keyword
https://read.qxmd.com/read/38545586/major-nerve-resections-in-extremity-soft-tissue-sarcomas-functional-and-oncological-outcomes
#1
JOURNAL ARTICLE
Ranganath Ratnagiri, Megha S Uppin, Shantveer G Uppin, Rajshekar Shantappa
Soft tissue sarcomas form 1% of all cancers and are rare. The lower limb is one of the commonest sites of sarcoma, with the thigh accounting for the majority of these tumors. Large tumors abut the neurovascular bundles both anteriorly and in the hamstring compartment. Nerve involvement, especially the major nerves such as the femoral and the sciatic, by these tumors, was considered to be an absolute contraindication for limb salvage procedures. We present our data of major nerve resection without amputation, in an attempt to demonstrate the possibility of equivalent functional and oncological outcomes in these rare tumors...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38545351/a-case-of-lung-adenocarcinoma-developing-chylothorax-after-transthoracic-tru-cut-biopsy
#2
Şerife Torun, Çağrı Kesim, Mehmet Dalokay Kılıç
Chylothoraces are mostly secondary to trauma and tumors, and rarely idiopathic. Chylothoraces secondary to lung tumors are mostly seen postoperatively. In this article, we, for the first time, present massive chylothorax developing after diagnostic transthoracic Tru-cut biopsy in a lung adenocarcinoma case. The patient was successfully treated with drainage and octreotide. In conclusion, it should be kept in mind that chylothorax can be also seen as a complication after interventional biopsy procedures; therefore, the patients should be followed carefully...
January 2024: Türk Göğüs Kalp Damar Cerrahisi Dergisi
https://read.qxmd.com/read/38544678/a-rare-case-of-colorectal-cancer-metastasis-to-the-pancreas-a-case-report
#3
Hesameddin Eghlimi, Moein Mirzadeh, Hamidreza Movahedi, Tala Tabrizi
Colon cancer is the third leading cause of cancer worldwide. On presentation, 20% of patients will have metastatic disease, and the most common sites for metastatic colon cancer are liver, lung, and peritoneum. Our patient was a 55-year-old man with a history of rectal adenocarcinoma cancer and colectomy surgery for the past 2 years, who had presented changes in bowel movements, rectal bleeding and thin. In the new visit and positron emission tomography-computed tomography scan, the results showed that there are two ill-defined foci of increased FDG (F-fluorodeoxyglucose) uptake in the body (metabolic diameter = 26 mm, SUVmax = 7...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38544634/a-case-report-and-literature-review-of-skeletal-muscle-metastasis-of-non-small-cell-lung-cancer
#4
Linda Youn, Mirra Srinivasan, Amber Kuta, Jacyln Barnard, Mazen Khalil
Non-small cell lung cancer metastasis to skeletal muscle is an uncommon occurrence. Lung cancers are more likely to spread to the brain, bone, liver, and adrenals. Here, we present a rare case of non-small cell lung cancer metastasis to the skeletal muscle in a 54-year-old male. In addition, we present a literature review on skeletal metastasis of non-small cell lung cancer. The most frequent presentation of skeletal muscle metastasis is muscular pain with or without swelling. The mechanism of metastasis to muscle is not well understood; it is theorized that hematogenous spread is the most likely route...
February 2024: Curēus
https://read.qxmd.com/read/38541718/non-infectious-pneumonitis-and-acute-respiratory-distress-syndrome-in-a-patient-on-ustekinumab-treatment-case-report-and-literature-review
#5
Valentina Cioffi, Giulia Di Napoli, Pierfrancesco Tozzi, Sabina Martelli, Katia Bruno, Andrea Longo, Helena Buso, Francesco Pugliese, Cinzia Milito
Ustekinumab is a monoclonal antibody targeting the p40 subunit of IL-12 and IL-23, approved for treating psoriasis, psoriatic arthritis, and inflammatory bowel disease. Despite a remarkable success in treating chronic inflammatory conditions and a generally favorable safety profile, its role in inducing rare adverse events, such as interstitial pneumonia and acute respiratory distress syndrome (ARDS), remains largely uncharted. We report a case of a 66-year-old male patient treated with Ustekinumab for severe psoriasis who, after almost two years of treatment, developed dyspnea, asthenia, and fever progressing to non-infectious pneumonia and ARDS leading to ICU admission...
