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https://read.qxmd.com/read/30753463/morbidity-and-mortality-outcomes-in-neonates-who-were-transferred-from-home-and-hospitals-to-the-only-neonatal-intensive-care-unit-in-guinea-a-descriptive-report-using-routinely-collected-health-data
#1
Mahamoud Sama Cherif, Prabin Dahal, Rashid Mansoor, Facely Camara, Abdourahamane Bah, Alpha Kone, Fatoumata Cherif, Dienaba Kasse, Mandiou Diakite, Mamadou Pathe Diallo
Background: The Sustainable Development Goal (SDG) for neonatal mortality has identified its reduction as one of the main targets to be achieved by 2030. We provide a descriptive report on neonatal outcomes from the only neonatal intensive care unit (NICU) in Guinea. Methods: Data collection took place between November 2004 and May 2005 at the NICU of the Institute of Child Health in the capital, Conakry. A descriptive summary of the neonatal, maternal and intrapartum characteristics is reported...
February 7, 2019: International Health
https://read.qxmd.com/read/30738594/magnetic-resonance-imaging-technologist-breast-subspecialty-program-a-quality-improvement-project-gone-right
#2
Audrey L Hartman, Stacey Sullivan, Sama Alshora, Jeanette Chun, Michelle McSweeney, Cathleen Kim
We describe a Lean based Quality Improvement Project (QIP) to improve the defect rate of breast magnetic resonance imaging (MRI) studies by developing a MRI Technologist Breast Sub-specialization Program. Key stakeholders (physician and technologist) drove the QIP. Both the overall defect rate and the callback rate (severe defects requiring patients return for repeat imaging) were measured over a 2-month period as 17% and 6%, respectively. Lean visualization tools of Pareto Chart & Fishbone Diagram identified lack of multiple trends, but discerned that most defect causes were within the responsibility of the technologists...
December 18, 2018: Current Problems in Diagnostic Radiology
https://read.qxmd.com/read/30703210/the-human-ocular-surface-fungal-microbiome
#3
Sisinthy Shivaji, Rajagopalaboopathi Jayasudha, Gumpili Sai Prashanthi, Sama Kalyana Chakravarthy, Savitri Sharma
Purpose: To enumerate the ocular surface fungal microbiome of healthy human eyes by using next-generation sequencing (NGS). Methods: Tarsal and fornix conjunctiva from the lower and upper lids of both eyes of healthy individuals were swabbed in duplicate separately. A total of 34 samples were collected from both the eyes of 17 individuals, which were used for the generation of ocular surface fungal microbiomes by NGS. Twenty-four swabs were used for the detection of culturable fungi by the conventional cultivable method...
January 2, 2019: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/30699192/correction-alterations-in-the-gut-bacterial-microbiome-in-fungal-keratitis-patients
#4
Sama Kalyana Chakravarthy, Rajagopalaboopathi Jayasudha, Konduri Ranjith, Anirban Dutta, Nishal Kumar Pinna, Sharmila S Mande, Savitri Sharma, Prashant Garg, Somasheila I Murthy, Sisinthy Shivaji
[This corrects the article DOI: 10.1371/journal.pone.0199640.].
2019: PloS One
https://read.qxmd.com/read/30696908/new-insights-into-culture-negative-endophthalmitis-by-unbiased-next-generation-sequencing
#5
Dhanshree Deshmukh, Joveeta Joseph, Moumita Chakrabarti, Savitri Sharma, Rajagopalaboopathi Jayasudha, Kalyana C Sama, Bhavani Sontam, Mudit Tyagi, Raja Narayanan, S Shivaji
The proof-of-concept, study to investigate the presence of microorganisms in presumed infectious endophthalmitis using Next generation sequencing (NGS) was carried out in vitreous biopsies from 34 patients with endophthalmitis, and thirty patients undergoing surgery for non-infectious retinal disorders as controls. Following DNA extraction using the Qiagen mini kit and PCR amplification of the V3-V4 regions of the bacterial 16S rRNA and ITS 2 region of fungus, they samples were sequenced on an Illumina HiSeq 2500 Machine...
