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CCN1 cytoskeletal

Shr-Jeng Jim Leu, Jung-Sung Sung, Meng-Ling Huang, Mei-Yu Chen, Tsai-Wei Tsai
CCN1, a secreted matrix-associated molecule, is involved in multiple cellular processes. Accumulating evidence supports that CCN1 plays an important role in tumorigenesis and progression of breast cancer. In this study, we have developed a novel CCN1 function-blocking monoclonal antibody (mAb), designated YM1B. YM1B binds to human CCN1 with high specificity, recognizing the native CCN1 structure with undisturbed disulfide linkages. Our analyses have mapped the YM1B recognition region to domain IV of CCN1, likely in proximity to the DM site...
May 17, 2013: Biochemical and Biophysical Research Communications
Kei Higuchi, Hisashi Iizasa, Yoshimichi Sai, Satomi Horieya, Kyeong-Eun Lee, Masami Wada, Masayuki Deguchi, Tomohiro Nishimura, Tomohiko Wakayama, Atsushi Tamura, Sachiko Tsukita, Noriko Kose, Young-Sook Kang, Emi Nakashima
The syncytiotrophoblast, which regulates maternal-fetal transfer of drugs, consists of a single layer in humans, but two layers, i.e., SynI and SynII, in rodents. Polar distribution of transporters in the apical and basal plasma membranes of syncytiotrophoblast is important for placental function in terms of vectorial transport of substrates, but the mechanisms that control protein distribution in the syncytiotrophoblast remain unclear. We have previously established rat syncytiotrophoblast cell lines, TR-TBT 18d-1 and TR-TBT 18d-2, which retain characteristics of SynI and SynII, respectively...
2010: Biological & Pharmaceutical Bulletin
Indrajit Sinha, Yan-Ming Wang, Robin Philp, Chang-Run Li, Wai Ho Yap, Yue Wang
Cyclin-dependent kinases (Cdks) control cytoskeleton polarization in yeast morphogenesis. However, the target and mechanism remain unclear. Here, we show that the Candida albicans Cdk Cdc28, through temporally controlled association with two cyclins Ccn1 and Hgc1, rapidly establishes and persistently maintains phosphorylation of the septin cytoskeleton protein Cdc11 for hyphal development. Upon hyphal induction, Cdc28-Ccn1 binds to septin complexes and phosphorylates Cdc11 on Ser394, a nonconsensus Cdk target...
September 2007: Developmental Cell
Peter Sudbery
In this issue of Developmental Cell, Sinha et al. describe a posttranscriptional mechanism necessary for hyphal development of the human pathogen, Candida albicans. In this context, the kinase Gin4 phosphorylates the septin Cdc11 in uninduced yeast cells to prime them for fast action by the cyclin-dependent kinase Cdc28/Ccn1 at the time of hyphal induction. Joint phosphorylation of Cdc11 by these two kinases is essential for stable polarization of hyphal growth.
September 2007: Developmental Cell
Brahim Chaqour, Margarete Goppelt-Struebe
Cells in various anatomical locations are constantly exposed to mechanical forces from shear, tensile and compressional forces. These forces are significantly exaggerated in a number of pathological conditions arising from various etiologies e.g., hypertension, obstruction and hemodynamic overload. Increasingly persuasive evidence suggests that altered mechanical signals induce local production of soluble factors that interfere with the physiologic properties of tissues and compromise normal functioning of organ systems...
August 2006: FEBS Journal
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