keyword
https://read.qxmd.com/read/38498272/association-of-urinary-calcium-excretion-with-chronic-kidney-disease-in-patients-with-type-2-diabetes
#1
JOURNAL ARTICLE
Yanru Wang, Yuxing Chen, Yanping Yu, Xin Pan, Guoxiang Fu
PURPOSE: Herein, we investigated the correlation between urinary calcium excretion (UCaE) and chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). METHODS: From August 2018 to January 2023, a total of 2031 T2DM patients providing 24-h urine samples were included in the final analyses. Patients were separated into four cohorts, based on the UCaE quartiles. We then analyzed renal functional indicators like estimated glomerular filtration rate (eGFR) and urinary albumin excretion (UAE) among the four groups...
March 18, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38462692/azilsartan-improves-urinary-albumin-excretion-in-hypertension-mice
#2
JOURNAL ARTICLE
Jun Cao, Dandan Zhang, Wenfeng Li, Wenjin Yuan, Gang Luo, Shaofeng Xie
Hypertension is one of the most important risk factors for chronic kidney diseases, leading to hypertensive nephrosclerosis, including excessive albuminuria. Azilsartan, an angiotensin II type 1 receptor blocker, has been widely used for the treatment of hypertension. However, the effects of Azilsartan on urinary albumin excretion in hypertension haven't been reported before. In this study, we investigated whether Azilsartan possesses a beneficial property against albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS)...
March 10, 2024: Aging
https://read.qxmd.com/read/38402463/urine-cotinine-versus-self-reported-smoking-and-the-risk-of-chronic-kidney-disease
#3
JOURNAL ARTICLE
Setor K Kunutsor, Richard S Dey, Daan J Touw, Stephan J L Bakker, Robin P F Dullaart
BACKGROUND AND HYPOTHESIS: Evidence on the role of smoking in the development of chronic kidney disease (CKD) has mostly relied on self-reported smoking status. We aimed to compare the associations of smoking status as assessed by self-reports and urine cotinine with CKD risk. METHODS: Using the PREVEND prospective study, smoking status was assessed at baseline using self-reports and urine cotinine in 4333 participants (mean age, 52 years) without a history of CKD at baseline...
February 24, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38269408/mitochondria-derived-reactive-oxygen-species-contribute-to-synergistic-interaction-of-diabetes-and-hypertension-in-causing-chronic-kidney-injury
#4
JOURNAL ARTICLE
Zhen Wang, Yiling Fu, Alexandre A da Silva, Jussara M do Carmo, Alan Mouton, Ana Carolina M Omoto, Xuan Li, Jaylan Sears, John E Hall
Diabetes (DM) and hypertension (HTN) are major risk factors for chronic kidney injury, together accounting for >70% of end-stage renal disease. The combination of DM and HTN significantly accelerates development of renal injury; however, the underlying mechanisms of this synergy are still poorly understood. This study assessed whether mitochondria (MT) dysfunction is essential in developing renal injury in a rat model with combined DM and HTN. Type 1 DM was induced in Wistar rats by streptozotocin (STZ)...
January 25, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38086133/postpartum-hemorrhage-with-associated-placenta-previa-in-a-kidney-transplant-recipient-a-case-report
#5
Toshinao Suzuki, Takahiro Sugiura, Junko Okazaki, Hiroaki Kimura
INTRODUCTION: The efficacy and safety of uterine artery embolization (UAE) and prophylactic resuscitative endovascular balloon occlusion of the aorta (REBOA) against postpartum hemorrhage (PPH) in pregnant women after kidney transplantation have not been reported. Here, we describe a case of PPH associated with placenta previa in pregnancy following kidney transplantation, which was managed with UAE and prophylactic REBOA. CASE PRESENTATION: A 35-year-old, gravida 2, para 1 woman with total placenta previa presented with vaginal bleeding (460 mL) at 33 weeks and 3 days of gestation...
December 8, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38073119/sodium-butyrate-improves-mitochondrial-function-and-kidney-tissue-injury-in-diabetic-kidney-disease-via-the-ampk-pgc-1%C3%AE-pathway
#6
JOURNAL ARTICLE
Yue Yu, Yuan-Yuan Jia, Hong-Jun Li
PURPOSE: Investigate the mechanism of how sodium butyrate (NaBut) improves mitochondrial function and kidney tissue injury in diabetic kidney disease (DKD) via the AMPK/PGC-1α pathway. METHODS: Assess the effects of NaBut on glucose and insulin tolerance, urine, and gut microbial composition in db/db and db/m mice. Use flow cytometry and western blotting to detect the effects of NaBut on apoptosis, kidney mitochondrial function, and AMPK/PGC-1α signaling...
