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https://read.qxmd.com/read/30785921/ibrutinib-increases-the-risk-of-hypertension-and-atrial-fibrillation-systematic-review-and-meta-analysis
#1
Daniel Caldeira, Daniela Alves, João Costa, Joaquim J Ferreira, Fausto J Pinto
INTRODUCTION: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction. METHODS: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials...
2019: PloS One
https://read.qxmd.com/read/30783189/signal-transducer-and-activator-of-transcription-stat-5-an-opportunity-for-drug-development-in-oncohematology
#2
Carlota Recio, Borja Guerra, Miguel Guerra-Rodríguez, Haidée Aranda-Tavío, Patricia Martín-Rodríguez, Mercedes de Mirecki-Garrido, Yeray Brito-Casillas, José M García-Castellano, Ana Estévez-Braun, Leandro Fernández-Pérez
The signal transducer and activator of transcription (STAT) are transcription factors that work via JAK/STAT pathway regulating the expression of genes involved in cell survival, proliferation, differentiation, development, immune response, and, among other essential biological functions, hematopoiesis. JAK/STAT signaling is strictly regulated under normal physiological conditions. However, a large group of diverse diseases has been associated to an aberrant regulation of STAT factors. Erroneous modulation of the pathway leads to constitutive STAT activation, thereby driving proliferation, inflammation, and an uncontrolled immune response...
February 19, 2019: Oncogene
https://read.qxmd.com/read/30779044/lymphoma-and-leukemia-cell-vulnerabilities-and-resistance-identified-by-compound-library-screens
#3
Katarzyna Tomska, Sebastian Scheinost, Thorsten Zenz
Response to anticancer agents is often restricted to subsets of patients. The recognition of factors underlying this heterogeneity and the identification of biomarkers associated with response to drugs would greatly improve the efficacy of drug treatment. Platforms that can comprehensively map drug response in high-throughput ex vivo provide a unique tool to identify associated biomarkers and provide hypotheses for mechanisms underlying variable response. Such screens can be performed on cell lines and short-term cultures of primary cells to take advantage of the respective models' strength, which include, e...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30779036/mrd-detection-in-b-cell-non-hodgkin-lymphomas-using-ig-gene-rearrangements-and-chromosomal-translocations-as-targets-for-real-time-quantitative-pcr
#4
Christiane Pott, Monika Brüggemann, Matthias Ritgen, Vincent H J van der Velden, Jacques J M van Dongen, Michael Kneba
Minimal residual disease (MRD) diagnostics is of high clinical relevance in patients with indolent B-cell non-Hodgkin lymphomas (B-NHL) and serves as a surrogate parameter to evaluate treatment effectiveness and long-term prognosis. MRD diagnostics performed by real-time quantitative PCR (RQ-PCR) is still the gold standard and currently the most sensitive and the most broadly applied method in follicular lymphoma (FL) and mantle cell lymphoma (MCL). Alternatively, droplet digital PCR (ddPCR) can be used for MRD monitoring in multiple myeloma, mantle cell lymphoma, and follicular lymphoma with comparable sensitivity, accuracy, and reproducibility...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30779035/flow-cytometric-mrd-detection-in-selected-mature-b-cell-malignancies
#5
Sebastian Böttcher
The quantification of submicroscopic minimal residual disease (MRD) after therapy proved to have independent prognostic significance in many mature B-cell malignancies. With the advent of routine benchtop cytometers capable of simultaneously analyzing ≥4 colors and with improved standardization, flow cytometry has become the method of choice for MRD assessments in some lymphoma entities. Herein we describe general aspects of flow cytometric standardization. Chronic lymphocytic leukemia and multiple myeloma (MM) are used as examples to explain the technical standardization of flow cytometry for MRD detection according to EuroFlow strategies...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30779034/stereotyped-b-cell-receptor-immunoglobulins-in-b-cell-lymphomas
#6
Andreas Agathangelidis, Fotis Psomopoulos, Kostas Stamatopoulos
Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B cell neoplasms has led to the identification of significant repertoire restrictions, culminating in the discovery of subsets of patients expressing highly similar, stereotyped BcR IG. This finding strongly supports selection by common epitopes or classes of structurally similar epitopes in the ontogeny of these tumors. BcR IG stereotypy was initially described in chronic lymphocytic leukemia (CLL), where the stereotyped fraction of the disease accounts for a remarkable one-third of patients...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30779032/expression-cloning-of-antibodies-from-single-human-b-cells
#7
Hedda Wardemann, Christian E Busse
The majority of lymphomas originate from B cells at the germinal center stage. Preferential selection of B-cell clones by a limited set of antigens has been suggested to drive lymphoma development. While recent studies in chronic lymphocytic leukemia have shown that self-reactive B-cell receptors (BCR) can generate cell-autonomous signaling and proliferation, our knowledge about the role of BCRs for the development or survival of other lymphomas remains limited. Here, we describe a strategy to characterize the antibody reactivity of human B cells...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30776747/dna-methylation-profiling-implicates-exposure-to-pcbs-in-the-pathogenesis-of-b-cell-chronic-lymphocytic-leukemia
#8
Panagiotis Georgiadis, Marios Gavriil, Panu Rantakokko, Efthymios Ladoukakis, Maria Botsivali, Rachel S Kelly, Ingvar A Bergdahl, Hannu Kiviranta, Roel C H Vermeulen, Florentin Spaeth, Dennie G A J Hebbels, Jos C S Kleinjans, Theo M C M de Kok, Domenico Palli, Paolo Vineis, Soterios A Kyrtopoulos
OBJECTIVES: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. METHODS: We conducted an epigenome-wide association study on 611 adults free of diagnosed disease, living in Italy and Sweden, in whom we also measured plasma concentrations of 6 PCB congeners, DDE and hexachlorobenzene. RESULTS: We identified 650 CpG sites whose methylation correlates strongly (FDR < 0...
February 15, 2019: Environment International
https://read.qxmd.com/read/30775881/a-case-of-renal-involvement-in-b-lymphoblastic-lymphoma-leukemia
#9
Ling Zhang, Yashu Feng, Na Cheng, Qiong Zou, Wenxing Lai, Jia Jun Liu
BACKGROUND: Renal involvement is rare in B lymphoblastic lymphoma (B-LBL). The authors describe a rare case of renal involvement in a 21-year-old male patient with B lymphoblastic lymphoma leukemia, presenting with severe lactic acidosis. METHODS: Hematologic investigation, bone marrow aspirate and biopsy, cytogenetic analysis and renal biopsy were performed. RESULTS: The patient achieved complete hematological remission (CHR) after induction therapy with the regimen of VDCP and received consolidation chemotherapy regularly...
January 1, 2019: Clinical Laboratory
https://read.qxmd.com/read/30773504/by-regulating-mir-182-5p-bcl10-cycs-sufentanil-reduces-the-apoptosis-of-umbilical-cord-mesenchymal-stem-cells-caused-by-ropivacaine
#10
Lisha Li, Yan Sun, Na Zhang, Xuemin Qiu, Ling Wang, Qingyan Luo
Sufentanil is a type of opioid analgesic and is usually used to facilitate painless labor in combination with the local anesthetic ropivacaine. One aim of the current study was to investigate the effects of sufentanil and ropivacaine on umbilical cord mesenchymal stem cells (UCMSCs). A second aim of this study was to determine whether sufentanil attenuated the cytotoxicity of ropivacaine in vitro. UCMSCs were divided into 3 groups: one was treated with ropivacaine at a concentration of 50, 100, 200, or 400 μg/mL, another was treated with sufentanil at a concentration of 0...
February 17, 2019: Bioscience Trends
https://read.qxmd.com/read/30770900/latent-infection-with-kaposi-s-sarcoma-associated-herpesvirus-enhances-retrotransposition-of-long-interspersed-element-1
#11
Ryota Nakayama, Yumiko Ueno, Keiji Ueda, Tomoyuki Honda
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), a gamma-2 herpesvirus, is the causative agent of KS, primary effusion lymphoma (PEL), and a plasma cell variant of multicentric Castleman's disease. Although KSHV latency is detected in KS-related tumors, oncogenic pathways activated by KSHV latent infection are not fully understood. Here, we found that retrotransposition of long interspersed element-1 (L1), a retrotransposon in the human genome, was enhanced in PEL cells. Among the KSHV latent genes, viral FLICE-inhibitory protein (vFLIP) enhanced L1 retrotransposition in an NF-κB-dependent manner...
