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Premenopausal Breast Cancer

M Ekholm, P O Bendahl, M Fernö, B Nordenskjöld, O Stål, L Rydén
AIMS: The primary aim was to compare 2 years of adjuvant tamoxifen versus no systemic treatment in premenopausal patients with oestrogen receptor (ER)-positive tumours, regarding breast cancer-free interval (BCFi) and distant recurrence-free interval (D-RFi), with 30 years of follow-up and for specified intervals. Moreover, we aimed to investigate the effects of adjuvant tamoxifen on the incidence of secondary malignancies and survival after distant recurrence. METHODS: Premenopausal patients with primary breast cancer were randomised to 2 years of tamoxifen (n = 277) or no systemic treatment (n = 287), irrespective of ER status...
February 12, 2019: European Journal of Cancer
Alexandra J White, Clarice R Weinberg, Ellen S O'Meara, Dale P Sandler, Brian L Sprague
BACKGROUND: Breast density is strongly related to breast cancer. Identifying associations between environmental exposures and density may elucidate relationships with breast cancer. Metals and polycyclic aromatic hydrocarbons (PAHs) may influence breast density via oxidative stress or endocrine disruption. METHODS: Study participants (n = 222,581) underwent a screening mammogram in 2011 at a radiology facility in the Breast Cancer Surveillance Consortium. Zip code residential levels of airborne PAHs and metals (arsenic, cadmium, chromium, cobalt, lead, manganese, mercury, nickel, and selenium) were assessed using the 2011 EPA National Air Toxics Assessment...
February 13, 2019: Breast Cancer Research: BCR
Martin Porsch, Esra Özdemir, Martin Wisniewski, Sebastian Graf, Fabian Bull, Katrin Hoffmann, Atanas Ignatov, Johannes Haybaeck, Ivo Große, Thomas Kalinski, Norbert Nass
Acquired tamoxifen resistance is a persistent problem for the treatment of estrogen receptor positive, premenopausal breast cancer patients and predictive biomarkers are still elusive. We here analyzed gene expression changes in a cellular model to identify early and late changes upon tamoxifen exposure and thereby novel prognostic biomarkers. Estrogen receptor positive MCF-7 cells were incubated with 4OH-tamoxifen (10 nM) and gene expression analyzed by array hybridization during 12 weeks. Array results were confirmed by nCounter- and qRT-PCR technique...
February 13, 2019: RNA Biology
Barbara A Cohn, Piera M Cirillo, Mary Beth Terry
Background: In a previous Child Health and Development Studies report, p, p'-DDT was associated with a fivefold increased risk of premenopausal (before age 50 years) breast cancer for women first exposed before puberty. Here we extend our observation to breast cancer diagnosed during early postmenopause (ages 50-54 years) to determine whether age at diagnosis modifies the interaction of DDT with age at exposure. Methods: We conducted a second prospective, nested case-control study in the Child Health and Development Studies (153 incident breast cancer cases diagnosed at ages 50-54 years and 432 controls matched to cases on birth year)...
February 13, 2019: Journal of the National Cancer Institute
Kjirsten Carlson, Alice Chung, James Mirocha, Cory Donovan, Sylvia Estrada, Emily Siegel, Armando Giuliano, Farin Amersi
Outcomes based on menopausal status of breast cancer (BC) patients who are BRCA mutations carriers (BRCAm) are not well known. A prospective database identified 88 BRCAm with BC from 2005 to 2015. Of the 88 patients, 68 (77.3%) women were premenopausal (Pre-M) and 20 (22.7%) were postmenopausal (Post-M). In the Pre-M group, 52.9 per cent of patients had triple-negative (TN) BC, whereas in the Post-M group, there were more estrogen receptor +(65%; P = 0.129) and less TN (25%; P = 0.041) tumors. Median tumor size was significantly larger in the Pre-M group compared with the Post-M group ( P <0...
October 1, 2018: American Surgeon
Kathy Pan, Linda Diana Bosserman, Rowan T Chlebowski
No abstract text is available yet for this article.
February 11, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Halla Mohamed Ragab, Nervana Samy, Mie Afify, Nabila Abd El Maksoud, HebatAllah Mohamed Shaaban
Breast cancer is the most common cancer in females, it accounts for one third of all malignancies affecting women. Appropriate biomarkers play significant role in predicting the prognosis and decide the specific therapy to each patient. In this study we aimed at evaluating the value of Ki-67 as a prognostic marker in breast cancer patients and to analyze the associations between Ki-67 and their clinicopathological parameters. This study included 92 patients with developed non metastatic breast cancer and 10 women had benign breast tumor served as controls...
