keyword
https://read.qxmd.com/read/38384489/use-of-the-gene-expression-test-prosigna-%C3%A2-in-premenopausal-patients-with-hr-her2-early-breast-cancer-correlation-of-the-results-with-the-proliferation-marker-ki-67
#21
JOURNAL ARTICLE
Cordula Ziegler, Karl Sotlar, Daniel Maria Hofmann, Thomas Kolben, Nadia Harbeck, Rachel Wuerstlein
INTRODUCTION: In hormone receptor-positive (ER+/PR+) and human epidermal growth factor receptor 2-negative (HER2-) early-stage breast cancer (EBC), gene expression tests such as the Prosigna are increasingly used since classic clinicopathological parameters and the proliferation factor Ki-67 often do not allow a definite therapy decision regarding an adjuvant chemotherapy. While the Prosigna test has been validated for postmenopausal patients, few data are available regarding its use in premenopausal patients...
February 2024: Breast Care
https://read.qxmd.com/read/38378562/the-association-between-mammographic-density-and-breast-cancer-risk-in-chinese-women-a-systematic-review-and-meta-analysis
#22
JOURNAL ARTICLE
Song Bai, Di Song, Ming Chen, Xiaoshu Lai, Jinfeng Xu, Fajin Dong
PURPOSE: Breast density has consistently been shown to be an independent risk factor for breast cancer in Western populations; however, few studies have evaluated this topic in Chinese women and there is not yet a unified view. This study investigated the association between mammographic density (MD) and breast cancer risk in Chinese women. METHODS: The PubMed, Cochrane Library, Embase, and Wanfang databases were systematically searched in June 2023 to include all studies on the association between MD and breast cancer risk in Chinese women...
February 20, 2024: BMC Women's Health
https://read.qxmd.com/read/38377945/bmi-and-breast-cancer-risk-around-age-at-menopause
#23
JOURNAL ARTICLE
Ann Von Holle, Hans-Olov Adami, Laura Baglietto, Amy Berrington, Kimberly A Bertrand, William Blot, Yu Chen, Jessica Clague DeHart, Laure Dossus, A Heather Eliassen, Agnes Fournier, Montse Garcia-Closas, Graham Giles, Marcela Guevara, Susan E Hankinson, Alicia Heath, Michael E Jones, Corinne E Joshu, Rudolf Kaaks, Victoria A Kirsh, Cari M Kitahara, Woon-Puay Koh, Martha S Linet, Hannah Lui Park, Giovanna Masala, Lene Mellemkjaer, Roger L Milne, Katie M O'Brien, Julie R Palmer, Elio Riboli, Thomas E Rohan, Martha J Shrubsole, Malin Sund, Rulla Tamimi, Sandar Tin Tin, Kala Visvanathan, Roel Ch Vermeulen, Elisabete Weiderpass, Walter C Willett, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Hazel B Nichols, Dale P Sandler, Anthony J Swerdlow, Minouk J Schoemaker, Clarice R Weinberg
BACKGROUND: A high body mass index (BMI, kg/m2 ) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology. METHODS: We examined the association between BMI and breast cancer risk in the Premenopausal Breast Cancer Collaborative Group, from age 45 up to breast cancer diagnosis, loss to follow-up, death, or age 55, whichever came first...
February 19, 2024: Cancer Epidemiology
https://read.qxmd.com/read/38375880/associations-between-breast-cancer-risk-factors-and-mammographic-breast-density-in-a-large-cross-section-of-korean-women
#24
JOURNAL ARTICLE
Soyeoun Kim, Thi Xuan Mai Tran, Mi Kyung Kim, Min Sung Chung, Eun Hye Lee, Woojoo Lee, Boyoung Park
BACKGROUND: We investigated the association between established risk factors for breast cancer and mammographic breast density in Korean women. METHODS: This large cross-sectional study included 8 460 928 women aged >40 years, who were screened for breast cancer between 2009 and 2018. Breast density was assessed using the Breast Imaging Reporting and Data System. This study used multiple logistic regression analyses of age, BMI, age at menarche, menopausal status, menopausal age, parity, breastfeeding status, oral contraceptive use, family history of breast cancer, physical activity, smoking, drinking and hormone replacement therapy use to investigate their associations with mammographic breast density...
