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JOURNAL ARTICLE
Madison A Ward, Janakiram R Vangala, Hatem Elif Kamber Kaya, Holly A Byers, Nayyerehalsadat Hosseini, Antonio Diaz, Ana Maria Cuervo, Susmita Kaushik, Senthil K Radhakrishnan
Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring proteostasis. Our previous studies have established a firm role for the transcription factor Nuclear factor-erythroid derived-2-related factor-1 (Nrf1) in responding to proteotoxic stress elicited by inhibition of cellular proteasome. Following proteasome inhibition, Nrf1 mediates new proteasome synthesis, thus enabling the cells to mitigate the proteotoxic stress. Here, we report that under similar circumstances, multiple components of the autophagy-lysosomal pathway (ALP) were transcriptionally upregulated in an Nrf1-dependent fashion, thus providing the cells with an additional route to cope with proteasome insufficiency...
June 3, 2024: Journal of Cell Biology
#2
JOURNAL ARTICLE
Jean M Pujo, Frederic Lapostolle, Dewi Fitriani, Karim Tazarourte, Renauld Koswiranagara, Alexis Fremery, Rémi Mutricy, Boubacar Signaté, Antoine Burin, Dabor Resiere, Muchtaruddin Mansyur, Marsen Isbayuputra, Wawan Mulaywan, Bruno Megarbane, Hatem Kallel
Indonesia and French Guiana share many geographic and medical concerns regarding access to care. The organisational needs in emergency management, particularly in the prehospital phase, are similar. Whereas emergency medicine (EM) is an academic and entire speciality in France, it is still under construction in Indonesia. In the framework of the French and Indonesian academic cooperation, the Medical school in Jakarta University and the French Guiana University in Cayenne signed a Memorandum of Understanding encompassing education programmes, joint research work and students' and health professionals' exchanges in EM...
April 23, 2024: Emergency Medicine Australasia: EMA
#3
JOURNAL ARTICLE
Rehab Ahmed, Sawsan A Zaitone, Asmaa K K Abdelmaogood, Huda M Atef, Mona F M Soliman, Alaa M Badawy, Howaida S Ali, AbdelNaser Zaid, Hatem I Mokhtar, Lamiaa M Elabbasy, Emad Kandil, Asmaa Mokhtar Yosef, Rama I Mahran
Introduction: Betanin (C₂₄H₂₆N₂O₁₃) is safe to use as food additives approved by the FDA with anti-inflammatory and anticancer effects in many types of cancer cell lines. The current experiment was designed to test the chemotherapeutic effect of the combination of betanin with the standard chemotherapeutic agent, capecitabine, against chemically induced colon cancer in mice. Methods: Bioinformatic approach was designed to get information about the possible mechanisms through which the drugs may control cancer development...
2024: Frontiers in Pharmacology
#4
JOURNAL ARTICLE
Philipe S Breiding, Ana Maria Turrion Gomollon, Katharina Martini, Dominik Nakhostin, Hatem Alkadhi, André Euler
RATIONALE AND OBJECTIVES: To evaluate and compare the effectiveness of contrast media subtraction and kidney stone detection between a virtual non-iodine reconstruction algorithm (VNI; PureCalcium) and a virtual non-contrast (VNC) algorithm in excretory phase photon-counting detector computed tomography (PCD-CT), using a 3D printed kidney phantom under various tube voltages and radiation doses. MATERIALS AND METHODS: A 3D-printed kidney phantom, holding Calcium Oxalate (CaOx) and uric acid stones within contrast-enhanced calyces, was created...
April 18, 2024: Academic Radiology
#5
JOURNAL ARTICLE
Hatem Bouzaiene, Fatma Saadallah, Hanen Bouaziz, Olfa Jaidane, Jamel Ben Hassouna, Tarak Dhieb, Khaled Rahal
Breast cancer surgery is the primary treatment for early-stage breast cancer. However, inflammatory breast cancer (IBC), with its specific presentation characterized by skin invasion, is unfit for primary surgery. According to the different guidelines, the management of IBC is trimodal with the coordination of oncologists, surgeons, and radiation therapists. Advances in breast cancer imaging and the development of more targeted therapies make new challenges for this aggressive cancer. This chapter aims to provide an update on the role of surgery in IBC...
