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Mourad Boufi, Benjamin O Patterson, Anderson D Loundou, Laurent Boyer, Matthew Joe Grima, Ian M Loftus, Peter J Holt
BACKGROUND: The respective place of endovascular versus open surgery in thoracic dissecting aneurysm treatment remains debatable. This comprehensive review seeks to analyse the outcomes of endovascular repair (ER) compared to open surgery (OS) in chronic type B aortic dissection treatment. METHODS: Embase and Medline searches (2000 - 2017)were performed following Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Outcomes data extracted comprised firstly early mortality and major complications: stroke, spinal cord ischemia (SCI), dialysis, respiratory complications; secondly, late survival and reinterventions...
November 24, 2018: Annals of Thoracic Surgery
Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Antonio Tagua, Cristina Forja, Ana M Castro, Marta Letrán, Andrea Valencia-Expósito, Clara Grima, Marina Bermúdez-Gallardo, Óscar Serrano-Pérez-Higueras, Florencia Cavodeassi, Sol Sotillos, María D Martín-Bermudo, Alberto Márquez, Javier Buceta, Luis M Escudero
The original version of this Article contained an error in ref. 39, which incorrectly cited 'Fristrom, D. & Fristrom, J. W. in The Development of Drosophila melanogaster (eds. Bate, M. & Martinez-Arias, A.) II, (Cold spring harbor laboratory press, 1993)'. The correct reference is 'Condic, M.L, Fristrom, D. & Fristrom, J.W. Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism. Development 111: 23-33 (1991)'. Furthermore, the last sentence of the fourth paragraph of the introduction incorrectly omitted citation of work by Rupprecht et al...
October 8, 2018: Nature Communications
F D'Arco, C A Alves, C Raybaud, W K K Chong, G E Ishak, S Ramji, M Grima, A J Barkovich, V Ganesan
BACKGROUND AND PURPOSE: Arg179His mutations in ACTA2 are associated with a distinctive neurovascular phenotype characterized by a straight course of intracranial arteries, absent basal Moyamoya collaterals, dilation of the proximal internal carotid arteries, and occlusive disease of the terminal internal carotid arteries. We now add to the distinctive neuroimaging features in these patients by describing their unique constellation of brain malformative findings that could flag the diagnosis in cases in which targeted cerebrovascular imaging has not been performed...
September 27, 2018: AJNR. American Journal of Neuroradiology
S Hornok, G Baneth, A Grima, N Takács, J Kontschán, M L Meli, V Suter, H Salant, R Farkas, R Hofmann-Lehmann
Rickettsia felis , the causative agent of flea-borne spotted fever, occurs on all continents except Antarctica, owing to the cosmopolitan distribution of its cat flea vector. In this study, cat fleas were collected in two countries where the occurrence of R. felis was either unknown (Malta) or where accurate prevalence data were lacking (Israel). Altogether 129 fleas were molecularly analysed for the presence of rickettsial DNA. On the basis of three genetic markers, R. felis was identified in 39.5% (15/38) of the cat fleas from Malta...
September 2018: New Microbes and New Infections
Katherine M Stenson, Benjamin O Patterson, Matthew Joe Grima, Jorg L De Bruin, Peter J E Holt, Ian Loftus
BACKGROUND: Endovascular aneurysm sealing (EVAS) represents a novel approach to the treatment of abdominal aortic aneurysms. It uses polymer technology to achieve an anatomic seal within the sac of the aneurysm. This cohort study reports the early clinical outcomes, technical refinements, and learning curve during the initial EVAS experience at a single institution. METHODS: Results from 150 consecutive EVAS cases for intact, infrarenal abdominal aortic aneurysms are reported here...
May 24, 2018: Journal of Vascular Surgery
Ahlem Jebali, F Gabriel Acién, Erika Rodriguez Barradas, Eugenia J Olguín, Sami Sayadi, Emilio Molina Grima
This work investigated the production of Scenedesmus sp. in semi-continuous mode in three pilot-scale outdoor raceways (7.2 m2 ) using flue gas for CO2 supply and centrate from the anaerobic digestion of urban wastewater as the sole nutrient source. Experiments were performed at different culture depths, 5, 10 and 15 cm, while evaluating two centrate concentrations (30% and 45%) at dilution rates of 0.2 and 0.3 d-1 . Under optimal conditions of 30% centrate, 0.3 d-1 dilution rate and a 15 cm culture depth, a maximum biomass productivity of 22...
