keyword
https://read.qxmd.com/read/36026753/combined-exosomal-and-plasma-non-coding-rna-signature-associated-with-urinary-albumin-excretion-in-hypertension
#21
JOURNAL ARTICLE
Ana Ortega, Olga Martinez-Arroyo, Angela Leticia Riffo-Campos, Javier Perez-Hernandez, Ana Flores-Chova, Josep Redon, Raquel Cortes
OBJECTIVE: Non-coding RNA (ncRNA), released into circulation or packaged into exosomes, play important roles in many biological processes in the kidney. The purpose of the present study is to identify a common ncRNA signature associated with early renal damage and its related molecular pathways by constructing a RNA-based transcriptional network. DESIGN AND METHOD: This is an observational case-control study which included 43 hypertensives, twenty-one patients with essential hypertension and twenty-two without persistent elevated urinary albuminuria (UAE) (higher or equal to 30 mg/g urinary creatinine)...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36026749/imbalance-in-bone-morphogenic-proteins-2-and-7-is-associated-with-hypertension-and-arterial-stiffness-in-chronic-kidney-disease
#22
JOURNAL ARTICLE
Francisco J Manzano-Lista, Marta Sanz-Gómez, Daniel González-Moreno, Elena Vega-Martín, Marta Gil-Ortega, Isabel Aránguez, Angela Schulz, Miguel Ángel Rubio, Gema Ruiz-Hurtado, Luis M Ruilope, Reinhold Kreutz, María S Fernández-Alfonso
OBJECTIVE: Patients with chronic kidney disease (CKD) exhibit an elevated cardiovascular risk from the early stages (I-III) with an exponentially increasing risk of cardiovascular death as kidney function worsens. The hypothesis of this study is that there is a imbalance in bone morphogenetic proteins BMP-2 (procalcifying) and BMP-7 (renoprotective) at early CKD stages associated with the development of hypertension, vascular stiffness and progressive kidney damage. DESIGN AND METHOD: BMP-2 and BMP-7 levels were determined by ELISA in samples of CKD patients (stages I-III; n = 95) and of Munich Wistar Frömter (MWF) rats (22 weeks old; n = 6), a genetic model with spontaneous nondiabetic CKD, compared to age-matched Wistar rats...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/35993461/diabetic-nephropathy-pathogenesis-to-cure
#23
JOURNAL ARTICLE
Kriti Kushwaha, Dr Uma Kabra, Rupal Dubey, Jeena Gupta
Diabetic nephropathy (DN) is a leading cause of end-stage renal disorder (ESRD). It is defined as the increase in urinary albumin excretion (UAE) when no other renal disease is present. DN is categorized into microalbuminuria and macroalbuminuria. Factors like high blood pressure, high blood sugar levels, genetics, oxidative stress, hemodynamic and metabolic changes affect DN. Hyperglycemia causes renal damage through activating protein kinase C (PKC), producing advanced end glycation products (AGEs) and reactive oxygen species (ROS)...
August 20, 2022: Current Drug Targets
https://read.qxmd.com/read/35854195/sinomenine-alleviates-glomerular-endothelial-permeability-by-activating-the-c-ebp-%C3%AE-claudin-5-signaling-pathway
#24
JOURNAL ARTICLE
Li Zhang, Junxia Wang
Diabetic nephropathy (DN) is one of the main complications of diabetes. It is closely associated with the dysfunction of glomerular endothelial cells (GECs) under hyperglycemia. Severe inflammation is an important inducer for the development of GECs dysfunction, and it contributes to the disruption of tight junctions in GECs and the increased endothelial permeability. Sinomenine, an alkaloid monomer extracted from the rhizome of Sinomenium acutum, is recognized for its multiple pharmacological functions, including an anti-DN property...
September 2022: Human Cell
https://read.qxmd.com/read/35702110/efficacy-of-epalrestat-combined-with-alprostadil-for-diabetic-nephropathy-and-its-impacts-on-renal-fibrosis-and-related-factors-of-inflammation-and-oxidative-stress
#25
JOURNAL ARTICLE
Yanan Zhou, Rongrong Wang, Fengmei Han, Jincheng Zhang
OBJECTIVE: To explore the efficacy of epalrestat (Ep) combined with alprostadil (Alp) in the treatment of diabetic nephropathy (DN) and its impacts on renal fibrosis (RF) and inflammation and oxidative stress (OS)-related factors. METHODS: In this retrospective study, 120 patients with DN treated in the Cangzhou Central Hospital from January 2020 to January 2021 were selected as the research subjects. Among them, 80 cases treated with Ep combined with Alp were assigned to group A, and the rest 40 patients treated with Alp only were assigned to group B...
