keyword
https://read.qxmd.com/read/38435935/effectiveness-of-narrowband-ultraviolet-light-in-chronic-kidney-disease-associated-pruritus
#21
JOURNAL ARTICLE
Imane Shabi, Zineb Aboudar, Mounia Sidki, Said Amal, Ouafa Hocar, Maryem Aboudourib, Nabil Hamouche, Mariam Chettati, Wafaa Fadili, Inass Laouad
INTRODUCTION:  Chronic kidney disease-associated pruritus (CKDaP) is a prevalent and challenging symptom in individuals suffering from advanced chronic kidney disease (CKD). Its underlying mechanism remains inadequately understood, leading to a limited array of unsatisfactory therapeutic interventions. Despite various attempts, identifying the most effective treatment remains inconclusive. Nevertheless, there is a growing interest in employing ultraviolet phototherapy, particularly for non-responsive patients, although its efficacy is not definitively established...
January 2024: Curēus
https://read.qxmd.com/read/38428530/mucoadhesive-liposomal-delivery-system-synergizing-anti-inflammation-and-anti-oxidation-for-enhanced-treatment-against-dry-eye-disease
#22
JOURNAL ARTICLE
Kexin Huang, Rong Guo, Haoyuan Luo, Houqin Liu, Dong Chen, Tao Deng, Jiaxin Li, Jiao He, Zhuping Xu, Man Li, Qin He
Dry eye disease (DED) is a common and frequent ocular surface disease worldwide, which can cause severe ocular surface discomfort and blurred vision. Inflammation and reactive oxygen species (ROS) play decisive roles in the development of DED. However, existing treatments usually focus on anti-inflammation while ignore the role of ROS in DED. Ever worse, the clinical preparations are easily cleared by nasolacrimal ducts, resulting in poor therapeutic effect. To circumvent these obstacles, here we designed a phenylboronic acid (PBA) modified liposome co-loading immunosuppressant cyclosporin A (CsA) and antioxidant crocin (Cro)...
February 28, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38421315/functional-opsin-patterning-for-drosophila-color-vision-is-established-through-signaling-pathways-in-adjacent-object-detection-neurons
#23
JOURNAL ARTICLE
Manabu Kitamata, Yoshiaki Otake, Hideaki Kitagori, Xuanshuo Zhang, Yusuke Maki, Rika Boku, Masato Takeuchi, Hideki Nakagoshi
Vision is mainly based on two different tasks, object detection and color discrimination through activities of photoreceptor (PR) cells. Drosophila compound eye consists of ∼800 ommatidia. Every ommatidium contains eight PR cells; six outer cells (R1-R6) and two inner cells (R7 and R8) by which object detection and color vision are achieved, respectively. Expression of opsin genes in R7 and R8 is highly coordinated through the instructive signal from R7 to R8, and two major ommatidial subtypes are distributed stochastically; pale type expresses Rh3/Rh5, while yellow type expresses Rh4/Rh6 in R7/R8...
March 1, 2024: Development
https://read.qxmd.com/read/38409359/opioid-free-anesthesia-with-ultrasound-guided-quadratus-lumborum-block-in-the-supine-position-for-lower-abdominal-or-pelvic-surgery-a-randomized-controlled-trial
#24
JOURNAL ARTICLE
Jingwei Dai, Shanliang Li, Qijun Weng, Jinxiong Long, Duozhi Wu
In the past, quadratus lumborum block (QLB) was mostly used for postoperative analgesia in patients, and few anesthesiologists applied it during surgery with opioid-free anesthesia (OFA). Consequently, it is still unclear whether QLB in the supine position can provide perfect analgesia and inhibit anesthetic stress during surgery under the OFA strategy. To observe the clinical efficacy of ultrasound-guided quadratus lumborum block (US-QLB) in the supine position with OFA for lower abdominal and pelvic surgery...