August 2018: Bioresource Technology
Ke Zhang, J Gavin Daigle, Kathleen M Cunningham, Alyssa N Coyne, Kai Ruan, Jonathan C Grima, Kelly E Bowen, Harsh Wadhwa, Peiguo Yang, Frank Rigo, J Paul Taylor, Aaron D Gitler, Jeffrey D Rothstein, Thomas E Lloyd
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common genetic cause of ALS/FTD. Furthermore, nucleocytoplasmic transport disruption has also been implicated in other neurodegenerative diseases with protein aggregation, suggesting a shared mechanism by which protein stress disrupts nucleocytoplasmic transport. Here, we show that cellular stress disrupts nucleocytoplasmic transport by localizing critical nucleocytoplasmic transport factors into stress granules, RNA/protein complexes that play a crucial role in ALS pathogenesis...
May 3, 2018: Cell
M C Cerón-García, C V González-López, J Camacho-Rodríguez, L López-Rosales, F García-Camacho, E Molina-Grima
Microalgae are an interesting source of natural pigments that have valuable applications. However, further research is necessary to develop processes that allow us to achieve high levels of carotenoid recovery while avoiding degradation. This work presents a comprehensive study on the recovery of carotenoids from several microalgae genera, optimizing carotenoid extraction using alkaline saponification at various temperatures and KOH concentrations. Results show that I. galbana requires a temperature of 60 °C and <10% KOH, N...
August 15, 2018: Food Chemistry
M Serrano-Alonso, F Guillen-Grima, P Martin-Moreno, G Rabago, J Manrique, M Garcia-Del-Barrio, G Reina, J Torre-Cisneros, M Fernandez-Alonso, J I Herrero
BACKGROUND: Cytomegalovirus (CMV) is the most important viral pathogen in solid organ transplant (SOT) recipients. The role of secondary CMV prophylaxis in this population remains unclear. METHODS: Retrospective cohort study in a single center. SOT recipients treated for CMV infection from 2007 to 2014 were studied to determine the efficacy and safety of secondary prophylaxis and its impact on graft loss and mortality. The outcome variable was CMV replication in the first 3 months after the end of therapy...
June 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
A Karthikesalingam, M J Grima, P J Holt, A Vidal-Diez, M M Thompson, A Wanhainen, M Bjorck, K Mani
BACKGROUND: There is substantial international variation in mortality after abdominal aortic aneurysm (AAA) repair; many non-operative factors influence risk-adjusted outcomes. This study compared 90-day and 5-year mortality for patients undergoing elective AAA repair in England and Sweden. METHODS: Patients were identified from English Hospital Episode Statistics and the Swedish Vascular Registry between 2003 and 2012. Ninety-day mortality and 5-year survival were compared after adjustment for age and sex...
April 2018: British Journal of Surgery
Paul G Ramchandani, Christine O'Farrelly, Daphne Babalis, Marian J Bakermans-Kranenburg, Sarah Byford, Ellen S R Grimas, Jane E Iles, Marinus H van IJzendoorn, Julia McGinley, Charlotte M Phillips, Alan Stein, Jane Warwick, Hillary C Watt, Stephen Scott
BACKGROUND: Behavioural problems are common in early childhood, and can result in enduring costs to the individual and society, including an increased risk of mental and physical illness, criminality, educational failure and drug and alcohol misuse. Most previous research has examined the impact of interventions targeting older children when difficulties are more established and harder to change, and have rarely included fathers. We are conducting a trial of a psychological intervention delivered to families with very young children, engaging both parents where possible...
November 15, 2017: Trials
Shaneel R Patel, Chris Allen, Matthew J Grima, Jack R W Brownrigg, Benjamin O Patterson, Peter J E Holt, Matt M Thompson, Alan Karthikesalingam
BACKGROUND: Current surveillance protocols after endovascular aneurysm repair (EVAR) are ineffective and costly. Stratifying surveillance by individual risk of reintervention requires an understanding of the factors involved in developing post-EVAR complications. This systematic review assessed risk factors for reintervention after EVAR and proposals for stratified surveillance. METHODS: A systematic search according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed using EMBASE and MEDLINE databases to identify studies reporting on risk factors predicting reintervention after EVAR and proposals for stratified surveillance...
August 2017: Vascular and Endovascular Surgery
M D Grima Murcia, Francisco Sánchez Ferrer, Jennifer Sorinas, J M Ferrandez, Eduardo Fernandez
Much is currently being studied on the negative visual impact associated to the installation of large wind turbines or photovoltaic farms. However, methodologies for quantitatively assessing landscape impact are scarce. In this work we used electroencephalographic (EEG) recordings to investigate the brain activity of 14 human volunteers when looking at the same landscapes with and without wind turbines, solar panels and nuclear power plants. Our results showed no significant differences for landscapes with solar power systems or without them, and the same happened for wind turbines, what was in agreement with their subjective scores...
