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Zheyu Shen, Ting Liu, Yan Li, Joseph Lau, Zhen Yang, Wenpei Fan, Zijian Zhou, Changrong Shi, Chaomin Ke, Vladimir I Bregadze, Swadhin K Mandal, Yijing Liu, Zihou Li, Ting Xue, Guizhi Zhu, Jeeva Munasinghe, Gang Niu, Aiguo Wu, Xiaoyuan Chen
Cancer is one of the leading causes of morbidity and mortality in the world, but more cancer therapies are needed to complement existing regimens due to problems of existing cancer therapies. Herein, we term ferroptosis therapy (FT) as a form of cancer therapy and hypothesize that the FT efficacy can be significantly improved via accelerating the Fenton reaction by simultaneously increasing the local concentrations of all reactants (Fe2+ , Fe3+ , and H2 O2 ) in cancer cells. Thus, Fenton-reaction-acceleratable magnetic nanoparticles, i...
November 27, 2018: ACS Nano
Xiao Sun, Ruohong Du, Li Zhang, Guilong Zhang, Xiaojia Zheng, Junchao Qian, Xiaohe Tian, Jiewen Zhou, Jiacai He, Yuanyin Wang, Yiqun Wu, Kai Zhong, Dongqing Cai, Duohong Zou, Zhengyan Wu
Incorporation of T1 and T2 contrast material in one nanosystem performing their respective MR contrast role and simultaneously serving as an efficient drug delivery system (DDS) has a significant potential application for clinical diagnosis and chemotherapy of cancer. However, inappropriate incorporation always encountered many issues, such as low contact area of T1 contrast material with water-proton, inappropriate distance between T2 contrast material and water molecule, and undesirable disturbance of T2 contrast material for T1 imaging...
July 25, 2017: ACS Nano
Jingjing Li, Shan Wang, Chen Wu, Yue Dai, Pingfu Hou, Cuiping Han, Kai Xu
Activatable molecular MRI nanoprobe for intracellular GSH sensing was designed. As an alternative to "always on" nanoprobe, activatable imaging nanoprobes which are designed to amplify or boost imaging signals only in response to the targets have attracted more and more attention. In this paper, we designed a novel activatable molecular magnetic resonance imaging (MRI) nanoprobe for tumor cell recognization based on a MRI signal variation induced by the distance change between T1 and T2 contrast agents (CAs) in the presence of glutathione (GSH)...
December 15, 2016: Biosensors & Bioelectronics
Fenfen Li, Debo Zhi, Yufeng Luo, Jiqian Zhang, Xiang Nan, Yunjiao Zhang, Wei Zhou, Bensheng Qiu, Longping Wen, Gaolin Liang
T1-T2 dual modal magnetic resonance imaging (MRI) has attracted considerable interest because it offers complementary diagnostic information, leading to more precise diagnosis. To date, a number of nanostructures have been reported as T1-T2 dual modal MR contrast agents (CAs). However, hybrids of nanocubes with both iron and gadolinium (Gd) elements as T1-T2 dual modal CAs have not been reported. Herein, we report the synthesis of novel core/shell Fe3O4/Gd2O3 nanocubes as T1-T2 dual-modal CAs and their application for enhanced T1-T2 MR imaging of rat livers...
July 7, 2016: Nanoscale
Xiao Sun, Chuanjie Cai, Qian Wang, Dongqing Cai, Junchao Qian, Yu Chi, Kang Zheng, Xin Zhang, Guilong Zhang, Kai Zhong, Zhengyan Wu
A wormstructured and nanosized porous/hollow polyethyleneimine (PEI) functionalized Gd2O3/Fe3O4 composite was fabricated as a drug carrier and a bioimaging agent. The effect of PEI's chain length on the size and morphology of the nanoworm was investigated and the results indicated that the nanoworm modified with PEI (10,000 molecular weight) (designated as p-nanoworm) possessed a suitable size and a porous/hollow structure. Meanwhile, the p-nanoworm could effectively prevent the leakage of Gd ions under different pH conditions because of plenty of amino groups on their surface...
March 21, 2016: Physical Chemistry Chemical Physics: PCCP
Jie Fang, Yong Yang, Wen Xiao, Bingwen Zheng, Yun-Bo Lv, Xiao-Li Liu, Jun Ding
An extremely low frequency alternating magnetic field (ELF-AMF) was demonstrated to be able to effectively trigger drug release from carefully engineered magnetic ZIF-90 nanoparticles. The embedded Fe3O4 nanoparticles or alternatively Gd2O3 nanoparticles serve as effective MRI tracers for potential visualization of drug delivery to ensure drug delivery accuracy.
February 14, 2016: Nanoscale
Zijian Zhou, Changqiang Wu, Hanyu Liu, Xianglong Zhu, Zhenghuan Zhao, Lirong Wang, Ye Xu, Hua Ai, Jinhao Gao
Magnetic resonance angiography using gadolinium-based molecular contrast agents suffers from short diagnostic window, relatively low resolution and risk of toxicity. Taking into account the chemical exchange between metal centers and surrounding protons, magnetic nanoparticles with suitable surface and interfacial features may serve as alternative T1 contrast agents. Herein, we report the engineering on surface structure of iron oxide nanoplates to boost T1 contrast ability through synergistic effects between exposed metal-rich Fe3O4(100) facets and embedded Gd2O3 clusters...
March 24, 2015: ACS Nano
Guixin Yang, Ruichan Lv, Shili Gai, Yunlu Dai, Fei He, Piaoping Yang
A series of hollow and luminescent capsules have been fabricated by covering luminescent Gd2O3:Yb/Tm nanoparticles on the surface of uniform hollow mesoporous silica capsules (HMSCs), which were obtained from an etching process using Fe3O4 as hard templates. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), up-conversion (UC) fluorescence spectra, and N2 adsorption-desorption were used to characterize these samples...
October 20, 2014: Inorganic Chemistry
Hang Sun, Jiating He, Jiangyan Wang, Shuang-Yuan Zhang, Cuicui Liu, Thirumany Sritharan, Subodh Mhaisalkar, Ming-Yong Han, Dan Wang, Hongyu Chen
Growing oxide shells on seed nanoparticles requires the control of several processes: (a) the nucleation and growth of the shell material; (b) the "wetting" of the shell material on the seeds; and (c) the aggregation of the nanoparticles. These processes are influenced by a number of factors, many of which are related. Without understanding the interdependence of these contributing factors, it is difficult to circumvent problems and achieve rational synthesis. We first did a case study on encapsulating Au nanoparticles with ZnO to understand the multiple roles of polyvinylpyrrolidone (PVP) and their dependence on other factors...
June 19, 2013: Journal of the American Chemical Society
Ahjeong Son, Dosi Dosev, Mikaela Nichkova, Zhiya Ma, Ian M Kennedy, Kate M Scow, Krassimira R Hristova
Nanoscale magnetic/luminescent core-shell particles were used for DNA quantification in a hybridization-in-solution approach. We demonstrated a rapid, simple, and non-polymerase chain reaction-based DNA hybridization-in-solution assay for quantifying bacteria capable of biodegrading methyl tertiary-butyl ether. Fe3O4/Eu:Gd2O3 core-shell nanoparticles synthesized by spray pyrolysis were biofunctionalized with NeutrAvidin. Following immobilization of a biotinylated probe DNA on the particles' surfaces via passive adsorption, target DNA labeled with fluorescein isothiocyanate was hybridized with probe DNA...
November 15, 2007: Analytical Biochemistry
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