February 20, 2024: European Journal of Cancer Prevention
https://read.qxmd.com/read/38365800/ambient-air-pollutants-and-breast-cancer%C3%A2-stage-in-tehran-iran
#25
JOURNAL ARTICLE
Zahra Khorrami, Mohsen Pourkhosravani, Ali Karamoozian, Ali Jafari-Khounigh, Mohammad Esmaeil Akbari, Maysam Rezapour, Reihaneh Khorrami, Seyed Mahmood Taghavi-Shahri, Heresh Amini, Koorosh Etemad, Narges Khanjani
This study aimed to examine the impacts of single and multiple air pollutants (AP) on the severity of breast cancer (BC). Data of 1148 diagnosed BC cases (2008-2016) were obtained from the Cancer Research Center and private oncologist offices in Tehran, Iran. Ambient PM10 , SO2 , NO, NO2 , NOX , benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene, and BTEX data were obtained from previously developed land use regression models. Associations between pollutants and stage of BC were assessed by multinomial logistic regression models...
February 16, 2024: Scientific Reports
https://read.qxmd.com/read/38365100/excess-morbidity-and-mortality-associated-with-underuse-of-estrogen-replacement-therapy-in-premenopausal-women-who-undergo-surgical-menopause
#26
JOURNAL ARTICLE
Jennifer S Ferris, Yukio Suzuki, Matthew T Prest, Ling Chen, Elena B Elkin, Chin Hur, Dawn L Hershman, Jason D Wright
BACKGROUND: Contrary to clinical guidelines, there has been a decrease over time in estrogen therapy use in premenopausal women undergoing bilateral oophorectomy for benign indications. OBJECTIVE: The objective of this study was to estimate the excess morbidity and mortality associated with current patterns of estrogen therapy use in women who undergo bilateral oophorectomy with hysterectomy for benign indications. STUDY DESIGN: We developed two Bayesian sampling Markov state-transition models to estimate the excess disease incidence (incidence model) and mortality (mortality model)...
February 14, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38360722/a-novel-bystander-effect-in-tamoxifen-treatment-ppib-derived-from-er-cells-attenuates-er-cells-via-endoplasmic-reticulum-stress-induced-apoptosis
#27
JOURNAL ARTICLE
Tinglin Yang, Wenhui Li, Jun Zhou, Ming Xu, Ziwei Huang, Jie Ming, Tao Huang
Tamoxifen (TAM) is the frontline therapy for estrogen receptor-positive (ER+) breast cancer in premenopausal women that interrupts ER signaling. As tumors with elevated heterogeneity, amounts of ER-negative (ER-) cells are present in ER+ breast cancer that cannot be directly killed by TAM. Despite complete remissions have been achieved in clinical practice, the mechanism underlying the elimination of ER- cells during TAM treatment remains an open issue. Herein, we deciphered the elimination of ER- cells in TAM treatment from the perspective of the bystander effect...
February 15, 2024: Cell Death & Disease
https://read.qxmd.com/read/38360633/dual-effect-of-vitamin-d-3-on-breast-cancer-associated-fibroblasts
#28
JOURNAL ARTICLE
Natalia Łabędź, Artur Anisiewicz, Martyna Stachowicz-Suhs, Joanna Banach, Dagmara Kłopotowska, Adam Maciejczyk, Patrycja Gazińska, Aleksandra Piotrowska, Piotr Dzięgiel, Rafał Matkowski, Joanna Wietrzyk
BACKGROUND: Cancer-associated fibroblasts (CAFs) play an important role in the tumor microenvironment. Despite the well-known in vitro antitumoral effect of vitamin D3 (VD3 ), its impact on breast CAFs is almost unknown. In this study, we analyzed the ex vivo effects of calcitriol on CAFs isolated from breast cancer tissues. METHODS: CAFs were cultured with 1 and 10 nM calcitriol and their phenotype; gene expression, protein expression, and secretion were assessed...
