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Einat Levy, Eyal Sela, Vadim Letichevsky, Ohad Ronen
BACKGROUND: The currently accepted treatment for idiopathic sudden sensorineural hearing loss (ISSHL) is systemic steroids as first-line and intratympanic steroids as salvage therapy. Intratympanic (IT) treatment is applied worldwide in many different ways with no universally accepted protocol. OBJECTIVES: To present the current disparity in ISSHL management and to discuss the necessity for establishing a common national protocol. METHODS: In 2014 we conducted a national survey by sending questionnaires on ISSHL management to otologists in every otolaryngology department in the country...
February 2019: Israel Medical Association Journal: IMAJ
Zahava Vadasz, Alexandra Balbir Gurman, Pierluigi Meroni, Dominique Farge, Yair Levi, Francesca Ingegnoli, Yolada Braun-Moscovici, Itzhak Rosner, Gleb Slobodin, Michael Rozenbaum, Nizar Jiries, Lisa Kaly, Nina Boulman, Karina Zilber, Shira Ginsberg, Abid Awisat, Yair Goldberg, Michael Lurie, Maria-Rosa Ghigna, Christophe Guignabert, Marc Humbert, Doron Rimar
OBJECTIVE: Lysyl oxidase (LOX) is an extracellular enzyme that cross-links collagen fibrils. LOX was found to be increased in serum of SSc patients and was suggested to be related to skin fibrosis, yet a vascular source of LOX has been demonstrated in idiopathic pulmonary arterial hypertension (iPAH). We aimed to validate elevated LOX serum levels in SSc and to study its correlation with clinical characteristics and investigate its main source at the tissue level. METHODS: A total of 86 established SSc patients were compared with 86 patients with very early diagnosis of systemic sclerosis (VEDOSS), 110 patients with primary RP (PRP) and 80 healthy controls...
February 15, 2019: Rheumatology
Jordi Ruiz-Camp, Jennifer Quantius, Ettore Lignelli, Philipp F Arndt, Francesco Palumbo, Claudio Nardiello, David E Surate Solaligue, Elpidoforos Sakkas, Ivana Mižíková, José Alberto Rodríguez-Castillo, István Vadász, William D Richardson, Katrin Ahlbrecht, Susanne Herold, Werner Seeger, Rory E Morty
Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth characterized by arrested lung alveolarization, which generates lungs that are incompetent for effective gas exchange. We report here deregulated expression of miR-34a in a hyperoxia-based mouse model of BPD, where miR-34a expression was markedly increased in platelet-derived growth factor receptor (PDGFR)α-expressing myofibroblasts, a cell type critical for proper lung alveolarization. Global deletion of miR-34a; and inducible, conditional deletion of miR-34a in PDGFRα+ cells afforded partial protection to the developing lung against hyperoxia-induced perturbations to lung architecture...
February 15, 2019: EMBO Molecular Medicine
Alexander S Reshetnikov, Natalia P Solntseva, Olga N Rozova, Ildar I Mustakhimov, Yuri A Trotsenko, Valentina N Khmelenina
The genes encoding adenosine triphosphate (ATP)- and polyphosphate (polyP)-dependent glucokinases (Glk) were identified in the aerobic obligate methanotroph Methylomonas sp. 12. The recombinant proteins were obtained by the heterologous expression of the glk genes in Esherichia coli . ATP-Glk behaved as a multimeric protein consisting of di-, tri-, tetra-, penta- and hexamers with a subunit molecular mass of 35.5 kDa. ATP-Glk phosphorylated glucose and glucosamine using ATP (100% activity), uridine triphosphate (UTP) (85%) or guanosine triphosphate (GTP) (71%) as a phosphoryl donor and exhibited the highest activity in the presence of 5 mM Mg2+ at pH 7...
February 14, 2019: Microorganisms
Wanchana Singhan, Somratai Vadcharavivad, Nutthada Areepium, Supeecha Wittayalertpanya, Weerachai Chaijamorn, Nattachai Srisawat
PURPOSE: To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH). MATERIAL AND METHODS: After intravenous infusion of 1 g meropenem over 3 h repeated every 8 h for at least 3 doses, 2 serial blood and ultrafiltration fluid samples were collected: one over a dose interval of meropenem with DHP-PMX therapy; and the other on the following day over a dose interval of meropenem with no DHP-PMX therapy...
February 5, 2019: Journal of Critical Care
Beniamino Palmieri, Carmen Laurino, Maria Vadalà
OBJECTIVES: Our main aim was to investigate the short-term therapeutic effects, safety/tolerability and potential side effects of the cannabis galenical preparation (Bedrocan) in patients with a range of chronic conditions unresponsive to other treatments. METHODS: In this retrospective, 'compassionate use', observational, open-label study, 20 patients (age 18-80 years) who had appealed to our 'Second Opinion Medical Consulting Network' (Modena, Italy), were instructed to take sublingually the galenical oil twice a day for 3 months of treatment...
