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JOURNAL ARTICLE
Lior Ben-Harosh, Suzanne Barker-Collo, Alicja Nowacka, Joanne Garrett, Anna Miles
Background Acoustic neuromas (ANs) are consistently associated with decreased quality of life (QOL) related to the physical and psychosocial impacts of symptoms experienced from the tumour and its treatment. This study explored patient-reported experiences of ANs in New Zealand, with a focus on the impact on QOL and the provision of information, support and services. Methods A mixed methods approach was taken, conducting an online community survey that included the Penn Acoustic Neuroma Quality of Life Scale (N = 52)...
January 2024: Brain Impairment: a Multidisciplinary Journal of the Australian Society for the Study of Brain Impairment
#2
JOURNAL ARTICLE
Alicja Nowacka, Suzanne Barker-Collo, Anna Miles
People diagnosed with Vestibular Schwannoma (VS) can experience several symptoms both pre and post-treatment. These, alongside the diagnosis experience, can significantly impact their daily life. The present research is a continuation of a larger study aiming to explore the impacts of symptomology and body image/fear of negative evaluation (FNAE) on the quality of life (QOL) for people with VS. The research design was exploratory and involved a nationwide survey with a total of 52 participants. FNAE was assessed using a measurement of the same name, and QOL was assessed using the Penn Acoustic Neuroma Quality of Life scale (PANQOL)...
March 19, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#3
JOURNAL ARTICLE
Jonathan P Bradfield, Rachel L Kember, Anna Ulrich, Zhanna Balkiyarova, Akram Alyass, Izzuddin M Aris, Joshua A Bell, K Alaine Broadaway, Zhanghua Chen, Jin-Fang Chai, Neil M Davies, Dietmar Fernandez-Orth, Mariona Bustamante, Ruby Fore, Amitavo Ganguli, Anni Heiskala, Jouke-Jan Hottenga, Carmen Íñiguez, Sayuko Kobes, Jaakko Leinonen, Estelle Lowry, Leo-Pekka Lyytikainen, Anubha Mahajan, Niina Pitkänen, Theresia M Schnurr, Christian Theil Have, David P Strachan, Elisabeth Thiering, Suzanne Vogelezang, Kaitlin H Wade, Carol A Wang, Andrew Wong, Louise Aas Holm, Alessandra Chesi, Catherine Choong, Miguel Cruz, Paul Elliott, Steve Franks, Christine Frithioff-Bøjsøe, W James Gauderman, Joseph T Glessner, Vicente Gilsanz, Kendra Griesman, Robert L Hanson, Marika Kaakinen, Heidi Kalkwarf, Andrea Kelly, Joseph Kindler, Mika Kähönen, Carla Lanca, Joan Lappe, Nanette R Lee, Shana McCormack, Frank D Mentch, Jonathan A Mitchell, Nina Mononen, Harri Niinikoski, Emily Oken, Katja Pahkala, Xueling Sim, Yik-Ying Teo, Leslie J Baier, Toos van Beijsterveldt, Linda S Adair, Dorret I Boomsma, Eco de Geus, Mònica Guxens, Johan G Eriksson, Janine F Felix, Frank D Gilliland, Penn Medicine Biobank, Torben Hansen, Rebecca Hardy, Marie-France Hivert, Jens-Christian Holm, Vincent W V Jaddoe, Marjo-Riitta Järvelin, Terho Lehtimäki, David A Mackey, David Meyre, Karen L Mohlke, Juha Mykkänen, Sharon Oberfield, Craig E Pennell, John R B Perry, Olli Raitakari, Fernando Rivadeneira, Seang-Mei Saw, Sylvain Sebert, John A Shepherd, Marie Standl, Thorkild I A Sørensen, Nicholas J Timpson, Maties Torrent, Gonneke Willemsen, Elina Hypponen, Chris Power, Mark I McCarthy, Rachel M Freathy, Elisabeth Widén, Hakon Hakonarson, Inga Prokopenko, Benjamin F Voight, Babette S Zemel, Struan F A Grant, Diana L Cousminer
BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated height measurements from age 5 years to adulthood. We performed genetic analysis on six phenotypes representing the magnitude, timing, and intensity of the pubertal growth spurt...