February 15, 2024: BMC Cancer
https://read.qxmd.com/read/38354603/the-risk-factors-for-premalignant-and-malignant-endometrial-polyps-in-premenopausal-and-postmenopausal-women-and-trends-over-the-past-decade-a-retrospective-study-in-a-single-center-south-korea
#29
JOURNAL ARTICLE
Shina Jang, Sung Ook Hwang
OBJECTIVES: To assess the prevalence and risk factors for premalignancy and malignancy in endometrial polyps and to evaluate trends over the past decade. STUDY DESIGN: This was a retrospective study of patients who underwent hysteroscopic polypectomy at Inha University Hospital, South Korea between January 2013 and June 2023. The demographic and clinical characteristics of the patients reviewed to identify risk factors for premalignancy and malignancy in endometrial polyps included the following: age, parity, body mass index, menopausal status, abnormal uterine bleeding symptoms, diabetes mellitus, hypertension, polycystic ovarian syndrome, use of menopausal hormonal therapy or oral contraceptives, tamoxifen treatment in patients with breast cancer, and the number of polyps...
January 28, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38328845/assessment-of-circulating-mirna-levels-in-breast-cancer-patients-depending-on-clinical-characteristics-and-chemotherapy
#30
JOURNAL ARTICLE
О Harashchenko
BACKGROUND: Breast cancer (BC) stands out as the most prevalent cancer in women. The levels of miRNA expression before and after chemotherapy are considered a potential indicator for the prognosis of the disease. AIM: To study blood plasma miRNA levels in BC patients and to assess their correlation with the menopausal status, disease stage, and molecular BC subtype. MATERIALS AND METHODS: Blood plasma levels of 6 miRNAs (miRNA-25, miRNA-27, miRNA-155, miRNA-200, miRNA-335, and miRNA-497) were studied in 70 BC patients and 18 healthy individuals using RT-PCR...
February 3, 2024: Experimental Oncology
https://read.qxmd.com/read/38327745/breast-cancer-but-not-the-menopausal-status-is-associated-with-small-changes-of-the-gut-microbiota
#31
JOURNAL ARTICLE
Natalia Zeber-Lubecka, Maria Kulecka, Agnieszka Jagiełło-Gruszfeld, Michalina Dąbrowska, Anna Kluska, Magdalena Piątkowska, Katarzyna Bagińska, Maria Głowienka, Piotr Surynt, Michał Tenderenda, Michał Mikula, Jerzy Ostrowski
BACKGROUND: Possible relationships between gut dysbiosis and breast cancer (BC) development and progression have been previously reported. However, the results of these metagenomics studies are inconsistent. Our study involved 88 patients diagnosed with breast cancer and 86 cancer-free control women. Participants were divided into groups based on their menopausal status. Fecal samples were collected from 47 and 41 pre- and postmenopausal newly diagnosed breast cancer patients and 51 and 35 pre- and postmenopausal controls, respectively...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38303227/-recurrent-breast-cancer-with-bone-metastasis-effectively-treated-with-abemaciclib-plus-endocrine-therapy-a-case-report
#32
JOURNAL ARTICLE
Keita Adachi, Junko Nagae, Hitomi Kubota, Shuhei Suzuki, Tomohiro Hirano, Kenichi Sakurai
We report a case of recurrent breast cancer with bone metastasis in a premenopausal woman. A 46-year-old woman underwent mastectomy for right breast cancer 6 years ago. Histopathological diagnosis was invasive ductal carcinoma, T2N3aM0, stage ⅢC. She received adjuvant chemotherapy and irradiation followed by tamoxifen. Four and a half years after surgery, serum tumor marker levels elevated, and bone metastasis in the sacral region was revealed by PET-CT scan. After suppressing ovarian function with LH-RH agonist, we switched the endocrine therapy from tamoxifen to letrozole with a CDK4/6 inhibitor...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38302488/comparative-analysis-of-breast-cancer-characteristics-in-young-premenopausal-and-postmenopausal-women-in-ghana
#33
JOURNAL ARTICLE
Kingsley Bosompem, Joseph Yorke, Tonnies Abeku Buckman, Samuel Gyasi Brenu, Michael Nyantakyi, Francis Somiah-Kwaw Aitpillah, Ishmael Kyei, Michael Ofoe Adinku, Dennis Afful Yorke, Christian Obirikorang, Emmanuel Acheampong
Breast cancer is increasingly common among young women in Ghana. BCa is heterogeneous with unique traits that impact causes, prognostic, and predictive outcomes of patients before and after menopause. However, limited evidence exists on differences between young premenopausal (YPM) and postmenopausal cases in Ghana. This study compared breast tumour characteristics between YPM women (under 35 years) and postmenopausal women. We conducted a prospective cross-sectional study involving 140 BCa-diagnosed women at the Breast Care Clinic of Komfo Anokye Teaching Hospital (KATH), Kumasi from November 2019 to June 2021...
