Arno R Bourgonje, Amaal E Abdulle, Martin F Bourgonje, S Heleen Binnenmars, Sanne J Gordijn, Marian L C Bulthuis, Sacha la Bastide-van Gemert, Lyanne M Kieneker, Ron T Gansevoort, Stephan J L Bakker, Douwe J Mulder, Andreas Pasch, Martin H de Borst, Harry van Goor
BACKGROUND: Serum sulfhydryl groups (R-SH, free thiols) reliably reflect the systemic redox status in health and disease. As oxidation of R-SH occurs rapidly by reactive oxygen species (ROS), oxidative stress is accompanied by reduced levels of free thiols. Oxidative stress has been implicated in the pathophysiology of chronic kidney disease (CKD), in which redox imbalance may precede the onset of CKD. Therefore, we aimed to investigate associations between serum free thiols and the risk of incident CKD as defined by renal function decline and albuminuria in a population-based cohort study...
December 9, 2021: Redox Biology