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Megan L Hutchcraft, Blair Smith, Eric M McLaughlin, Erinn M Hade, Floor J Backes, David M O'Malley, David E Cohn, Jeffrey M Fowler, Larry J Copeland, Ritu Salani
OBJECTIVE: The impact of pathologic features of a cone biopsy on the management of women with early stage cervical cancer is understudied. Our objective was to evaluate the additive value of pathologic features of a cone biopsy toward identifying patients with high risk tumors for which adjuvant therapy may be indicated. METHODS: Patients with early stage cervical cancer undergoing a conization followed by radical hysterectomy from 1995 to 2016 were retrospectively identified...
February 2, 2019: Gynecologic Oncology
Yuki Koyanagi, Chiaki Kubo, Shigenori Nagata, Ayumi Ryu, Koji Hatano, Rieko Kano, Satoshi Tanada, Jun-Ichi Ashimura, Atsushi Idota, Shoji Kamiura, Tomoyuki Yamasaki, Shin-Ichi Nakatsuka
BACKGROUND: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. CASE PRESENTATION: A 68-year-old Japanese postmenopausal woman developed brown vaginal discharge after radical cystectomy for bladder cancer (high-grade UC, pT2a pN0 cM0 [Union for International Cancer Control, 8th edition]) concomitant with focal in-situ UC in the urethra...
February 2, 2019: Diagnostic Pathology
Jing Ye, Xiao-Dong Cheng, Bei Cheng, Yi-Fan Cheng, Xiao-Jing Chen, Wei-Guo Lu
BACKGROUND: Low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by colposcopy guided biopsy is recommended conservative follow-up, although some of these lesions are actually high-grade lesions, which are missed on an initial colposcopy. Therefore, in this work, we evaluate the potential role of miRNA detection in cervical exfoliated cells in a clinic-based population for predicting missed high-grade lesions in women diagnosed with LSIL/CIN1 after colposcopy-guided biopsy...
January 30, 2019: BMC Cancer
Bartosch Georg Wolnicki, Friederike von Wedel, Niki Mouzakiti, Ammar Al Naimi, Akos Herzeg, Franz Bahlmann, Ioannis Kyvernitakis
BACKGROUND: Patients with cervical shortening obtained by transvaginal ultrasound and/or previous preterm delivery are at increased risk for preterm birth in the current pregnancy. The aim of the present cohort study was to compare the rate of preterm birth and early neonatal parameters in patients at risk and screening patients who received either a cerclage or a combined treatment of cerclage and cervical pessary. METHODS: A retrospective cohort study was conducted from March 2005 to March 2017 including all patients in our department which received a McDonald cerclage or a combined treatment of McDonald cerclage and an Arabin pessary...
January 30, 2019: Journal of Maternal-fetal & Neonatal Medicine
Y P Xiao, X Tao, C Y Zhao, Y Q Qu, F Xie, Y Ning
Objective: To investigate the relationship between various loop electrosurgical excision procedure (LEEP) margin status and residual high grade squamous intraepithelial lesion (HSIL) or worse at hysterectomy following conization. Methods: The relevant clinicopathological data were collected in the Obstetrics and Gynecology Hospital, Fudan University from Jan. 2014 to Dec. 2015, including 947 cases who underwent hysterectomy within 6 months of LEEP. The residual HSIL or worse at hysterectomy were analyzed among the groups...
January 25, 2019: Zhonghua Fu Chan Ke za Zhi
Amaya Caballero, Donald Dudley, James Ferguson, Kate Pettit, Annelee Boyle
INTRODUCTION: To determine whether maternal human papillomavirus (HPV) infection is associated with preterm premature rupture of membranes (PPROM). MATERIALS AND METHODS: We conducted a retrospective cohort study of singleton deliveries at our institution from 2010 to 2015. Women, ages 16-49, with HPV genotyping or cervical cytology results 3 years before delivery were included. Chi-squared and logistic regression analyses were used. RESULTS: In our cohort of 2153 women, 38...
January 24, 2019: Journal of Women's Health
D Schmidt
BACKGROUND: The histological and immunohistochemical evaluation of tissue samples obtained in the course of the investigation and treatment of precancerous squamous lesions of the cervix uteri is an essential task of the pathologist. Given the surprising variety of morphological findings, including the many possible differential diagnoses of dysplastic changes, this is not an easy task. DIFFERENTIATION: Biologically, only two prognostically different groups can be distinguished, which according to the WHO classification are referred to as low-grade or high-grade squamous intraepithelial lesions (LSILs or HSILs)...
