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https://read.qxmd.com/read/30896565/evaluation-of-the-vaginal-microbiome-in-clinical-diagnosis-and-management-of-vaginal-infectious-diseases
#1
Ting Li, Zhao-Hui Liu, Kui Li, Hui-Hui Bai
OBJECTIVE: The Vaginal Microecology Evaluation System (VMES) is a technical and economically feasible tool to assess the vaginal microbiomes of gynecological outpatients. The aim of this review was to introduce knowledge on the potential changes that can occur in the vaginal microbiome and how to use the Evaluation System to diagnose and manage a broad range of vaginal infections. DATA SOURCES: This review was based on data in articles published in PubMed up to December 10, 2018, with the following keywords: "Vaginal microecosystem", "vaginal microbiome", "vaginal microbiota", and "vaginal flora"...
March 19, 2019: Chinese Medical Journal
https://read.qxmd.com/read/30869011/does-scientific-effort-reflect-global-need-a-review-of-infectious-disease-publications-over-100-years
#2
D T S Hayman, M G Baker
In a rational world, scientific effort would reflect society's needs. We tested this hypothesis using the area of infectious diseases, where the research response to emerging threats has obvious potential to save lives through informing interventions such as vaccination and prevention policies. Pathogens continue to evolve, emerge and re-emerge and infectious diseases that were once common become less so or their global distribution changes. A question remains as to whether scientific endeavours can adapt. Here, we identified papers on infectious diseases published in the four highest ranking, health-related journals over the 118 years from 1900...
January 2019: Epidemiology and Infection
https://read.qxmd.com/read/30863354/the-role-of-decompressive-craniectomy-in-limited-resource-environments
#3
REVIEW
Angélica Clavijo, Ahsan A Khan, Juliana Mendoza, Jorge H Montenegro, Erica D Johnson, Amos O Adeleye, Andrés M Rubiano
Decompressive craniectomy (DC) is a neurosurgical procedure useful to prevent and manage the impact of high intracranial pressure (ICP) that leads to brain herniation and brain's tissue ischemia. In well-resourced environment this procedure has been proposed as a last tier therapy when ICP is not controlled by medical therapies in the management of different neurosurgical emergencies like traumatic brain injury (TBI), stroke, infectious diseases, hydrocephalus, tumors, etc. The purpose of this narrative review is to discuss the role of DC in areas of low neurosurgical and neurocritical care resources...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30860805/quantifying-the-interactions-between-biomolecules-guidelines-for-assay-design-and-data-analysis
#4
Peter J Tonge
The accurate and precise determination of binding interactions plays a central role in fields such as drug discovery where structure-activity relationships guide the selection and optimization of drug leads. Binding is often assessed by monitoring the response caused by varying one of the binding partners in a functional assay, or by using methods where the concentrations of free and/or bound ligand can be directly determined. In addition, there are also many approaches where binding leads to a change in the properties of the binding partner(s) that can be directly quantified such as an alteration in mass or in a spectroscopic signal...
March 12, 2019: ACS Infectious Diseases
https://read.qxmd.com/read/30855742/a-longitudinal-study-of-ebola-sequelae-in-liberia
#5
Michael C Sneller, Cavan Reilly, Moses Badio, Rachel J Bishop, Allen O Eghrari, Soka J Moses, Kumblytee L Johnson, Dehkontee Gayedyu-Dennis, Lisa E Hensley, Elizabeth S Higgs, Avindra Nath, Kaylie Tuznik, Justin Varughese, Kenneth S Jensen, Bonnie Dighero-Kemp, James D Neaton, H Clifford Lane, Mosoka P Fallah
BACKGROUND: Multiple health problems have been reported in survivors of Ebola virus disease (EVD). Attribution of these problems to the disease without a control group for analysis is difficult. METHODS: We enrolled a cohort of EVD survivors and their close contacts and prospectively collected data on symptoms, physical examination findings, and laboratory results. A subset of participants underwent ophthalmologic examinations. Persistence of Ebola virus (EBOV) RNA in semen samples from survivors was determined...
