Shih-Shan Lang, Amber Valeri, Phillip B Storm, Gregory G Heuer, Alexander M Tucker, Benjamin C Kennedy, Benjamin W Kozyak, Anjuli Sinha, Todd J Kilbaugh, Jimmy W Huh
OBJECTIVE: Single-ventricle congenital heart disease (CHD) in pediatric patients with Glenn and Fontan physiology represents a unique physiology requiring the surgical diversion of the systemic venous return from the superior vena cava (Glenn) and then the inferior vena cava (Fontan) directly to the pulmonary arteries. Because many of these patients are on chronic anticoagulation therapy and may have right-to-left shunts, arrhythmias, or lymphatic disorders that predispose them to bleeding and/or clotting, they are at risk of experiencing neurological injury requiring intubation and positive pressure ventilation, which can significantly hamper pulmonary blood flow and cardiac output...
July 9, 2021: Journal of Neurosurgery. Pediatrics