Anna L Kersey, Daniel Y Cheng, Kaivalya A Deo, Christina R Dubell, Ting-Ching Wang, Manish K Jaiswal, Min Hee Kim, Aparna Murali, Sarah E Hargett, Sumana Mallick, Tanmay P Lele, Irtisha Singh, Akhilesh K Gaharwar
Engineered matrices provide a valuable platform to understand the impact of biophysical factors on cellular behavior such as migration, proliferation, differentiation, and tissue remodeling, through mechanotransduction. While recent studies have identified some mechanisms of 3D mechanotransduction, there is still a critical knowledge gap in comprehending the interplay between 3D confinement, ECM properties, and cellular behavior. Specifically, the role of matrix stiffness in directing cellular fate in 3D microenvironment, independent of viscoelasticity, microstructure, and ligand density remains poorly understood...
January 18, 2024: Biomaterials