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Hussein Algahtani, Bader Shirah, Raghad Algahtani, Muhammad Imran Naseer, Mohammad H Al-Qahtani, Angham Abdulrahman Abdulkareem
Ataxia with ocular apraxia type 2 is an autosomal recessive disorder caused by a mutation in the senataxin ( SETX ) gene. The disease is characterized by early onset cerebellar ataxia, cerebellar atrophy, axonal sensorimotor neuropathy, oculomotor apraxia, and increased levels of α-fetoprotein. Reported here is a rare homozygous frameshift deletion c.5308_5311del, p.(Glu1770Ilefs*15) in the SETX gene in a Saudi family. Ataxia with ocular apraxia type 2 was diagnosed based on the patient's history, an examination, and genetic testing...
November 2018: Intractable & Rare Diseases Research
Raghad Hashim, Ayman Abo-Fanas, Ali Al-Tak, Amer Al-Kadri, Yousef Abu Ebaid
Objectives: The aim of this study was to evaluate the knowledge, opinions and practices of dentists regarding early detection of oral cancer in the United Arab Emirates (UAE). Method: A cross-sectional study was conducted using a simple random sampling technique with a self-reported questionnaire applied to 298 dentists, working in private and public sectors in three cities (Abu Dhabi, Dubai and Sharjah) in the UAE. Dentists’ knowledge about risk factors and diagnostic concepts of oral cancer, current practices and opinions as well as interest in continuing education programs were assessed...
August 24, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Raghad S Mohammed, Rasha S Ahmed, Rana O Abdaljalil
Studies have been conducted in some southern Iraqi governorates to measure the radioactive contamination in the soil and have revealed that these areas are contaminated with radioactive materials. In these test sites, where many military operations have been conducted and that may have been affected by the Chernobyl accident, pollution and its impact on the truffle crop have been examined. Truffles are fungi that grow in the ground and can be contaminated by radiation from polluted soil. Uranium, thorium, potassium, and cesium activities were analyzed in truffles collected from the desert of Samawah governorate in the southern part of Iraq, and the results were compared with global values...
September 2018: Journal of Food Protection
Raghad Dhyea Abdul Jalill
Different chemo-physical methods are used to synthesise titanium oxide nanoparticles (TiO2 NPs), which are often expensive, unfriendly to the environment, toxic, not biocompatible, with a small yield. To resolve these problems, the researchers use green procedures to synthesise TiO2 -NPs by plant extracts of Capsicum annum L. and Allium cepa (onion) and characterise using atomic force microscopy, scanning electron microscopy, transmission electronic microscopy, X-ray diffraction, ultraviolet (UV)-visible (Vis) spectra and Fourier transform infrared spectroscopy...
August 2018: IET Nanobiotechnology
Raghad N Saleh, Razan A Salameh, Heba H Yhya, Waleed M Sweileh
Background: Eating disorders (ED) are serious psychiatric disorders characterized by unhealthy eating habits. There is a limited number of studies on eating disorders among female university students in Arab countries. Therefore, the objective of this study was to examine the prevalence of disordered eating attitudes (EA) among female students at An-Najah National University, Palestine. Methods: A survey study on 2001 female students at An-Najah National University was carried out...
2018: Journal of Eating Disorders
Raghad Alkanhal, Ibrahim Alhoshan, Sadal Aldakhil, Nouf Alromaih, Nesrin Alharthy, Mahmoud Salam, Adel F Almutairi
Anaphylaxis is a systemic and hypersensitive allergic reaction caused by various triggers such as environmental, food, drug, and insects. The aim of this study was to identify the prevalence, triggers, and clinical severity of anaphylaxis in 2 emergency departments (EDs) in Saudi Arabia.A cross-sectional study based on a screening of medical records was conducted between January 2015 and August 2017, to identify confirmed cases of anaphylaxis. Patient characteristics were age, sex, previously known allergies, and the triggering allergens...
August 2018: Medicine (Baltimore)
Hussein Algahtani, Bader Shirah, Raghad Algahtani
Lacosamide is one of the third-generation antiseizure drugs that block voltage-gated sodium channels by enhancing slow inactivation. The most common adverse effects of lacosamide include dizziness, headache, nausea, vomiting, diplopia, fatigue, and sedation. Less common side effects include memory impairment, weight gain, rash, and atrioventricular block. In this article, we describe a patient with Lennox-Gastaut syndrome who developed excessive laughing as a rare side effect of lacosamide with complete resolution after discontinuation of the medication...
2018: Epilepsy & Behavior Case Reports
Rasha S Ahmed, Raghad S Mohammed, Rana O Abdaljalil
Clay soil samples (0, 30, and 60 cm depths) were collected from two districts (Abu Al Khasib and Ad Dayr) in Basrah governorate in southern Iraq for gamma-ray spectroscopy. The activity concentrations for natural existing radionuclides in 18 soil samples were measured using high-purity germanium detector HPGe. From the obtained results of γ -ray spectroscopy, the 238 U activity concentrations were found to be ranging from 2.4 to 5.6 ppm with an average of 3.5 ppm in Abu Al Khasib and ranging from 2.1 to 4...
