof-ms
#10
Mital J Kaneria, K D Rakholiya, L R Marsonia, R A Dave, B A Golakiya
The objective of the present study was to identify the metabolome pattern and study the biological efficacy of Almond (Terminalia catappa L.) peels. In the present study, metabolite profiling was carried out using GC-QTOF-MS and LC-QTOF-MS techniques, from the potent extract showed highest antioxidant efficacy. Antioxidant efficacy of the various extracts derived by six different extraction methods was assessed by different assays viz. 2,2-diphenyl-1-picrylhydrazyl, superoxide, 2,2'-Azino-bis-(3-ethyl)benzothiazoline)-6-sulfonic acid diammonium salt radical cation inhibition assays and ferric reducing antioxidant power...
October 25, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/30088266/fiberoptic-intubation-of-severely-obese-patients-through-supraglottic-airway-a-prospective-randomized-trial-of-the-ambu-%C3%A2-auragain%C3%A2-laryngeal-mask-vs-the-i-gel%C3%A2-airway
#11
Berthold Moser, Christian Keller, Laurent Audigé, Mital H Dave, Heinz R Bruppacher
INTRODUCTION: Airway management in severely obese patients remains a challenging issue for anaesthetists and may lead to life-threatening situations. Supraglottic airway devices, such as the i-gel™ or the AuraGain™, were developed, with the possibility to ventilate the patient or use them as a conduit for endotracheal intubation. METHODS: In our randomized prospective trial, we hypothesized a 10 seconds faster fiberoptic trans-device intubation time through the AuraGain™ laryngeal mask compared to the i-gel™ laryngeal mask in severely obese patients...
February 2019: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/30057374/acquired-von-willebrand-syndrome-during-systemic-mastocytosis-an-analysis-of-21-cases
#12
Andrzej Mital, Witold Prejzner, Andrzej Hellmann
No abstract text is available yet for this article.
August 31, 2018: Polish Archives of Internal Medicine
https://read.qxmd.com/read/29970754/poststreptococcal-glomerulonephritis-with-atypical-hemolytic-uremic-syndrome-an-unusual-presentation
#13
Mital Parekh, Abhijit Konnur, Sishir Gang
A 14-year-old female presented with oliguric dialysis requiring kidney injury due to acute poststreptococcal glomerulonephritis (PSGN) with hypertension strongly suggestive of atypical hemolytic uremic syndrome (aHUS) with microangiopathic hemolytic anemia and elevated factor H antibody levels. Renal biopsy revealed crescentic glomerulonephritis with typical subepithelial, intramembranous and mesangial electron-dense deposits (humps) on electron microscopy. She was treated with glucocorticoids following which she recovered, remained dialysis free and her Factor H antibody levels and depressed complement 3 levels normalized...
May 2018: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/29861570/autosomal-dominant-polycystic-kidney-disease-and-hypertension-masquerading-primary-aldosteronism
#14
P D Mital, K Abhijit, G Shishir
Hypertension is a frequent early manifestation of autosomal dominant polycystic kidney disease (ADPKD). Many mechanisms cause hypertension in ADPKD; however, primary aldosteronism (PA) as a possible manifestation of hypertension in ADPKD is extremely rare. The diagnosis of PA in ADPKD is extremely challenging because multiple renal cysts can mask the identification of adrenal adenomas, and ADPKD is associated with hypertension in majority of cases. Here, we report a unique case of a young lady with ADPKD with hypertension masquerading PA...
March 2018: Indian Journal of Nephrology
https://read.qxmd.com/read/29806162/airway-dimensions-from-fetal-life-to-adolescence-a-literature-overview
#15
REVIEW
Mital H Dave, Kathrin Schmid, Markus Weiss
BACKGROUND: Data on airway dimensions in pediatric patients are important for proper selection of pediatric airway equipment such as endotracheal tubes, double-lumen tubes, bronchial blockers, or stents. The aim of the present work was to provide a synopsis of the available data on pediatric airway dimensions. METHODS: A systematic literature search was carried out in the PubMed database, Scopus, Embase, Web of Science, Prisma, and Google Scholar and secondarily completed by a reference search...