2024: International Review of Cell and Molecular Biology
#6
JOURNAL ARTICLE
Hatem A Zwai, Al-Sayed R Al-Attar, Abdulla E Morsi, Moustafa S Abou El-Fetouh
BACKGROUND: Cutaneous neoplastic disorders are often observed in small mammal pets, such as dogs, regardless of their gender. AIM: An important objective of this work was to give a full account of the clinical, pathological, and immune-histochemical features of several skin tumors in dogs. METHODS: This study was a case series in the hospital clinic, Faculty of Veterinary Medicine, Zagazig University, Egypt. Twenty-five dogs (14 males and 11 females) were examined clinically during the period from March 2022 to October 2023...
January 2024: Open Veterinary Journal
#7
JOURNAL ARTICLE
Lupo Manes, Sebastiano Fichera, Hatem Fakhruldeen, Andrew I Cooper, Paolo Paoletti
Robotic automation is proving itself indispensable in the modern Chemistry laboratory, but adoption is slowed down by the technical challenges of implementing such systems. This paper reports on a novel adaptive gripper mechanism that can easily and reliably grasp cylindrical and prismatic objects of various sizes with limited clearance required. The proposed design exploits the inherent compliance of a cable that is driven to fully envelope the target object. The cable is run through a rigid finger, allowing the loop to be placed around objects with minimal clearance required and to provide support for the object once the grip is complete...
April 17, 2024: Scientific Reports
#8
REVIEW
Giuseppe Muscogiuri, Jonathan R Weir-McCall, Mariia Tregubova, Sebastian Ley, Christian Loewe, Hatem Alkadhi, Rodrigo Salgado, Rozemarijn Vliegenthart, Michelle C Williams
Stable chest pain is a common symptom with multiple potential causes. Non-invasive imaging has an important role in diagnosis and guiding management through the assessment of coronary stenoses, atherosclerotic plaque, myocardial ischaemia or infarction, and cardiac function. Computed tomography (CT) provides the anatomical evaluation of coronary artery disease (CAD) with the assessment of stenosis, plaque type and plaque burden, with additional functional information available from CT fractional flow reserve (FFR) or CT myocardial perfusion imaging...
April 16, 2024: European Radiology
#9
JOURNAL ARTICLE
Subbarama Kousik Suraparaju, Hatem Ahmad Aljaerani, Mahendran Samykano, Kumaran Kadirgama, Muhamad Mat Noor, Sendhil Kumar Natarajan
Molten salts are the operational fluid for most concentrated solar power (CSP) systems, which has attracted more attention among the scientific community due to the augmentation of their properties with the doping of nanoparticles. Hexagonal boron nitride (h-BN) nanoparticles were dispersed in HITEC molten salt to create a novel nanofluid and evaluate the h-BN nanoparticles' influence on HITEC thermophysical properties. The influence of nanoparticle concentration (0.1, 0.5, and 1wt.%) of h-BN and HITEC was studied in this research...
April 16, 2024: Environmental Science and Pollution Research International
#10
Hugo Bes-Berlandier, Margaux Garzaro, Claire Rouzaud, Sylvain Bodard, Emmanuelle Bille, Maxence Ficheux, Dominique Cazals-Hatem, Nicolas Veziris, Fanny Lanternier, Olivier Lortholary
Immune reconstitution inflammatory syndrome (IRIS) has been reported in immunocompromised patients with disseminated Mycobacterium genavense . Management relies on high-dose corticosteroids. We describe two cases of late-onset corticosteroid-refractory IRIS related to disseminated infection in a HIV-positive patient and a renal transplant patient who had a favorable outcome with a monoclonal TNF-α blocker.
April 15, 2024: Heliyon
#11
JOURNAL ARTICLE
Claire Bongrain, Nathalie Guedj, Gaelle Pierron, Alain Sauvanet, Dominique Cazals-Hatem
No abstract text is available yet for this article.
