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https://read.qxmd.com/read/30720852/macrophage-migration-inhibitory-factor-antagonist-p425-ameliorates-kidney-histopathological-and-functional-changes-in-diabetic-rats
#1
Jamal Khalilpour, Shiva Roshan-Milani, Farzaneh Hosseini Gharalari, Amin Abdollahzade Fard
INTRODUCTION: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. METHODS: Eighteen male Wistar rats (230 ± 20 g) were divided into three groups: 1) control, 2) diabetic (STZ, 50 mg/kg, dissolved in saline, ip), 3) diabetic + MIF antagonist (p425, 1 mg/kg per day, ip, on the 21th day, for 21 consecutive days)...
January 24, 2019: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://read.qxmd.com/read/30704890/vitamin-b-complex-supplementation-as-a-homocysteine-lowering-therapy-for-early-stage-diabetic-nephropathy-in-pediatric-patients-with-type-1-diabetes-a-randomized-controlled-trial
#2
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Mamdouh Ahmed Zaki, Yasser Wagih Darwish, Marwa Zaki Ibrahim, Manal El-Hamamsy
BACKGROUND: Homocysteine levels are elevated in patients with type 1 diabetes mellitus (T1DM) and could induce renal injury. B vitamins have an important role in preventing microvascular complications of diabetes. AIM: We performed a randomized-controlled trial of oral supplementation with vitamin B complex as an adjuvant therapy for nephropathy in pediatric T1DM patients and assessed its relation to homocysteine and cystatin C as a marker of nephropathy. METHODS: This trial included 80 T1DM patients with microalbuminuria, despite oral angiotensin-converting enzyme inhibitors, aged 12-18 years with at least 5 years disease duration and HbA1c ≤8...
January 17, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/30701803/normoalbuminuric-chronic-kidney-disease-in-diabetes
#3
REVIEW
V V Klimontov, A I Korbut
Urinary albumin excretion (UAE) is widely used in clinical practice as indicator of diabetic kidney disease. According to the classical concept of the natural course of diabetic nephropathy, an increase in UAE usually precedes a decline in renal function. Meanwhile, a growing body of evidences indicates a high prevalence of normoalbuminuric chronic kidney disease (NA-CKD) in diabetic subjects, especially among patients with type 2 diabetes. An increase in NA-CKD prevalence can be results of improved glucose, blood pressure, and lipid control, widespread use of renin-angiotensin system blockers, and smoking cessation...
November 22, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30607775/association-of-neutrophil-to-lymphocyte-ratio-with-early-renal-dysfunction-and-albuminuria-among-diabetic-patients
#4
Ryuichi Kawamoto, Daisuke Ninomiya, Asuka Kikuchi, Taichi Akase, Yoshihisa Kasai, Tomo Kusunoki, Nobuyuki Ohtsuka, Teru Kumagi
PURPOSE: Neutrophil-to-lymphocyte ratio (NLR) was widely studied as a prognostic marker in various medical and surgical specialties, but its significance in diabetic kidney disease is not yet established. METHODS: The subjects comprised 199 men aged 73 ± 11 (mean ± standard deviation) years and 187 women aged 77 ± 10 years from a rural hospital. We examined the relationship between NLR calculated by analyzing differential leukocyte count in complete blood picture and renal function evaluated by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study Group equation and urinary albumin excretion (UAE)...
January 3, 2019: International Urology and Nephrology
https://read.qxmd.com/read/30477059/prevalence-and-clinical-correlates-of-microalbuminuria-in-patients-with-essential-hypertension-a-tertiary-care-center-cross-sectional-study
#5
H K Aggarwal, Deepak Jain, Sudhir Mor, R K Yadav, Promil Jain
Introduction: Albuminuria is predictor of target organ damage and worse cardiovascular outcomes. Microalbuminuria has been found in a large number of patients with essential hypertension. Aim of our study was to evaluate the frequency of microalbuminuria in essential hypertension and to study its correlation with severity of hypertension and target organ damage. Materials and Methods: This cross-sectional study was conducted at the outpatient clinic of General Medicine department of Pt...
May 2018: Journal of the Association of Physicians of India
https://read.qxmd.com/read/30444201/the-ascent-of-mineralocorticoid-receptor-antagonists-in-diabetic-nephropathy
#6
Luxitaa Goenka, R Padmanaban, Melvin George
Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone escape phenomenon...