March 7, 2019: New England Journal of Medicine
https://read.qxmd.com/read/30850420/community-based-testing-of-migrants-for-infectious-diseases-combat-id-impact-acceptability-and-cost-effectiveness-of-identifying-infectious-diseases-among-migrants-in-primary-care-protocol-for-an-interrupted-time-series-qualitative-and-health-economic-analysis
#6
Manish Pareek, Helen C Eborall, Fatimah Wobi, Kate S Ellis, Evangelos Kontopantelis, Fang Zhang, Rebecca Baggaley, T Deirdre Hollingsworth, Darrin Baines, Hemu Patel, Pranabashis Haldar, Mayur Patel, Iain Stephenson, Ivan Browne, Paramjit Gill, Rajesh Kapur, Azhar Farooqi, Ibrahim Abubakar, Chris Griffiths
BACKGROUND: Migration is a major global driver of population change. Certain migrants may be at increased risk of infectious diseases, including tuberculosis (TB), HIV, hepatitis B and hepatitis C, and have poorer outcomes. Early diagnosis and management of these infections can reduce morbidity, mortality and onward transmission and is supported by national guidelines. To date, screening initiatives have been sporadic and focused on individual diseases; systematic routine testing of migrant groups for multiple infections is rarely undertaken and its impact is unknown...
March 7, 2019: BMJ Open
https://read.qxmd.com/read/30809150/the-top-100-highly-cited-original-articles-on-drug-therapy-for-ventilator-associated-pneumonia
#7
Chao-Yang Wang, Bing-Hui Li, Lin-Lu Ma, Ming-Juan Zhao, Tong Deng, Ying-Hui Jin, Xue-Qun Ren
Background: In recent decades, research on drug therapy for ventilator-associated pneumonia (VAP) remains one of the major hot-spots in the field of critical care medicine, but relevant data are not satisfactory. Our aim was to assess the status and trends of the most cited articles on drug therapy for VAP through bibliometric approaches. Methods: The Institute for Scientific Information (ISI) Web of Science core collection database was searched for the VAP-related articles. The time period for retrieval was from the beginning of the database to September 30, 2018...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/30807357/rules-of-anti-infection-therapy-for-sepsis-and-septic-shock
#8
Xiang Zhou, Long-Xiang Su, Jia-Hui Zhang, Da-Wei Liu, Yun Long
OBJECTIVE: Sepsis is a deadly infection that causes injury to tissues and organs. Infection and anti-infective treatment are the eternal themes of sepsis. The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. This evidence is combined with clinical experiments to reveal the rules and a standard flowchart of anti-infection therapy for sepsis. DATA SOURCES: We retrieved information from the PubMed database up to October 2018 using various search terms and their combinations, including sepsis, septic shock, infection, antibiotics, and anti-infection...
March 5, 2019: Chinese Medical Journal
https://read.qxmd.com/read/30807311/rules-of-anti-infection-therapy-for-sepsis-and-septic-shock
#9
Xiang Zhou, Long-Xiang Su, Jia-Hui Zhang, Da-Wei Liu, Yun Long
OBJECTIVE: Sepsis is a deadly infection that causes injury to tissues and organs. Infection and anti-infective treatment are the eternal themes of sepsis. The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. This evidence is combined with clinical experiments to reveal the rules and a standard flowchart of anti-infection therapy for sepsis. DATA SOURCES: We retrieved information from the PubMed database up to October 2018 using various search terms and their combinations, including sepsis, septic shock, infection, antibiotics, and anti-infection...
February 20, 2019: Chinese Medical Journal
https://read.qxmd.com/read/30804039/identifying-risk-factors-for-neurological-complications-and-monitoring-long-term-neurological-sequelae-protocol-for-the-guangzhou-prospective-cohort-study-on-hand-foot-and-mouth-disease
#10
Kuanrong Li, Xufang Li, Wenyue Si, Huiying Liang, Hui-Min Xia, Yi Xu
INTRODUCTION: Hand-foot-and-mouth disease (HFMD) is a paediatric infectious disease that is particularly prevalent in China. Severe HFMDs characterised by neurological involvement are fatal and survivors who have apparently fully recovered might still be afflicted later in life with neurocognitive impairments. Only when a well-designed, prospective cohort study is in place can we develop clinical tools for early warning of neurological involvement and can we obtain epidemiological evidence regarding the lingering effects of the sequelea...