February 15, 2019: International Journal of Pharmacy Practice
Vadim B Krylov, Arsenii S Solovev, Dmitry A Argunov, Jean-Paul Latgé, Nikolay E Nifantiev
Great progresses have been made in the recent years in the detection of circulating galactofuranose-bearing molecules for the diagnosis of aspergillosis. However, the test used in the clinical practice is hampered by the occurrence of false positives. A glycoarray with dozens of oligosaccharides structurally related to the Aspergillus fumigatus galactomannan has allowed us to reinvestigate the carbohydrate specificity of the EB-A2 monoclonal antibody used in the PlateliaTM Aspergillus sandwich immune assay...
January 2019: Heliyon
Elena N Danilovtseva, Viktor A Pal'shin, Uma M Krishnan, Vadim V Annenkov, Stanislav N Zelinskiy
Polymeric amines and complex amine containing system are actively studied and applied as gene delivery agents in gene therapy and genetic engineering. Optimizing polymer - nucleic acid ratio is the key stage in elaboration of procedures in this area. Application of fluorescent tagged oligonucleotides is widespread approach which allows to visualize nucleic acid in gel electrophoresis experiments and to find conditions of the full binding of the nucleic acid. We suggest to use succinimidyl ester of 7-(diethylamino)coumarin-3-carboxylic acid as an agent for fluorescent labeling of polymeric amines and to use the tagged polymers in optimizing polymer - nucleic acid ratio...
2019: MethodsX
Vadivel Selvamani, Venkatachalam Rajagopal, Noel Nesakumar, David Velayutham, Vembu Suryanarayanan
Electrodeposition of lanthanum (La) thin film had been successfully carried out in the triethylmethy-lammonium methyl sulfate (TEMAMS) ionic liquid on boron-doped diamond (BDD), glassy carbon (GC) and platinum (Pt) electrodes. The electrolyte shows highest electrochemical stability window of 4.88 V on the BDD, followed by the GC (4.5 V) and Pt (4.1 V). The electrochemical reduction of La(III) ions takes place significantly at a less positive potential on the BDD than the GC, while on the Pt electrode, predominant decomposition current associated with electrochemical reduction/oxidation of TEMAMS dominates the overall process...
July 1, 2019: Journal of Nanoscience and Nanotechnology
Monaj Kumar Sarkar, Vellingiri Vadivel, Mamilla R Charan Raja, Santanu Kar Mahapatra
In the present work, 16 different plant drugs used by traditional healers from West Bengal were screened through in vitro cell line model. Herbal drugs used by traditional tribal healers in Purulia, Birbhum and Bankura districts of West Bengal were collected and screening against acute myeloid leukemia (AML) cell line (HL-60). Among 16 plant extracts, bark of Flacourtia indica (66.67%), leaf of Madhuca longifolia (69.17%), and leaf of Prosopis cineraria (68.08%) showed better cytotoxicity results than other herbals...
February 15, 2019: Natural Product Research
Tianyu Zhou, Yan Hu, Yunxia Wang, Chao Sun, Yijue Zhong, Jiping Liao, Guangfa Wang
Fine particulate matter (PM2.5 ) is an essential risk factor of chronic obstructive pulmonary disease (COPD). Recent studies showed weak association between PM2.5 and COPD incidence, but smokers who exposed to higher PM2.5 concentration had more opportunity to gain COPD. Cigarette smoking is the most important risk factor of COPD. Thus, we hypothesized: the role of PM2.5 played on cigarette-inflamed airways was more significant than normal airways. The study firstly established an animal model of C57BL/6J mice with cigarette smoke exposure and PM2...
November 21, 2018: Environmental Pollution
Anwin Joseph Kavanal, Joyita Bharati, Shelvin Kumar Vadi, Krishan Lal Gupta, Rajender Kumar, Bhagwant Rai Mittal
We present a case of a 22-year-old man with history of allogenic renal transplantation on immunosuppression, who underwent F-FDG-PET/CT to characterize a lesion in the transplanted kidney on ultrasonogram and contrast-enhanced computed tomography imaging. PET/CT revealed FDG avid lesion in the transplanted kidney and mural thickening involving the distal ileum, ileocecal junction, and ileocolic lymph nodes. Subsequent histopathological examination from the renal lesion revealed renal cell carcinoma in the transplanted kidney...
February 8, 2019: Clinical Nuclear Medicine
Gurmukh Singh, Priti Arun, Subhash Das, Damanjeet Kaur
OBJECTIVE: The objective of the study is to predict the early changes in electroencephalography (EEG) at 1 week and its correlation to clinical response at 6 weeks after treatment with atomoxetine in children with ADHD. METHOD: In 50 children (6-14 years) with ADHD ( Diagnostic and Statistical Manual of Mental Disorders [5th ed.; DSM-5]), Vanderbilt ADHD Parent Rating Scale (VADPRS) and Vanderbilt ADHD Teachers Rating Scale (VADTRS) were applied at baseline, 1, 4, and 6 weeks...