February 26, 2024: Scientific Reports
https://read.qxmd.com/read/38407858/retrolaminar-demyelination-of-structurally-intact-axons-in-nonhuman-primate-experimental-glaucoma
#25
JOURNAL ARTICLE
Priya Chaudhary, Howard Lockwood, Cheri Stowell, Eric Bushong, Juan Reynaud, Hongli Yang, Stuart K Gardiner, Galen Wiliams, Imee Williams, Mark Ellisman, Nick Marsh-Armstrong, Claude Burgoyne
PURPOSE: To determine if structurally intact, retrolaminar optic nerve (RON) axons are demyelinated in nonhuman primate (NHP) experimental glaucoma (EG). METHODS: Unilateral EG NHPs (n = 3) were perfusion fixed, EG and control eyes were enucleated, and foveal Bruch's membrane opening (FoBMO) 30° sectoral axon counts were estimated. Optic nerve heads were trephined; serial vibratome sections (VSs) were imaged and colocalized to a fundus photograph establishing their FoBMO location...
February 1, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38407686/visual-outcomes-and-patient-satisfaction-after-bilateral-implantation-of-an-enhanced-monofocal-intraocular-lens-a-single-masked-prospective-randomized-study
#26
RANDOMIZED CONTROLLED TRIAL
Rosa Giglio, Alex Lucia Vinciguerra, Marianna Presotto, Kamil Jonak, Robert Rejdak, Mario Damiano Toro, Mayank Ambarish Nanavaty, Daniele Tognetto
PURPOSE: To evaluate and compare the visual outcomes of an enhanced monofocal intraocular lens (IOL) with two different monofocal IOLs. SETTING: Eye Clinic, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. DESIGN: Prospective, single-center, single-masked, randomized controlled clinical study. METHODS: The study included patients undergoing phacoemulsification and IOL implantation...
February 26, 2024: International Ophthalmology
https://read.qxmd.com/read/38391923/a-bird-s-eye-view-of-chromosomic-evolution-in-the-class-aves
#27
REVIEW
Rebecca E O'Connor, Rafael Kretschmer, Michael N Romanov, Darren K Griffin
Birds (Aves) are the most speciose of terrestrial vertebrates, displaying Class-specific characteristics yet incredible external phenotypic diversity. Critical to agriculture and as model organisms, birds have adapted to many habitats. The only extant examples of dinosaurs, birds emerged ~150 mya and >10% are currently threatened with extinction. This review is a comprehensive overview of avian genome ("chromosomic") organization research based mostly on chromosome painting and BAC-based studies. We discuss traditional and contemporary tools for reliably generating chromosome-level assemblies and analyzing multiple species at a higher resolution and wider phylogenetic distance than previously possible...
February 7, 2024: Cells
https://read.qxmd.com/read/38386849/a-sustainable-retinal-drug-codelivery-for-boosting-therapeutic-efficacy-in-wamd-unveiling-multifaceted-evidence-and-synergistic-mechanisms
#28
JOURNAL ARTICLE
Congyan Liu, Wenting Su, Xi Jiang, Yanli Lv, Fei Kong, Qin Chen, Qun Zhang, Huangqin Zhang, Yuping Liu, Xiaoqi Li, Xinrong Xu, Yan Chen, Ding Qu
Sustainable retinal codelivery poses significant challenges technically, although it is imperative for synergistic treatment of wet age-related macular degeneration (wAMD). Here, a microemulsion-doped hydrogel (Bor/PT-M@TRG) is engineered as an intravitreal depot composing of temperature-responsive hydrogel (TRG) and borneol-decorated paeoniflorin (PF) & tetramethylpyrazine (TMP)-coloaded microemulsions (Bor/PT-M). Bor/PT-M@TRG, functioning as the "ammunition depot", resides in the vitreous and continuously releases Bor/PT-M as the therapeutic "bullet", enabling deep penetration into the retina for at least 21 days...