February 15, 2019: Oncogene
https://read.qxmd.com/read/30770545/prevalence-of-deaths-in-a-cohort-of-girls-and-women-with-cryopreserved-ovarian-tissue
#12
Kirsten Tryde Macklon
INTRODUCTION: Ovarian tissue cryopreservation (OTC) is increasingly offered to women in need of fertility preservation. However, little is known about the risk of these women dying before they use the preserved material. MATERIAL AND METHODS: From 1999 to 2016, 927 girls and women underwent OTC in our center, prior to receiving gonadotoxic treatment. All patients were without disseminated disease and with an estimated chance of survival after 5 years of > 50%...
February 15, 2019: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/30769194/barriers-to-allogeneic-hematopoietic-stem-cell-transplant-for-human-t-cell-lymphotropic-virus-1-associated-adult-t-cell-lymphoma-leukemia-in-the-united-states-experience-from-a-large-cohort-in-a-major-tertiary-center
#13
Diego Adrianzen Herrera, Noah Kornblum, Ana Acuna-Villaorduna, R Alejandro Sica, Urvi Shah, Moya Butler, Nivetha Vishnuvardhan, Nishi Shah, Lizamarie Bachier-Rodriguez, Olga Derman, Aditi Shastri, Ioannis Mantzaris, Amit K Verma, Ira Braunchweig, Murali Janakiram
In the United States (U.S.), Adult T-Cell Lymphoma-Leukemia (ATLL) carries a dismal prognosis and mainly affects immigrants from Human T-Cell Lymphotropic Virus 1 (HTLV-1) endemic areas. Allogeneic Hematopoietic Stem Cell Transplant (alloHSCT) can be effective and is recommended as an upfront treatment in the NCCN guidelines. We studied the barriers to alloHSCT in one of the largest ATLL populations in the U.S. Comprehensive chart and donor registry reviews were conducted for 88 ATLL patients treated at Montefiore Medical Center from 2003 to 2018...
February 12, 2019: Biology of Blood and Marrow Transplantation
https://read.qxmd.com/read/30764841/clinical-trials-of-dual-target-car-t-cells-donor-derived-car-t-cells-and-universal-car-t-cells-for-acute-lymphoid-leukemia
#14
REVIEW
Juanjuan Zhao, Yongping Song, Delong Liu
The current treatment for pediatric acute lymphoblastic leukemia (ALL) is highly successful with high cure rate. However, the treatment of adult ALL remains a challenge, particularly for refractory and/or relapsed (R/R) ALL. The advent of new targeted agents, blinatumomab, inotuzumab ozogamycin, and chimeric antigen receptor (CAR) T cells, are changing the treatment paradigm for ALL. Tisagenlecleucel (kymriah, Novartis) is an autologous CD19-targeted CAR T cell product approved for treatment of R/R B cell ALL and lymphoma...
February 14, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30755837/central-nervous-system-lymphoma-in-a-patient-with-chronic-lymphocytic-leukemia-a-case-report-and-literature-review
#15
Abdulrahman Albakr, Wajda Alhothali, Peyman Samghabadi, Lauren Maeda, Seema Nagpal, Abdulrazag Ajlan
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia that affects older adults in the Western world. Symptomatic nervous system invasion in undiagnosed CLL is rare, poorly understood, challenging to treat, and associated with decreased survival. The average survival of CLL patients with central nervous system (CNS) involvement is 3.79 years as compared to six years in CLL patients without CNS involvement. Autopsy studies demonstrated a high incidence of undiagnosed CLL with CNS involvement, suggesting that CNS involvement is either underdiagnosed or subclinical...
November 30, 2018: Curēus
https://read.qxmd.com/read/30747437/evaluation-of-peripheral-blood-mononuclear-cell-collection-by-leukapheresis
#16
Jian Chen, Cheryl Goss, Scott T Avecilla, Hong Hong, Eileen Walsh, David Wuest, Peter Maslak, Melissa S Pessin
BACKGROUND: Adoptive immunotherapy using engineered lymphocytes has shown promising results in treating cancers even in patients who have failed other treatments. As the first essential step, the number of peripheral mononuclear cell (MNC) collection procedures is rapidly increasing. In this retrospective study, we reviewed the collection results to determine factors that affect MNC collection. STUDY DESIGN AND METHODS: We reviewed 184 collections that were performed on 169 adult allogenic donors and patients with acute lymphoid leukemia, chronic lymphoid leukemia, lymphoma, multiple myeloma, or solid-organ tumors...