November 15, 2018: Current Clinical Pharmacology
https://read.qxmd.com/read/30176347/protective-effect-of-the-ethanol-extract-from-ligusticum-chuanxiong-rhizome-against-streptozotocin-induced-diabetic-nephropathy-in-mice
#7
Wen-Jing Yang, Yan-Ru Li, Hui Gao, Xue-Yi Wu, Xiao-Ling Wang, Xiao-Ning Wang, Lan Xiang, Dong-Mei Ren, Hong-Xiang Lou, Tao Shen
ETHNOPHARMACOLOGY RELEVANCE: Rhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which are used to treat diabetic nephropathy (DN). The aims of the present study are to investigate the protective effect of the ethanol extract of LC rhizome (EEL) against DN in vivo, evaluate its potential mechanism, and find the evidence supporting its enthopharmacological use as an anti-DN agent. MATERIALS AND METHODS: Hepa 1c1c7 murine hepatoma cells, human breast carcinoma MDA-MB-231 cells, human renal glomerular endothelial cells (HRGEC), and RAW 264...
December 5, 2018: Journal of Ethnopharmacology
https://read.qxmd.com/read/30140038/association-between-hearing-organ-and-renal-function-in-young-adult-type-1-diabetic-patients-a-cross-sectional-study
#8
Mariusz Dąbrowski, Grażyna Mielnik-Niedzielska, Andrzej Nowakowski
Type 1 diabetes can lead to impaired function of many organs and tissues. The aim of this study was to evaluate associations between hearing and kidney function in young adult type 1 diabetic patients. 31 patients (9 women) with type 1 diabetes, aged <45, with disease duration <10 years were included. Blood and urine samples for laboratory tests and urinary albumin excretion (UAE) assessment were obtained. eGFR was calculated with CKD-EPI formula. In all patients pure-tone audiometry, transient evoked otoacoustic emissions and auditory brainstem responses were evaluated, also eye fundus was examined...
August 23, 2018: Scientific Reports
https://read.qxmd.com/read/30050584/qiditangshen-granules-reduced-diabetic-kidney-injury-by-regulating-the-phosphorylation-balance-of-the-tyrosine-and-serine-residues-of-insulin-receptor-substrate-1
#9
Xue Gao, Hongfang Liu, Zhichao An, Qiying He
Background: Diabetic nephropathy (DN) is a microvascular complication induced by diabetes mellitus (DM), which can affect life quality and long-term prognosis of patients with DM. Angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) are currently recommended for treating DN proteinuria, but patients receiving ACEI/ARB are at risk of elevated serum creatinine or potassium levels. Based on the "yin-yang" theory of traditional Chinese medicine, the present study explored the effect of QiDiTangShen (QDTS) granules on DN and the phosphorylation balance of tyrosine and serine residues of IRS-1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30027695/plasma-neutrophil-gelatinase-associated-lipocalin-as-a-marker-of-tubular-damage-in-diabetic-nephropathy
#10
So Young Kim, Tae Dong Jeong, Woochang Lee, Sail Chun, Sung Sunwoo, Soon Bae Kim, Won Ki Min
BACKGROUND: An increase in neutrophil gelatinase-associated lipocalin (NGAL) indicates tubular injury. Diabetic nephropathy causes typical changes in the kidney, characterized by glomerulosclerosis and eventual tubular damage. We validated the usefulness of plasma NGAL (pNGAL) as a biomarker of tubular damage in patients with diabetic nephropathy. METHODS: We included 376 patients with diabetes mellitus (260 patients with chronic renal insufficiency who had not received hemodialysis and 116 hemodialyzed due to diabetic nephropathy) and 24 healthy controls...
November 2018: Annals of Laboratory Medicine
https://read.qxmd.com/read/30009367/the-effect-of-nitro-oleic-versus-losartan-in-diabetic-nephropathy-modulation-of-parathyroid-hormone-related-protein
#11
Asmaa Mohammed, Nermeen Sadek, Mohamed Eshra, Effat Khowailed, Laila Rashed, Basma Aboulhoda
BACKGROUND: Parathyroid hormone related protein (PTHrP) involvement in the mechanisms related to angiotensin II (Ang II)- induced renal injury has become an emerging concern. The current study was thus designed to compare the possible preventive and therapeutic effect of Ang II antagonists; losartan and nitro-oleic (NO2-OA) acid on diabetic nephropathy (DN), and evaluate their effect on PTHrP modulation as well as on the functional and histopathological parameters in the kidney of diabetic rats...