March 16, 2024: Life
https://read.qxmd.com/read/38540362/the-eng-vegf%C3%AE-pathway-is-likely-affected-by-a-nonsense-variant-of-endoglin-eng-cd105-causing-hereditary-hemorrhagic-telangiectasia-type-1-hht1-in-a-chinese-family
#6
JOURNAL ARTICLE
Kemeng Liu, Jiewen Fu, Kan Guo, Mazaher Maghsoudloo, Jingliang Cheng, Junjiang Fu
Hereditary hemorrhagic telangiectasia (HHT), also called Rendu-Osler syndrome, is a group of rare genetic diseases characterized by autosomal dominance, multisystemic vascular dysplasia, and age-related penetrance. This includes arteriovenous malformations (AVMs) in the skin, brain, lung, liver, and mucous membranes. The correlations between the phenotype and genotype for HHT are not clear. An HHT Chinese pedigree was recruited. Whole exome sequencing (WES) analysis, Sanger verification, and co-segregation were conducted...
February 27, 2024: Genes
https://read.qxmd.com/read/38540243/immunological-similarities-and-differences-between-post-covid-19-lung-sequelae-and-idiopathic-pulmonary-fibrosis
#7
JOURNAL ARTICLE
Sara Gangi, Laura Bergantini, Paolo Cameli, Irene Paggi, Marco Spalletti, Fabrizio Mezzasalma, Elena Bargagli, Miriana d'Alessandro
INTRODUCTION: Pulmonary fibrosis is an irreversible condition that may be caused by known (including viral triggers such as SARS-CoV-2) and unknown insults. The latter group includes idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive fibrosing interstitial pneumonia of unknown cause. The longer the insult acts on lung tissue, the lower the probability of a complete resolution of the damage. An emerging clinical entity post-COVID-19 is pulmonary fibrosis (PCPF), which shares many pathological, clinical, and immunological features with IPF...
March 12, 2024: Biomedicines
https://read.qxmd.com/read/38538283/sexual-dimorphism-in-the-physiopathology-and-immune-response-during-acute-toxocara-canis-infection
#8
JOURNAL ARTICLE
Víctor Hugo Del Río-Araiza, Yazmín Alcalá-Canto, Claudia Angélica Garay-Canales, Karen Elizabeth Nava-Castro, Jorge Morales-Montor
BACKGROUND: Toxocara canis ( T. canis ) is a helminth parasite of zoonotic and veterinary health significance that causes the disease known as Toxocariasis. This disease has been associated with conditions of poverty, especially in tropical climate zones throughout the world. Although it rarely causes important clinical manifestations, T. canis can lead to blindness, meningoencephalitis, or other nervous manifestations in humans. Moreover, some studies show its importance in the development of tumor growth, which have been associated with the parasite's ability to modulate the host's immune response...
March 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38537149/urinary-bladder-involvement-in-igg4-related-disease-a-case-based-review
#9
JOURNAL ARTICLE
Parag Vijayvergia, Sayan Mukherjee, Lily Singh, Urmila Dhakad
Immunoglobulin G4-related disease (IgG4-RD) is an immune-driven fibroinflammatory disease that presents as tumefactive lesions that not only commonly affects the pancreas, lacrimal and salivary glands, lung, liver and kidney but can also affect any organs. However, involvement of the urinary bladder in IgG4-RD is rarely reported. We describe a case of IgG4-RD involving the urinary bladder mimicking carcinoma and review the published literature-a 39-year-old male presented with complaints of dysuria, urgency and hesitancy...
March 2, 2024: Modern rheumatology case reports
https://read.qxmd.com/read/38534712/multiple-drug-resistant-streptococcus-strains-an-actual-problem-in-pig-farms-in-western-romania
#10
JOURNAL ARTICLE
Luminita Costinar, Corina Badea, Adela Marcu, Corina Pascu, Viorel Herman
Streptococci are a type of bacteria that can cause severe illnesses in humans and animals. Some typical species like S. suis , or atypical species like S. porcinus and, S. dysgalactiae subsp. dysgalactiae , can cause infections like septicemia, meningitis, endocarditis, arthritis, and septic shock. S. suis is considered a newly emerging zoonotic pathogen. Although human streptococcal infection outbreaks are rare, it is appropriate to review the main streptococcal species isolated in pig farms in western Romania, due to the high degree of antibiotic resistance among most isolates commonly used in human treatment...