December 2018: Journal, Genetic Engineering & Biotechnology
Kaifeng Deng, Shanying Mo, Xuexiang Liu, Jifei Chen, Qiaoyun Zhang, Xiaoli Chen, Jianming Chen, Shengming Dai
BACKGROUND: Based on estrogen active substances, many women consume soy foods in the belief that it could prevent breast cancer (BC). Women with different molecular subtypes would be likely to have diverse reactions to soy foods, especially those with the estrogen-receptor-positive (ER+ ) subtype. The aim of the current study is to identify the differentially expressed genes (DEGs) on soy foods in premenopausal patients with Lumina A subtype of BC (LABC) after soy food treatment, and to further investigate the critical molecule change...
December 12, 2018: Clinical Breast Cancer
Zeping Yu, Shenli Tang, Hongbing Ma, Hong Duan, Yong Zeng
BACKGROUND: Emerging published studies have indicated that adiponectin is involved in tumorigenesis of breast cancer. However, the results of available studies were inconsistent. The aim of this updated meta-analysis was to assess the association of adiponectin with breast cancer. MATERIALS AND METHODS: PubMed, EMBASE, Wanfang databases, and the China National Knowledge Infrastructure (CNKI) were systematically searched from inception to June 2018. The mean difference (MD) with 95% confidence interval (CI) were estimated and pooled to investigate the effect sizes...
February 2019: Medicine (Baltimore)
Inarie Jacobs, Christine Taljaard-Krugell, Cristian Ricci, Hester Vorster, Sabina Rinaldi, Herbert Cubasch, Ria Laubscher, Maureen Joffe, Tertia van Zyl, Shane A Norris, Isabelle Romieu
Incidence rates of breast cancer (BC) are increasing in South Africa. The aim of this study was to investigate the association between dietary intake and BC risk in black South African women. The study population included 396 BC cases and 396 population-based controls matched on age and residence, participating in the South African Breast Cancer study. Diet was assessed using a validated quantified FFQ from which twelve energy-adjusted food groups were formed and analysed. OR were estimated using conditional logistic regressions, adjusted for confounding factors, comparing highest v...
February 1, 2019: British Journal of Nutrition
Yunjun Xiao, Junjie Xia, Liping Li, Yuebin Ke, Jinquan Cheng, Yaojie Xie, Winnie Chu, Polly Cheung, Jean Hee Kim, Graham A Colditz, Rulla M Tamimi, Xuefen Su
BACKGROUND: Epidemiologic evidence suggests that certain dietary patterns were associated with breast cancer risk, but the results have been inconclusive. We assessed the associations between different dietary patterns and the risk of breast cancer by conducting a meta-analysis of observational studies. METHODS: Relevant articles were searched in PubMed, Embase, and Cochrane library databases through September 2017. Multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) comparing the highest and lowest categories of Western and prudent dietary patterns were combined by using the random-effects meta-analyses...
January 29, 2019: Breast Cancer Research: BCR
Takahide Okamoto, Akemi Ito
BACKGROUND: Mammographic density (MD), the proportion of radiological dense breast, has been reported to be a strong risk factor for breast cancer in many studies. Epidemiological evidence indicates that alcohol consumption increases the risk of breast cancer. In Western countries, a positive association between alcohol consumption and MD has been reported. METHODS: To investigate the effect of alcohol consumption on MD, we conducted a cross-sectional analysis of healthy women enrolled in a breast cancer screening program at the Ebina Health Service Center, Japan, in 2012, comprising 477 premenopausal women and 308 postmenopausal women...
January 24, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Nguiessan Alphonse Aman, Brahima Doukoure, Kouadio Donatien Koffi, Baumaney Sylvanus Koui, Zie Cheick Traore, Mohamed Kouyate, Ahoua Benjamin Effi
Background: The overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. The objective of this study was to determine the frequency of HER2 and its association with clinicopathologic factors in breast cancer in Ivory Coast. Methods: The study included 608 patients who were histologically diagnosed with invasive primary breast carcinoma. The immunohistochemistry testing for ER, PR, and HER2 was performed on the formalin fixed paraffin-embedded blocks of breast tissue of these patients...
2019: BMC Clinical Pathology
Albina Dolores Resende, Sandra Leal, Carla Batista-Pinto, Fernanda Garcez, Susana Isabel Sá
The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long-term TAM administration to cycling young adult female rats was used to evaluate its effects in the liver. Body weight and food consumption were monitored, and at the end of the study, both parameters were lower in TAM-treated rats. Biochemical measurements showed that the TAM administration induced alterations in serum levels of liver enzymes when compared with control rats at different stages of the estrous cycle...