July 16, 2018: Folia Morphologica (Warsz)
https://read.qxmd.com/read/29979643/provision-of-renal-care-for-patients-with-end-stage-kidney-disease-in-persistent-vegetative-state-in-united-arab-emirates-a-national-survey-of-renal-physicians
#12
Fayez Ebrahim Alshamsi, Ahmed Chaaban, Mona Alrukhaimi, Bassam Bernieh, Omran Bakoush
Patients with end stage kidney disease (ESKD) with severely impaired cognitive function have no survival benefit from dialysis. We therefore undertook a survey to explore the renal physicians' practices of withholding and withdrawal of dialysis treatment in vegetative state patients in the United Arab Emirates (UAE). A cross sectional survey of 29 nephrology practices in UAE exploring physicians' practices in making decisions of withholding and withdrawal of dialysis treatment during provision end-of-life care for patients in persistent vegetative state (PVS)...
December 2018: Libyan Journal of Medicine
https://read.qxmd.com/read/29937906/retinol-binding-protein-4-versus-albuminuria-as-predictors-of-estimated-glomerular-filtration-rate-decline-in-patients-with-type-2-diabetes
#13
Aleksandra Klisic, Nebojsa Kavaric, Ana Ninic
Background: Since the increase in some tubular damage biomarkers can be observed at the early stage of diabetic nephropathy, even in the absence of albuminuria, we aimed to investigate if urinary albumin is superior than tubular damage marker, such as serum retinol-binding protein 4 (RBP4), in predicting renal function decline (defined as estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2 ) in the cohort of patients with type 2 diabetes mellitus (T2D). Materials and Methods: A total of 106 sedentary T2D patients (mean [± standard deviation] age 64...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://read.qxmd.com/read/29685824/monitoring-of-patients-with-type-2-diabetes-and-nephropathy-in-a-specialized-diabetic-nephropathy-clinic-seems-to-be-beneficial
#14
N Vallianou, T Stratigou, A Paikopoulou, T Apostolou, B Vlassopoulou, S Tsagarakis, G Ioannidis
BACKGROUND: The purpose of this study was to evaluate the outcome of DM2 patients with nephropathy when they are under surveillance of a joined clinic run by endocrinologists & nephrologists. PATIENTS AND METHODS: A cohort of 106 patients with DM2, 42-83 years of age, and eGFR < 60 ml/min/m2 were included. Age, sex, duration of diabetes, duration of attending our clinic, smoking habits, BMI, data regarding ischemic heart disease and induction of hemodialysis, urine albumin excretion (UAE) levels, eGFR (MDRD equation) and values of various biochemical parameters were recorded too...
September 2018: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/29466891/proenkephalin-and-risk-of-developing-chronic-kidney-disease-the-prevention-of-renal-and-vascular-end-stage-disease-study
#15
Lyanne M Kieneker, Oliver Hartmann, Andreas Bergmann, Rudolf A de Boer, Ron T Gansevoort, Michel M Joosten, Joachim Struck, Stephan J L Bakker
BACKGROUND: Proenkephalin (pro-ENK) was recently found to be associated with low estimated glomerular filtration rate (eGFR). The association of pro-ENK with urinary albumin excretion (UAE), another marker for chronic kidney disease (CKD), has not been investigated. We examined the association of pro-ENK with eGFR and UAE as markers of CKD. METHODS: We included 4375 subjects of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. CKDeGFR was defined as development of eGFR <60 ml/min/1...
July 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/29422652/rage-aptamer-attenuates-deoxycorticosterone-acetate-salt-induced-renal-injury-in-mice
#16
Kensei Taguchi, Sho-Ichi Yamagishi, Miyuki Yokoro, Sakuya Ito, Goh Kodama, Yusuke Kaida, Yosuke Nakayama, Ryotaro Ando, Nana Yamada-Obara, Katsuhiko Asanuma, Takanori Matsui, Yuichiro Higashimoto, Craig R Brooks, Seiji Ueda, Seiya Okuda, Kei Fukami
The mineralocorticoid receptor (MR) and its downstream signaling play an important role in hypertensive renal injury. The interaction of advanced glycation end products (AGE) with their receptor (RAGE) is involved in the progression of renal disease. However, the pathological crosstalk between AGE-RAGE axis and MR system in kidney derangement remains unclear. We screened DNA-aptamer directed against RAGE (RAGE-apt) in vitro and examined its effects on renal injury in uninephrectomized deoxycorticosterone acetate (DOCA)/salt-induced hypertensive mice...
