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Hatem Shili, Sonia Ben Hadj Hassen, Taycir Daoud, Hichem Denguir, Françoise Ounalli
The Tunisian health care system is experiencing a significant period of change and needs reforms so as to adapt. The nursing profession, which is the main actor of this system, in terms of number and function, is barely known or utterly unknown. The present paper's authors, who are paramedical teachers, aim to shed light on the specificity of the nursing and the nursing profession based on data collecting, and rare articles and legislation texts. In four sections, the paper will discuss the following issues: the nursing population demography, providing several indicators, their training throughout the reforms period, their training which has been "hooked" to university studies, their job profile and career plan...
October 2018: La Tunisie Médicale
Alex L Suherman, Giorgia Zampardi, Hatem M A Amin, Neil P Young, Richard G Compton
We report the key role of the capping agent in the detection of metal cations using tannic acid (TA) capped gold nanoparticles at both ensembles (using cyclic voltammetry) and with individual particles (using oxidative and reductive nanoimpacts). The results show that the capping agent complexes with Zn2+ and Hg2+ in a reversible and Langmuirian manner in both cases. The sensitivity of detection is determined by the amount of capping agent present on the nanoparticles with similar values seen for both oxidation and reduction reactions...
February 8, 2019: Physical Chemistry Chemical Physics: PCCP
Wagdy M Eldehna, Ghada S Hassan, Sara T Al-Rashood, Tarfah Al-Warhi, Ahmed E Altyar, Hamad M Alkahtani, Abdulrahman A Almehizia, Hatem A Abdel-Aziz
In connection with our research program on the development of novel anticancer candidates, herein we report the design and synthesis of novel series of 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas 5a-l. The target pyridins were evaluated for their in vitro anticancer activity against two cancer cell lines: non-small cell lung cancer A549 cell line and colon cancer HCT-116 cell line. Compound 5l emerged as the most active congener towards both A549 and HCT-116 cell lines with IC50 values equal to 3.22 ± 0...
December 2019: Journal of Enzyme Inhibition and Medicinal Chemistry
M Boukobza, S Goutagny, D Cazals-Hatem, J-P Laissy
We report an unusual case of a frontal partially calcified pilocytic astrocytoma (PA) (WHO grade 1) in an 18-year-old woman who presented with acute, spontaneous intracerebral hemorrhage. Histopathology revealed the PA was mixed with psammoma bodies and areas of vascular proliferation responsible for a hypervascular pattern. The patient underwent a total gross resection. MRI showed no residual tumor at the 18-month follow-up and her neurological deficits improved after rehabilitation. Only 20 cases, including ours, of hemorrhagic presentation of PA in adults have been reported to date with enough radiological data...
January 30, 2019: Neuro-Chirurgie
Mohamed E Mostafa, Ahmed A Shaaban, Hatem A Salem
The current study was designed to assess the antifibrotic effect of dimethylfumarate (DMF) on CCl4 -induced hepatic injury in rats. Hepatic injury was induced by intraperitoneal twice weekly injection of CCl4 for 2 and 3 months. DMF was administered orally during the last 4 weeks in each model. Liver injury was estimated using biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), total serum bilirubin (TSB), total protein, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)...
January 28, 2019: Chemico-biological Interactions
Hatem Elalfy, Mohamed Abd El-Maksoud, Sally Abed, Mohammed Abd El Aziz, Ayman Z Elsamanoudy, Salwa Abo-Khair, Mie A Mohamed, Wagdi Elkashef, Khaled Zalata, Raghda Farag, Mona Arafa
INTRODUCTION: Previous studies examining the prevalence of serum autoantibodies in patients with NAFLD reported a wide range of prevalence rates depending on the threshold values used for an abnormal titer. We aimed to evaluate the association of anti-smooth muscle antibodies (ASMAbs) with pathological changes including liver fibrosis in NAFLD patients. PATIENTS AND METHODS: 124 patients were enrolled and classifed on ASMAbs positive (>1/40) or negative (= or <1/40)...
January 31, 2019: British Journal of Biomedical Science
Hatem Shalaby, Amira El Namaky, Omnia Kandil, Noha Hassan
Background: The effectiveness of anthelmintics may diminish within approximately 10 yr of use relying on several factors such as anthelmintic resistance. This study aimed to assess in vitro effect of Balanites aegyptiaca fruits extract on the cuticle of adult worm of Toxocara canis as naturally alternative therapy. Methods: B. aegyptiaca fruits were procured from the local markets in Aswan, Upper Egypt and authenticated at the Herbarium of National Research Centre...