2022: American Journal of Translational Research
https://read.qxmd.com/read/35553511/mitochondrial-derived-ros-contribute-to-the-development-of-hypertensive-diabetic-kidney-injury
#26
JOURNAL ARTICLE
Zhen Wang, Yiling Fu, Jaylan Sears, Alexandre A da Silva, Jussara M do Carmo, Xuan Li, Alan Mouton, Ana Carolina M Omoto, John E Hall
Hypertension (HTN) is common in diabetes mellitus (DM) and substantially increases the risk for diabetic nephropathy. Current therapies only slow the progression to end-stage renal disease (ESRD) in hypertensive-diabetic patients rather than halt it. Thus, new insights into the mechanisms of this disease are needed. To investigate the mechanisms by which HTN and DM interact to promote renal injury, we developed a model combining streptozotocin (STZ)-induced type 1 DM and inter-renal aorta constriction (AC)-induced HTN in male Wistar rats...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35023700/-anthropometric-indicators-and-poor-glycemic-control-in-type-2-diabetes-with-kidney-disease
#27
JOURNAL ARTICLE
Lubia Velázquez-López, Leonardo Lebib Azar-Hernández, Luisa Díaz-García
Background: The relationship of anthropometric and body composition indicators with the evolution of kidney disease in patients with type 2 diabetes, is still inconsistent. Objective: To identify the association of indicators of kidney disease with indicators of metabolic and anthropometric control in patients with type 2 diabetes. Material and methods: An analytical cross-sectional study was carried out in 395 patients of the first level of care...
August 2, 2021: Revista Médica del Instituto Mexicano del Seguro Social
https://read.qxmd.com/read/34937811/impact-of-salt-intake-on-urinary-albumin-excretion-in-patients-with-type-2-diabetic-nephropathy-a-retrospective-cohort-study-based-on-a-generalized-additive-model
#28
JOURNAL ARTICLE
Yuka Kotake, Shigehiro Karashima, Masaki Kawakami, Satoshi Hara, Daisuke Aono, Seigo Konishi, Mitsuhiro Kometani, Hiroyuki Mori, Yoshiyu Takeda, Takashi Yoneda, Hidetaka Nambo, Kenji Furukawa
Diabetic kidney disease is an important and common cause of end-stage renal disease. Measurement of urinary albumin excretion (UAE) requires the diagnosis of the stage of diabetic nephropathy and the prognosis of renal function. We aimed to analyze the impact of lifestyle modification on UAE in patients with stage 2 and 3 type 2 diabetic nephropathy who received comprehensive medical care, using a generalized additive model (GAM), an explanatory machine learning model. In this retrospective observational study, we used changes in HbA1c, systolic blood pressure (SBP), and diastolic blood pressure (DBP) levels; body mass index (BMI); and daily salt intake as factors contributing to changes in UAE...
May 30, 2022: Endocrine Journal
https://read.qxmd.com/read/34896941/serum-free-sulfhydryl-status-associates-with-new-onset-chronic-kidney-disease-in-the-general-population
#29
JOURNAL ARTICLE
Arno R Bourgonje, Amaal E Abdulle, Martin F Bourgonje, S Heleen Binnenmars, Sanne J Gordijn, Marian L C Bulthuis, Sacha la Bastide-van Gemert, Lyanne M Kieneker, Ron T Gansevoort, Stephan J L Bakker, Douwe J Mulder, Andreas Pasch, Martin H de Borst, Harry van Goor
BACKGROUND: Serum sulfhydryl groups (R-SH, free thiols) reliably reflect the systemic redox status in health and disease. As oxidation of R-SH occurs rapidly by reactive oxygen species (ROS), oxidative stress is accompanied by reduced levels of free thiols. Oxidative stress has been implicated in the pathophysiology of chronic kidney disease (CKD), in which redox imbalance may precede the onset of CKD. Therefore, we aimed to investigate associations between serum free thiols and the risk of incident CKD as defined by renal function decline and albuminuria in a population-based cohort study...
December 9, 2021: Redox Biology
https://read.qxmd.com/read/34775979/buyang-huanwu-decoction-protects-against-stz-induced-diabetic-nephropathy-by-inhibiting-tgf-%C3%AE-smad3-signaling-mediated-renal-fibrosis-and-inflammation
#30
JOURNAL ARTICLE
Weifeng Wu, Yifan Wang, Haidi Li, Haiyong Chen, Jiangang Shen
BACKGROUND: Buyang Huanwu Decoction (BHD) is a classical Chinese Medicine formula empirically used for diabetic nephropathy (DN). However, its therapeutic efficacies and the underlying mechanisms remain obscure. In our study, we aim to evaluate the renoprotective effect of BHD on a streptozotocin (STZ)-induced diabetic nephropathy mouse model and explore the potential underlying mechanism in mouse mesangial cells (MCs) treated with high glucose in vitro, followed by screening the active compounds in BHD...