2023: Renal Failure
https://read.qxmd.com/read/37872916/association-between-monocyte-to-high-density-lipoprotein-hdl-cholesterol-ratio-and-proteinuria-in-patients-with-type-2-diabetes-mellitus-a-prospective-observational-study
#7
JOURNAL ARTICLE
Yashilha D, Shini Rubina Sk, Nanda Kumar R, Anuba Pa
Background Diabetes mellitus (DM) refers to a group of metabolic disorders that share the phenotype of hyperglycemia. "Diabetic nephropathy (DN)" is a microvascular complication of DM, and it is the leading cause of end-stage renal failure. Increased urinary albumin excretion (UAE) and a decrease in glomerular filtration rate (GFR) are associated with DN along with elevated blood pressure and end-stage renal disease (ESRD). The purpose of this study is to analyze the prognostic significance of the monocyte-to-high-density lipoprotein (HDL) cholesterol ratio (MHR) in DN patients...
September 2023: Curēus
https://read.qxmd.com/read/37853936/evaluation-of-changes-in-glycemic-control-and-diabetic-complications-over-time-and-factors-associated-with-the-progression-of-diabetic-complications-in-japanese-patients-with-juvenile-onset-type-1-diabetes-mellitus
#8
JOURNAL ARTICLE
Takafumi Masuda, Naoto Katakami, Hirotaka Watanabe, Naohiro Taya, Kazuyuki Miyashita, Mitsuyoshi Takahara, Ken Kato, Akio Kuroda, Munehide Matsuhisa, Iichiro Shimomura
BACKGROUND: This study aimed to evaluate the changes in glycemic control and diabetic complications over time in Japanese patients with juvenile-onset type 1 diabetes mellitus and to clarify the factors associated with the progression of diabetic complications. METHODS: We tracked 129 patients with type 1 diabetes mellitus (21.8 ± 4.1 years old [mean ± SD] with a diabetes duration of 12.6 ± 5.7 years) for up to 19 years and analyzed data on glycated hemoglobin (HbA1c) and indicators related to the severity of diabetic complications (estimated glomerular filtration rate [eGFR], urinary albumin excretion rate [UAE], carotid intima-media thickness [CIMT], and brachial-ankle pulse wave velocity [baPWV]) using linear mixed model and decision tree analysis...
October 18, 2023: Journal of Diabetes
https://read.qxmd.com/read/37369507/dietary-intake-of-polyunsaturated-fatty-acids-and-diabetic-nephropathy-cohort-analysis-of-the-tsugaru-study
#9
JOURNAL ARTICLE
Norio Nakamura, Daiki Nagawa, Masamichi Nakata, Ikuyo Narita-Kinjo, Takeshi Fujita, Reiichi Murakami, Michiko Shimada, Akiko Okita, Kanako Sekino, Atsuro Tazawa, Hirofumi Tomita
BACKGROUND/AIM: Diabetic nephropathy (DN) is the leading cause of end-stage renal failure and its incidence continues to increase. To decrease this, a countermeasure from an early stage is required. This is a DN stage 2 observation study that analyzed the results of a concurrent dietary survey in the Tsugaru study and discussed the relationship between dietary intake of n-3 fatty acid and DN. PATIENTS AND METHODS: Patients with stage 2 DN and aged 20 years or older in the Tsugaru region of Aomori Prefecture were enrolled...
2023: In Vivo
https://read.qxmd.com/read/37312105/elevated-angiopoietin-like-protein-3-serum-levels-in-diabetic-nephropathy-patients-and-its-association-with-renal-function-and-lipid-profile
#10
JOURNAL ARTICLE
Samaneh Mohassel Azadi, Reza Fadaei, Ramtin Omid-Shafaat, Jalil Hosseini, Nariman Moradi
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease that has life-threatening consequences like micro and macrovascular complication. Diabetic nephropathy (DN) is one of the common consequences of T2DM which is related to secretory factors like hepatokines. Angiopoietin-Like Protein 3 (ANGPTL3) is a hepatokine that is perturbated in cardiometabolic diseases and experimental studies showed its effect on renal functions and lipid metabolism. For the first time, ANGPTL3 was measured in patients with T2DM and DN in the present study...
