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Transport Nano particle

Proloy T Das, R C Sahoo, T Chabri, T K Nath
Gadolinium doping effects on structural-, electronic transport and magnetic properties of Pr0.6 Gd0.1 Sr0.3 MnO₃ (PGSMO) nanomanganite (40-65 nm) have been investigated. We have considered the core-shell structure of our PGSMO nanoparticles, which can explain its intriguing magnetic and transport properties. It is reported 65 nm sample exhibits higher metal to insulator transition temperature, TP (∼215 K) and less resistive behavior compare to its nano counterparts. Enhanced low-field magnetoresistance (LFMR) is observed with a reduction of particle size; however maximum change in magnetoresistance (MR), ∼72% is recorded for 65 nm sample around TP at 60 kOe field...
July 1, 2019: Journal of Nanoscience and Nanotechnology
Hanaa A Abdel-Messih, Rania A H Ishak, Ahmed S Geneidi, Samar Mansour
The transdermal route is a convenient non-invasive way for drug delivery, however, the hydrophobic compact nature of stratum corneum (SC) forms an obstacle hindering the diffusion of drugs particularly hydrophilic ones. Hence, the purpose of this study was to develop novel soft nano-vesicles, entitled Flexosomes, amalgamating two penetration enhancers, ethanol and one edge activator (EA) from various types and different hydrophilic-lipophilic balances. The tailored vesicles were loaded with tropisetron hydrochloride (TRO), a potent highly-soluble anti-emetic, and compared with ethosomes...
February 9, 2019: International Journal of Pharmaceutics
Olga D'Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine, Jean-Bosco Tagne
BACKGROUND: MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migration, and development [Oncotarget, 2015. 6(9): p. 6472-98, Cancer Manag Res, 2014. 6: p. 205-16]. miR-200c is part of the miR-200c/141 cluster on chromosome 12p13. Its mechanism of action when encapsulated is critical in lung cancer when patients express changes in miRNAs...
February 11, 2019: BMC Cancer
Victor U Weiss, Karin Wieland, Andreas Schwaighofer, Bernhard Lendl, Günter Allmaier
Gas-phase electrophoresis employing a nano Electrospray Differential Mobility Analyzer (nES DMA) aka Gas-phase Electrophoretic Mobility Molecular Analyzer (nES GEMMA) enables nanoparticle separation in the gas-phase according to their surface-dry diameter with number-based detection. Moreover, particles in the nanometer size range can be collected after size-selection on supporting materials. It has been shown by subsequent analyses employing orthogonal methods, for instance microscopic or antibody-based techniques, that the surface integrity of collected analytes remains intact...
February 8, 2019: Analytical Chemistry
Wenhai Lei, Chiyu Xie, Tianjiang Wu, Xingcai Wu, Moran Wang
Deformable micro-gel particles (DMP) have been used to enhanced oil recovery (EOR) in reservoirs with unfavourable conditions. Direct pore-scale understanding of the DMP transport mechanism is important for further improvements of its EOR performance. To consider the interaction between soft particle and fluid in complex pore-throat geometries, we perform an Immersed Boundary-Lattice Boltzmann (IB-LB) simulation of DMP passing through a throat. A spring-network model is used to capture the deformation of DMP...
February 5, 2019: Scientific Reports
M van Pomeren, W J G M Peijnenburg, R C Vlieg, S J T van Noort, M G Vijver
Important questions raised in (nano)ecotoxicology are whether biodistribution of nanoparticles (NPs) is affected by particle shape and to what extent local adverse responses are subsequently initiated. For nanomedicine, these same questions become important when the labeled NPs lose the labeling. In this study, we investigated the biodistribution patterns of gold nanoparticles (AuNPs) as well as immune-related local and systemic sublethal markers of exposure and behavioral assessment. Hatched zebrafish embryos were exposed to four differently shaped non-coated AuNPs with comparable sizes: nanospheres, nanorods, nano-urchins, and nano-bipyramids...
February 4, 2019: Nanotoxicology
Peng Liu, Carol J Ptacek, David W Blowes, Y Zou Finfrock
A previous long-term microcosm experiment showed mercury (Hg) in the aqueous phase of contaminated sediment was effectively stabilized through the addition of biochar. The present study focuses on the application of synchrotron-related methods to evaluate the distribution and speciation of Hg in the biochar particles reacted for 235, 387, and 1030 days. The study provided more information on Hg stabilization mechanisms in addition to the information obtained by the previous studies. Confocal micro-X-ray fluorescence imaging (CMXRFI) and micro-X-ray fluorescence (micro-XRF) maps show that mercury co-exists with S, Cu, Fe, Mn, and Zn on the surface and inside the particles of biochar...