January 16, 2024: Genome Biology
#4
JOURNAL ARTICLE
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Gluten-containing (GC) and gluten-free (GF) pasta consumption has been growing in recent years. The market offers a wide variety of pasta types, with differences in shape and formulation that influence the mastication process and, consequently, their nutritional behaviors ( i.e. starch digestibility and glycemic response). This study investigated the effect of shape, gluten, and structural breakdown on in vitro starch digestibility and predicted the glycemic index (pGI) of GC and GF penne, spaghetti, and risoni...
December 15, 2023: Food & Function
#5
Anton Safonov, Tomoki T Nomakuchi, Elizabeth Chao, Carrie Horton, Jill S Dolinsky, Amal Yussuf, Marcy Richardson, Virginia Speare, Shuwei Li, Zoe C Bogus, Maria Bonanni, Anna Raper, Staci Kallish, Marylyn D Ritchie, Katherine L Nathanson, Theodore G Drivas
Loss of function variants in the NF1 gene cause neurofibromatosis type 1 (NF1), a genetic disorder characterized by complete penetrance, prevalence of 1 in 3,000, characteristic physical exam findings, and a substantially increased risk for malignancy. However, our understanding of the disorder is entirely based on patients ascertained through phenotype-first approaches. Leveraging a genotype-first approach in two large patient cohorts, we demonstrate unexpectedly high prevalence (1 in 450-750) of NF1 pathogenic variants...
August 10, 2023: medRxiv
#6
JOURNAL ARTICLE
Ramy Abramsky, Ceyda Acun, Jesse Alt, Hany Aly, Noa Arad, Lisanne M Baak, Dana Bakalar, Thameya Balasingham, Theo Bammler, Manon J N L Benders, Diana Benitez, Elisa Boni, Geraldine Boylan, Ellie Campbell, Paola Castri, Priyanka Chandrashekar, Raul Chavez-Valdez, May Chen, Elisabetta Chiodin, Bryan Comstock, Janie Damien, Janie Damien, Linda S de Vries, Linda de Vries, Jacky Dickman, Leslie Doucette, Ellie Duckworth, Ellie Duckworth, Carlos Echeverria-Palacio, Ramy El Jalbout, Mohamed El-Dib, Hoda Elshibiny, Debbie Flock, Anne Gallagher, Enrica Gasperoni, Hannah Glass, Johanneke C Harteman, Kelly Harvey-Jones, Itay Hazan, Patrick Heagerty, Terrie Inder, Lauren Jantzie, Sandra Juul, Sreenivas Karnati, Nazli Kute, Helene Lacaille, Frederic Lange, Petra M A Lemmers, Wei Liu, Nathalie Llaguno, Mauricio Magalhães, Ivan Mambule, Bohdana Marandyuk, Kyla Marks, Lee J Martin, An Massaro, Sean Mathieson, Sean Mathieson, Melisa Carrasco McCaul, Christopher Meehan, Irina Meledin, Elisa Menna, Federica Menzato, Alison Mintoft, Subhabrata Mitra, Annettee Nakimuli, Carol Nanyunya, Georgina Norris, Frances J Northington, Adam Numis, Jiaqi J O'Reilly, Sandra Ortiz, Swetha Padiyar, Natacha Paquette, Lucio Parmeggiani, Silvia Patrizi, Elena Pavlidis, Serena Pellegrin, Anna A Penn, Laurence Petitpas, Elana Pinchefsky, Alessandra Ponta, Jacopo Proietti Subhash Puthuraya, Rana Rais, Nicola J Robertson, Daniela Rodrigues, Michela Salandin, Jacquelyn Salzbank, Lilia Sánchez, Nienke Schalij, Carolina Serrano-Tabares, Eilon Shany, Alex Staffler, Sylke Steggerda, Ilias Tachtsidis, Cally Tann, Maria Luisa Tataranno, Chiara Trabatti, Julie Tremblay, Selma Tromp, Katie Tucker, Victoria Turnbill, Claire-Marie Vacher, Frank van Bel, Niek E van der Aa, Krisa Van Meurs, Andrea Van Steenis, Linda van Wyk, Phetsamone Vannasing, Gabriel Variane, Vinita Verma, Emily Voldal, Nienke Wagenaar, Yvonne Wu, Courtney Wustoff
No abstract text is available yet for this article.
