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https://read.qxmd.com/read/30888588/overexpression-of-hexcer-and-laccer-containing-2-hydroxylated-fatty-acids-in-cholangiocarcinoma-and-the-association-of-the-increase-of-laccer-d18-1-h23-0-with-shorter-survival-of-the-patients
#1
Atit Silsirivanit, Chatchai Phoomak, Karuntarat Teeravirote, Sasiprapa Wattanavises, Wunchana Seubwai, Charupong Saengboonmee, Zhaoqi Zhan, Jin-Ichi Inokuchi, Akemi Suzuki, Sopit Wongkham
Alteration of glycosphingolipid (GSL) synthesis is observed in many types of cancer. In this study, we have analyzed the expression of sphingolipids and GSLs in cholangiocarcinoma (CCA) tissues and adjacent normal liver tissues. Neutral lipids were extracted from tissue samples using mild-alkaline treatment method followed by TLC and LC-MS analysis. The expression of ceramides, hexosylceramides (HexCer), and lactosylceramides (LacCer) was altered in CCA tissues, 61.1% (11/18) of them showing an increase whereas 38...
March 19, 2019: Glycoconjugate Journal
https://read.qxmd.com/read/30888580/oncologic-outcomes-and-radiation-safety-of-nipple-sparing-mastectomy-with-intraoperative-radiotherapy-for-breast-cancer
#2
Lingxiao Pan, Changsheng Ye, Lun Chen, Wei Tang, Xiaoshen Zhang, Jin Gao, Rui Wu, Xigang Ye, Weige Tan, Minghui Wan, Wenbo Zheng
BACKGROUND: Nipple-sparing mastectomy combined with breast reconstruction helps to optimize the contour of the breast after mastectomy. However, the indications for nipple-sparing mastectomy are still controversial. Local radiation to the nipple-areola complex may play some roles in improving the oncological safety of this procedure. METHODS: From January 2014 to December 2017, 41 consecutive patients who underwent nipple-sparing mastectomy combined with Intrabeam intraoperative radiotherapy to the nipple-areola complex flap and breast reconstruction were enrolled in this prospective study...
March 19, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30888521/bone-spect-based-segmented-attenuation-correction-for-quantitative-analysis-of-bone-metastasis-b-sac-comparison-with-ct-based-attenuation-correction
#3
Tadaki Nakahara, Yoshiki Owaki, Tsubasa Shindou, Kiyotaka Nakajima, Masahiro Jinzaki
BACKGROUND: Evidence has shown the clinical usefulness of measuring the metastatic tumor burden of bone for prognostic assessment especially in prostate cancer; quantitative evaluation by dedicated SPECT is difficult due to the lack of attenuation correction (AC) method. We developed a novel method for attenuation correction using bone SPECT emission data (bone SPECT-based segmented attenuation correction; B-SAC) where emission data were virtually segmented into three tissues (i.e., bone, soft tissue, and air)...
March 19, 2019: EJNMMI Research
https://read.qxmd.com/read/30888515/trpm2-mediates-distruption-of-autophagy-machinery-and-correlates-with-the-grade-level-in-prostate-cancer
#4
Ahmet Tektemur, Seda Ozaydin, Ebru Etem Onalan, Nalan Kaya, Tuncay Kuloglu, İbrahim Hanifi Ozercan, Suat Tekin, Halit Mohammed Elyas
PURPOSE: Transient receptor potential melastatin 2 (TRPM2), a calcium-permeable ion channel, is shown as a prognostic marker candidate in prostate cancer (PCa) and an important regulator of autophagy. We aimed to determine the changes in TRPM2 and autophagic-apoptotic gene expression levels in human prostate adenocarcinomas, and to investigate the affect of TRPM2 on autophagic pathways in PC-3 cell line. METHODS: Human prostate tissues were classified considering the grade levels and were divided into the control, BPH, and grade 1-5 groups...
March 19, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30888391/influence-of-proliferation-on-the-motions-of-epithelial-monolayers-invading-adherent-strips
#5
Estelle Gauquelin, Sham Tlili, Cyprien Gay, Grégoire Peyret, René-Marc Mège, Marc A Fardin, Benoît Ladoux
Biological systems integrate dynamics at many scales, from molecules, protein complexes and genes, to cells, tissues and organisms. At every step of the way, mechanics, biochemistry and genetics offer complementary approaches to understand these dynamics. At the tissue scale, in vitro monolayers of epithelial cells provide a model to capture the influence of various factors on the motions of the tissue, in order to understand in vivo processes from morphogenesis, cancer progression and tissue remodelling. Ongoing efforts include research aimed at deciphering the roles of the cytoskeleton, of cell-substrate and cell-cell adhesions, and of cell proliferation-the point we investigate here...
