Congyan Liu, Wenting Su, Xi Jiang, Yanli Lv, Fei Kong, Qin Chen, Qun Zhang, Huangqin Zhang, Yuping Liu, Xiaoqi Li, Xinrong Xu, Yan Chen, Ding Qu
Sustainable retinal codelivery poses significant challenges technically, although it is imperative for synergistic treatment of wet age-related macular degeneration (wAMD). Here, a microemulsion-doped hydrogel (Bor/PT-M@TRG) is engineered as an intravitreal depot composing of temperature-responsive hydrogel (TRG) and borneol-decorated paeoniflorin (PF) & tetramethylpyrazine (TMP)-coloaded microemulsions (Bor/PT-M). Bor/PT-M@TRG, functioning as the "ammunition depot", resides in the vitreous and continuously releases Bor/PT-M as the therapeutic "bullet", enabling deep penetration into the retina for at least 21 days...
February 22, 2024: Advanced Healthcare Materials