2023: Journal of Neonatal-perinatal Medicine
#7
JOURNAL ARTICLE
Alicja Nowacka, Suzanne Barker-Collo, Anna Miles, Lior Ben-Harosh
INTRODUCTION: Acoustic neuroma (AN) research largely employs a medical framework to understand health outcomes. An alternative is to examine quality of life (QOL) outcomes. This study explored whether mental well-being (i.e., anxiety and depression) were predictive of QOL in those with AN over and above symptomatology. METHODS: A nationwide online survey was distributed to 24 community organisations. The inclusion criteria were a diagnosis of AN irrespective of the treatment approach...
October 2023: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#8
EDITORIAL
Claire-Marie Vacher, Alexandre Bonnin, Imran N Mir, Anna A Penn
No abstract text is available yet for this article.
2023: Frontiers in Endocrinology
#9
JOURNAL ARTICLE
Penn Smith, Alison Thompson, Anna Madill
This organizational case study addresses the research question: What are the experiences of staff who work in a novel in-reach rehabilitation and recovery service for people with profound and enduring mental health needs? Fifteen purposefully sampled staff were recruited from across a novel mental health service that embeds the community sector within inpatient provision. The sample comprises twelve National Health Service and three community voluntary organization staff (four men and eleven women). Data were generated via photo-elicitation in which interviews focused on the photographs participants brought to help convey their experiences of the Service...
May 3, 2023: International Journal of Mental Health Nursing
#10
JOURNAL ARTICLE
Morgan R Firestein, Lauren C Shuffrey, Yunzhe Hu, Margaret Kyle, Maha Hussain, Catherine Bianco, Violet Hott, Sabrina P Hyman, Mia Kyler, Cynthia Rodriguez, Melanie Tejeda Romero, Helen Tzul Lopez, Carmela Alcántara, Dima Amso, Judy Austin, Jennifer M Bain, Jennifer Barbosa, Ashley N Battarbee, Ann Bruno, Sharon Ettinger, Pam Factor-Litvak, Suzanne Gilboa, Sylvie Goldman, Cynthia Gyamfi-Bannerman, Panagiotis Maniatis, Rachel Marsh, Tyler Morrill, Mirella Mourad, Rebecca Muhle, Gabriella Newes-Adeyi, Kimberly G Noble, Kally C O'Reilly, Anna A Penn, Lawrence Reichle, Ayesha Sania, Vera Semenova, Wendy G Silver, Grace Smotrich, Alan T Tita, Nim Tottenham, Michael Varner, Martha G Welch, Noelia Zork, Donna Garey, William P Fifer, Melissa S Stockwell, Catherine Monk, Fatimah Dawood, Dani Dumitriu
IMPORTANCE: Associations between prenatal SARS-CoV-2 exposure and neurodevelopmental outcomes have substantial public health relevance. A previous study found no association between prenatal SARS-CoV-2 infection and parent-reported infant neurodevelopmental outcomes, but standardized observational assessments are needed to confirm this finding. OBJECTIVE: To assess whether mild or asymptomatic maternal SARS-CoV-2 infection vs no infection during pregnancy is associated with infant neurodevelopmental differences at ages 5 to 11 months...