February 14, 2019: Journal of Attention Disorders
Gregor Poglajen, Igor D Gregoric, Rajko Radovancevic, Bojan Vrtovec
Ventricular assist device (VAD) technology has evolved significantly over the past decades and currently represents one of the most important treatment strategies for patients with advanced chronic heart failure. There is increasing evidence that in selected patients undergoing long-term VAD support, improvement of myocardial structure and function may occur. However, there seems to be a significant discrepancy between structural and functional recovery of the failing myocardium, as only a small fraction of VAD-supported patients demonstrate reverse structural remodeling and eventually reach clinically significant and stable, functional improvement...
February 2019: Circulation. Heart Failure
Anna E Saw, Andrew S McIntosh, Alex Kountouris, Phil Newman, James E Gaida
BACKGROUND: Vertebral artery dissection (VAD) is a potentially catastrophic injury that may occur during sports participation. A comprehensive review is needed to collate documented cases to improve understanding and inform future preventative approaches. OBJECTIVE: This review aimed to understand the extent of VAD in sport and characterise trends suggestive of mechanisms of injury. METHODS: Electronic databases were searched using terms related to VAD and sport...
February 13, 2019: Sports Medicine
Alexey Gusev, Ivan Nemec, Radovan Herchel, Victor Shul'gin, Irina Ryush, Michail Kiskin, Nickolay Efimov, Elena Ugolkova, Vadim Minin, Konstantin Lyssenko, Igor Eremenko, Wolfgang Linert
The reaction of two structurally related bridging ligands bis[5-(2-pyridyl)-1,2,4-triazole-3-yl]methane (H2L1) and bis[5-(2-pyridyl)-1,2,4-triazole-3-yl]ethane (H2L2) with copper(ii) salts resulted in a surprising wide variety of complex structures [Cu2(H2L1)Cl2]Cl2·4CH3OH (1), [Cu4(L1)4]·4H2O (2), [Cu(H2L2)(ClO4)2] (3) and [Cu3(OH)Na2(L')6](ClO4)·5H2O·C3H6O (4), where HL' is 3,5-bis-(pyridin-2-yl)-1,2,4-triazole, which were structurally characterized by the X-ray diffraction method. Complexes 1 and 2 were prepared on the H2L1 basis and have binuclear and tetranuclear structures, respectively, demonstrating strong impact of the type of counter anion on the coordination mode of the ligand...
February 13, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Manchula Navaratnam, Katsuhide Maeda, Seth A Hollander
Pediatric ventricular assist devices (VADs) are evolving as a standard therapy for end stage heart failure in children. Major recent developments include the increased use of continuous flow (CF) devices in children and increased experience with congenital heart disease (CHD) and outpatient management. In the current and future era anesthesiologists will encounter more children presenting for VAD implantation, subsequent procedures and heart transplantation. Successful peri-operative management requires an understanding of the interaction between the patient's physiology and the device and a framework to troubleshoot problems...
February 13, 2019: Paediatric Anaesthesia
Sri Murugan Poongkavithai Vadevoo, Smriti Gurung, Fatima Khan, Md Enamul Haque, Gowri Rangaswamy Gunassekaran, Lianhua Chi, Uttapol Permpoon, Byungheon Lee
Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses...
February 12, 2019: Archives of Pharmacal Research
Vadim Mitrokhin, Tatiana Filatova, Andrey Shim, Andrey Bilichenko, Denis Abramochkin, Andre Kamkin, Mitko Mladenov
The purpose of this study was to examine the effects of interferon-γ (IFN-γ) on calcium movement in rat ventricular myocytes. L-type Ca2+ currents (ICa,L ) were recorded with the whole-cell configuration of the patch-clamp techniques. IFN-γ induces current density reduction at the test potential of 0 mV by 47.6 ± 7.4%. Heparin, a selective inhibitor of inositol-1,4,5-triphosphate (IP3 )-induced Ca2+ release, applied via a patch pipette, induced an ICa,L amplitude decrease of about 46 ± 5.6%. The addition of IFN-γ to heparin-treated cells has no effect on ICa,L ...
February 12, 2019: Journal of Physiology and Biochemistry
Jiqian Xu, Hong-Bin Li, Lin Chen, Ya-Xin Wang, Shengzhong Lu, Sheng-Nan Li, Shu-Nan Cui, Hai-Rong Xiao, Lu Qin, Houxiang Hu, Shanglong Yao, You Shang
The timely resolution of pulmonary inflammation coordinated by endogenous pro-resolving mediators helps limit lung tissue injury, but few endogenous pro-resolving mediators that are normally operative during acute inflammation. The protective effects of BML-111 (5(S)-6(R)-7-trihydroxyheptanoic acid methyl ester), a potent commercially available anti-inflammatory and pro-resolving mediator, on ventilation-induced lung injury (VILI) have been extensively studied, but its characteristics as a pro-resolving mediator have not...
February 8, 2019: International Immunopharmacology
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