January 15, 2019: Science of the Total Environment
Laura Tiozzo Fasiolo, Michele Dario Manniello, Fabrizio Bortolotti, Francesca Buttini, Alessandra Rossi, Fabio Sonvico, Paolo Colombo, Georgia Valsami, Gaia Colombo, Paola Russo
Neuroinflammation occurs in the early stages of Alzheimer's disease (AD). Thus, anti-inflammatory drugs in this asymptomatic initial phase could slow down AD progression, provided they enter the brain. Direct nose-to-brain drug transport occurs along olfactory or trigeminal nerves, bypassing the blood-brain barrier. Nasal administration may enable the drug to access the brain. Here, flurbiprofen powders for nose-to-brain drug transport in early AD-related neuroinflammation were studied. Their target product profile contemplates drug powder deposition in the nasal cavity, prompt dissolution in the mucosal fluid and attainment of saturation concentration to maximise diffusion in the tissue...
January 29, 2019: Journal of Drug Targeting
Bingqing Song, Ming Chen, Ling Zhao, Hao Qiu, Xinde Cao
The ever-increasing land application of biochar may raise the environmental issue of micronparticle (MP) and nanoparticle (NP) biochars for their high mobility or as a carrier to facilitate transport of contaminants in soil. In this study, a variety of biochars were produced from pyrolysis of nine biomass sources and then subjected to the extraction of MP and NP biochars. The diverse physicochemical properties and electrokinetic stability of MP and NP biochars were further investigated. MP and NP biochars accounted for 1...
January 16, 2019: Science of the Total Environment
Valon Lushta, Dirk Dietzel, Bernhard Roling, Andre Schirmeisen
Detailed understanding of electrochemical transport processes on the nanoscale is considered not only as a topic of fundamental scienctific interest but also as a key to optimize material systems for application in electrochemical energy storage. A prominent example are solid state electrolytes, where transport properties are strongly influenced by the microscopic structure of grain boundaries or interface regimes. However, direct characterization of ionic transport processes on the nanoscale remains a challenge...
January 8, 2019: ACS Applied Materials & Interfaces
Amir Shamloo, Mohamadamin Forouzandehmehr
Endothelial inflammation as a prominent precursor to atherosclerosis elicits a distinct pathological surface expression of particular vascular proteins. To exhibit a site-specific behaviour, micro- and nanoparticles, as carriers of therapeutics or imaging agents, can distinguish and use these proteins as targeted docking sites. Here, a computational patient-specific model capturing the exclusive luminal qualities has been developed to study the transport and adsorption of particles decorated with proper antibodies over an atherosclerotic plaque located in the LAD artery of the patient...
January 7, 2019: Biomechanics and Modeling in Mechanobiology
Rong Chen, Qun Chen, Huan Qin, Da Xing
Drug delivery to a tumor site with an insufficient microvascular network remains a challenge due to the size preference for transport in terms of circulation and distribution. In this work, an integrated nano-therapeutic parcel disintegrable by a photoacoustic shockwave was developed. Nano-therapeutic particles with red absorbance are packaged into a larger parcel to generate a longer circulation half-life and improved accumulation in tumor tissue. Pulse-laser irradiation is absorbed by the nanoparticles and it generates a photoacoustic shockwave...
January 4, 2019: Nanoscale
Qizhen Zhu, Xiaqing Chang, Ning Sun, Renjie Chen, Yineng Zhao, Bin Xu, Feng Wu
Nanoscale Na3V2(PO4)3 particles are grown in the interconnected conductive framework via a simple sol-gel method with the assistance of a hierarchical porous carbon. The porous carbon with strong adsorption ability absorbs the Na3V2(PO4)3 reactants from the aqueous solution during the sol-gel process. After the crystallization, the Na3V2(PO4)3 particles are grown in the carbon pores with a spatially confined effect. Due to the pore size confinement, the Na3V2(PO4)3 particles are limited to nanoscale size and prevented from aggregation...
December 26, 2018: ACS Applied Materials & Interfaces
Anwesha Sarkar, Shuning Zhang, Melvin Holmes, Rammile Ettelaie
Lipid digestion is a bio-interfacial process that is largely governed by the binding of the lipase-colipase-biosurfactant (bile salts) complex onto the surface of emulsified lipid droplets. Therefore, engineering oil-water interfaces that prevent competitive displacement by bile salts and/or delay the transportation of lipase to the lipidoidal substrate can be an effective strategy to modulate lipolysis in human physiology. In this review, we present the mechanistic role of Pickering emulsions i.e. emulsions stabilised by micron-to-nano sized particles in modulating the important fundamental biological process of lipid digestion by virtue of their distinctive stability against coalescence and resilience to desorption by intestinal biosurfactants...