August 2018: Pediatric Pulmonology
https://read.qxmd.com/read/29778489/trends-in-non-medical-prescription-opioids-and-heroin-co-use-among-adults-2003-2014
#16
Sasha Mital, Michael Windle, Hannah L F Cooper, Natalie D Crawford
BACKGROUND: Patterns in non-medical prescription opioid (NMPO) and heroin use have recently shifted, with evidence that NMPO-only users transition to NMPO and heroin co-use. Co-use is associated with increased risk of morbidity and overdose, highlighting the need for further investigation. This study aims to quantify, describe, and explore trends in co-use. METHODS: Using data from the 2003-2014 National Surveys on Drug Use and Health, we compared co-use to NMPO- and heroin-only use across demographic, substance use and mental health characteristics with chi-squared tests...
November 2018: Addictive Behaviors
https://read.qxmd.com/read/29774745/interplay-between-copper-neprilysin-and-n-truncation-of-%C3%AE-amyloid
#17
Mariusz Mital, Wojciech Bal, Tomasz Frączyk, Simon C Drew
Sporadic Alzheimer's disease (AD) is associated with an inefficient clearance of the β-amyloid (Aβ) peptide from the central nervous system. The protein levels and activity of the Zn2+ -dependent endopeptidase neprilysin (NEP) inversely correlate with brain Aβ levels during aging and in AD. The present study considered the ability of Cu2+ ions to inhibit human recombinant NEP and the role for NEP in generating N-truncated Aβ fragments with high-affinity Cu2+ binding motifs that can prevent this inhibition...
June 4, 2018: Inorganic Chemistry
https://read.qxmd.com/read/29714154/high-prevalence-of-abandoned-needlesticks-from-injecting-drug-users-in-milton-keynes-uk-analysing-access-to-needle-exchange-centres-and-drug-dependency-services
#18
Dushyant Mital, Steve Conway, Joanne Trueman
BACKGROUND: In 2015, Milton Keynes (MK) Council waste management team shows an increase in the numbers of abandoned used needles being found across MK. MK is an area of high Human Immunodeficiency Virus (HIV) prevalence and high Hepatitis C (HCV) in People Who Inject Drugs (PWID), the overriding concern was for the safety of the public. METHODS: Analysis of data collection to understand the scale and spread of the problem, preventing/ reducing the incidence of abandoned needles and looking at access to the designated Drug Dependency Unit (DDU) and the Blood Borne Virus (BBV) service...
2017: Current Drug Abuse Reviews
https://read.qxmd.com/read/29442638/nickel-nanocatalyst-ex-solution-from-ceria-nickel-oxide-solid-solution-for-low-temperature-co-oxidation
#19
Amit Singhania, Shipra Mital Gupta
In this work, in situ growth of Ni nanocatalysts to attach onto the ceria (CeO2) surface through direct Ni ex-solution from the NiO-CeO2 solid solution in a reducing atmosphere at high temperatures with an aim to improve the catalytic activity, and stability for low temperature carbon monoxide (CO) oxidation reaction have been reported. The NiO-CeO2 solid solutions were prepared by solution combustion method, and the results of XRD and RAMAN showed that doping of Ni increases the oxygen vacancies due to charge compensation...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/29437119/transplant-free-survival-and-interventions-at-6-years-in-the-svr-trial
#20
Jane W Newburger, Lynn A Sleeper, J William Gaynor, Danielle Hollenbeck-Pringle, Peter C Frommelt, Jennifer S Li, William T Mahle, Ismee A Williams, Andrew M Atz, Kristin M Burns, Shan Chen, James Cnota, Carolyn Dunbar-Masterson, Nancy S Ghanayem, Caren S Goldberg, Jeffrey P Jacobs, Alan B Lewis, Seema Mital, Christian Pizarro, Aaron Eckhauser, Paul Stark, Richard G Ohye
BACKGROUND: In the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for the Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared with a modified Blalock-Taussig shunt in patients with hypoplastic left heart and related syndromes. At 6 years, we compared transplant-free survival and other outcomes between the groups. METHODS: Medical history was collected annually using medical record review, telephone interviews, and the death index...
May 22, 2018: Circulation
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