January 18, 2019: Der Pathologe
N Rippinger, J Heinzler, T Bruckner, J Brucker, C Dinkic, J Hoffmann, N Dornhöfer, S Seitz, J Rom, C Sohn, T C Schott, Sarah Schott
PURPOSE: Annual cervical cancer screening is recommended in Germany as a part of the statutory preventive care. Abnormal results can provoke psychological distress and anxiety, compromising women's adherence. Little is known about how a cervical dysplasia impacts adherence follow-up visits and prevention habits over time. To optimize care strategies, this study aims to identify women at risk for nonadherence to follow-up visits after a screening event. METHODS: Between November 2015 and May 2017, participants with an abnormal Pap smear at the Heidelberg and Leipzig University Hospitals received a four-part questionnaire (sociodemographic data, PHQ-D, self-designed fear and prevention habit questions) at the first consultation (T1) and subsequently after 3 (T2) and 6 (T3) months; healthy controls completed the questionnaire at T1...
January 4, 2019: Archives of Gynecology and Obstetrics
Marinela Grabovac, Anne Mary Lewis-Mikhael, Sarah D McDonald
OBJECTIVES: The most effective preterm birth (PTB) intervention is unknown for women who are at risk of PTB due to a history of conization. The objective of this systematic review was to determine whether PTB interventions, progesterone, cerclage, and pessary decrease the risk of PTB compared to no treatment in singleton-and separately in twin-pregnancies of women with history of conization. METHODS: We searched Cochrane Central, MEDLINE, EMBASE, CINAHL, and ClinicalTrials...
January 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Jung Mi Byun, Dae Hoon Jeong, Young Nam Kim, Eun Jung Jung, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim
High-grade cervical intraepithelial neoplasia (CIN) is a precancerous lesion of cervical cancer. The aims of this study were to evaluate the risk factors for recurrence of high-grade CIN and to determine if the specific genotype of human papillomavirus (HPV) is a predictor of recurrent high-grade CIN. Between January 2010 and December 2014, 172 patients with CIN 2+ underwent cold knife conization or a loop electrosurgical excision. The HPV DNA chip was used to detect HPV. Recurrent lesions were histologically confirmed and considered to be recurrence of CIN2+...
December 2018: Medicine (Baltimore)
Xinming Yin, Li Zhu, Weiwei Tan, Xiaolan Zhu, Songping Liu, Wenlin Xu
BACKGROUND This study was conducted to observe the influence of different time intervals between prior cervical conization and posterior hysterectomy on postoperative infection in female patients with cervical intraepithelial neoplasia or cancer. MATERIAL AND METHODS Medical records of 170 patients who underwent hysterectomy following cervical conization between November 2010 and September 2016 at the Zhenjiang 4th Hospital were reviewed. According to the interval between hysterectomy and cervical conization, patients were classified into 1-2-week, 4-5-week, and 6-week groups...
December 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Yelin Lou, Yimin Zhou, Hong Lu, Weiguo Lyu
OBJECTIVE: To establish a prognostic model for preterm birth in women after cervical conization, and to evaluate its effectiveness. METHODS: Seventy three women after cervical conization in Women's Hospital of Zhejiang University were included for this retrospective study. The influencing factors of preterm delivery were analyzed by Logistic regression analysis and a prognostic model was created. Receiver operating characteristic (ROC) curve was used for evaluation of the predictive ability of the model...
February 25, 2018: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
María Reynel, Yván Villegas, Helmut Kiene, Paul G Werthmann, Gunver S Kienle
RATIONALE: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended. PATIENT CONCERNS: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. DIAGNOSES: The patient was diagnosed with CIS after cervical conization procedure...
November 2018: Medicine (Baltimore)
Chao Zhang, Hongyan Zhang, Linqing Yang, Yunfei Wang, Xiaoyu Li, Jinfeng Guo, Jing Xu
RATIONALE: Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE. PATIENT CONCERNS: A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia. DIAGNOSES: The patient was diagnosed with stage IIIc primary and moderately differentiated endometrial squamous cell carcinoma...