February 1, 2024: Scientific Reports
https://read.qxmd.com/read/38267349/abbreviated-breast-magnetic-resonance-imaging-mri-or-digital-breast-tomosynthesis-for-breast-cancer-detection-in-dense-breasts-a-retrospective-preliminary-study-with-comparable-results
#34
JOURNAL ARTICLE
M T Ramli Hamid, N Ab Mumin, S Abdul Hamid, M S Ahmad Saman, K Rahmat
AIM: To compare the diagnostic performance of abbreviated breast magnetic resonance (AB-MR) imaging (MRI) and digital breast tomosynthesis (DBT) for breast cancer detection in Malaysian women with dense breasts, using histopathology as the reference standard. MATERIALS AND METHODS: This was a single-centre cross-sectional study of 115 women with American College of Radiology (ACR) Breast Imaging-Reporting and Data System (BIRADS) breast density C and D on DBT with breast lesions who underwent AB-MR from June 2018 to December 2021...
January 10, 2024: Clinical Radiology
https://read.qxmd.com/read/38266423/preoperative-neutrophil-to-lymphocyte-ratio-in-postmenopausal-breast-cancer-patients
#35
JOURNAL ARTICLE
Hideki Ijichi, Wakako Tajiri, Yumiko Koi, Chinami Koga, Yoshiaki Nakamura, Masahiro Okamoto, Eriko Tokunaga
INTRODUCTION: Neutrophil-to-lymphocyte ratio (NLR) has been recognized as a marker of systemic inflammation with a prognostic impact in patients with various cancers, including breast cancer. The aim of this study was to investigate the relationships between the preoperative NLR and breast cancer prognosis in the patients before and after menopausal age, and its relationship with other prognostic factors. METHODS: A total of 1868 patients with clinical Stage I-III primary breast cancer were enrolled...
January 23, 2024: Journal of Surgical Research
https://read.qxmd.com/read/38247846/breast-cancer-mitochondria-centered-metabolic-alterations-in-tumor-and-associated-adipose-tissue
#36
JOURNAL ARTICLE
Tamara Zakic, Andjelika Kalezic, Zorka Drvendzija, Mirjana Udicki, Tatjana Ivkovic Kapicl, Biljana Srdic Galic, Aleksandra Korac, Aleksandra Jankovic, Bato Korac
The close cooperation between breast cancer and cancer-associated adipose tissue (CAAT) shapes the malignant phenotype, but the role of mitochondrial metabolic reprogramming and obesity in breast cancer remains undecided, especially in premenopausal women. Here, we examined mitochondrial metabolic dynamics in paired biopsies of malignant versus benign breast tumor tissue and CAAT in normal-weight and overweight/obese premenopausal women. Lower protein level of pyruvate dehydrogenase and citrate synthase in malignant tumor tissue indicated decreased carbon flux from glucose into the Krebs cycle, whereas the trend was just the opposite in malignant CAAT...