February 22, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38365883/direct-observation-and-measurement-of-circumlental-space-and-its-relation-to-anterior-chamber-angle-characteristics-in-iridotomized-phakic-eyes-with-primary-angle-closure-disease
#29
JOURNAL ARTICLE
Zhiqiao Liang, Kangyi Yang, Kun Lv, Yao Ma, Xuanzhu Chen, Zeqin Ren, Yong Liang, Xianru Hou, Huijuan Wu
Primary angle closure disease (PACD) is a major cause of blindness worldwide. It has a high prevalence in East Asia, especially in China, which leads to a higher incidence of blindness than open-angle glaucoma. The aim of this study was to directly observe the circumlental space (CLS) in laser peripheral iridotomized eyes with PACD and to determine whether this structure plays a role in the pathogenesis of PACD. Fifty eyes of 50 patients with PACD, who had received laser peripheral iridotomy performed with neodymium:yttrium-aluminum-garnet were recruited from glaucoma clinics from March 2021 to May 2022, including 17 primary angle closure suspect (PACS), 16 primary angle closure (PAC) and 17 primary angle closure glaucoma (PACG)...
February 16, 2024: Scientific Reports
https://read.qxmd.com/read/38349825/deep-learning-based-eye-tracking-analysis-for-diagnosis-of-alzheimer-s-disease-using-3d-comprehensive-visual-stimuli
#30
JOURNAL ARTICLE
Fangyu Zuo, Peiguang Jing, Jinglin Sun, Jizhong Duan, Yong Ji, Yu Liu
Alzheimer's Disease (AD) is a neurodegenerative disorder that causes a continuous decline in cognitive functions and eventually results in death. An early AD diagnosis is important for taking active measures to slow its deterioration. Traditional diagnoses are usually based on clinical experience, which is limited by several realistic factors. In this paper, we focus on exploiting deep learning techniques to diagnose AD based on eye-tracking behaviors. Visual attention, as a typical eye-tracking behavior, is of great clinical value in detecting cognitive abnormalities in AD patients...
February 13, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38348265/autobiographical-implicit-association-test-and-eye-movements-fixations-topography-enables-detection-of-autobiographical-memories
#31
JOURNAL ARTICLE
Andrea Zangrossi, Liisa Camilla Gatto, Virginia Lanfranchi, Cristina Scarpazza, Miriam Celli, Giuseppe Sartori
INTRODUCTION: Autobiographical memory is the capacity to recollect memories of personally experienced events. The detection of such memories plays a key role in criminal trials. Among behavioral memory-detection methods, the autobiographical Implicit Association Test (aIAT) has gained popularity for its flexibility and suitability for forensic applications. The aIAT is a reaction time-based methodology aiming to assess whether information about an event is encoded in the respondent's mind...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38347576/prolonged-critical-avalanche-burial-for-nearly-23%C3%A2-h-with-severe-hypothermia-and-severe-frostbite-with-good-recovery-a-case-report
#32
JOURNAL ARTICLE
Elisabeth Gruber, Rosmarie Oberhammer, Hermann Brugger, Elisa Bresadola, Matteo Avogadri, Julia Kompatscher, Marc Kaufmann
BACKGROUND: Accidental hypothermia with severe frostbite is a rare combination of injuries with a high risk for long-term sequelae. There are widely accepted recommendations for the management of avalanche victims and for frostbite treatment, but no recommendation exists for the treatment of frostbite in severe hypothermic patients, specifically for the management of hypothermic avalanche victims presenting with frostbite. CASE PRESENTATION: We present a case of a previously healthy, 53-year-old male skier who was critically buried by an avalanche at 2300 m of altitude at an ambient temperature of - 8 °C for nearly 23 h...
