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https://read.qxmd.com/read/30763536/phage-therapy-a-renewed-approach-to-combat-antibiotic-resistant-bacteria
#1
REVIEW
Kaitlyn E Kortright, Benjamin K Chan, Jonathan L Koff, Paul E Turner
Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in Western medicine. This stems from the rise in frequency of multi-drug-resistant bacterial infections in humans. There also have been recent case reports of phage therapy demonstrating clinical utility in resolving these otherwise intractable infections. Nevertheless, bacteria can readily evolve phage resistance too, making it crucial for modern phage therapy to develop strategies to capitalize on this inevitability. Here, we review the history of phage therapy research...
February 13, 2019: Cell Host & Microbe
https://read.qxmd.com/read/30763226/resident-run-urology-clinics-a-tool-for-use-in-competency-based-medical-education-for-teaching-and-assessing-transition-to-practice-skills
#2
Luke Witherspoon, Shreya Jalali, Matthew T Roberts
INTRODUCTION: In a competency-based approach to resident education, a component of training should focus on skills needed for the transition from residency to independent practice. The ability to run an outpatient clinic represents one such skill. Resident-run clinics (RRC) have been implemented in family medicine programs to allow residents to practice this skill, and have enhanced learning while providing excellent patient satisfaction. To date, there has been little experience with RRCs in surgical residency programs...
January 21, 2019: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://read.qxmd.com/read/30762815/electrical-stimulation-on-adverse-events-caused-by-chemotherapy-in-patients-with-cervical-cancer-a-protocol-for-a-systematic-review-of-randomized-controlled-trial
#3
Peng-Hui Dou, Dan-Feng Zhang, Cui-Hong Su, Xiao-Li Zhang, Ying-Jie Wu
BACKGROUND: This protocol of systematic review aims to investigate the effectiveness of electrical stimulation (ES) on adverse events (AEs) caused by chemotherapy in patients with cervical cancer (CC). METHODS: This systematic review of randomized controlled trials will be identified through searchers of PUBMED, PsycINFO, Scopus, Opengrey, Cochrane Central Register of Controlled Trials, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762808/acupuncture-for-perimenopausal-depressive-disorder-a-systematic-review-and-meta-analysis-protocol
#4
Jialei Feng, Wei Wang, Yuan Zhong, Chonghui Xing, Taipin Guo
BACKGROUND: Perimenopausal depressive disorder (PDD) is a disease that plagues many perimenopausal women. There is an urgent need for a safe way to treat the disease. With few side effects, acupuncture treatment for PDD has been gradually accepted. However, at present, the evidence is insufficient and relevant studies are not in-depth enough. The purpose of this study is to explore the efficacy and safety of acupuncture for PDD. METHODS: All randomized controlled trials articles on acupuncture treatment of PDD will be searched in databases such as MEDLINE, EBASE, Cochrane Library, Springer, World Health Organization International Clinical Trials Registry Platform, China National Knowledge Infrastructure, Wan Fang, Chinese Biomedical Literature Database, Chinese Scientific Journal Database and so on...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762805/the-effectiveness-and-safety-of-cervus-and-cucumis-polypeptide-injection-in-promoting-fracture-healing-after-bone-fracture-surgeries-protocol-for-a-systematic-review-and-meta-analysis
#5
Xia Yang, Kecheng Niu, Xiaoyan Zhang, Baiqing Gao, Bo Feng, Ha Si
BACKGROUND: Bone fractures are a common occurrence, and, according to clinical investigations, approximately 5% to 10% of patients with fractures will suffer from delayed healing or even non-healing. The high efficacy of traditional Chinese medicine in promoting fracture healing has been fully verified over a long history of diagnosis and treatment. Traditional Chinese medicine has a long history of applying Chinese herbs to treat fractures. Cervus and cucumis polypeptide injection has been widely used to promote fracture healing after fracture surgery in clinic, but its efficacy and safety are controversial...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762780/effectiveness-of-extracorporeal-shock-wave-therapy-for-frozen-shoulder-a-protocol-for-a-systematic-review-of-randomized-controlled-trial
#6
Dong-Zi Cao, Cun-Liang Wang, Zhong Qing, Lie-Dong Liu
BACKGROUND: This systematic review aims to explore the effectiveness and safety of extracorporeal shock-wave therapy (ESWT) for patients with frozen shoulder. METHODS: The sources of Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and Websites of Clinical Trials Registry will be searched. All databases and other sources will be searched from inception to the date of the search will be run...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762772/effectiveness-and-safety-of-fluoxetine-for-premature-ejaculation-protocol-for-a-systematic-review
#7
Xiao Li, Juntao Li, Xianrui Li, Jisheng Wang, Hengheng Dai, Jingshang Wang
BACKGROUND: Premature ejaculation (PE) is one of the most common male sexual dysfunctions, which can directly harm men's self-esteem and affect the stability of the relationship between husband and wife. To some extent, PE even affects the harmony and stability of society. So, men's health has gained more and more attention. As one of the long-acting selective serotonin reuptake inhibitors (SSRIs), fluoxetine has been proven to be effective in the treatment of PE by many trails. In this study, we aim to evaluate the effectiveness and safety of fluoxetine for PE to provide the newest evidence for clinical use...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762612/genetic-profiling-for-disease-stratification-in-chronic-obstructive-pulmonary-disease-and-asthma
#8
Senani N H Rathnayake, Maarten Van den Berge, Alen Faiz
PURPOSE OF REVIEW: In asthma and chronic obstructive pulmonary disease (COPD), the movement towards genetic profiling with a push towards 'personalized medicine' has been hindered by complex environment--gene interactions and lack of tools to identify clear causal genetic traits. In this review, we will discuss the need for genetic profiling in asthma and COPD, what methods are currently used in the clinics and the recent finding using new sequencing methods. RECENT FINDINGS: Over the past 10-15 years, genome-wide association studies analysis of common variants has provide little in the way of new genetic profiling markers for asthma and COPD...