April 3, 2023: JAMA Network Open
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Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J Taylor, Xianyong Yin, Kim M Lorenz, Ravi Mandla, Alicia Huerta-Chagoya, Nigel W Rayner, Ozvan Bocher, S V Arruda Ana Luiza de, Kyuto Sonehara, Shinichi Namba, Simon S K Lee, Michael H Preuss, Lauren E Petty, Philip Schroeder, Brett Vanderwerff, Mart Kals, Fiona Bragg, Kuang Lin, Xiuqing Guo, Weihua Zhang, Jie Yao, Young Jin Kim, Mariaelisa Graff, Fumihiko Takeuchi, Jana Nano, Amel Lamri, Masahiro Nakatochi, Sanghoon Moon, Robert A Scott, James P Cook, Jung-Jin Lee, Ian Pan, Daniel Taliun, Esteban J Parra, Jin-Fang Chai, Lawrence F Bielak, Yasuharu Tabara, Yang Hai, Gudmar Thorleifsson, Niels Grarup, Tamar Sofer, Matthias Wuttke, Chloé Sarnowski, Christian Gieger, Darryl Nousome, Stella Trompet, Soo-Heon Kwak, Jirong Long, Meng Sun, Lin Tong, Wei-Min Chen, Suraj S Nongmaithem, Raymond Noordam, Victor J Y Lim, Claudia H T Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, Laura M Raffield, Bram Peter Prins, Aude Nicolas, Lisa R Yanek, Guanjie Chen, Jennifer A Brody, Edmond Kabagambe, Ping An, Anny H Xiang, Hyeok Sun Choi, Brian E Cade, Jingyi Tan, K Alaine Broadaway, Alice Williamson, Zoha Kamali, Jinrui Cui, Linda S Adair, Adebowale Adeyemo, Carlos A Aguilar-Salinas, Tarunveer S Ahluwalia, Sonia S Anand, Alain Bertoni, Jette Bork-Jensen, Ivan Brandslund, Thomas A Buchanan, Charles F Burant, Adam S Butterworth, Mickaël Canouil, Juliana C N Chan, Li-Ching Chang, Miao-Li Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengming Chen, Lee-Ming Chuang, Mary Cushman, John Danesh, Swapan K Das, H Janaka de Silva, George Dedoussis, Latchezar Dimitrov, Ayo P Doumatey, Shufa Du, Qing Duan, Kai-Uwe Eckardt, Leslie S Emery, Daniel S Evans, Michele K Evans, Krista Fischer, James S Floyd, Ian Ford, Oscar H Franco, Timothy M Frayling, Barry I Freedman, Pauline Genter, Hertzel C Gerstein, Vilmantas Giedraitis, Clicerio González-Villalpando, Maria Elena González-Villalpando, Penny Gordon-Larsen, Myron Gross, Lindsay A Guare, Sophie Hackinger, Sohee Han, Andrew T Hattersley, Christian Herder, Momoko Horikoshi, Annie-Green Howard, Willa Hsueh, Mengna Huang, Wei Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Mohammad Arfan Ikram, Martin Ingelsson, Md Tariqul Islam, Masato Isono, Hye-Mi Jang, Farzana Jasmine, Guozhi Jiang, Jost B Jonas, Torben Jørgensen, Fouad R Kandeel, Anuradhani Kasturiratne, Tomohiro Katsuya, Varinderpal Kaur, Takahisa Kawaguchi, Jacob M Keaton, Abel N Kho, Chiea-Chuen Khor, Muhammad G Kibriya, Duk-Hwan Kim, Florian Kronenberg, Johanna Kuusisto, Kristi Läll, Leslie A Lange, Kyung Min Lee, Myung-Shik Lee, Nanette R Lee, Aaron Leong, Liming Li, Yun Li, Ruifang Li-Gao, Symen Lithgart, Cecilia M Lindgren, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Adam E Locke, Tin Louie, Jian'an Luan, Andrea O Luk, Xi Luo, Jun Lv, Julie A Lynch, Valeriya Lyssenko, Shiro Maeda, Vasiliki Mamakou, Sohail Rafik Mansuri, Koichi Matsuda, Thomas Meitinger, Andres Metspalu, Huan Mo, Andrew D Morris, Jerry L Nadler, Michael A Nalls, Uma Nayak, Ioanna Ntalla, Yukinori Okada, Lorena Orozco, Sanjay R Patel, Snehal Patil, Pei Pei, Mark A Pereira, Annette Peters, Fraser J Pirie, Hannah G Polikowsky, Bianca Porneala, Gauri Prasad, Laura J Rasmussen-Torvik, Alexander P Reiner, Michael Roden, Rebecca Rohde, Katheryn Roll, Charumathi Sabanayagam, Kevin Sandow, Alagu Sankareswaran, Naveed Sattar, Sebastian Schönherr, Mohammad