January 23, 2019: Journal of Biochemical and Molecular Toxicology
I B Gultekin, G I Imamoglu, S Gultekin, E A Yilmaz, Z Yilmaz, A Alkan, T Kucukozkan
Objectives: A prospective case-control study was carried out to assess the value of elastosonography in identifying endometrial pathology in women using Tamoxifen (TAM) for breast cancer. Materials and Methods: In total, 66 women using TAM for breast cancer were enrolled for the study with 61 premenopausal and 61 postmenopausal healthy controls. Ultrasonographic findings (strain ratio, endometrial thickness) were evaluated in regard to the duration of TAM usage, histopathological findings, and menopausal status...
January 2019: Nigerian Journal of Clinical Practice
Xuyu Chen, Qiru Wang, Yanan Zhang, Qian Xie, Xiaodong Tan
OBJECTIVES: To evaluate and quantify the association between physical activity (PA) and risk of breast cancer. METHODS: A systematic review meta-analysis was conducted. The literature was independently and manually searched by 2 reviewers through 3 English databases (PubMed, Embase, and ISI Web of Science) for data till October 2017. The quality of included studies was assessed by the Newcastle-Ottawa Quality Assessment Scale. Fixed-effects models were used to estimate the pooled relative risk and 95% confidence intervals (95% CI)...
January 2019: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Hee Kyung Kim, Soo-Hyeon Lee, Yu Jin Kim, Song Ee Park, Han Sang Lee, Sung Won Lim, Jang Ho Cho, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Jong Han Yu, Yeon Hee Park
BACKGROUND: In this study, we observe the patterns initial palliative treatment for premenopausal patients with HR-positive/HER2-negative MBC and determine if nonadherence to clinical guidelines are associated with worse clinical outcomes in terms of progression-free survival (PFS) and overall survival (OS) in the South Korean population. METHODS: A retrospective review was performed for premenopausal patients diagnosed with HR-positive/HER2-negative MBC between October 1997 and May 2016 who received palliative systemic treatments at a large tertiary medical center...
January 17, 2019: BMC Cancer
Magali Olivier, Liacine Bouaoun, Stephanie Villar, Alexis Robitaille, Vincent Cahais, Adriana Heguy, Graham Byrnes, Florence Le Calvez-Kelm, Gabriela Torres-Mejía, Isabel Alvarado-Cabrero, Fazlollah Shahram Imani-Razavi, Gloria Inés Sánchez, Roberto Jaramillo, Carolina Porras, Ana Cecilia Rodriguez, Maria Luisa Garmendia, José Luis Soto, Isabelle Romieu, Peggy Porter, Jamie Guenthoer, Sabina Rinaldi
BACKGROUND: In Latin America (LA), there is a high incidence rate of breast cancer (BC) in premenopausal women, and the genomic features of these BC remain unknown. Here, we aim to characterize the molecular features of BC in young LA women within the framework of the PRECAMA study, a multicenter population-based case-control study of BC in premenopausal women. METHODS: Pathological tumor tissues were collected from incident cases from four LA countries. Immunohistochemistry (IHC) was performed centrally for ER, PR, HER2, Ki67, EGFR, CK5/6, and p53 protein markers...
2019: PloS One
Jie Zeng, Kun Wang, Fayin Ye, Lin Lei, Yun Zhou, Jia Chen, Guohua Zhao, Hui Chang
Epidemiological studies focusing on the association between folate and breast cancer risk reported inconsistent findings. We conducted a systematic search of the literature using PubMed and EMBASE databases. A total of 23 prospective studies involving 41,516 cases and 1,171,048 individuals were included for meta-analysis. Folate intake may decrease the risk of oestrogen receptor (ER) negative (-) and ER-/progesterone receptor (PR)- breast cancer, with pooled risk ratios (RRs) of 0.88 [95% confidence interval (CI): 0...
January 15, 2019: European Journal of Clinical Nutrition
Jian-Wei Li, Guang-Yu Liu, Ya-Jie Ji, Xia Yan, Da Pang, Ze-Fei Jiang, De-Dian Chen, Bin Zhang, Bing-He Xu, Zhi-Ming Shao
Purpose: To assess the efficacy, safety, and quality-of-life impact of switching adjuvant treatment in hormone receptor-positive primary breast cancer patients who are still premenopausal after 2-3 years of tamoxifen therapy to anastrozole plus goserelin as compared with continuing tamoxifen over a total period of 5 years. Patients and methods: Hormone receptor-positive, premenopausal, lymph node-positive, or tumor size ≥4 cm breast cancer patients who had received tamoxifen for 2-3 years were randomly assigned to continue tamoxifen treatment (TAM group) or switch to adjuvant anastrozole plus goserelin (ADD group) and continue treatment for another 2-3 years (total treatment duration 5 years)...
2019: Cancer Management and Research
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