February 12, 2019: Transfusion
https://read.qxmd.com/read/30747249/comparison-of-the-safety-and-efficacy-of-prophylactic-donor-lymphocyte-infusion-after-haploidentical-versus-matched-sibling-pbsct-in-very-high-risk-acute-myeloid-leukemia
#17
Xiao-Ning Gao, Ji Lin, Li-Jun Wang, Fei Li, Hong-Hua Li, Shu-Hong Wang, Wen-Rong Huang, Chun-Ji Gao, Li Yu, Dai-Hong Liu
Donor lymphocyte infusion (DLI) might be used prophylactically to reduce relapse after allogeneic hematopoietic stem cell transplantation for very high-risk leukemia/lymphoma without effective targeted therapy. To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective analysis in a cohort of 21 HID-SCT and 13 MSD-SCT recipients, displaying similar baseline characteristics except for donor's gender distribution...
February 12, 2019: Annals of Hematology
https://read.qxmd.com/read/30746327/transcatheter-aortic-valve-replacement-and-cardiac-resynchronization-therapy-in-cancer-related-cardiotoxicity
#18
Enrico Melillo, Luigi Ascione, Giuseppe Palmiero, Valentina Maria Caso, Pio Caso
Cardiotoxicity related to antineoplastic agents is a rising and growing issue, therefore early recognition and prompt management can impact on the overall prognosis of cancer patients. We report the case of a 70-year-old woman without cardiovascular risk factors, with a medical history of non-Hodgkin lymphoma and chronic myeloid leukemia treated with chemotherapy and radiotherapy, who underwent transcatheter aortic valve replacement for severe aortic stenosis and cardiac resynchronization therapy for further development of complete left bundle branch block, with a significant improvement of her functional status and left ventricle systolic function in a long-term follow-up...
October 2018: Journal of Cardiovascular Echography
https://read.qxmd.com/read/30742566/dynamo-a-phase-ii-study-of-duvelisib-ipi-145-in-patients-with-refractory-indolent-non-hodgkin-lymphoma
#19
Ian W Flinn, Carole B Miller, Kirit M Ardeshna, Scott Tetreault, Sarit E Assouline, Jiri Mayer, Michele Merli, Scott D Lunin, Andrew R Pettitt, Zoltan Nagy, Olivier Tournilhac, Karem-Etienne Abou-Nassar, Michael Crump, Eric D Jacobsen, Sven de Vos, Virginia M Kelly, Weiliang Shi, Lori Steelman, NgocDiep Le, David T Weaver, Stephanie Lustgarten, Nina D Wagner-Johnston, Pier Luigi Zinzani
PURPOSE: Indolent non-Hodgkin lymphoma (iNHL) remains largely incurable and often requires multiple lines of treatment after becoming refractory to standard therapies. Duvelisib was approved by the Food and Drug Administration for relapsed or refractory (RR) chronic lymphocytic leukemia or small lymphocytic lymphoma (SLL) and RR follicular lymphoma (FL) after two or more prior systemic therapies. On the basis of the activity of duvelisib, a first-in-class oral dual inhibitor of phosphoinositide 3-kinase-δ,-γ, in RR iNHL in a phase I study, the safety and efficacy of duvelisib monotherapy was evaluated in iNHL refractory to rituximab and either chemotherapy or radioimmunotherapy...
February 11, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://read.qxmd.com/read/30741755/neutropenic-enterocolitis-in-critically-ill-patients-spectrum-of-the-disease-and-risk-of-invasive-fungal-disease
#20
Baptiste Duceau, Muriel Picard, Romain Pirracchio, Anne Wanquet, Frédéric Pène, Sybille Merceron, Djamel Mokart, Anne-Sophie Moreau, Etienne Lengliné, Emmanuel Canet, Virginie Lemiale, Eric Mariotte, Elie Azoulay, Lara Zafrani
OBJECTIVES: Neutropenic enterocolitis occurs in about 5.3% of patients hospitalized for hematologic malignancies receiving chemotherapy. Data from critically ill patients with neutropenic enterocolitis are scarce. Our objectives were to describe the population of patients with neutropenic enterocolitis admitted to an ICU and to investigate the risk factors of invasive fungal disease. DESIGN: A multicentric retrospective cohort study between January 2010 and August 2017...
February 7, 2019: Critical Care Medicine
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