November 2018: Medicine (Baltimore)
Giorgio Bogani, Elena Tagliabue, Stefano Ferla, Fabio Martinelli, Antonino Ditto, Valentina Chiappa, Umberto Leone Roberti Maggiore, Francesca Taverna, Claudia Lombardo, Domenica Lorusso, Francesco Raspagliesi
The widespread introduction of screening methods allow to identify cervical dysplasia before having invasive cancer. The risk of developing cervical dysplasia persistence/recurrence following conization represent a major health issue. Although several studies tried to identify predictors for cervical dysplasia persistence/recurrence, no previous study has been conducted to develop a risk calculator. The current study aimed to identify predictors of cervical dysplasia persistence/recurrence among women undergoing primary conization...
November 26, 2018: European Journal of Cancer Prevention
Masayuki Shintaku, Hiromi Taniguchi, Yoshihiro Yamamoto, Fumihiko Kono, Masahiro Sumitomo
Serous tubal intraepithelial carcinoma (STIC) has attracted attention as a precursor lesion of high-grade serous carcinoma (HGSC) of the ovary. We report the rare case of a woman in whom adenocarcinoma cells were detected in cervical smears and demonstrated to be derived from STIC in the fimbria. The patient was a 48-year-old woman, in whom cervical smears contained adenocarcinoma cells, but cervical conization did not reveal adenocarcinoma. Because the post-conization smears again demonstrated adenocarcinoma cells, hysterectomy with bilateral salpingectomy was performed 16 months after the first detection of adenocarcinoma cells in cervical smears...
October 30, 2018: Diagnostic Cytopathology
Sarah Schott, Judith Heinzler, Nathalie Rippinger, Thomas Bruckner, Janina Brucker, Janine Hoffmann, Nadja Dornhöfer, Christine Dinkic, Stephan Seitz, Joachim Rom, Christof Sohn, Timm C Schott
BACKGROUND: Dental and cervical controls are two established screening programs in Germany. Compliance to orthodontic treatment in childhood is essential for dental health and one of the first health interventions that requires adherent behavior; therefore, it may be associated with participation in further screening programs in adulthood. However, it is not yet known whether early orthodontic treatment influences long-term screening adherence. METHODS: Using a questionnaire administered during a visit to a special dysplasia outpatient service, this case-control study evaluated women's personal history of orthodontic care, long-term satisfaction, and dental and gynecological screening adherence...
October 30, 2018: Archives of Gynecology and Obstetrics
Limei Chen, Li Liu, Xiang Tao, Luopei Guo, Hongwei Zhang, Long Sui
OBJECTIVE: The aim of the study was to analyze the clinical outcomes of high-grade squamous intraepithelial lesion (HSIL) 6 months after loop electrosurgical excision procedure (LEEP). We explored the risk factors of persistent cervical HSIL after LEEP and evaluated the methods of follow-up. PATIENTS AND METHODS: This retrospective study included women who underwent a LEEP and had a diagnosis of HSIL in their LEEP specimen during 2011 to 2015. The purpose was to determine the risk factors among these women for having persistent HSIL disease at their 6-month follow-up visit...
October 26, 2018: Journal of Lower Genital Tract Disease
Liang Wang
Serial cervical length (CL) measurement in mid-trimester is recommended in post-conization pregnancy to estimate the risk of spontaneous preterm birth (SPTB). A short mid-trimester cervix (CL < 25 mm) has been considered as a strong predictor for SPTB. However, the low incidence of short cervix limits the utility of mid-trimester CL measurement in prediction of SPTB. A great proportion of women who develop SPTB don't have a short mid-trimester cervix. Therefore, this study was aimed to investigate the additional value of serial CL measurement in predicting SPTB in addition to detecting short cervix alone...
October 17, 2018: Scientific Reports
Jun-Yu Chen, Zhi-Ling Wang, Zhao-Yang Wang, Xing-Sheng Yang
The aim of this study was to illuminate risks factors of residual lesions, and recurrence of the high-grade cervical intraepithelial lesions (HSIL) patients with positive margin who underwent cervical conization.A retrospective cohort study of 218 patients with positive margin after conization, including cold knife conization (CKC) and loop electrosurgical excisional procedure (LEEP), and follow-up from 2013 through 2016. The diagnosis of residual disease and recurrence were established and confirmed by biopsy...
October 2018: Medicine (Baltimore)
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