March 19, 2019: Soft Matter
https://read.qxmd.com/read/30888199/utilization-of-archived-plasma-to-detect-epidermal-growth-factor-receptor-mutation-in-non-small-cell-lung-cancer-patients
#6
Ae-Chin Oh, Jin Kyung Lee, Ji-Young Kim, Hyeon-Ok Jin, Jae Won Jung, Yoon Hwan Chang, Young Jun Hong
Precision medicine has received increased attention as an effective approach for the treatment of cancer patients. Because of challenges associated with the availability of archived tissue, liquid biopsies are often performed to detect cancer-specific mutations. One of the major advantages of the liquid biopsy is that the treatment can be monitored longitudinally, even after the tumor tissue is no longer available. In a clinical setting, one component of precision medicine is the detection of cancer-specific mutations using archived samples...
March 19, 2019: Biopreservation and Biobanking
https://read.qxmd.com/read/30888184/metabolic-profiling-of-tumors-sera-and-skeletal-muscles-from-an-orthotopic-murine-model-of-gastric-cancer-associated-cachexia
#7
Pengfei Cui, Caihua Huang, Jiaqi Guo, Qianwen Wang, Zhiqing Liu, Huiqin Zhuo, Donghai Lin
Cachexia is a complex metabolic derangement syndrome that affects approximately 50-80% of cancer patients. So far few works have been reported to provide a global overview of gastric cancer cachexia (GCC)-related metabolic changes. We established a GCC murine model by orthotopicly implanting BGC823 cell line, and conducted NMR-based metabolomic analysis of gastric tissues, sera and gastrocnemius. The model with typical cachexia symptoms, confirmed by significant weight loss and muscle atrophy, showed distinctly distinguished metabolic profiles of tumors, sera and gastrocnemius from sham mice...
March 19, 2019: Journal of Proteome Research
https://read.qxmd.com/read/30888149/smart-ph-responsive-nanocubes-controlled-delivery-of-dna-vaccine-and-chemotherapeutic-drug-for-chemoimmunotherapy
#8
Huu Thuy Trang Duong, Thavasyappan Thambi, Yue Yin, Jung Eun Lee, Young Kyu Seo, Ji Hoon Jeong, Doo Sung Lee
The combination of chemotherapeutic agents with immune stimulating agents for treating degenerative diseases, called chemoimmunotherapy, has emerged as a promising cancer treatment modality. Despite the tremendous potential, chemoimmunotherapy by the combination of drugs and immune stimulators often suffers, due to the lack of controlled delivery nanostructures in the microenvironment. To this end, we show that by using pH-responsive smart nanocubes (NCs), cancer cells and tumor-associated immune cells can be precisely targeted with chemotherapeutic agent (Doxorubicin, DOX) and immune stimulating agent (plasmid OVA, pOVA) for enhanced chemoimmunotherapy...
March 19, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30888127/to-freeze-or-not-to-freeze-an-update-on-fertility-preservation-in-females-with-turner-syndrome
#9
M J Schleedoorn, van Alfen van der Velden, Ddm Braat, R Peek, K Fleischer
Introduction Infertility is a major concern for females with Turner syndrome (TS), regardless of their age. While fertility preservation is now routinely offered to girls and young women with cancer, there are currently no recommendations on fertility preservation in girls and young women with TS who generally face an even higher risk for infertility. Despite the lack of international guidelines, preservation procedures have been performed experimentally in females with TS. Methods A systematic literature search based on the PRISMA-P methodology for systematic reviews was performed in order to collect all published data on fertility preservation options in females with TS between January 1980 and April 2018...
March 2019: Pediatric Endocrinology Reviews: PER
https://read.qxmd.com/read/30888060/palliative-interventions-for-controlling-vaginal-bleeding-in-advanced-cervical-cancer
#10
REVIEW
George U Eleje, Ahizechukwu C Eke, Gabriel O Igberase, Anthony O Igwegbe, Lydia I Eleje
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 5, 2015.Cervical cancer is the fourth most common cancer among women worldwide, with estimated 569,847 new diagnoses and 311,365 deaths per year. However, incidence and stage at diagnosis vary greatly between geographic areas and are largely dependent on the availability of a robust population screening programme. For example, in Nigeria, advanced-stage disease at presentation is common (86% to 89...