November 14, 2021: Chinese Medicine
https://read.qxmd.com/read/34754693/cost-effectiveness-of-home-hemodialysis-with-bedside-portable-dialysis-machine-dimi-in-the-united-arab-emirates
#31
JOURNAL ARTICLE
Chandra Mauli Jha
Background and objective The incidence and prevalence of patients requiring renal replacement therapies (RRTs) are increasing worldwide and a large number of these patients die prematurely due to the unavailability of treatment. While in-center hemodialysis remains the most commonly practiced modality globally, more and more patients find it unsuitable due to their frail condition, difficulty in ambulation, and time lost in traveling, etc. Such patients find the self-administered or nurse-assisted home hemodialysis (NAHHD) more suitable...
October 2021: Curēus
https://read.qxmd.com/read/34740544/glucose-control-diabetic-retinopathy-and-hemodialysis-induction-in-subjects-with-normo-microalbuminuric-type-2-diabetic-patients-with-normal-renal-function-followed-for-15-years
#32
JOURNAL ARTICLE
Tatsumi Moriya, Akinori Hayashi, Madoka Matsubara, Akihiko Suzuki, Motoshi Ouchi
AIMS: A high urinary albumin excretion (UAE) and low glomerular filtration rate (GFR) are risk factors for progressive renal function loss in type 2 diabetic patients. In addition, diabetic retinopathy (DR) is also a risk factor for progressive renal function decline in microalbuminuric type 2 diabetic patients. We aimed to elucidate the factors, including DR, associated with a more severe situation of diabetic nephropathy, i.e., hemodialysis (HD) induction in normo- and microalbuminuric type 2 diabetic patients without renal dysfunction...
January 2022: Journal of Diabetes and its Complications
https://read.qxmd.com/read/34718120/comparison-of-the-renal-effects-of-bisphenol-a-in-mice-with-and-without-experimental-diabetes-role-of-sexual-dimorphism
#33
JOURNAL ARTICLE
Rafael Moreno-Gómez-Toledano, María I Arenas, Carmen Muñoz-Moreno, Nuria Olea-Herrero, Paula Reventun, Adriana Izquierdo-Lahuerta, Alba Antón-Cornejo, Marta González-Santander, Carlos Zaragoza, Marta Saura, Ricardo J Bosch
Bisphenol-A (BPA), a chemical -xenoestrogen- used in the production of the plastic lining of food and beverage containers, is present in the urine of almost the entire population. Recent studies have shown that BPA exposure is associated with podocytopathy, increased urinary albumin excretion (UAE), and hypertension. Since these changes are characteristic of early diabetic nephropathy (DN), we explored the renal effects of BPA and diabetes including the potential role of sexual dimorphism. Male and female mice were included in the following animals' groups: control mice (C), mice treated with 21...
October 27, 2021: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/34690664/evaluating-the-understanding-about-kidney-stones-among-adults-in-the-united-arab-emirates
#34
JOURNAL ARTICLE
Hussain S Aldaher, Safa Z Kadhim, Nora M Al-Roub, Ahmed H Alsadi, Dana A Salam, Eva A Tillo
Objectives: The prevalence of kidney stones is increasing worldwide. Multiple risk factors are believed to contribute to the development of kidney stones such as lifestyle, diet, and global warming. In the United Arab Emirates (UAE), there has been limited research exploring the prevalence and risk factors of kidney stones. This study attempts to assess the understanding and prevalence of kidney stones among adults in the UAE. Methods: In this cross-sectional study, data were collected using a self-administered questionnaire, distributed among 515 participants (20-49 years old) from Abu Dhabi, Dubai, Ajman, and Sharjah states...
October 2021: Journal of Taibah University Medical Sciences
https://read.qxmd.com/read/34679109/characteristics-and-outcome-of-critically-ill-patients-with-coronavirus-disease-2019-covid-19-pneumonia-admitted-to-a-tertiary-care-center-in-the-united-arab-emirates-during-the-first-wave-of-the-sars-cov-2-pandemic-a-retrospective-analysis
#35
JOURNAL ARTICLE
Khaled Ismail, Hatim Bensasi, Ahmed Taha, Aamir Nazir, Mohamed Abdelkhalek, Walid Mohamed, Dipak Lodhe, Samuel Buschbeck, Michael Bauer, Yasser Sakr
BACKGROUND: The aim of this study was to describe the clinical characteristics and outcome of patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to an intensive care unit (ICU) of a tertiary care center in the United Arab Emirates (UAE) and to identify early risk factors for in-hospital mortality in these patients. METHODS: A total of 371 adult patients (>18 years) admitted to the ICU of Al Ain Hospital between March 16 and July 19, 2020 with SARS-CoV-2 infection confirmed using real-time reverse transcription polymerase chain reaction (rt-PCR) on nasopharyngeal swabs were included...