January 29, 2019: Scientific Reports
https://read.qxmd.com/read/30692222/lactate-mediates-the-effects-of-exercise-on-learning-and-memory-through-sirt1-dependent-activation-of-hippocampal-brain-derived-neurotrophic-factor-bdnf
#6
Lauretta El Hayek, Mohamad Khalifeh, Victor Zibara, Rawad Abi Assaad, Nancy Emmanuel, Nabil Karnib, Rim El-Ghandour, Patrick Nasrallah, Maria Bilen, Pascale Ibrahim, Joe Younes, Edwina Abou Haidar, Nour Barmo, Vanessa Jabre, Joseph S Stephan, Sama F Sleiman
Exercise promotes learning and memory formation. These effects depend on increases in hippocampal BDNF, a growth factor associated with cognitive improvement and the alleviation of depression symptoms. Identifying molecules that are produced during exercise and that mediate hippocampal Bdnf expression will allow us to harness the therapeutic potential of exercise. Here, we report that an endogenous molecule produced during exercise in male mice induces the Mus musculus Bdnf gene and promotes learning and memory formation...
January 28, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://read.qxmd.com/read/30660759/limitations-of-the-results-from-randomized-clinical-trials-involving-intravenous-and-nebulised-magnesium-sulphate-in-adults-with-severe-acute-asthma
#7
REVIEW
Eugen Javor, Sanja Popović Grle
The role of intravenous (IV) or nebulised magnesium sulphate (MgSO4 ) in the treatment of severe acute asthma in adults is unclear. A controversy exists regarding its efficacy. In children MgSO4 has a more evident clinical effect, but the child population has not been considered in this work. The applicability of the results from randomized clinical trials (RCTs) involving MgSO4 in adult population is questioned in the optimal treatment of asthma exacerbations. According to the newest guidelines from the Global Initiative for Asthma (GINA), optimal treatment in the emergency department (ED) is based on short-acting beta2 -agonists (SABA), oral or IV corticosteroids (CS), short acting muscarinic antagonists (SAMA) and the controlled oxygen therapy...
January 17, 2019: Pulmonary Pharmacology & Therapeutics
https://read.qxmd.com/read/30647450/lactate-is-an-antidepressant-that-mediates-resilience-to-stress-by-modulating-the-hippocampal-levels-and-activity-of-histone-deacetylases
#8
Nabil Karnib, Rim El-Ghandour, Lauretta El Hayek, Patrick Nasrallah, Mohamad Khalifeh, Nour Barmo, Vanessa Jabre, Pascale Ibrahim, Maria Bilen, Joseph S Stephan, Edward B Holson, Rajiv R Ratan, Sama F Sleiman
Chronic stress promotes depression in some individuals, but has no effect in others. Susceptible individuals exhibit social avoidance and anxious behavior and ultimately develop depression, whereas resilient individuals live normally. Exercise counteracts the effects of stress. Our objective was to examine whether lactate, a metabolite produced during exercise and known to reproduce specific brain exercise-related changes, promotes resilience to stress and acts as an antidepressant. To determine whether lactate promotes resilience to stress, male C57BL/6 mice experienced daily defeat by a CD-1 aggressor, for 10 days...
January 8, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://read.qxmd.com/read/30644389/tyrosyl-phosphorylation-of-kras-stalls-gtpase-cycle-via-alteration-of-switch-i-and-ii-conformation
#9
Yoshihito Kano, Teklab Gebregiworgis, Christopher B Marshall, Nikolina Radulovich, Betty P K Poon, Jonathan St-Germain, Jonathan D Cook, Ivette Valencia-Sama, Benjamin M M Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S Irwin, Jeffrey E Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh
Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes is commonly associated with cancer development. Protein tyrosine phosphatase SHP2 promotes RAF-to-MAPK signaling pathway and is an essential factor in RAS-driven oncogenesis. Despite the emergence of SHP2 inhibitors for the treatment of cancers harbouring mutant KRAS, the mechanism underlying SHP2 activation of KRAS signaling remains unclear. Here we report tyrosyl-phosphorylation of endogenous RAS and demonstrate that KRAS phosphorylation via Src on Tyr32 and Tyr64 alters the conformation of switch I and II regions, which stalls multiple steps of the GTPase cycle and impairs binding to effectors...