February 11, 2019: Current Opinion in Pulmonary Medicine
https://read.qxmd.com/read/30762495/citation-analysis-of-the-most-influential-articles-on-traumatic-spinal-cord-injury
#9
Ronak H Jani, Arpan V Prabhu, James J Zhou, Nima Alan, Nitin Agarwal
OBJECTIVE: We conducted a citation analysis in order to catalog and pay tribute to the 100 most influential clinical research articles in traumatic spinal cord injury. DESIGN: The Thomson Reuters Web of Science was searched in a two-step process without time period limitations. Review articles were excluded. In the first stage of data extraction, a Boolean query was used to identify the top 100 most cited clinical papers on traumatic spinal cord injury. One hundred and seven keywords were manually chosen and extracted from titles and abstracts...
February 14, 2019: Journal of Spinal Cord Medicine
https://read.qxmd.com/read/30762323/clinical-standards-for-patient-blood-management-and-perioperative-hemostasis-and-coagulation-management-position-paper-of-the-italian-society-of-anesthesia-analgesia-resuscitation-and-intensive-care-siaarti
#10
Gilda Cinnella, Marco Pavesi, Andrea De Gasperi, Marco Ranucci, Lucia Mirabella
Patient blood management is currently defined as the application of evidence based medical and surgical concepts designed to maintain hemoglobin (Hb), optimize hemostasis and minimize blood loss to improve patient outcome. Blood management focus on the perioperative management of patients undergoing surgery or other invasive procedures in which significant blood loss occurs or is expected. Preventive strategies are emphasized to identify and manage anemia, reduce iatrogenic blood losses, optimize hemostasis (e...
February 13, 2019: Minerva Anestesiologica
https://read.qxmd.com/read/30761985/a-personal-account-regarding-the-origin-and-evolution-of-controversies-in-the-management-of-neurocysticercosis
#11
Oscar H Del Brutto
A panel of experts from the Infectious Disease Society of America and The American Society of Tropical Medicine and Hygiene recently published guidelines for management of neurocysticercosis, showing that clinical manifestations as well as the stage of involution and the anatomical location of parasites must be taken into account before the start of a rational therapy. Soon thereafter, isolated opinions attempted to discredit these guidelines, arguing insufficient or inadequate evidence and suggesting that they should not be followed worldwide...
February 11, 2019: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/30761948/invasive-fungal-infection-in-crtically-ill-patients-hurdles-and-next-challenges
#12
Peral José, Francisco Alvarez-Lerma, Emilio Maseda, Pedro Olaechea, Javier Pemán, Cruz Soriano, Rafael Zaragoza
A narrative review from a multidisciplinary task force of experts in critical care medicine and clinical mycology was carried out. The multi drug-resistant species Candida auris has emerged simultaneously on several continents, causing hospital outbreaks, especially in critically ill patients. Although there are not enough data to support the routine use of continuous antibiotic prophylaxis in patients subjected to extracorporeal membrane oxygenator, a clear increase of invasive fungal infection (IFI) has been described with the use of this device...
February 14, 2019: Journal of Chemotherapy
https://read.qxmd.com/read/30761862/clinical-applications-of-microenvironment-controlled-immunosuppressive-properties-of-mesenchymal-stem-cells-derived-exosomes-a-review
#13
R Domenis, A Cifù, M Fabris, F Curcio
No abstract text is available yet for this article.
July 2018: Journal of Biological Regulators and Homeostatic Agents
https://read.qxmd.com/read/30761822/personalization-of-therapies-in-rare-diseases-a-translational-approach-for-the-treatment-of-cystic-fibrosis
#14
Valeria R Villella, Antonella Tosco, Speranza Esposito, Eleonora Ferrari, Gianni Bona, Guido Kroemer, Valeria Raia, Luigi Maiuri
High variability in the response rates to treatments can make the interpretation of data from clinical trials very difficult, particularly in rare genetic diseases in which the enrolment of thousands of patients is problematic. Personalized medicine largely depends on the establishment of appropriate early detectors of drug efficacy that may guide the administration (or discontinuation) of specific treatments. Such biomarkers should be capable of predicting the therapeutic response of individual patients and of monitoring early benefits of candidate drugs before late clinical benefits become evident...