September 15, 2017: Journal of Environmental Management
H Niu, I Alvarez-Alvarez, F Guillen-Grima, M J Al-Rahamneh, I Aguinaga-Ontoso
BACKGROUND AND PURPOSE: In many countries, Alzheimer's disease (AD) has gradually become a common disease in elderly populations. The aim of this study was to analyse trends of mortality caused by AD in the 28 member countries in the European Union (EU) over the last two decades. METHODS: We extracted data for AD deaths for the period 1994-2013 in the EU from the Eurostat and World Health Organization database. Age-standardized mortality rates per 100 000 were computed...
June 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Mourad Boufi, Benjamin O Patterson, Matthew Joe Grima, Alan Karthikesalingam, Mohammed T Hudda, Peter J Holt, Ian M Loftus, Matthew M Thompson
This review analyzed the incidence, mechanisms, and risk factors of aortic-related reintervention after endovascular repair of chronic dissections. The systematic review identified 28 studies describing 1,249 patients at median 27 months follow-up (range, 10.3 to 64.4). There were six reinterventions, 0.7 ruptures, and 1.2 surgical conversions per 100 patient-years of follow-up. Stent-related reinterventions were more frequent than nonstent related (80.2% vs 19.8%). Distal false lumen perfusion was the most common complication (40...
June 2017: Annals of Thoracic Surgery
Nora E Straznicky, Mariee T Grima, Carolina I Sari, Nina Eikelis, Paul J Nestel, John B Dixon, Gavin W Lambert, Markus P Schlaich, Sarah E Phillips, Elisabeth A Lambert
Background: Neck circumference (NC) is a predictor of cardiometabolic risk. The objective of this study was to explore the relationship of NC to muscle sympathetic nerve activity (MSNA) within an overweight and obese population. Methods: The study design was a retrospective cross-sectional analysis. Un-medicated persons (72 men, 53 postmenopausal women) aged 56 ± 1 years (mean ± SEM) with body mass index (BMI) 32.8 ± 0.4 kg/m(2), were studied. NC was measured together with traditional anthropometric measures, supine blood pressure, fasting blood lipids, insulin, and glucose...
2017: Frontiers in Physiology
Jonathan C Grima, J Gavin Daigle, Nicolas Arbez, Kathleen C Cunningham, Ke Zhang, Joseph Ochaba, Charlene Geater, Eva Morozko, Jennifer Stocksdale, Jenna C Glatzer, Jacqueline T Pham, Ishrat Ahmed, Qi Peng, Harsh Wadhwa, Olga Pletnikova, Juan C Troncoso, Wenzhen Duan, Solomon H Snyder, Laura P W Ranum, Leslie M Thompson, Thomas E Lloyd, Christopher A Ross, Jeffrey D Rothstein
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. Nucleocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (NUPs). Previous studies offered clues that mHTT may disrupt nucleocytoplasmic transport and a mutation of an NUP can cause HD-like pathology. Therefore, we evaluated the NPC and nucleocytoplasmic transport in multiple models of HD, including mouse and fly models, neurons transfected with mHTT, HD iPSC-derived neurons, and human HD brain regions...
April 5, 2017: Neuron
Nina Eikelis, Elisabeth A Lambert, Sarah Phillips, Carolina Ika Sari, Piyushkumar A Mundra, Jacquelyn M Weir, Kevin Huynh, Mariee T Grima, Nora E Straznicky, John B Dixon, Markus P Schlaich, Peter J Meikle, Gavin W Lambert
Background: Asian subjects are at increased cardio-metabolic risk at comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of increased adiposity, appear to be related. We therefore analyzed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young adult Asian and white subjects. Methods: Blood samples were collected from 101 participants of either Asian or white background (age, 18 to 30 years; BMI, 28...
June 1, 2017: Journal of Clinical Endocrinology and Metabolism
V J Leung, M Grima, N Khan, H R Jones
AIM: To determine the adequacy of the split-bolus computed tomography (CT) technique in terms of vascular enhancement and solid-organ injury assessment in paediatric trauma. MATERIALS AND METHODS: A retrospective review was undertaken of all split-bolus trauma CT examinations performed in patients <16 years during the period from 1 January 2015 to 31 January 2016. Twelve examinations were performed in this time on patients with an age range of 2-15 years (mean 10...
June 2017: Clinical Radiology
Maria J Ortiz, M D Grima Murcia, E Fernandez
No abstract text is available yet for this article.
April 2017: Brain and Cognition
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