October 2018: Iranian Journal of Parasitology
M Sankari, H Hridya, P Sneha, C George Priya Doss, J Godwin Christopher, Jill Mathew, Hatem Zayed, Siva Ramamoorthy
The effect of salt stress on pigment synthesis and antioxidant enzyme activity as well as in the genes involved in the biosynthetic pathway of bixin was studied. The 14-day germinated seedlings of Bixa orellana were induced into the various NaCl concentration (0, 25, 50, 75, 100 mM). After 45 days, leaves were taken for pigment analysis, antioxidant assays, and gene expression analysis to study the response of salt stress. The pigment content such as chlorophyll level was increased upon salt stress with a reduction in total carotenoid clearly indicating the adaptability of plants towards the stressed state...
January 29, 2019: Functional & Integrative Genomics
Mohammad Abd Alkhalik Basha, Rania Refaat, Ayman F Ahmed, Hala Y Yousef, Ahmed Mohamed Alsowey, Maha Ibrahim Metwally, Sameh Abdelaziz Aly, Hatem M Hussien, Hosam F El-Saadany, Asghan A AlGhobashy, Mohamed A Talat, Mona M Amer, Ashraf Mahrous Eid
PURPOSE: Although brain magnetic resonance spectroscopy (MRS) imaging findings in adult Wilson disease (WD) have been explained in extensive details, a paucity of information currently exists regarding brain MRS imaging findings in pediatric WD. The purpose of this study was to clarify the role of brain MRS in detecting early metabolite abnormalities in children with WD. PATIENT AND METHODS: A case-controlled prospective study included 26 children with WD and 26 healthy controls...
February 2019: European Journal of Radiology
Solabomi Olaitan Ogunyemi, Yasmine Abdallah, Muchen Zhang, Hatem Fouad, Xianxian Hong, Ezzeldin Ibrahim, Md Mahidul Islam Masum, Afsana Hossain, Jianchu Mo, Bin Li
The synthesis of metal oxide nanoparticles with the use of plant extract is a promising alternative to the conventional chemical method. This work aimed to synthesize zinc oxide nanoparticles (ZnONPs) using plant extract of chamomile flower (Matricaria chamomilla L.), olive leave (Olea europaea) and red tomato fruit (Lycopersicon esculentum M.). The synthesized ZnONPs were characterized by UV-Visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) with EDS profile...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
P Millet, M Vinchant, S Sharifzadehgan, S Vieillefosse, G Hatem-Gantzer, X Deffieux
INTRODUCTION: The purpose of this article is to summarise the data available in literature on Lower Urinary Tract Symptoms [lower urinary tract symptoms (LUTS)] after female genital mutilation (MSF). METHODS: Our review identified 177 publications, 14 of which were included in the article. RESULTS: With regard to short-term complications, the prevalence of Acute Urinary Retention (RAU) after MSF is estimated between 3% and 12%. With respect to long-term complications, the data is discordant on repeat urinary tract infections (IUR) after MSF with an estimated prevalence between 9% and 39%...
January 22, 2019: Progrès en Urologie
Ricardo Costa, Saif Zaman, Susan Sharpe, Irene Helenowski, Colleen Shaw, Hyo Han, Hatem Soliman, Brian Czerniecki
Human epidermal growth factor receptor 2 (HER2)-targeted vaccines are under development, but have so far demonstrated only modest clinical efficacy. Additionally, there has been a lack of adequate safety assessment in large-scale prospective clinical trials. Therefore, we performed a meta-analysis of available clinical trial data to summarize the toxicity profiles of these treatments. Literature search was conducted in February 2018. The trials analyzed had at least one study arm consisting of HER2 vaccine monotherapy...
2019: Drug Design, Development and Therapy
Laurent Ettouati, Zoé Senta-Loys, Sandrine Bourgeois, Bernard Fenet, Marc Le Borgne, Hatem Fessi
Thorough studies of previous analytical stress data of tetrabenazine, a dopamine depleting agent, showed a potential susceptibility to acidic conditions. Hence, the behavior of tetrabenazine acidic solutions was studied by LC-MS and NMR spectroscopy. Reverse-phase LC-MS analysis of tetrabenazine acidic aqueous solutions consistently showed a main lipophilic impurity in a proportion of 15 to 20%. NMR spectroscopy studies did not allow to completely ascertain its structure. However, we hypothesize an interconversion of trans -tetrabenazine with its unstable cis isomer via an open isoquinolinium intermediate...