Shahriar, Botong Shen, Jinxiu Shi, Dong Mun Shin, Nobuhiro Shojima, Jennifer A Smith, Wing Yee So, Alena Stančáková, Valgerdur Steinthorsdottir, Adrienne M Stilp, Konstantin Strauch, Kent D Taylor, Barbara Thorand, Unnur Thorsteinsdottir, Brian Tomlinson, Tam C Tran, Fuu-Jen Tsai, Jaakko Tuomilehto, Teresa Tusie-Luna, Miriam S Udler, Adan Valladares-Salgado, Rob M van Dam, Jan B van Klinken, Rohit Varma, Niels Wacher-Rodarte, Eleanor Wheeler, Ananda R Wickremasinghe, Ko Willems van Dijk, Daniel R Witte, Chittaranjan S Yajnik, Ken Yamamoto, Kenichi Yamamoto, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, Matthew Zawistowski, Liang Zhang, Wei Zheng, Biobank Japan Project, Penn Medicine BioBank, Regeneron Genetics Center, eMERGE Consortium, Leslie J Raffel, Michiya Igase, Eli Ipp, Susan Redline, Yoon Shin Cho, Lars Lind, Michael A Province, Myriam Fornage, Craig L Hanis, Erik Ingelsson, Alan B Zonderman, Bruce M Psaty, Ya-Xing Wang, Charles N Rotimi, Diane M Becker, Fumihiko Matsuda, Yongmei Liu, Mitsuhiro Yokota, Sharon L R Kardia, Patricia A Peyser, James S Pankow, James C Engert, Amélie Bonnefond, Philippe Froguel, James G Wilson, Wayne H H Sheu, Jer-Yuarn Wu, M Geoffrey Hayes, Ronald C W Ma, Tien-Yin Wong, Dennis O Mook-Kanamori, Tiinamaija Tuomi, Giriraj R Chandak, Francis S Collins, Dwaipayan Bharadwaj, Guillaume Paré, Michèle M Sale, Habibul Ahsan, Ayesha A Motala, Xiao-Ou Shu, Kyong-Soo Park, J Wouter Jukema, Miguel Cruz, Yii-Der Ida Chen, Stephen S Rich, Roberta McKean-Cowdin, Harald Grallert, Ching-Yu Cheng, Mohsen Ghanbari, E-Shyong Tai, Josee Dupuis, Norihiro Kato, Markku Laakso, Anna Köttgen, Woon-Puay Koh, Donald W Bowden, Colin N A Palmer, Jaspal S Kooner, Charles Kooperberg, Simin Liu, Kari E North, Danish Saleheen, Torben Hansen, Oluf Pedersen, Nicholas J Wareham, Juyoung Lee, Bong-Jo Kim, Iona Y Millwood, Robin G Walters, Kari Stefansson, Mark O Goodarzi, Karen L Mohlke, Claudia Langenberg, Christopher A Haiman, Ruth J F Loos, Jose C Florez, Daniel J Rader, Marylyn D Ritchie, Sebastian Zöllner, Reedik Mägi, Joshua C Denny, Toshimasa Yamauchi, Takashi Kadowaki, John C Chambers, Maggie C Y Ng, Xueling Sim, Jennifer E Below, Philip S Tsao, Kyong-Mi Chang, Mark I McCarthy, James B Meigs, Anubha Mahajan, Cassandra N Spracklen, Josep M Mercader, Michael Boehnke, Jerome I Rotter, Marijana Vujkovic, Benjamin F Voight, Andrew P Morris, Eleftheria Zeggini
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. We identify 1,289 independent association signals at genome-wide significance (P<5×10 - 8 ) that map to 611 loci, of which 145 loci are previously unreported. We define eight non-overlapping clusters of T2D signals characterised by distinct profiles of cardiometabolic trait associations...
March 31, 2023: medRxiv
#12
JOURNAL ARTICLE
Damian Czarnecki, Marcin Ziółkowski, Jan Chodkiewicz, Marta Gorzkiewicz, Napoleon Waszkiewicz, Anna Długosz, Jacek Budzyński, Anna Junkiert-Czarnecka, Agnieszka Kułak-Bejda
PURPOSE: The aim of this study was to assess changes in the severity of alcohol craving according to allelic variants of the 5-HTTLPR gene polymorphism during hospitalisation and their association with selected clinical variables in alcohol-dependent patients. PATIENTS AND METHODS: The study is exploratory. Participants were investigated at the 2nd and 6th week of alcohol-dependence therapy in the addiction treatment unit. Recruitment was conducted among alcohol-dependent patients from several Polish drug treatment centres...