February 12, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/38345011/prevalence-of-keratoconus-based-on-scheimpflug-corneal-tomography-metrics-in-a-pediatric-population-from-a-chicago-based-school-age-vision-clinic
#33
JOURNAL ARTICLE
Jennifer S Harthan, John D Gelles, Sandra S Block, William Tullo, Andrew S Morgenstern, Becky Su, Daniel Chung, Austin Yu, Steven A Greenstein, Peter S Hersh, Steven Barry Eiden
PURPOSE: Determine the pediatric prevalence of keratoconus (KC) using Scheimpflug corneal tomography. METHODS: A prospective observational study was done on subjects aged 3 to 18 years at the Princeton Vision Clinic, Chicago, IL. Scheimpflug tomography (Pentacam HR, OCULUS Optikgerate GmbH) scans (Belin/Ambrósio Enhanced Ectasia BAD3) yielded BAD Final D (Final D) and Back Elevation at the Thinnest Point (BETP) measurements. Criteria differentiating non-KC from KC suspects & KC were, Non-KC-Final D <2...
February 7, 2024: Eye & Contact Lens
https://read.qxmd.com/read/38342335/gsdmd-mediated-pyroptosis-induced-inflammation-of-graves-orbitopathy-via-the-nf-%C3%AE%C2%BAb-aim2-caspase-1-pathway
#34
JOURNAL ARTICLE
Xiaotong Sha, Huijing Ye, Xing Wang, Zhihui Xu, Anqi Sun, Wei Xiao, Te Zhang, Shenglan Yang, Huasheng Yang
Gasdermin D (GSDMD) is a key executor which triggers pyroptosis as well as an attractive checkpoint in various inflammatory and autoimmune diseases but it has yet to prove its function in Graves'orbitopathy (GO). Our aim was to investigate GSDMD levels in orbital connective tissue and serum of GO patients and then assess the association between serum levels and patients' clinical activity score (CAS). Further, GSDMD-mediated pyroptosis and the underlying mechanism in inflammatory pathogenesis in the cultured orbital fibroblasts (OFs) of GO patients were examined...
February 9, 2024: Experimental Eye Research
https://read.qxmd.com/read/38339011/joint-cb1-and-ngf-receptor-activation-suppresses-trpm8-activation-in-etoposide-resistant-retinoblastoma-cells
#35
JOURNAL ARTICLE
Szymon Ludwiczak, Jacqueline Reinhard, Peter S Reinach, Aruna Li, Jakub Oronowicz, Aisha Yousf, Vinodh Kakkassery, Stefan Mergler
In childhood, retinoblastoma (RB) is the most common primary tumor in the eye. Long term therapeutic management with etoposide of this life-threatening condition may have diminishing effectiveness since RB cells can develop cytostatic resistance to this drug. To determine whether changes in receptor-mediated control of Ca2+ signaling are associated with resistance development, fluorescence calcium imaging, semi-quantitative RT-qPCR analyses, and trypan blue dye exclusion staining patterns are compared in WERI-ETOR (etoposide-insensitive) and WERI-Rb1 (etoposide-sensitive) cells...
January 31, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38336323/self-assembled-sodium-alginate-polymannuronate-nanoparticles-for-synergistic-treatment-of-ophthalmic-infection-and-inflammation-preparation-optimization-and-in-vitro-vivo-evaluation
#36
JOURNAL ARTICLE
Nondita Datta, Tohfatul Jinan, Siew Yee Wong, Saumitra Chakravarty, Xu Li, Ishtiaque Anwar, M Tarik Arafat
Frequent administrations are often needed during the treatment of ocular diseases due to the low bioavailability of the existing eye drops owing to inadequate corneal penetration and rapid drug washout. Herein, sodium alginate polymannuronate (SA) nanocarriers were developed using ionic gelation method that can provide better bioavailability through mucoadhesivity and sustained drug release by binding to the ocular mucus layer. This study disproves the common belief that only the G block of SA participates in the crosslinking reaction during ionic gelation...