June 13, 2023: BMC Nephrology
https://read.qxmd.com/read/37282824/trajectories-of-renal-biomarkers-and-new-onset-heart-failure-in-the-general-population-findings-from-the-prevend-study
#11
JOURNAL ARTICLE
Ryoto Sakaniwa, Jasper Tromp, Koen W Streng, Navin Suthahar, Lyanne M Kieneker, Douwe Postmus, Hiroyasu Iso, Ron T Gansevoort, Stephan J L Bakker, Hans L Hillege, Rudolf A de Boer, Biniyam G Demissei
AIMS: Renal dysfunction is one of the most critical risk factors for developing heart failure (HF). However, the association between repeated measures of renal function and incident HF remains unclear. Therefore, this study investigated the longitudinal trajectories of urinary albumin excretion (UAE) and serum creatinine and their association with new-onset HF and all-cause mortality. METHODS AND RESULTS: Using group-based trajectory analysis, we estimated trajectories of UAE and serum creatinine in 6881 participants from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study and their association with new-onset HF and all-cause death during the 11-years of follow-up...
June 7, 2023: European Journal of Heart Failure
https://read.qxmd.com/read/37248423/interference-of-periostin-attenuates-pathological-changes-proinflammatory-markers-and-renal-fibrosis-in-diabetic-kidney-injury
#12
JOURNAL ARTICLE
Xiaoting Duan, Cheng Chen, Xiaoli Liu, Taoxia Wang, Shuning Feng, Jianwei Li, Guiying Li
BACKGROUND: Diabetic nephropathy (DN) is a prevalent complication of diabetes, in which inflammation and fibrosis are the significant pathogenesis. Periostin is a matricellular protein that functions on stabilizing the extracellular matrix by binding to integrins during development. This study aimed to explored the role of periostin in DN. METHODS: The animal and cell models of DN were constructed in streptozocin (STZ)-induced mice and high glucose-challenged human mesangial cells (HMCs)...
May 29, 2023: Genes & Genomics
https://read.qxmd.com/read/37226556/urinary-albumin-excretion-and-cancer-risk-the-prevend-cohort-study
#13
JOURNAL ARTICLE
Li Luo, Lyanne M Kieneker, Bert van der Vegt, Stephan J L Bakker, Eke G Gruppen, Niek F Casteleijn, Rudolf A de Boer, Navin Suthahar, Geertruida H de Bock, Joseph Pierre Aboumsallem, Priya Vart, Ron T Gansevoort
BACKGROUND: Chronic kidney disease (CKD) is believed to be associated with an increased risk for cancer, especially urinary tract cancer. However, previous studies predominantly focused on the association of decreased estimated glomerular filtration rate (eGFR) with cancer. In this study, we investigated the association of albuminuria with cancer incidence, adjusted for eGFR. METHODS: We included 8490 subjects in the Prevention of Renal and Vascular End-stage Disease (PREVEND) observational study...
November 30, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/37187668/factors-associated-with-urolithiasis-a-hospital-based-case-control-study
#14
JOURNAL ARTICLE
Syed Owais, Mohamed Saif, Ahmad Omaid, Sofia Alfalasi, Anusha Sreejith, Muthana S Altaie
BACKGROUND: Urolithiasis is a common preventable ailment. Previous studies showed that there are a lot of factors, such as dietary, health and environmental factors, which are likely to develop this condition. Only a few research have been conducted on urolithiasis in the UAE. Therefore, our study aimed to identify the factors associated with urolithiasis in the country, identify the symptoms of urolithiasis among the cases and identify the most common diagnostic methods. METHODOLOGY: It was a case-control study design...
April 2023: Curēus
https://read.qxmd.com/read/36830706/plasma-neutrophil-gelatinase-associated-lipocalin-associates-with-new-onset-chronic-kidney-disease-in-the-general-population
#15
JOURNAL ARTICLE
Arno R Bourgonje, Amaal E Abdulle, Martin F Bourgonje, Lyanne M Kieneker, Sacha la Bastide-van Gemert, Sanne J Gordijn, Clara Hidden, Tom Nilsen, Ron T Gansevoort, Douwe J Mulder, Robin P F Dullaart, Martin H de Borst, Stephan J L Bakker, Harry van Goor
Circulating levels of neutrophil gelatinase-associated lipocalin (NGAL) have been associated with acute kidney injury and the severity and progression of chronic kidney disease (CKD). This study investigated its potential utility as a biomarker for the risk of new-onset CKD in a population-based cohort study. Individuals without CKD at baseline (n = 4660) who participated in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) prospective population-based cohort study in the Netherlands were included...