2023: Psychology Research and Behavior Management
#13
JOURNAL ARTICLE
Stephen M Rao, Rachel Galioto, Megan Sokolowski, Madelyn Pierce, Lisa Penn, Anna Sturtevant, Blazenka Skugor, Brent Anstead, James B Leverenz, David Schindler, David Blum, Jay L Alberts, Lori Posk
BACKGROUND: The self-administered iPad-based Cleveland Clinic Cognitive Battery (C3B) was designed specifically for the efficient screening of cognitive functioning of older adults in a primary care setting. OBJECTIVE: 1) Generate regression-based norms from healthy participants to enable demographic corrections to facilitate clinical interpretation; 2) estimate test-retest reliability and practice effects; 3) examine ability to discriminate mild cognitive impairment (MCI) from healthy aging; 4) d etermine validity of screening in a distracting clinical environment; and 5) determine completion rates and patient satisfaction in a primary care setting...
February 20, 2023: Journal of Alzheimer's Disease: JAD
#14
JOURNAL ARTICLE
Sindhu Vangeti, Sara Falck-Jones, Meng Yu, Björn Österberg, Sang Liu, Muhammad Asghar, Klara Sondén, Clare Paterson, Penn Whitley, Jan Albert, Niclas Johansson, Anna Färnert, Anna Smed-Sörensen
During respiratory viral infections, the precise roles of monocytes and dendritic cells (DCs) in the nasopharynx in limiting infection and influencing disease severity are incompletely described. We studied circulating and nasopharyngeal monocytes and DCs in healthy controls (HC) and in patients with mild to moderate infections (primarily influenza A virus, IAV). As compared to HCs, patients with acute IAV infection displayed reduced DC but increased intermediate monocytes frequencies in blood, and an accumulation of most monocyte and DC subsets in the nasopharynx...
February 8, 2023: ELife
#15
JOURNAL ARTICLE
Nicholas Mikolajewicz, Shahbaz Khan, Mara Trifoi, Anna Skakdoub, Vladmir Ignatchenko, Sheila Mansouri, Jeffrey Zuccatto, Brad E Zacharia, Michael Glantz, Gelareh Zadeh, Jason Moffat, Thomas Kislinger, Alireza Mansouri
BACKGROUND: Diagnosis and prognostication of intra-axial brain tumors hinges on invasive brain sampling, which carries risk of morbidity. Minimally-invasive sampling of proximal fluids, also known as liquid biopsy, can mitigate this risk. Our objective was to identify diagnostic and prognostic cerebrospinal fluid (CSF) proteomic signatures in glioblastoma (GBM), brain metastases (BM), and primary central nervous system lymphoma (CNSL). METHODS: CSF samples were retrospectively retrieved from the Penn State Neuroscience Biorepository and profiled using shotgun proteomics...
2022: Neuro-oncology advances
#16
JOURNAL ARTICLE
Dana Bakalar, Jiaqi J O'Reilly, Helene Lacaille, Jacquelyn Salzbank, Jacob Ellegood, Jason P Lerch, Toru Sasaki, Yuka Imamura, Kazue Hashimoto-Torii, Claire-Marie Vacher, Anna A Penn
Placental endocrine function is essential to fetal brain development. Placental hormones include neurosteroids such as allopregnanolone (ALLO), a regulator of neurodevelopmental processes via positive allosteric modulation of the GABAA receptor (GABAA -R). Using a mouse model (plKO) in which the gene encoding the ALLO synthesis enzyme is specifically deleted in trophoblasts, we previously showed that placental ALLO insufficiency alters cerebellar white matter development and leads to male-specific autistic-like behavior...
2022: Frontiers in Endocrinology
#17
JOURNAL ARTICLE
Kevin J Sykes, Heather Gibbs, Nathan Farrokhian, Anna Arthur, John Flynn, Yelizaveta Shnayder, Kiran Kakarala, Rohit Nallani, Joshua B Smith, Joseph Penn, Scott Fassas, Emily Cummings, Zack Arambula, Omar Karadaghy, Andrés M Bur
BACKGROUND: Several prospective studies report improved outcomes with pretreatment nutrition interventions prior to radiation therapy for head and neck cancer (HNC), but none have assessed similar interventions before surgery for HNC. METHODS: POINT, a pilot randomized controlled trial, was conducted to evaluate a multimodal nutrition intervention. Patients undergoing primary surgery with free flap reconstruction for HNC were randomly assigned to the control arm or a preoperative multimodal nutrition intervention...