March 19, 2024: Antibiotics
https://read.qxmd.com/read/38534381/protein-stability-regulation-in-osteosarcoma-the-ubiquitin-like-modifications-and-glycosylation-as-mediators-of-tumor-growth-and-as-targets-for-therapy
#11
REVIEW
Jacopo Di Gregorio, Laura Di Giuseppe, Sara Terreri, Michela Rossi, Giulia Battafarano, Olivia Pagliarosi, Vincenzo Flati, Andrea Del Fattore
The identification of new therapeutic targets and the development of innovative therapeutic approaches are the most important challenges for osteosarcoma treatment. In fact, despite being relatively rare, recurrence and metastatic potential, particularly to the lungs, make osteosarcoma a deadly form of cancer. In fact, although current treatments, including surgery and chemotherapy, have improved survival rates, the disease's recurrence and metastasis are still unresolved complications. Insights for analyzing the still unclear molecular mechanisms of osteosarcoma development, and for finding new therapeutic targets, may arise from the study of post-translational protein modifications...
March 18, 2024: Cells
https://read.qxmd.com/read/38534077/synovial-sarcoma-of-the-viscera-lung-and-jejunum-a-case-report
#12
JOURNAL ARTICLE
Jixin He, Jiwei Wang, Lina Yang, Kai Wang, Maijian Wang, Jianguo Li
We report the case of a woman nearing 70 years old who was admitted to the hospital with a complaint of "epigastric distension for 1 month". Her main signs and symptoms were progressive abdominal distension and occasional abdominal pain. Computed tomography suggested an abdominal mass. She had a surgical history of synovial sarcoma (SS) of the lungs. After admission, she was diagnosed with jejunal SS following a puncture biopsy and laparoscopic surgery. This disease usually occurs in the soft tissues of the limbs, and it is extremely rare for SS to originate in the jejunum...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38532909/aluminosis-pneumoconiosis-presenting-as-hyperdense-lung-nodules
#13
Sara E Mantz, Matthew J DeVries
We present the case of a 66-year-old man who presented with new incidentally found hyperdense pulmonary nodules. Further workup with a PET/CT revealed that the nodules were FDG-avid and that there was associated hypermetabolic lymphadenopathy. Due to his history of aluminum toxicity from welding, aluminosis pneumoconiosis was suspected. Biopsy of one of the nodules was done which reinforced this diagnosis. Aluminosis pneumoconiosis is a rare occupational lung disease mostly associated with industrial workers with prolonged unprotected exposure to fine aluminum dust...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38532450/lymphangioleiomyomatosis-in-patients-with-tuberous-sclerosis-a-national-centre-audit
#14
JOURNAL ARTICLE
Jan Johnson, Wendy Somerfield, Simon R Johnson
BACKGROUND: Lymphangioleiomyomatosis (LAM) is common in tuberous sclerosis complex (TSC) yet under recognised with management mostly based upon evidence obtained from patients with sporadic LAM. We performed a prospective audit of patients with TSC-LAM attending a national referral centre to inform management guidelines. METHODS: The UK LAM Centre was established in 2011 and conducts a prospective audit of pre-defined quality outcomes for all subjects. Audit data are reported on all patients with TSC-LAM and a comparator population of patients with sporadic LAM...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38529652/diagnostic-strategy-for-suspected-unilateral-absence-of-the-pulmonary-artery
#15
JOURNAL ARTICLE
Van Luong Hoang, Viet Anh Lam, Thanh Nguyen Pham
UNLABELLED: <p>Background: Unilateral absence of the pulmonary artery (UAPA) is a very rare congenital anomaly. OBJECTIVE: To analyze the diagnostic strategy applied to seven patients with UAPA who were examined and subsequently treated at the National Lung Hospital, Hanoi, Vietnam. METHODS: All seven patients, including three pediatric cases (1, 2, and 14 years old) and four adult cases (21, 26, 44, and 53 years old), had a history of recurrent pneumonia, and the clinical symptoms on admission included cough, progressive dyspnea, chest pain, and fatigue...