March 19, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30887755/prospective-study-of-the-efficacy-and-utility-of-tp53-mutations-in-circulating-tumor-dna-as-a-non-invasive-biomarker-of-treatment-response-monitoring-in-patients-with-high-grade-serous-ovarian-carcinoma
#11
Yong Man Kim, Shin Wha Lee, Young Jae Lee, Ha Young Lee, Jong Eun Lee, Eun Kyung Choi
OBJECTIVE: Somatic TP53 mutation ( TP53 mut ) is a characteristic finding in high-grade serous ovarian cancer (HGSOC). The aim of this study was to assess the clinical efficacy and utility of TP53 mut circulating tumor DNA (ctDNA) monitoring as a biomarker for managing HGSOC. METHODS: TP53 muts were evaluated in patients who received primary treatment for suspected ovarian cancer at Asan Medical Center. In patients diagnosed with HGSOC and with TP53 mut , ctDNA, cancer antigen 125 (CA 125), and computed tomography were followed up according to the treatment course...
May 2019: Journal of Gynecologic Oncology
https://read.qxmd.com/read/30887707/fam3c-yy1-axis-is-essential-for-tgf%C3%AE-promoted-proliferation-and-migration-of-human-breast-cancer-mda-mb-231-cells-via-the-activation-of-hsf1
#12
Weili Yang, Biaoqi Feng, Yuhong Meng, Junpei Wang, Bin Geng, Qinghua Cui, Hongquan Zhang, Yang Yang, Jichun Yang
Family with sequence similarity three member C (FAM3C) (interleukin-like EMT inducer [ILEI]), heat shock factor 1 (HSF1) and Ying-Yang 1 (YY1) have been independently reported to be involved in the pathogenesis of various cancers. However, whether they are coordinated to trigger the development of cancer remains unknown. This study determined the role and mechanism of YY1 and HSF1 in FAM3C-induced proliferation and migration of breast cancer cells. In human MDA-MB-231 breast cancer cell line, transforming growth factor-β (TGFβ) up-regulated FAM3C, HSF1 and YY1 expressions...
March 19, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30887697/pmepa1-induces-emt-via-a-non-canonical-tgf-%C3%AE-signalling-in-colorectal-cancer
#13
Lei Zhang, Xue Wang, Chong Lai, Honghe Zhang, Maode Lai
Prostate transmembrane protein androgen induced 1 (PMEPA1) has been reported to promote cancer progression. Metastasis is the main factor leading to cancer progression and poor prognosis, and at the beginning of metastasis, epithelial-to-mesenchymal transition (EMT) is a crucial activation. However, the relationship between PMEPA1 and EMT in colorectal cancer metastasis is still poorly understood. In this study, we first testified that PMEPA1 expresses higher in tumour than normal tissue in Gene Expression Omnibus database, in the Cancer Genome Atlas (TCGA) as well as in the clinical data we collected...
March 19, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30887673/re-biopsy-and-liquid-biopsy-for-patients-with-non-small-cell-lung-cancer-after-egfr-tyrosine-kinase-inhibitor-failure
#14
Juan Zhou, Chao Zhao, Jing Zhao, Qi Wang, Xiangling Chu, Jiayu Li, Fei Zhou, Shengxiang Ren, Xuefei Li, Chunxia Su, Caicun Zhou
BACKGROUND: Re-biopsy is important for exploring resistance mechanisms, especially for non-small cell lung cancer (NSCLC) patients who develop resistance to EGFR-tyrosine kinase inhibitors (TKIs). Liquid biopsy using circulating tumor DNA has come into use for this purpose. This retrospective study investigated the status of re-biopsy and liquid biopsy in NSCLC patients with EGFR mutations and evaluated their effect on clinical strategies and prognosis. METHODS: Five hundred fifty-five NSCLC patients with resistance to EGFR-TKIs were included and divided into three groups: re-biopsy, liquid biopsy, and no re-biopsy...
March 18, 2019: Thoracic Cancer
https://read.qxmd.com/read/30887508/microrna-329-suppresses-epithelial-to-mesenchymal-transition-and-lymph-node-metastasis-in-bile-duct-cancer-by-inhibiting-laminin-subunit-beta-3
#15
Chun-Hong Liao, Yi Liu, Yi-Fei Wu, Si-Wei Zhu, Rong-Yao Cai, Lei Zhou, Xin-Min Yin
Bile duct cancer (BDC), also known as cholangiocarcinoma, is a highly desmoplastic cancer with a growth pattern characterized by periductal extension and infiltration. Studies have suggested that microRNAs (miRNAs) play an important role in BDC progression. Here we aim at investigating the effects of miR-329 on BDC development, focusing especially on epithelial-to-mesenchymal transition (EMT) in vitro and lymph node metastasis in vivo. Expression microarrays associated with BDC tissues were collected and differentially expressed genes were analyzed, followed by miRNA target prediction and verification...