October 17, 2022: Head & Neck
#18
JOURNAL ARTICLE
Anna Winnicki, James Gadd, Vahagn Ohanyan, Gilbert Hernandez, Yang Wang, Molly Enrick, Hannah McKillen, Matthew Kiedrowski, Dipan Kundu, Karlina Kegecik, Marc Penn, William M Chilian, Liya Yin, Feng Dong
Background: CXCL12/CXCR4 signaling is essential in cardiac development and repair, however, its contribution to aortic valve stenosis (AVS) remains unclear. In this study, we tested the role of endothelial CXCR4 on the development of AVS. Materials and methods: We generated CXCR4 endothelial cell-specific knockout mice (EC CXCR4 KO) by crossing CXCR4fl/fl mice with Tie2-Cre mice to study the role of endothelial cell CXCR4 in AVS. CXCR4fl/fl mice were used as controls...
2022: Frontiers in Cardiovascular Medicine
#19
JOURNAL ARTICLE
Ondrej Bezdicek, Josef Mana, Filip Růžička, Filip Havlik, Anna Fečíková, Tereza Uhrová, Evžen Růžička, Dušan Urgošík, Robert Jech
Background: Everyday functioning and instrumental activities of daily living (IADL) play a vital role in preserving the quality of life in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). Objective: The main goal of the current study was to examine IADL change in pre-and post-surgery of the STN-DBS. We also analyzed the influence of the levodopa equivalent daily dose (LEDD) and global cognitive performance (Dementia Rating Scale; DRS-2) as covariates in relation to IADL...
2022: Frontiers in Aging Neuroscience
#20
JOURNAL ARTICLE
Khadar Abdi, Ramy Abramsky, Nickie Andescavage, Jephté Bambi, Sudeepta Basu, Cynthia Bearer, Eric J Benner, Thérèse Biselele, Nikolay Bliznyuk, Jeroen Breckpot, Galen Carey, Agnes Chao, Line Iadsatian Christiansen, Silvia Comani, Pierpaolo Croce, Maarten De Vos, Anneleen Dereymaeker, Laura Dubois, Amelia J Eisch, Adrian Epstein, Neta Geva, Yael Geva, Marc Gewillig, Sheyenne Gillis, Ronald N Goldberg, Magnus Gram, Simon Gregory, Danielle Guez-Barber, Masahiro Hayakawa, Nicole Lind Henriksen, Tim Hermans, Reli Hershkovitz, Kristine Holgersen, Bo Holmqvist, Vaibhav Jain, Katrien Jansen, Vinay Kandula, Kushal Kapse, Masahiro Kawaguchi, Abdulhafeez Khair, Mohammad Khazaei, Hiroyuki Kidokoro, Frederico C Kiffer, Katherine Kisilewicz, Sumire Kumai, Helene Lacaille, David Ley, Catherine Limperopoulos, Sandy Ebba Hallengreen Lindholm, Prosper Lukusa, Rebecca Lundberg, Peter MacFarlane, Pavle Matak, Laetitia Mavinga, Catherine Mayer, Gloire Mbayabo, Takamasa Mitsumatsu, Gerrye Mubungu, Jonathan Murnick, Tomohiko Nakata, Hajime Narita, Parvathi Nataraj, Jun Natsume, Gunnar Naulaers, Rahul Nikam, Niklas Ortenlöf, Katherine Ottolini, Xiaoyu Pan, Kelly Pegram, Anna A Penn, Subechhya Pradhan, Khadijeh Raeisi, Nicholas Rickman, Blaire Rikard, Reut Rotem, Per Torp Sangild, Yoshiaki Sato, Fumi Sawamura, Eilon Shany, Ilan Shelef, Anna Shiraki, Laura Smets, Livia Sura, Ryosuke Suzui, Takeshi Suzuki, Bruno-Paul Tady, Gentaro Taga, Gabriella Tamburro, Liesbeth Thewissen, J Will Thompson, Thomas Thymann, Cansu Tokat, Claire-Marie Vacher, Cyndi Valdes, Suvi Vallius, Sergei Vatolin, Hama Watanabe, Adi Yehuda Weintraub, Michael Weiss, Hiroyuki Yamamoto, Salem Shimrit Yaniv, Noelle Younge, Sanghee Yun, Filippo Zappasodi
No abstract text is available yet for this article.
2022: Journal of Neonatal-perinatal Medicine
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