April 15, 2024: Histopathology
#12
JOURNAL ARTICLE
Hatem Tallima, Menerva M Tadros, Rashika El Ridi
The study aimed to elicit protective immune responses against murine schistosomiasis mansoni at the parasite lung- and liver stage. Two peptides showing amino acid sequence similarity to gut cysteine peptidases, which induce strong memory immune effectors in the liver, were combined with a peptide based on S. mansoni thioredoxin peroxidase (TPX), a prominent lung-stage schistosomula excretory-secretory product, and alum as adjuvant. Only one of the 2 cysteine peptidases-based peptides in a multiple antigenic peptide construct (MAP-3 and MAP-4) appeared to adjuvant protective immune responses induced by the TPX peptide in a MAP form...
April 13, 2024: Acta Tropica
#13
JOURNAL ARTICLE
Melissa M Wolf, Matthew Z Madden, Emily N Arner, Jackie E Bader, Xiang Ye, Logan Vlach, Megan L Tigue, Madelyn D Landis, Patrick B Jonker, Zaid Hatem, KayLee K Steiner, Dakim K Gaines, Bradley I Reinfeld, Emma S Hathaway, Fuxue Xin, M Noor Tantawy, Scott M Haake, Eric Jonasch, Alexander Muir, Vivian L Weiss, Kathryn E Beckermann, W Kimryn Rathmell, Jeffrey C Rathmell
Clear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling and a tumor microenvironment (TME) highly enriched in myeloid and lymphoid cells. Loss of the von Hippel Lindau (VHL) gene is a critical early event in ccRCC pathogenesis and promotes stabilization of HIF. Whether VHL loss in cancer cells affects immune cells in the TME remains unclear. Using Vhl WT and Vhl-KO in vivo murine kidney cancer Renca models, we found that Vhl-KO tumors were more infiltrated by immune cells...
April 15, 2024: Journal of Clinical Investigation
#14
JOURNAL ARTICLE
Madona Pakkam, Atakan Orscelik, Basel Musmar, Hatem Tolba, Sherief Ghozy, Yigit Can Senol, Cem Bilgin, Sandeep Samethadka Nayak, Ramanathan Kadirvel, Waleed Brinjikji, Alejandro A Rabinstein, David F Kallmes
OBJECTIVES: Stroke is a leading cause of mortality and disability globally, with limited treatment options available for acute ischemic stroke (AIS) patients. Type 2 diabetes mellitus (T2DM) is not only widespread but also a known risk factor for stroke. Our meta-analysis aims to assess the influence of pre-stroke metformin use on the clinical outcomes in AIS patients with T2DM. MATERIALS AND METHODS: We conducted this study following PRISMA guidelines, searching the following databases: Medline, Embase, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials up to February 29, 2024...
April 9, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#15
JOURNAL ARTICLE
Georges Hatem, Ali Ankouni, Sethrida Salhab, Walaa Kteich, Sanaa Awada
INTRODUCTION: The Coronavirus disease of 2019 (COVID-19) pandemic has imposed several challenges leading to the shortage of medications due to the disruption of their supply chains. Among others, patients using psychotropics encountered difficulties finding their medication despite the efforts of investing in local production. Encouraging patients to use generic drugs can be an effective strategy to ensure sustainable access to medication. OBJECTIVES: This study aimed to describe the consumption of psychotropic medications during the COVID-19 pandemic and the willingness together with the reasons for using generic drugs...
June 2023: Journal of Generic Medicines
#16
Arif Albulushi, Shabib Al-Asmi, Moosa Al-Abri, Hatem Al-Farhan
Our case report details the journey of a 16-year-old male patient with Shone complex and advanced heart failure. We highlight the pivotal role of the HeartWare Ventricular Assist Device (Medtronic) implantation in mitigating severe pulmonary hypertension, thereby facilitating his eligibility for a heart transplant. We discuss the subsequent management of post-transplant pulmonary hypertension and right ventricular dysfunction using targeted pulmonary vasodilators and inotropic support, underscoring the intricacies of postoperative care in pediatric heart transplant patients...