January 2019: Advances in Colloid and Interface Science
Isabel García, Malou Henriksen-Lacey, Javier Calvo, Dorleta Jimenez de Aberasturi, Manuel M Paz, Luis M Liz-Marzán
This work aims at learning how the size of gold nanocarriers influences the transport of DNA-alkylating antitumoral drugs. For this purpose, we devised conjugates of mercaptoethylmi-tomycin C (MEMC), a DNA alkylating agent, with gold nano-particles of different sizes (2, 5 and 14 nm), and studied how size affects drug cytotoxicity, tumor penetrability, cellular uptake and intracellular localization using two-dimensional (2D) and three-dimensional (3D) cell models. We show that only small, 2 nm nanoparticles can transport MEMC to the cell nucleus, whereas MEMC cell uptake is much lower when delivered by these small nanoparticles than with the larger ones...
December 19, 2018: Bioconjugate Chemistry
Brindha Appavu, Sivakumar Thiripuranthagan, Thamaraiselvi Kanagaraj, Sakthivel Kumaravel, Elangovan Erusappan
In this study, we report the synthesis of NiWO₄/nitrogen doped reduced graphene oxide nano composite by one-pot hydrothermal method. The NiWO₄ nano particles were dispersed uniformly on graphene sheets. The as prepared NiWO₄, NiWO₄/5% rGO and NiWO₄/N-5% rGO composites were analytically characterized by Powder X-ray diffraction (XRD), Raman spectroscopy, Diffuse reflectance spectroscopy (DRS-UV), Scanning electron microscopy (SEM) and N₂ adsorption-desorption isotherm. The photocatalytic performances of the synthesized composites were evaluated towards the photo degradation of congo red (CR) under visible light radiation...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Julia Kastner, Iurii Gnatiuk, Michael Wagner, Dieter Holzinger, Victoria Rudelstorfer, Günter Hesser, Anita Fuchsbauer, Sabine Hild
The production of printable graphene flakes is not easy to scale up when produced by ultrasonication and purified by centrifugation. In this work, natural graphite flakes were exfoliated by wet ball milling in water supported by the addition of sodium deoxycholate as a surfactant and the dispersion was formulated for inkjet printing. By subsequent dilution and filtration of the milling paste, more than 45 l of a stable dispersion of nano-graphite particles in one batch process was obtained. The dispersion was characterized by thermogravimetric analysis and UV-vis spectroscopy to determine concentration, and experiments to measure long-term stability were conducted...
January 25, 2019: Nanotechnology
Yu Xiang, Pengcheng Zhao, Zhaoqing Jin, Bo Chen, Hai Ming, Hao Zhang, Wenfeng Zhang, Gaoping Cao, Xiayu Zhu
Because of the disadvantages of commercial graphite anodes for high-power lithium-ion batteries, a kind of spinel nanolithium titanate (Li4 Ti5 O12 )/graphene microsphere composite [denoted as LTO/reduced graphene oxide (rGO)] is successfully synthesized. The as-prepared composite is made up of curled graphene sheets which are anchored with nano-Li4 Ti5 O12 particles. These nano-Li4 Ti5 O12 particles are uniformly decorated on the conductive graphene framework and their sizes range from just 15 to 20 nm. In the as-prepared composite, the curled graphene sheets form a unique mesopore-oriented structure which provides plenty of three-dimensional channels for ion transportation...
November 27, 2018: ACS Applied Materials & Interfaces
Zhigang Yu, Liming Hu, Irene M C Lo
In this study, the effects of surface modification of nZVI and arsenic (As) loading on the mobility of the three types of As-loaded nZVI (As-loaded pristine, chitosan-modified and polyaniline-modified nZVI) in quartz sand-packed columns were investigated. Breakthrough curves and retention profiles for the three types of As-loaded nZVI were analyzed by the Tufenkji-Elimelech equations and the HYDRUS-1D model. The mobility of both types of As-loaded modified nZVI was higher than the As-loaded pristine nZVI at both low and high As loadings...
February 2019: Chemosphere
Naiyu Zhang, Charlotte E L Thompson, Ian H Townend, Kathryn E Rankin, David M Paterson, Andrew J Manning
Biofilm-sediment aggregate (BSA) contains a high water content, either within internal pores and channels or bound by extracellular polymeric substances (EPS) forming a highly hydrated biofilm matrix. Desiccation of BSAs alters the biofilm morphology and thus the physical characteristics of porous media, such as the binding matrix within BSA and internal pore geometry. Observing BSAs in their naturally hydrated form is essential but hampered due to the lack of techniques for imaging and discerning hydrated materials...
November 6, 2018: Environmental Science & Technology
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