January 15, 2019: Nature Communications
https://read.qxmd.com/read/30640138/the-effect-of-retinyl-palmitate-on-the-level-of-pro-and-anti-inflammatory-cytokines-in-multiple-sclerosis-patients-a-randomized-double-blind-clinical-trial
#10
Sama Bitarafan, Zinat Mohammadpour, Sima Jafarirad, Mohammad-Hossein Harirchian, Mir Saeed Yekaninejad, Ali Akbar Saboor-Yaraghi
OBJECTIVE: Multiple sclerosis (MS) is an inflammatory and autoimmune disease associated with the imbalance of cytokines secreted from CD4+ T cells. Studies have shown that vitamin A and its active derivatives are able to modulate the immune system in MS patients. The aim of the present study was to investigate the effect of supplementation of retinyl palmitate (RP), the dietary form of vitamin A, on pro- and anti-inflammatory cytokines in the plasma and supernatants of cultured peripheral blood mononuclear cells (PBMCs) of MS patients...
February 2019: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/30632221/inhibition-of-enhancer-of-zest-homologue-2-is-a-potential-therapeutic-target-for-high-myc-medulloblastoma
#11
Manabu Natsumeda, Yang Liu, Satoshi Nakata, Hiroaki Miyahara, Allison Hanaford, Sama Ahsan, Duncan Stearns, Nicolas Skuli, Ulf D Kahlert, Eric H Raabe, Fausto J Rodriguez, Charles G Eberhart
MYC amplification is common in Group 3 medulloblastoma and is associated with poor survival. Group 3 and Group 4 medulloblastomas are also known to have elevated levels of histone H3-lysine 27-tri-methylation (H3K27me3), at least in part due to high expression of the H3K27 methyltransferase enhancer of zest homologue 2 (EZH2), which can be regulated by MYC. We therefore examined whether MYC expression is associated with elevated EZH2 and H3K27me3 in medulloblastoma, and if high-MYC medulloblastomas are particularly sensitive to pharmacological EZH2 blockade...
January 10, 2019: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://read.qxmd.com/read/30619913/procalcitonin-guided-antibiotic-therapy-reduces-antibiotic-use-for-lower-respiratory-tract-infections-in-a-united-states-medical-center-results-of-a-clinical-trial
#12
Jennifer Townsend, Victoria Adams, Panagis Galiatsatos, David Pearse, Hardin Pantle, Mary Masterson, Flora Kisuule, Elsen Jacob, Catherine Kiruthi, Paul Ortiz, Albert Agbanlog, Robert Jurao, Sam Stern, Seema Nayak, Michael Melgar, Jacob Sama, Jillian Irwin, Cyrus Mazidi, Kevin Psoter, Robin McKenzie
Background: European trials using procalcitonin (PCT)-guided antibiotic therapy for patients with lower respiratory tract infections (LRTIs) have demonstrated significant reductions in antibiotic use without increasing adverse outcomes. Few studies have examined PCT for LRTIs in the United States. Methods: In this study, we evaluated whether a PCT algorithm would reduce antibiotic exposure in patients with LRTI in a US hospital. We conducted a controlled pre-post trial comparing an intervention group of PCT-guided antibiotic therapy to a control group of usual care...
December 2018: Open Forum Infectious Diseases
https://read.qxmd.com/read/30617865/interleukin-6-is-prone-to-be-a-candidate-biomarker-for-predicting-incomplete-and-ivig-nonresponsive-kawasaki-disease-rather-than-coronary-artery-aneurysm
#13
Yue Wu, Fei Fei Liu, Yao Xu, Jing Jing Wang, Sama Samadli, Yang Fang Wu, Hui Hui Liu, Wei Xia Chen, Huang Huang Luo, Dong Dong Zhang, Wei Wei, Peng Hu
Kawasaki disease (KD) is an acute, systemic vasculitis and occurs mainly in childhood. Interleukin-6 (IL-6) is a pleiotropic cytokine synthesized predominantly by neutrophils and monocytes/macrophages and plays an important role in systemic inflammatory disease. However, a little information is currently available on the relationship of serum IL-6 with conventional inflammatory mediators, clinical classification, IVIG response and coronary artery aneurysm (CAA). 165 Chinese children with KD were enrolled and divided into six subgroups, including complete KD, incomplete KD, IVIG-responsive KD, IVIG-nonresponsive KD, coronary artery noninvolvement KD and coronary artery involvement KD...
