Marisol Maya-López, Luis Angel Monsalvo-Maraver, Ana Laura Delgado-Arzate, Carolina I Olivera-Pérez, Mohammed El-Hafidi, Alejandro Silva-Palacios, Omar Medina-Campos, José Pedraza-Chaverri, Michael Aschner, Alexey A Tinkov, Isaac Túnez, Socorro Retana-Márquez, Cecilia Zazueta, Abel Santamaría
Mitochondrial dysfunction plays a key role in the development of neurodegenerative disorders. In contrast, the regulation of the endocannabinoid system has been shown to promote neuroprotection in different neurotoxic paradigms. The existence of an active form of the cannabinoid receptor 1 (CB1R) in mitochondrial membranes (mitCB1R), which might exert its effects through the same signaling mechanisms as the cell membrane CB1R, has been shown to regulate mitochondrial activity. Although there is evidence suggesting that some cannabinoids may induce protective effects on isolated mitochondria, substantial evidence on the role of cannabinoids in mitochondria remains to be explored...
February 3, 2024: Molecular Neurobiology