February 24, 2019: BMJ Open
https://read.qxmd.com/read/30802624/world-tuberculosis-day-march-24th-2019-theme-it-s-time-international-journal-of-infectious-diseases-tuberculosis-theme-series
#11
EDITORIAL
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, David A J Moore, Katherine Gaskell, Joanna Nederby Öhd, Maria-Pia Hergens, Sriram Krishnamoorthy, Cesar Ugarte-Gil, Daniela E Kirwan, Isobella Honeyborne, Timothy D McHugh, Claudio U Köser, Katharina Kranzer, Simon Tiberi, Giovanni Battista Migliori, Qiang Mao, Yahong Yang, Simoni Pimenta de Oliveira, Rosilene Fressatti Cardoso, Anne Detjen, Ben Marais, David de Gijsel, C Fordham von Reyn, Lara Goscé, Ibrahim Abubakar, Markus Maeurer, Alimuddin Zumla
No abstract text is available yet for this article.
February 22, 2019: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/30746676/bibliometry-of-biomedical-scientific-publications-in-mauritania-medline-1992-2016
#12
Sid Ahmed Dahdi, Asma Ben Abdelaziz, Tarek Baroumi, Ousmane Ba, Mohamadou Diagana, Lebchir Dada, Ahmed Ben Abdelaziz
BACKGROUND: As part of the preparatory work for the elaboration of a strategic plan for the development of scientific research in Mauritania, an overview of national biomedical research was recommended by the supervisory authorities. AIM: Describe the bibliometric profile of biomedical scientific publications in Mauritania, indexed in Medline database, over the past 25 years. METHODS: A bibliometric study was carried out on Medline Database covering the period from 1 January 1992 to 31 December 2016...
October 2018: La Tunisie Médicale
https://read.qxmd.com/read/30702767/progress-and-history-of-the-10th-federation-of-african-immunological-societies-congress
#13
Elopy Sibanda, Mohamed-Ridha Barbouche
The 10th Federation of African Immunological Societies (FAIS) Congress, held in Tunisia in November 2017, marked a significant scientific milestone. It enabled scientists from across the continent to promote immunology research and to showcase major achievements made by immunologists throughout Africa. This issue of the Journal of Leukocyte Biology (JLB) features manuscripts from the FAIS Congress. As noted in these papers, research in infectious diseases remains the focus of the African immunology community; however, increasingly noncommunicable diseases-such as autoimmunity, allergy, primary immunodeficiency, cancer and transplantation immunology-are also an emerging priority...
February 2019: Journal of Leukocyte Biology
https://read.qxmd.com/read/30698999/crispr-based-tools-in-immunity
#14
Dimitre R Simeonov, Alexander Marson
CRISPR technology has opened a new era of genome interrogation and genome engineering. Discovered in bacteria, where it protects against bacteriophage by cleaving foreign nucleic acid sequences, the CRISPR system has been repurposed as an adaptable tool for genome editing and multiple other applications. CRISPR's ease of use, precision, and versatility have led to its widespread adoption, accelerating biomedical research and discovery in human cells and model organisms. Here we review CRISPR-based tools and discuss how they are being applied to decode the genetic circuits that control immune function in health and disease...
January 30, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30691105/tropical-medicine-and-infectious-disease-john-m-goldsmid-award-2018
#15
EDITORIAL
(no author information available yet)
For many years, The Australasian College of Tropical Medicine (ACTM) has awarded the John M Goldsmid Award for the best paper published in its official journal, the Annals of the ACTM, in the previous year [...].