January 8, 2019: Clinical and Experimental Medicine
https://read.qxmd.com/read/30616561/diagnostic-ambiguity-of-aseptic-necrobiosis-of-a-uterine-fibroid-in-a-term-pregnancy-a-case-report
#14
Julius Sama Dohbit, Esther Ngo Um Meka, Joel Noutakdie Tochie, Igor Kamla, Celestin Danwang, Frank-Leonel Tianyi, Pascal Foumane, Gervais Ondobo Andze
BACKGROUND: Uterine fibroids are the most common uterine tumours in females of reproductive age. During pregnancy, uterine fibroids may be complicated by aseptic necrobiosis. We herein report an ambiguous clinical presentation of uterine fibroids in pregnancy and discuss the diagnostic challenges encountered in our resource-constraint setting. CASE PRESENTATION: A term pregnant Cameroonian woman was admitted to our maternity unit with clinical findings suggestive of a strangulated umbilical hernia...
January 7, 2019: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/30560187/a-green-brown-plaque-on-the-dorsal-hand
#15
Anna-Marie Hosking, Delila Pouldar, Ashley Elsensohn, Sama Kassira, Janellen Smith, Sebastien de Feraudy
No abstract text is available yet for this article.
January 2019: JAAD Case Reports
https://read.qxmd.com/read/30541945/alterations-in-gut-bacterial-and-fungal-microbiomes-are-associated-with-bacterial-keratitis-an-inflammatory-disease-of-the-human-eye
#16
Rajagopalaboopathi Jayasudha, Sama Kalyana Chakravarthy, Gumpili Sai Prashanthi, Savitri Sharma, Prashant Garg, Somasheila I Murthy, Sisinthy Shivaji
Dysbiosis, or imbalance in the gut microbiome, has been implicated in auto-immune, inflammatory, neurological diseases as well as in cancers. More recently it has also been shown to be associated with ocular diseases. In the present study, the association of gut microbiome dysbiosis with bacterial Keratitis, an inflammatory eye disease which significantly contributes to corneal blindness, was investigated. Bacterial and fungal gut microbiomes were analysed using fecal samples of healthy controls (HC, n = 21) and bacterial Keratitis patients (BK, n = 19)...
December 2018: Journal of Biosciences
https://read.qxmd.com/read/30540783/risk-factors-for-ectopic-pregnancy-in-a-population-of-cameroonian-women-a-case-control-study
#17
Yvette Audrey Assouni Mindjah, Félix Essiben, Pascal Foumane, Julius Sama Dohbit, Emile Telesphore Mboudou
OBJECTIVE: To identify the risk factors for ectopic pregnancy (EP) in a population of Cameroonian women. SAMPLE AND METHODS: We performed a matched case-control study; 88 women with diagnosed EP (cases), and 176 women with first trimester intrauterine pregnancy (IUP) (controls), who underwent questionnaires. Odds Ratio (OR) and 95% confidence intervals (CIs) were calculated and adjusted for potential confounding factors via multivariate logistic regression analysis...
2018: PloS One
https://read.qxmd.com/read/30530785/predisposing-factors-of-childhood-henoch-sch-%C3%A3-nlein-purpura-in-anhui-province-china
#18
Yao Xu, Jing Jing Wang, Fei Fei Liu, Yue Wu, Yang Fang Wu, Sama Samadli, Huang Huang Luo, Dong Dong Zhang, Peng Hu
Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP is still unclear, whereas several types of predisposing factors have been proved to be the initial step. The objectives of present study were to analyze the distribution of predisposing factors, association of the predisposing factors with clinical manifestations and HSP relapse/recurrence. 1200 children with HSP were recruited between January 2015 and December 2017. We reviewed their laboratory tests and medical histories associated with HSP onset...
December 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30523358/unusual-presentation-of-emphysematous-pyelonephritis
#19
Sonu Sama, Nilesh Chandra
No abstract text is available yet for this article.
December 6, 2018: Intensive Care Medicine
https://read.qxmd.com/read/30473441/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-to-evaluating-the-trend-of-cytokines-to-vitamin-a-supplementation-in-autoimmune-diseases
#20
Mohammad Hossein Harirchian, Zinat Mohammadpour, Farzad Fatehi, Negar Firoozeh, Sama Bitarafan
BACKGROUND & AIMS: Vitamin A is considered as a supplement that effect on autoimmune diseases. We aimed to systematically review the effect of vitamin A on cytokines in patients with autoimmune disease. METHODS: Two researchers searched Scopus and PubMed until May 2018. Researchers extracted data from 6 eligible published papers. Extracted data included the gene expression of the inflammatory and anti-inflammatory cytokines. RESULTS: Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-γ and T-bet) and anti-inflammatory (TGF-β and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases...
November 14, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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