2018: International Journal of Analytical Chemistry
Raghad M Nowar, Essam Eldin A Osman, Sahar M Abou-Seri, Samir M El Moghazy, Dalal A Abou El Ella
AIM: Novel quinazolinone and triazinoquinazolinone derivatives were designed and synthesized as apoptotic inducers. METHODOLOGY/RESULTS: Most of the synthesized compounds showed excellent antiproliferative activity against MCF-7 and HCT-116 cell lines, respectively. Compounds 7a, 8a, 8d, 14a and 14d were superior to doxorubicin as activators of caspases 3, 8 and 9 in HCT-116 cell line. The most potent caspase inducers, 8d and 14a showed cell cycle arrest mainly in G1 and S phase, respectively and increased the levels of p53, Bax and the Bax/Bcl-2 ratio compared with doxorubicin in HCT-116 cells with excellent selectivity against CCD-18Co human colon normal cell line...
May 1, 2018: Future Medicinal Chemistry
Nadia Al-Hazmi, Turki Alhazzazi, Gareth Williams, Kai Stoeber, Raghad Al-Dabbagh
Oral squamous cell carcinoma (OSCC) is still an unabated global killer with little advancement in its survival rate. DNA replication licensing proteins and Aurora kinase A are biomarkers that play important roles in genomic stability. The expression profile of minichromosomal maintenance protein 2 (MCM2), Ki67, geminin, and Aurora-A were linked to clinicopathological and outcome parameters, survival, and DNA content in 125 cases of OSCC. Oral fibroepithelial polyps (OFEP) were controls. The OSCC tumour cells were in a rapidly proliferating state, as assessed by the increased expression profile of MCM2, Ki67, geminin, and Aurora-A and of the geminin/Ki67 ratio, and the decrease of the MCM2/Ki67 ratio, in OSCC compared with OFEP (P < 0...
June 2018: European Journal of Oral Sciences
Ahmed M Kabel, Amani M Al Thumali, Khayriah A Aldowiala, Raghad D Habib, Shoroq S Aljuaid, Huda A Alharthi
A sleep disorder is a medical disorder of the sleep pattern of a person that may be serious enough to interfere with normal physical, mental and emotional functioning. Disruptions in sleep can be caused by a variety of causes, from teeth grinding to night terrors. Sleep disorders are usually prevalent among adolescents and young adults, possibly due to factors related to life style, dietary habits, hormonal and emotional disturbances. Other factors that may precipitate sleep disorders include environmental, psychological and genetic factors...
September 2018: Diabetes & Metabolic Syndrome
Raghad A Abdaljaleel, Morouj Al-Ajeeli, Yasser Jameel, Mohammed M Hashim, Christopher A Bailey
The objective of this study was to evaluate whether or not the use of a prebiotic yeast cell wall (YCW) affects threonine requirements in starter broilers. Two hundred and forty 1-d-old Ross 308 broiler chickens were distributed among 2 Petersime battery brooder units (48 pens; 5 birds per pen). Different threonine to lysine ratios (0.60, 0.65, and 0.70 to 1.0) with 1.22% available lysine with and without YCW at 250 ppm was fed to the chickens in order to evaluate performance and intestinal morphology over a 21-d trial...
July 1, 2018: Poultry Science
Ahmed M Kabel, Amani M Al Thumali, Khayriah A Aldowiala, Raghad D Habib, Shoroq S Aljuaid
AIM: The aim of this study was to assess the incidence of sleep disorders and excessive daytime sleepiness (EDS) among Taif University students and to explore the precipitating factors of these disorders. METHODS: This study was carried out on 1066 students in Taif University of both sexes aging from 18 to 25 years. All included individuals were subjected to full history taking and thorough clinical examination, with special concern on anthropometric measurements (weight, height, waist-to-hip ratio and body mass index)...
July 2018: Diabetes & Metabolic Syndrome
Raghad Mubarak Aljuhaysh, Nagah Mohamed Abo El-Fetoh, Malak Ibrahim Alanazi, Afaf Shuaib Albaqawi, Wafa Mohammed Alanazi, Najah Salah Alanazi, Reham Muqbil Alanazi, Atheer Mutab Alanazi, Eiman Mohammad Alnemer, Rahma Abdulhadi Alenezi, Tasleem Khoudier Alabdullatif, Rehab Abdallah Alanazi, Samiyah Sarhan Alanazi, Kawthar Saeed Alsultan, Ibtisam Matan Alanazi, Duaa Sami Alsunayni
Background and aim: Rh isoimmunization still contributes to the neonatal morbidity and mortality due to non-immunization, under-immunization, and in rare cases, false Rh typing. The main objective of this study was to determine the prevalence of Rh incompatibility, mothers' knowledge about Rh incompatibility, mothers' knowledge about anti-D immunoglobulin and to show the pregnancy outcome of Rh negative mothers. Methods: A cross-sectional study was carried out at the Maternity and Children Hospital in Arar city from November 2016 to May 2017...