March 18, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30887484/pharmacokinetic-profile-of-curcumin-and-nanocurcumin-in-plasma-ovary-and-other-tissues
#16
Wawaimuli Arozal, Wenny Trias Ramadanty, Melva Louisa, Regina Puspa Utami Satyana, Gaviota Hartono, Serlie Fatrin, Sigit Purbadi, Ari Estuningtyas, Instiaty Instiaty
BACKGROUND: Curcumin is a natural diphenolic compound that is currently being investigated for various cancers, including ovarian cancer. Clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation at physiological pH. Particle size is one factor that can affect the absorption process, which thus increases compound solubility and transport across the membrane. This study was conducted to determine the effects of modifying the particle size of curcumin on its pharmacokinetic parameters in blood and other organs...
March 18, 2019: Drug Research
https://read.qxmd.com/read/30887286/analysis-of-functional-hub-genes-identifies-cdc45-as-an-oncogene-in-non-small-cell-lung-cancer-a-short-report
#17
Jianbing Huang, Yuan Li, Zhiliang Lu, Yun Che, Shouguo Sun, Shuangshuang Mao, Yuanyuan Lei, Ruochuan Zang, Ning Li, Sufei Zheng, Chengming Liu, Xinfeng Wang, Nan Sun, Jie He
PURPOSE: Hub genes are good molecular candidates for targeted cancer therapy. As yet, however, there is little information on the clinical implications and functional characteristics of hub genes in the development of non-small cell lung cancer (NSCLC). In this study, we set out to analyze the role of hub genes in NSCLC. METHODS: We performed weighted gene co-expression network analysis (WGCNA) to analyze gene networks during NSCLC development using transcriptomic data from normal, pre-cancer and cancer tissues...
March 18, 2019: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/30887204/annual-mammography-at-age-45-49-years-and-biennial-mammography-at-age-50-69-years-comparing-performance-measures-in-an-organised-screening-setting
#18
Lauro Bucchi, Alessandra Ravaioli, Flavia Baldacchini, Orietta Giuliani, Silvia Mancini, Rosa Vattiato, Fabio Falcini, Paolo Giorgi Rossi, Cinzia Campari, Debora Canuti, Enza Di Felice, Priscilla Sassoli de Bianchi, Stefano Ferretti, Nicoletta Bertozzi
OBJECTIVE: To compare the results of 5 years of annual mammography screening at age 45-49 with the results of 5 years of biennial screening at age 50-54 and 55-69. METHODS: In an Italian screening programme, data from 1,465,335 mammograms were analysed. Recall rates, invasive assessment rates, surgical biopsy (including excisional biopsy and definitive surgical treatment) rates, and cancer detection rates were calculated for the first screen (first) and, cumulatively, for the second and subsequent screens (second+)...
March 18, 2019: European Radiology
https://read.qxmd.com/read/30887161/cardiotoxicity-of-targeted-cancer-drugs-concerns-the-cart-before-the-horse-and-lessons-from-trastuzumab
#19
REVIEW
Pierantonio Menna, Giorgio Minotti, Emanuela Salvatorelli
PURPOSE OF REVIEW: Modern oncology is witnessing a renaissance of its pharmacologic armamentarium. Old generation drugs, such as anthracyclines and other cytotoxic or cytostatic drugs, were plagued with a lack of specificity and with the possible occurrence of untoward effects in the cardiovascular system and other healthy tissues. The old drugs are now combined with, or replaced by, new agents that are more specific in attacking some unique moieties and vital functions of cancer cells, causing less noxious effects in healthy tissues...
March 18, 2019: Current Cardiology Reports
https://read.qxmd.com/read/30887136/hynic-and-doma-conjugated-radiolabeled-bombesin-analogs-as-receptor-targeted-probes-for-scintigraphic-detection-of-breast-tumor
#20
Kakali De, Dibyanti Mukherjee, Samarendu Sinha, Shantanu Ganguly
BACKGROUND: Among the many peptide receptor systems, gastrin-releasing-peptide (GRP) receptors, the mammalian equivalent of bombesin (BN) receptors, are potential targets for diagnosis and therapy of breast tumors due to their overexpression in various frequently occurring human cancers. The aim of this study was to synthesize and comparative evaluation of 99m Tc-labeled new BN peptide analogs. Four new BN analogs, HYNIC-Asp[PheNle]BN(7-14)NH2 , BN1; HYNIC-Pro-Asp[TyrMet]BN(7-14)NH2 , BN2; HYNIC-Asp-Asn[Lys-CHAla-Nle]BN(7-14)NH2 , BN3; and DOMA-GABA[Pro-Tyr-Nle]BN(7-14)NH2 , BN4 were synthesized and biologically evaluated for targeted imaging of GRP receptor-positive breast-tumors...
March 18, 2019: EJNMMI Research
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