February 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38335720/comparison-of-preoperative-retrobulbar-bupivacaine-and-postoperative-subcutaneous-liposome-encapsulated-bupivacaine-on-postoperative-analgesia-in-dogs-undergoing-enucleation
#37
JOURNAL ARTICLE
Taylor A Opgenorth, Ellison Bentley, Lesley J Smith, Kyle J Bartholomew, Michael R Lasarev
OBJECTIVE: To compare the effectiveness of preoperative bupivacaine inferotemporal retrobulbar blocks to postoperative liposome-encapsulated bupivacaine (Nocita) line blocks for analgesia following enucleation. ANIMALS: 39 client-owned dogs (40 eyes) presenting to the Ophthalmology Service for enucleation. METHODS: Dogs were randomly assigned to receive either a preoperative inferotemporal retrobulbar block with 0.5% bupivacaine or a peri-incisional line block with liposome-encapsulated bupivacaine (Nocita) at closure...
February 9, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38332874/retinoblastoma-vulnerability-to-combined-de-novo-and-salvage-pyrimidine-ribonucleotide-synthesis-pharmacologic-blockage
#38
JOURNAL ARTICLE
Tanzina Mollick, Suhas Darekar, Basile Dalarun, Flavia Plastino, Juan Zhang, Andres Pastor Fernández, Twana Alkasalias, Helder André, Sonia Laín
Retinoblastoma is an eye cancer that commonly affects young children. Despite significant advances, current treatments cause side effects even when administered locally, and patients may still have to undergo enucleation. This is particularly disheartening in cases of bilateral retinoblastoma. Hence, there is an urgent need for novel therapeutic strategies. Inhibitors of the enzyme dihydroorotate dehydrogenase (DHODH), which is involved in the de novo pyrimidine ribonucleotide synthesis pathway, have proven to be effective in preclinical trials against several cancers including pediatric cancers...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38329299/subconjunctival-liposomal-sirolimus-vs-cyclosporine-or-tacrolimus-as-treatment-of-keratoconjunctivitis-sicca-in-dogs-a-double-blind-randomized-study
#39
JOURNAL ARTICLE
Rodrigo García-Santisteban, Mónica Anayatzin Linares-Alba, Andrés Botello-Bárcenas, Paola Margay, Carlos Soto, Joice Fonzar-Furtado, Dennis Brooks, Diego García, Gustavo Adolfo García Sánchez
PURPOSE: To compare the safety and efficacy of a 100 microgram subconjunctival injection of liposome-encapsulated sirolimus (SCJS) to cyclosporine (CsA) or tacrolimus (CsA/T) for the treatment of keratoconjunctivitis sicca (KCS) in dogs. METHODS: Dogs with signs and symptoms of KCS were block-randomized to one of two treatment groups: Biweekly SCJS or conventional treatment (CsA/T). Schirmer tear test 1 (STT-1) scores, conjunctival hyperemia (CH) scores, corneal opacity (CO) scores, and clinical evaluation of potential side effects were recorded every 2 weeks for 14 weeks for both groups...
February 8, 2024: Veterinary Ophthalmology
https://read.qxmd.com/read/38325709/dressing-and-undressing-mof-nanophotosensitizers-to-manipulate-phototoxicity-for-precise-therapy-of-tumors
#40
JOURNAL ARTICLE
Cheng Tao, Nuo Yu, Qian Ren, Mei Wen, Pu Qiu, Shining Niu, Maoquan Li, Zhigang Chen
Photodynamic therapy (PDT) is a clinically approved treatment for tumors, and it relies on the phototoxicity of photosensitizers by producing reactive oxygen species (ROS) to destroy cancer cells under light irradiation. However, such phototoxicity is a double-edged sword, which is also harmful to normal tissues. To manipulate phototoxicity and improve the therapy effect, herein we have proposed a dressing-undressing strategy for de-activating and re-activating therapy functions of photosensitizer nanoparticles...
February 5, 2024: Acta Biomaterialia
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