May 15, 2024: JACC. Case reports
#17
JOURNAL ARTICLE
Anissa Hannachi, Youness El Bakri, Kandasamy Saravanan, Carlos J Gómez-García, Hatem A Abuelizz, Rashad Al-Salahi, Wajda Smirani
Here we present the magnetic properties of two cobalt complexes formulated as: [Co(SCN)2 (L)2 ] (1) and (H2 L)2 [Co(SCN)4 ]·H2 O (2) (L = 1-(2-pyrimidyl)piperazine). The two compounds contain isolated tetrahedral CoII complexes with important intermolecular interactions that lead to the presence of a canted antiferromagnetic order below 11.5 and 10.0 K, with coercive fields at 2 K of 38 and 68 mT, respectively. Theoretical calculations have been used to explain this behaviour. Hirshfeld surface analysis shows the presence of strong intermolecular interactions in both compounds...
April 3, 2024: RSC Advances
#18
JOURNAL ARTICLE
Hayder K Hassoun, Anmar Oday Hatem, Akram Al-Mahdawi, Sarwer Jamal Al-Bajalan, Ali Kadim Karim, Sarmad Abdulrasool Al-Mashta, Saif Mohammed Tawfeeq, Majeed Salih Hamad, Nawfal M Sheaheed, Samer Mohammed Ridha, Murad Al-Naqshbandi, Hasan Aziz Al-Hamadani
In Iraq, a lack of evidence-based management protocols for diagnosing, treating, and managing multiple sclerosis (MS) poses risks of suboptimal outcomes and clinical practice variability and potential harm to the patients. This study aimed to develop consensus recommendations regarding the diagnosis and management of MS in Iraq, specifically focusing on treatment-naïve patients, suboptimal responders, and women of childbearing age during preconception, pregnancy planning, and lactation. A survey was conducted to collect feedback from a panel of ten key opinion leaders (KOLs), who evaluated and discussed the statements to determine agreement levels...
April 11, 2024: Current Medical Research and Opinion
#19
JOURNAL ARTICLE
Maged Abdel Naseer, Hatem Samir Shehata, Sarah Khalil, Amr Mohamed Fouad, Hend Abdelghany
BACKGROUND: Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system. It is characterized by symptoms such as visual disturbances, paresis with spasticity, paresthesia, numbness, and fatigue. However, several studies have shown a high prevalence of headaches in individuals with MS. Migraine and tension-type headaches are the most frequent types of headaches experienced by those with MS. Additionally, the role of MS disease-modifying agents must be considered...
April 3, 2024: Multiple Sclerosis and related Disorders
#20
JOURNAL ARTICLE
Dominik Linz, Jason G Andrade, Elena Arbelo, Giuseppe Boriani, Guenter Breithardt, A John Camm, Valeria Caso, Jens Cosedis Nielsen, Mirko De Melis, Tom De Potter, Wolfgang Dichtl, Søren Zoega Diederichsen, Dobromir Dobrev, Nicolas Doll, David Duncker, Elke Dworatzek, Lars Eckardt, Christoph Eisert, Larissa Fabritz, Michal Farkowski, David Filgueiras-Rama, Andreas Goette, Eduard Guasch, Guido Hack, Stéphane Hatem, Karl Georg Haeusler, Jeff S Healey, Hein Heidbuechel, Ziad Hijazi, Lucas H Hofmeister, Leif Hove-Madsen, Thomas Huebner, Stefan Kääb, Dipak Kotecha, Katarzyna Malaczynska-Rajpold, José Luis Merino, Andreas Metzner, Lluís Mont, Ghulam Andre Ng, Michael Oeff, Abdul Shokor Parwani, Helmut Puererfellner, Ursula Ravens, Michiel Rienstra, Prashanthan Sanders, Daniel Scherr, Renate Schnabel, Ulrich Schotten, Christian Sohns, Gerhard Steinbeck, Daniel Steven, Tobias Toennis, Stylianos Tzeis, Isabelle C van Gelder, Roderick H van Leerdam, Kevin Vernooy, Manish Wadhwa, Reza Wakili, Stephan Willems, Henning Witt, Stef Zeemering, Paulus Kirchhof
AIMS: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). METHODS AND RESULTS: Eighty-three international experts met in Münster for 2 days in September 2023...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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