January 26, 2019: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/30673535/disease-tolerance-as-an-inherent-component-of-immunity
#16
Rui Martins, Ana Rita Carlos, Faouzi Braza, Jessica A Thompson, Patricia Bastos-Amador, Susana Ramos, Miguel P Soares
Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs of infectious diseases. Immunity limits the severity of infectious diseases through resistance mechanisms that sense and target pathogens for containment, killing, or expulsion. These resistance mechanisms are viewed as the prevailing function of immunity. Under pathophysiologic conditions, however, immunity arises in response to infections that carry health and fitness costs to the host. Therefore, additional defense mechanisms are required to limit these costs, before immunity becomes operational as well as thereafter to avoid immunopathology...
January 23, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30659041/oral-cannabinoids-in-people-living-with-hiv-on-effective-antiretroviral-therapy-ctn-pt028-study-protocol-for-a-pilot-randomised-trial-to-assess-safety-tolerability-and-effect-on-immune-activation
#17
Cecilia T Costiniuk, Zahra Saneei, Jean-Pierre Routy, Shari Margolese, Enrico Mandarino, Joel Singer, Bertrand Lebouché, Joseph Cox, Jason Szabo, Marie-Josée Brouillette, Marina B Klein, Nicolas Chomont, Mohammad-Ali Jenabian
INTRODUCTION: Despite antiretroviral therapy (ART), people living with HIV have higher rates of non-infectious chronic diseases. These conditions are driven by relatively high levels of inflammation persisting on ART compared with uninfected individuals. Chronic inflammation also contributes to HIV persistence during ART. Cannabis when taken orally may represent a way to reduce inflammation and strengthen immune responses. Before planning large interventional studies, it is important to ensure that cannabis taken orally is safe and well tolerated in people living with HIV...
January 17, 2019: BMJ Open
https://read.qxmd.com/read/30658704/evaluating-the-published-critical-care-research-from-the-world-health-organization-eastern-mediterranean-region
#18
Mohamad Elaibaid, Lama H Nazer, Lama Shaikha, Nada Al-Qadheeb, Ruth Kleinpell, Keith M Olsen, Feras Hawari
OBJECTIVES: Evaluation of published research in a region provides insight into relevant aspects of clinical care and research priorities. This study aimed to provide a comprehensive assessment of the type of critical care research published in the World Health Organization Eastern Mediterranean region (EMR) over a 10-year period. RESULTS: During the study period (2007-2016), the search strategy revealed 4303 publications, of which 1537 were included in the analysis; studies were excluded for the following reasons: not critical care, conducted in non-EMR countries, editorials, case reports, in-vitro or animal studies, as well as those conducted in multiple countries and those that evaluated foreign military personal...
January 18, 2019: BMC Research Notes
https://read.qxmd.com/read/30658583/the-epidemiology-and-chemotherapeutic-approaches-to-the-control-of-urinary-schistosomiasis-in-school-age-children-sac-a-systematic-review
#19
Tolulope Ebenezer Atalabi, Taiwo Oluwakemi Adubi
BACKGROUND: Human schistosomiases are acute and chronic infectious diseases of poverty. Currently, epidemiological data of urinary schistosomiasis (US) in school-age children (SAC) and adults are often reported together making it difficult to ascertain the true status of the disease. Based on this premise, we set out to carry out this review. METHOD: To achieve this aim, we carried out a computer-aided search of PubMed, Web of Science, Science Direct, African Journals OnLine (AJOL) and the database of World Health Organization...
January 18, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30633713/earth-observation-investigating-noncommunicable-diseases-from-space
#20
Peng Jia, Alfred Stein, Peter James, Ross C Brownson, Tong Wu, Qian Xiao, Limin Wang, Clive E Sabel, Youfa Wang
The United Nations has called on all nations to take immediate actions to fight noncommunicable diseases (NCDs), which have become an increasingly significant burden to public health systems around the world. NCDs tend to be more common in developed countries but are also becoming of growing concern in low- and middle-income countries. Earth observation (EO) technologies have been used in many infectious disease studies but have been less commonly employed in NCD studies. This review discusses the roles that EO data and technologies can play in NCD research, including ( a) integrating natural and built environment factors into NCD research, ( b) explaining individual-environment interactions, ( c) scaling up local studies and interventions, ( d) providing repeated measurements for longitudinal studies including cohorts, and ( e) advancing methodologies in NCD research...
January 11, 2019: Annual Review of Public Health
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