January 15, 2024: Cells
https://read.qxmd.com/read/38221574/effect-of-combined-kinesiotaping-and-resistive-exercise-on-muscle-strength-and-quality-of-life-in-breast-cancer-survivors-a-randomized-clinical-trial
#37
RANDOMIZED CONTROLLED TRIAL
Alaa M Ramadan, Abeer M ElDeeb, Ahmed A Ramadan, Dina M Aleshmawy
BACKGROUND: Breast cancer (BC) and its treatment affect women's tissue architecture and physiology, which leads to impaired muscle strength and joint dysfunction, affecting quality of life (QOL). Most evidence has focused on exercises; however, due to the complexity and heterogeneity of patients' rehabilitation needs, further research is required to investigate more adjunctive methods to help optimal rehabilitation according to patients' needs, preferences, and effective interventions...
January 15, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38216737/identification-of-aberrant-luminal-progenitors-and-mtorc1-as-a-potential-breast-cancer-prevention-target-in-brca2-mutation-carriers
#38
JOURNAL ARTICLE
Rachel Joyce, Rosa Pascual, Luuk Heitink, Bianca D Capaldo, François Vaillant, Michael Christie, Minhsuang Tsai, Elliot Surgenor, Casey J A Anttila, Pradeep Rajasekhar, Felicity C Jackling, Marie Trussart, Michael J G Milevskiy, Xiaoyu Song, Mengbo Li, Charis E Teh, Daniel H D Gray, Gordon K Smyth, Yunshun Chen, Geoffrey J Lindeman, Jane E Visvader
Inheritance of a BRCA2 pathogenic variant conveys a substantial life-time risk of breast cancer. Identification of the cell(s)-of-origin of BRCA2-mutant breast cancer and targetable perturbations that contribute to transformation remains an unmet need for these individuals who frequently undergo prophylactic mastectomy. Using preneoplastic specimens from age-matched, premenopausal females, here we show broad dysregulation across the luminal compartment in BRCA2mut/+ tissue, including expansion of aberrant ERBB3lo luminal progenitor and mature cells, and the presence of atypical oestrogen receptor (ER)-positive lesions...
January 12, 2024: Nature Cell Biology
https://read.qxmd.com/read/38206277/systemic-treatment-of-patients-with-metastatic-breast-cancer-asco-resource-stratified-guideline
#39
JOURNAL ARTICLE
Sana Al Sukhun, Sarah Temin, Carlos H Barrios, Nicoleta Zenovia Antone, Yanin Chavarri Guerra, Mariana Chavez-MacGregor, Rakesh Chopra, Michael A Danso, Henry Leonidas Gomez, N'Da Marcelin Homian, Alaa Kandil, Benda Kithaka, Bogda Koczwara, Beverly Moy, Gertrude Nakigudde, Fernando Enrique Petracci, Hope S Rugo, Nagi S El Saghir, Banu K Arun
PURPOSE: To guide clinicians and policymakers in three global resource-constrained settings on treating patients with metastatic breast cancer (MBC) when Maximal setting-guideline recommended treatment is unavailable. METHODS: A multidisciplinary, multinational panel reviewed existing ASCO guidelines and conducted modified ADAPTE and formal consensus processes. RESULTS: Four published resource-agnostic guidelines were adapted for resource-constrained settings; informing two rounds of formal consensus; recommendations received ≥75% agreement...
January 2024: JCO global oncology
https://read.qxmd.com/read/38194899/health-related-quality-of-life-of-premenopausal-young-breast-cancer-survivors-undergoing-endocrine-therapy
#40
JOURNAL ARTICLE
Kyungmi Lee, Hye Suk Jun
PURPOSE: The incidence of breast cancer in premenopausal women in South Korea is higher compared to the West. This study aimed to identify factors associated with the health-related quality of life (HRQoL) among survivors with premenopausal young breast cancer undergoing endocrine therapy by examining the effects of menopausal symptoms, social support, and resilience on HRQoL. METHODS: Cross-sectional study was used to select survivors with breast cancer undergoing endocrine therapy...
December 29, 2023: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
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