December 2017: Electronic Physician
Abdulhadi A AlAmodi, Mohamad H Farhoud, Najwa Mohammad, Rawan Alatassi, Dana Alolayet, Noor AlQeshtaini, Raghad AlMamlouk, Mohamed Hussein Ahmed, Mahmoud Ashour, Sara S Kayyali, Abdullah AlShammari
BACKGROUND Leiomyomas are benign neoplasms of the smooth muscle. When found in the pulmonary system, a rare occurrence, leiomyomas can result in hypertrophic osteoarthropathy, or significant clubbing, associated with proliferation of long bone periosteum. Bronchopulmonary fistulas, or communications between the bronchial tree and pleural space, are an uncommon postoperative complication of pneumonectomies. Even more infrequent is the presence of a bronchopulmonary fistula that is determined to be sterile. CASE REPORT The patient presented in the current case report is a 40-year-old previously healthy woman who presented with a 5-year history of chronic cough, right-sided chest discomfort, and dyspnea associated with back pain, and lower leg pain...
March 9, 2018: American Journal of Case Reports
Samy A Azer, Raghad A Bokhari, Ghadah S AlSaleh, May M Alabdulaaly, Khawlah I Ateeq, Anthony P S Guerrero, Sarah Azer
The aims of this study were to determine the following: first, are there educationally useful videos of parents of children with autism sharing their experiences? Second, do any of the data related to videos help in identifying useful videos? And third, what do posted comments tell us? YouTube was searched for videos of parents sharing their experiences. The following parameters were collected: title, creator, URL, duration, number of viewers, likes, dislikes, comments, days on YouTube, and country. Based on agreed-upon criteria, videos were divided independently into educationally useful and non-useful categories...
September 2018: Informatics for Health & Social Care
Omar M Alabbasi, Maan Al-Barry, Raghad F Albasri, Haitham F Khashim, Mohammad M Aloufi, Mohammed F Abdulaal, Dareen W Alsaidalany, Adel S Alahmadi, Hanan Habeeb, Waseem A Aalam
Background: Data are required on ophthalmic cases that present to the emergency eye clinics in Madinah, Saudi Arabia for proper allocation of healthcare resources. Objectives: To determine the frequency and various diagnoses of patients presenting to the A&E at Ohud Hospital, Madinah, Saudi Arabia. Methods: Data was collected prospectively for all patients who presented to the A&E ophthalmology clinic from June 2014 to September 2014...
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Raghad M Abdul-Karim, C Lance Cowey
The last several years have seen a dramatic rise in the number of effective therapies that have been shown to improve survival outcomes for patients with advanced melanoma. Among these treatments are the immune checkpoint inhibitors, a new class of immunotherapy, that have demonstrated the ability to improve both response rates and survival outcomes. Pembrolizumab, an immune checkpoint inhibitor that blocks the negative regulatory PD-1 receptor on T-cell lymphocytes, has shown improved efficacy compared to standard therapies with an acceptable tolerability profile...
2017: Cancer Management and Research
Rajaa M Al-Raddadi, Noha A Dashash, Hani A Alghamdi, Zeyad M Al-Raddadi, Hanan S Alzahrani, Abdullah J Alsahafi, Abdullah M Algarni, Majed M Alghamdi, Raghad F Hakim, Abdulmohsen H Al-Zalabani, Fanar Hakim, Feras A Moria
The infection rate of the hepatitis C virus (HCV) in Saudi Arabia is among the lowest in the world. However, it is likely that poor knowledge and awareness of HCV infection could minimize the effectiveness of prevention and control programs in the kingdom. Thus, the study objective was to estimate the prevalence of HCV infection, and to assess current knowledge about it, in the targeted population. Data on 5482 Saudi people attending primary healthcare centers in Jeddah City in 2014/2015 were analyzed in this cross-sectional study...
March 2018: Journal of Medical Virology
Mohammadreza Mahaki, Gustavo Souto De Sá E Souza, Raghad Mimar, Marcus Fraga Vieira
This study aimed to compare the ground reaction forces (GRF) and lower limb muscles correlation and activation time delay between Forward (FW) and Backward (BW) walking. Twenty-four male students participated in this research. Electromyogram activities of gluteus medius, biceps femoris, medial gastrocnemius, soleus and anterior tibialis muscles along with GRFs were measured. Each participant performed two FW and two BW trials bare foot. Statistical parametric mapping (SPM) analysis was performed over anterior-posterior and vertical GRFs time series...
October 2017: Gait & Posture
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