February 8, 2018: Scientific Reports
https://read.qxmd.com/read/29378039/dietary-potential-renal-acid-load-is-positively-associated-with-serum-uric-acid-and-odds-of-hyperuricemia-in-the-german-adult-population
#17
Jonas Esche, Danika Krupp, Gert B M Mensink, Thomas Remer
Background: Initial interventional data indicate that a reduction in dietary acid load (e.g., by an increased consumption of alkalizing fruit and vegetables) can increase renal uric acid excretion and decrease serum uric acid (SUA). Objective: Against this background, we examined the association between dietary potential renal acid load (PRAL) and SUA in a representative population sample. Methods: Cross-sectional analyses were performed in 6894 participants (aged 18-79 y) of the German Health Interview and Examination Survey for Adults (DEGS1)...
January 1, 2018: Journal of Nutrition
https://read.qxmd.com/read/29227974/mir302a-3p-may-modulate-renal-epithelial-mesenchymal-transition-in-diabetic-kidney-disease-by-targeting-zeb1
#18
Wen-Bin Tang, Linfeng Zheng, Renheng Yan, Jiayi Yang, Jianping Ning, Linlin Peng, Qiaoling Zhou, Liping Chen
BACKGROUND: Recent study found that microRNA (miRNA) are involved in diabetic kidney disease (DKD). The objective of this study is to determine the role of miR302a-3p in the process of renal epithelial-mesenchymal transition (EMT) in DKD. METHODS: The miRNA expression profiling of the cell line stimulated by high glucose was performed by a microarray analysis. Then real-time polymerase chain reaction (PCR) were used to determine the expression of one of the miRNAs significantly upregulated in cell line stimulated by high glucose, miR302a-3p...
2018: Nephron
https://read.qxmd.com/read/29222708/correction-to-effect-of-renal-transplantation-on-cognitive-function-in-hemodialysis-patients-a-longitudinal-study
#19
Yogesh K Chhabra, Sanjay Sood, Omprakash Rathi, Sandeep Mahajan
In the original publication, the second author's affiliation was incorrectly published as "Department of Physiology, RAK College of Medical Sciences, Ras Al Khaimah, UAE". The correct affiliation should read as "Visiting Academic, Basic Medical Sciences Department, College of Medicine, University of Sharjah (UAE)".
January 2018: International Urology and Nephrology
https://read.qxmd.com/read/29130072/prediction-of-chronic-kidney-disease-stage-3-by-ckd273-a-urinary-proteomic-biomarker
#20
Claudia Pontillo, Zhen-Yu Zhang, Joost P Schanstra, Lotte Jacobs, Petra Zürbig, Lutgarde Thijs, Adela Ramírez-Torres, Hiddo J L Heerspink, Morten Lindhardt, Ronald Klein, Trevor Orchard, Massimo Porta, Rudolf W Bilous, Nishi Charturvedi, Peter Rossing, Antonia Vlahou, Eva Schepers, Griet Glorieux, William Mullen, Christian Delles, Peter Verhamme, Raymond Vanholder, Jan A Staessen, Harald Mischak, Joachim Jankowski
Introduction: CKD273 is a urinary biomarker, which in advanced chronic kidney disease predicts further deterioration. We investigated whether CKD273 can also predict a decline of estimated glomerular filtration rate (eGFR) to <60 ml/min per 1.73 m2 . Methods: In analyses of 2087 individuals from 6 cohorts (46.4% women; 73.5% with diabetes; mean age, 46.1 years; eGFR ≥ 60 ml/min per 1.73 m2 , 100%; urinary albumin excretion rate [UAE] ≥20 μg/min, 6.2%), we accounted for cohort, sex, age, mean arterial pressure, diabetes, and eGFR at baseline and expressed associations per 1-SD increment in urinary biomarkers...
November 2017: KI Reports
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