January 20, 2019: Pharmaceutics
Abdulrahman A Almehizia, Hatem A Abuelizz, Hanan A A Taie, Anouar ElHassane, Mohamed Marzouk, Rashad Al-Salahi
Previously, a series of 2-phenoxy-benzo[ g ]triazoloquinazolines 1-16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1 - 16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity...
January 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Hatem A F M Hassan, Sandra S Diebold, Lesley A Smyth, Adam A Walters, Giovanna Lombardi, Khuloud T Al-Jamal
Tumour-specific, immuno-based therapeutic interventions can be considered as safe and effective approaches for cancer therapy. Exploitation of nano-vaccinology to intensify the cancer vaccine potency may overcome the need for administration of high vaccine doses or additional adjuvants and therefore could be a more efficient approach. Carbon nanotube (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and nanometers to micrometers long. Stemming from the observed capacities of CNTs to enter various types of cells via diversified mechanisms utilising energy-dependent and/or passive routes of cell uptake, the use of CNTs for the delivery of therapeutic agents has drawn increasing interests over the last decade...
January 16, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Hany S Ibrahim, Mohamed E Albakri, Walaa R Mahmoud, Heba Abdelrasheed Allam, Ahmed M Reda, Hatem A Abdel-Aziz
Benzimidazole is an interesting scaffold constituting a main core in many anticancer agents against variable cell lines as Carbendazim (I) and Nocodazole (II). Accordingly, eighteen compounds of 2-((1H-benzoimidazol-2-yl)thio)-1-(aryl/heteroaryl)ethan-1-ones, in their sulfate salt and free forms, were designed and investigated as anticancer agents. In vitro preliminary screening of selected compounds by the National Cancer Institute (NCI) on a panel of 60 cell lines revealed renal cancer cell line (A498) as the most vulnerable cell line; accordingly, IC50 values against A498 cell line were determined for compounds with the best results...
January 8, 2019: Bioorganic Chemistry
Manar Al-Lawama, Jumana Albaramki, Mutaz Altamimi, Hatem El-Shanti
A three-day-old newborn girl presented with decreased feeding and dehydration. She was sick and in shock. She had renal impairment and hypernatremia. With the resumption of breast feeding, she developed watery stools and hypernatremia. Glucose-Galactose Malabsorption was suspected and confirmed by the presence of a likely pathogenic homozygous variant in SLC5A1 .
January 2019: Clinical Case Reports
Morgane van Wettere, Yvonne Purcell, Onorina Bruno, Audrey Payancé, Aurélie Plessier, Pierre-Emmanuel Rautou, Dominique Cazal-Hatem, Dominique Valla, Valérie Vilgrain, Maxime Ronot
BACKGROUND & AIM: To evaluate the diagnostic value of washout for the discrimination between benign and malignant lesions in patients with Budd-Chiari syndrome (BCS). METHODS: This IRB-approved retrospective study included all patients admitted to our institution with a diagnosis of BCS and focal lesions on MR imaging (MRI) from 2000 to 2016. MRI images were reviewed by two radiologists blinded to the nature of the lesions. Patient and lesion characteristics were recorded, with a focus on washout on portal venous and/or delayed phases...
January 14, 2019: Journal of Hepatology
D Thirumal Kumar, E Judith, J Priyadharshini Christy, R Siva, Iftikhar Aslam Tayubi, Chiranjib Chakraborty, C George Priya Doss, Hatem Zayed
Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in α-galactosidase A (GLA) protein were widely found to be causative for the Fabry's disease. These mutations result in alternate splicing methods that affect the stability and function of the protein. The mutations near the active site of the protein results in protein misfolding. In this study, we have retrieved the missense mutation data from the three public databases (NCBI, UniProt, and HGMD). We used multiple in silico tools to predict the pathogenicity and stability of these mutations...
2019: Advances in Protein Chemistry and Structural Biology
D Thirumal Kumar, Sharada Iyer, J Priyadharshini Christy, R Siva, Iftikhar Aslam Tayubi, C George Priya Doss, Hatem Zayed
Gaucher's disease (GD) is the most commonly known lysosomal disorder that occurs due to mutations in the β-glucocerebrosidase (GBA) protein. Our previous findings (Thirumal Kumar, Eldous, Mahgoub, George Priya Doss, Zayed, 2018) and other reports concluded that the mutations N370S and L444P are the most significant mutations that could cause disruptions in protein stability and structure. These disruptions lead to protein misfolding and result in a diseased condition. Enzyme Replacement Therapy (ERT) and Pharmacological chaperone therapy (PCT) are currently used to treat GD caused by mutations in the GBA protein...
2019: Advances in Protein Chemistry and Structural Biology
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