March 19, 2024: Current medical imaging
https://read.qxmd.com/read/38529351/ers-international-congress-2023-highlights-from-the-interstitial-lung-diseases-assembly
#16
JOURNAL ARTICLE
Laura Fabbri, Julien Guiot, Marie Vermant, Ewa Miądlikowska, Deborah Estrella, Marlies S Wijsenbeek, Wim Wuyts, Elena Bargagli, Antoine Froidure, Paolo Spagnolo, Marcel Veltkamp, Maria Molina-Molina, Cormac McCarthy, Katerina Antoniou, Michael Kreuter, Catharina C Moor
This article summarises a selection of scientific highlights in the field of interstitial lung diseases (ILDs) presented at the International Congress of the European Respiratory Society in 2023. Translational and clinical studies focused on the whole spectrum of ILDs, from (ultra)rare ILDs to sarcoidosis, ILDs associated with connective tissue disease and idiopathic pulmonary fibrosis. The main topics of the 2023 Congress presentations were improving the diagnostic process of ILDs, better prediction of disease course and investigation of novel treatment options...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38527005/ocular-effects-of-mek-inhibitor-therapy-literature-review-clinical-presentation-and-best-practices-for-mitigation
#17
JOURNAL ARTICLE
Karen W Jeng-Miller, Miles A Miller, Jeffrey S Heier
MEK signaling pathway targeting has emerged as a valuable addition to the options available for the treatment of advanced cancers including melanoma and non-small cell lung cancer. Ophthalmologic monitoring of patients taking part in clinical trials of MEK inhibitors has shown that while ocular effects are common, generally emerging during the first days to weeks of treatment, the majority are either asymptomatic or have minimal visual impact and are benign, resolving without intervention or the need to reduce or stop MEK inhibitor therapy...
March 25, 2024: Oncologist
https://read.qxmd.com/read/38525763/pulmonary-involvement-in-recurrent-respiratory-papillomatosis-a-systematic-review
#18
REVIEW
Illari Sechi, Narcisa Muresu, Biagio Di Lorenzo, Laura Saderi, Mariangela Puci, Stefano Aliberti, Ivana Maida, Michele Mondoni, Andrea Piana, Giovanni Sotgiu
Recurrent respiratory papillomatosis (RRP) is a non-malignant disease, characterized by the production of wart-like growths in the respiratory tract, affecting both young people and adults (juvenile-onset recurrent respiratory papillomatosis, JORRP, and adult-onset recurrent respiratory papillomatosis, AORRP, respectively). Infection caused by human papillomavirus (HPV) is known as the main factor involved in RRP development. Complications of RRP may rarely occur, including lung involvement and malignant transformation...
February 28, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38525374/extensive-stage-small-cell-lung-cancer-with-cystic-brain-metastases-a-report-of-two-cases
#19
Fei Cai, Di Wu, Junling Liu, Shuxi Song, Jingyu Li, Zhendong Zheng, Long Xu
OBJECTIVE: Cystic brain metastases (BMs) are rare in small cell lung cancer (SCLC), and there are limited data on the treatment and prognosis of cystic BMs. Whole brain radiotherapy has been the mainstay for BMs since several years. Immune checkpoint inhibitors in extensive stage small cell lung cancer (ES-SCLC) have been shown to be suitable for patients who experienced better overall survival and progress-free survival and have been approved as the first-line treatment for ES-SCLC. In this report, we described two ES-SCLC patients developed cystic BMs after immunotherapy, after which the patients continued to treat the primary lesion with immune checkpoint inhibitors and the cystic BMs with radiotherapy...
2024: Cancer Management and Research
https://read.qxmd.com/read/38524073/unremitting-asthma-as-a-presentation-of-pulmonary-nocardiosis-a-case-report
#20
Sandus Khan, Aleksandra Ignatowicz, Nivedha Balaji, Christopher R Chew, Aleksandros Mihilli, Urvesh Patel
Severe, refractory asthma requires a combination of multiple maintenance inhalers and medications including high-dose inhaled corticosteroids and immunomodulators to achieve control of symptoms. The use of inhaled corticosteroids, however, increases the susceptibility of opportunistic bacterial infections, such as Nocardia , resulting in pulmonary nocardiosis. This case describes a 46-year-old patient with a history of severe, refractory asthma who presented with progressively worsening asthma exacerbation symptoms...
February 2024: Curēus
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