February 13, 2019: Minerva Pediatrica
https://read.qxmd.com/read/30761367/a-search-for-training-of-practising-leadership-in-emergency-medicine-a-systematic-review
#15
Ture Larsen, Randi Beier-Holgersen, Jette Meelby, Peter Dieckmann, Doris Østergaard
Objective: This systematic review examines the medical, psychological and educational literature for training in practising leadership of a team leader in emergencies. The objectives of this paper are (1) describe how literature addresses operational training in practising leadership for the emergency medical team-leader (2) enhance understanding of leadership training in the medical environment. Background: Worldwide, medical supervisors find it difficult to get students to rise to the occasion as leaders of emergency teams...
November 2018: Heliyon
https://read.qxmd.com/read/30760328/compare-qualitative-analysis-of-researchers-responses-to-critical-correspondence-on-a-cohort-of-58-misreported-trials
#16
Ben Goldacre, Henry Drysdale, Cicely Marston, Kamal R Mahtani, Aaron Dale, Ioan Milosevic, Eirion Slade, Philip Hartley, Carl Heneghan
BACKGROUND: Discrepancies between pre-specified and reported outcomes are an important and prevalent source of bias in clinical trials. COMPare (Centre for Evidence-Based Medicine Outcome Monitoring Project) monitored all trials in five leading journals for correct outcome reporting, submitted correction letters on all misreported trials in real time, and then monitored responses from editors and trialists. From the trialists' responses, we aimed to answer two related questions. First, what can trialists' responses to corrections on their own misreported trials tell us about trialists' knowledge of correct outcome reporting? Second, what can a cohort of responses to a standardised correction letter tell us about how researchers respond to systematic critical post-publication peer review? METHODS: All correspondence from trialists, published by journals in response to a correction letter from COMPare, was filed and indexed...
February 14, 2019: Trials
https://read.qxmd.com/read/30760187/potential-therapeutic-applications-of-p2-receptor-antagonists-from-bench-to-clinical-trials
#17
Natiele Carla da Silva Ferreira, Luiz Anastacio Alves, Rômulo José Soares-Bezerra
BACKGROUND: Extracellular purines and pyrimidines have important physiological functions in mammals. Purines and pyrimidines act on P1 and P2 purinergic receptors, which are widely expressed in the plasma membrane in various cell types. P2 receptors act as important therapeutic targets and are associated with several disorders, such as pain, neurodegeneration, cancer, inflammation, and thrombosis. However, the use of antagonists for P2 receptors in clinical therapy, with the exception of P2Y12, is a great challenge...
February 12, 2019: Current Drug Targets
https://read.qxmd.com/read/30760118/preparing-next-generation-scientists-for-biomedical-big-data-artificial-intelligence-approaches
#18
Jason H Moore, Mary Regina Boland, Pablo G Camara, Hannah Chervitz, Graciela Gonzalez, Blanca E Himes, Dokyoon Kim, Danielle L Mowery, Marylyn D Ritchie, Li Shen, Ryan J Urbanowicz, John H Holmes
Personalized medicine is being realized by our ability to measure biological and environmental information about patients. Much of these data are being stored in electronic health records yielding big data that presents challenges for its management and analysis. Here, we review several areas of knowledge that are necessary for next-generation scientists to fully realize the potential of biomedical big data. We begin with an overview of big data and its storage and management. We then review statistics and data science as foundational topics followed by a core curriculum of artificial intelligence, machine learning and natural language processing that are needed to develop predictive models for clinical decision making...
February 14, 2019: Personalized Medicine
https://read.qxmd.com/read/30759787/a-review-of-immunotherapeutic-strategies-in-canine-malignant-melanoma
#19
REVIEW
Ramón M Almela, Agustina Ansón
In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas in advanced disease stages. Classical clinical management remains challenging; thus, novel and more efficacious treatment strategies are needed. Evidence-based medicine supports the role of the immune system to treat neoplastic diseases. Besides, immunotherapy offers the possibility of a precise medicinal approach to treat cancer...
February 12, 2019: Veterinary Sciences
https://read.qxmd.com/read/30759494/-weannet-the-network-of-respiratory-weaning-centers
#20
B Schönhofer
Invasive ventilation via endotracheal tube as access to the airways often is treatment of choice of acute respiratory failure. Multifactor-related increases the number of patients who are dependent on the ventilator for a longer period. The prolonged weaning (or "liberation") from mechanical ventilation therefore has an increasing importance.In Germany since the 90s of the last century, weaning units have been established in lung clinics. With the aim of achieving the highest possible quality of treatment in these weaning centers, the network "WeanNet" was founded in 2007 within the German Society of Pneumology and Respiratory Medicine (DGP)...
February 2019: Pneumologie
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