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CCN1 microtubule

Wan Jie Li, Yan Ming Wang, Xin De Zheng, Qing Mei Shi, Ting Ting Zhang, Chen Bai, Di Li, Jian Li Sang, Yue Wang
Both G1 and mitotic cyclins have been implicated in regulating Candida albicans filamentous growth. We have investigated the functions of Grr1 whose orthologue in Saccharomyces cerevisiae is known to mediate ubiquitin-dependent degradation of the G1 cyclins Cln1 and Cln2. Here, we report that deleting C. albicans GRR1 causes significant stabilization of two G1 cyclins Ccn1 and Cln3 and pseudohyphal growth. grr1Delta cells are highly heterogeneous in length and many of them fail to separate after cytokinesis...
October 2006: Molecular Microbiology
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