February 9, 2023: Biomolecules
https://read.qxmd.com/read/36779110/remdesivir-use-in-low-weight-premature-and-renally-impaired-infants-with-sars-cov-2-infection-in-sheikh-khalifa-medical-city-uae-case-series
#16
Wadha Mohammed, Nada Al Saqqa, Ayanbanke Ayanleke
Remdesivir possesses in vitro inhibitory effect against severe acute respiratory syndrome coronavirus 2 and the Middle East respiratory syndrome. It works by inhibiting severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase that is essential for viral replication. Remdesivir is approved by Food and Drug Administration for treating COVID-19 in hospitalized adult and pediatric patients aged 28 days and more and weighing 3 kg and more. This case series is describing two cases of low-weight, premature, and renally impaired infants where Remdesivir is used in Sheikh Khalifa Medical City pediatric intensive care unit...
January 2023: Curēus
https://read.qxmd.com/read/36613483/imbalance-in-bone-morphogenic-proteins-2-and-7-is-associated-with-renal-and-cardiovascular-damage-in-chronic-kidney-disease
#17
JOURNAL ARTICLE
Francisco Javier Manzano-Lista, Marta Sanz-Gómez, Daniel González-Moreno, Elena Vega-Martín, Marta Gil-Ortega, Angela Schulz, Miguel Ángel Rubio, Gema Ruiz-Hurtado, Luis Miguel Ruilope, Isabel Aránguez, Reinhold Kreutz, María S Fernández-Alfonso
Arterial stiffness is a major vascular complication of chronic kidney disease (CKD). The development of renal damage, hypertension, and increased pulse wave velocity (PWV) in CKD might be associated with an imbalance in bone morphogenetic proteins (BMP)-2 and BMP-7. Plasma BMP-2 and BMP-7 were determined by ELISA in CKD patients (stages I-III; n = 95) and Munich Wistar Frömter (MWF) rats. Age-matched Wistar rats were used as a control. The expression of BMP-2 , BMP-7 , and profibrotic and calcification factors was determined in kidney and perivascular adipose tissues (PVAT)...
December 20, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36359234/plasmacytoma-variant-translocation-1-pvt1-gene-as-a-potential-novel-target-for-the-treatment-of-diabetic-nephropathy
#18
JOURNAL ARTICLE
Helen Mok, Ahmed Al-Jumaily, Jun Lu
Introduction : Diabetic nephropathy (DN), a severe microvascular complication in patients with diabetes, is clinically characterized by progressive decline in glomerular filtration rate (GFR). DN is the most common cause of end-stage renal disease (ESRD), and has a consistently high mortality rate. Despite the fact that the prevalence of DN is increasing worldwide, the molecular mechanism underlying the pathogenesis of DN is not fully understood. Previous studies indicated PVT1 as a key determinant of ESRD as well as a mediator of extracellular matrix (ECM) accumulation in vitro...
October 26, 2022: Biomedicines
https://read.qxmd.com/read/36129558/kidney-function-and-renal-resistive-index-in-children-with-juvenile-idiopathic-arthritis
#19
REVIEW
Alessandro Cafarotti, Maria Loredana Marcovecchio, Giuseppe Lapergola, Caterina Di Battista, Manuela Marsili, Raffaella Basilico, Giulia Di Donato, Daniela David, Piernicola Pelliccia, Francesco Chiarelli, Luciana Breda
Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment. Blood urea nitrogen (BUN), creatinine, cystatin C (CysC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR), and renal resistive index (RRI) were assessed in 49 JIA children (9 boys/40 girls, mean age 10...
September 21, 2022: Clinical and Experimental Medicine
https://read.qxmd.com/read/36027280/decreased-urinary-levels-of-sirt1-as-non-invasive-biomarker-of-early-renal-damage-in-hypertension
#20
JOURNAL ARTICLE
Olga Martinez-Arroyo, Ana Ortega, Elena Solaz, Fernando Martinez, Sergio Martinez-Hervas, Josep Redon, Raquel Cortes
OBJECTIVE: Hypertension and diabetes mellitus (DM) produce renal injury. Sirtuins have become important players in renal damage, but their value as biomarkers is poorly assessed. The aims of the study were to evaluate the sirtuin1 levels (SIRT1), and miRNAs miR-34a and miR-200, that regulate SIRT1 expression in urinary cell pellet from hypertensive patients with incipient renal damage with and without diabetes. In addition, to mimic disease conditions and deepen into the implications of SIRT1 in podocyte injury, employed cultured podocytes subjected to high glucose (HG) and angiotensin II (Ang II) concentrations...
June 1, 2022: Journal of Hypertension
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