2021: PloS One
https://read.qxmd.com/read/34654394/a-study-on-the-timing-of-uterine-artery-embolization-followed-by-pregnancy-excision-for-cesarean-scar-pregnancy-a-prospective-study-in-china
#36
JOURNAL ARTICLE
Liping Yu, Bikang Yang, Qinyang Xu, Yincheng Teng, Zhuowei Xue
BACKGROUND: Cesarean scar pregnancy (CSP) remains a sporadic and special form of ectopic pregnancy in which the fertilized ovum is implanted on a previous cesarean scar within 12 weeks. This study aims to evaluate the optimal time interval between uterine artery embolization (UAE) and curettage modalities in order to provide the best clinical outcomes. METHODS: From January 2018 to December 2020, we recruited 61 patients with CSP. They were randomly divided into two groups depending on whether the time interval between UAE and dilatation and curettage (D&C) requires additional hospitalization: 31 patients received prophylactic UAE followed by D&C on the same day (0-12 h; group A) and 30 patients need hospitalization (12-72 h; group B)...
October 15, 2021: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/34602791/renal-dysfunction-in-prediabetes-confirmed-by-glomerular-hyperfiltration-and-albuminuria
#37
JOURNAL ARTICLE
Alagilawada S Shilpasree, Vidya S Patil, Manjunath Revanasiddappa, Vijayetha P Patil, Deepti Ireshnavar
Objectives Prediabetes is defined as an intermediate state of hyperglycemia with glucose levels above normal but below the diagnostic cutoff of diabetes mellitus. Prediabetes is considered as an important risk factor for the development of diabetes and complications associated with diabetes. Since glomerular hyperfiltration (elevated GFR) and albuminuria represent early and reversible stages of kidney damage seen in patients with type 2 diabetes, we aim to assess the impact of hyperglycemia in prediabetic range on renal functions measured by estimated GFR and urine albumin excretion (UAE)...
September 2021: Journal of Laboratory Physicians
https://read.qxmd.com/read/34386059/aldosterone-induces-the-proliferation-of-renal-tubular-epithelial-cells-in-vivo-but-not-in-vitro
#38
JOURNAL ARTICLE
Juan Hao, Lingjin Liu, Ziqian Liu, Gege Chen, Yunzhao Xiong, Xiangting Wang, Xuelian Ma, Qingyou Xu
OBJECTIVE: To investigate the proliferation effect of aldosterone on renal tubular epithelial cells in vivo and in vitro . METHODS: Thirty-two male C57BL/6J mice (20-22 g) were divided randomly into four groups: sham, unilateral nephrectomy (UN), unilateral nephrectomy plus aldosterone infusion (UA), and UA plus eplerenone (UAE). The kidneys were removed 6 weeks after treatment. Expression of proliferating cell nuclear antigen (PCNA) was detected by immunohistochemistry and western blotting...
2021: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://read.qxmd.com/read/34374989/spectrum-of-neuro-genetic-disorders-in-the-united-arab-emirates-national-population
#39
JOURNAL ARTICLE
Sirine Saleh, Ela Beyyumi, Aysha Al Kaabi, Jozef Hertecant, Doaa Barakat, Noura S Al Dhaheri, Lihadh Al-Gazali, Aisha Al Shamsi
Clinical and molecular characterization of neuro-genetic disorders among UAE national patients seen in the Genetic Clinic at Tawam hospital over a period of 3 years. A retrospective chart review of all Emirati patients assessed by clinical geneticists due to neuro-genetic disorders including global developmental delay, ASD, ID, ADHD, and epilepsy in combination with abnormalities of other organ systems. Each patient had proper assessment including detailed history, three-generation family history, developmental history and detailed physical examination looking for other system involvement...
November 2021: Clinical Genetics
https://read.qxmd.com/read/34304366/circulating-levels-of-asprosin-and-its-association-with-insulin-resistance-and-renal-function-in-patients-with-type-2-diabetes-mellitus-and-diabetic-nephropathy
#40
JOURNAL ARTICLE
Golnoosh Goodarzi, Leila Setayesh, Reza Fadaei, Mohammad Ebrahim Khamseh, Fereshteh Aliakbari, Jalil Hosseini, Nariman Moradi
INTRODUCTION: Adipokines play an important role in the development of type 2 diabetes mellitus (T2DM) and its complications like nephropathy. Asprosin is a newly discovered adipokine involved in glucose metabolism and inflammation process. The present study aimed to evaluate asprosin levels in patients with T2DM and T2DM + nephropathy (NP) compared to control subjects as well as investigating its relationship with insulin resistance, inflammation, and renal function markers. METHODS: Serum levels of asprosin, adiponectin, IL-6, and TNF-α were measured in 55 control subjects, 54 T2DM, and 55 T2DM + NP patients using ELISA kits...
July 2021: Molecular Biology Reports
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