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Positive results of IVF in older women

D Valerio, A Luddi, V De Leo, D Labella, S Longobardi, P Piomboni
STUDY QUESTION: Are cohesins SA1/SA2 and the NAD-dependent deacetylase SIRT1 involved in telomere homeostasis of cumulus cells and thus eligible as biomarkers of follicular physiology and ovarian aging? SUMMARY ANSWER: SA1/SA2 cohesins and SIRT1 are associated with telomere length in cumulus cells and may be eligible biomarkers of follicular physiology and ovarian aging. WHAT IS KNOWN ALREADY: In somatic cells, cohesins SA1/SA2 mediate sister chromatid cohesion at the telomere termini (for SA1) and along chromatid arms (for SA2)...
May 1, 2018: Human Reproduction
Lauren A Bishop, Kevin S Richter, George Patounakis, Leslie Andriani, Kimberly Moon, Kate Devine
OBJECTIVE: To assess the relationship between diminished ovarian reserve and pregnancy outcomes in a large cohort of women achieving pregnancy through in vitro fertilization (IVF). We evaluated antral follicle count (AFC) and baseline FSH as a measure of ovarian reserve. Secondarily, we assessed whether diminished ovarian reserve was associated with aneuploidy among spontaneous abortions. DESIGN: Retrospective cohort study. SETTING: Multicenter private practice...
December 2017: Fertility and Sterility
Abbas Aflatoonian, Maryam Eftekhar, Farnaz Mohammadian, Fariba Yousefnejad
BACKGROUND: Human fertility has been declined all over the world. Advanced women's age is one of the most important factors in determining the success of reproduction and ageing has negative impact on ART outcome and advanced female age decreases the chance of live birth rates achieved using ART, especially after 40 years of age. OBJECTIVE: To evaluate ART outcomes regarding to pregnancy, abortion, cycle cancellation and live birth rates in women 40 years and older...
2011: Iranian Journal of Reproductive Medicine
Marina Ferrario, Rita Secomandi, Matteo Cappato, Ester Galbignani, Luigi Frigerio, Mariangela Arnoldi, Francesco M Fusi
The aim of this retrospective analysis was to evaluate the association between serum levels of various hormones and in vitro fertilization (IVF) parameters in poor responder patients. Serum levels of anti-Müllerian hormone (AMH), dehydroepiandrosterone sulfate (DHEAS), androstenedione and testosterone were measured before the start of IVF treatment cycle. We found that serum AMH and DHEAS levels were positively correlated with the number of mature oocytes, fertilized oocytes and developed embryos, both in pregnant and in non-pregnant patients...
February 2015: Gynecological Endocrinology
Mustafa Kara, Tayfun Kutlu, Kenan Sofuoglu, Belgin Devranoglu, Tansel Cetinkaya
BACKGROUND: Estradiol (E2) is required for follicular development and play an important role in embryo implantation. OBJECTIVE: The aim of this study was to assess the impact of serum E2 levels on the day of hCG administration in IVF-ICSI patients who are performed controlled ovarian hyperstimulation (COH). MATERIALS AND METHODS: A total of 203 women who were undergone one time IVF cyclus were evaluated in this cross sectional study. All the patients were treated either with long protocol or with microdose flare protocol...
January 2012: Iranian Journal of Reproductive Medicine
Jirina Kocourkova, Boris Burcin, Tomas Kucera
BACKGROUND: Delayed childbearing in European countries has resulted in an increase in the number of women having children later in life. Thus more women face the problem of age-related infertility and cannot achieve their desired number of children. Childbearing postponement is one of the main reasons for the increasing use of assisted reproductive technology (ART) and conversely, the latter may be one of the factors contributing to the rise in female childbearing age. The research goal of our article is to evaluate the demographic importance of ART increased use and to examine its impact on both the fertility rate and birth timing...
2014: Reproductive Health
Urban Vrtacnik, Eda Vrtacnik Bokal, Rok Devjak
Since 1983, Slovenia has been offering well-established, successful, and fully reimbursed IVF programme to infertile couples. On the grounds of data gathered at the Slovenian IVF units we aimed to determine whether the fully accessible IVF treatment system can provide notable success considering cumulative delivery rate (cDR). Longitudinal analysis of getting cDR was performed in 810 IVF cycles of 395 couples who for the first time attended the IVF programme in year 2006 and were followed until year 2012. We calculated the actual and the optimistic cDR...
2014: BioMed Research International
Rosalie Cabry, Philippe Merviel, Andre Hazout, Stephanie Belloc, Alain Dalleac, Henri Copin, Moncef Benkhalifa
Women's fertility potential is declining with age because of multiples intrinsic and extrinsic factors such as life style, oxidative stress and/or endocrine disruptors and is affecting the ability of these women to conceive naturally. This declining fertility potential and the late age of motherhood is increasing significantly the number of patients consulting infertility specialists. Different strategies of investigation and management are proposed to patients over 40 in order to overcome their infertility and improve the live birth rate in these patients...
May 2014: Maturitas
Marco Antonio Palumbo, Eleonora Giuffrida, Ferdinando Antonio Gulino, Emanuela Leonardi, Giuseppina Cantarella, Renato Bernardini
OBJECTIVE: The aim of this study was to determine the levels of NGF in follicular fluid and serum samples, and to correlate them with some characteristics of the patients (age) and of the IVF protocol (E2 levels, number of collected oocytes, used FSHr IU) to investigate its rule in the folliculogenesis. METHODS: This study examined a sample of 78 women undergoing to FIVET/ICSI cycles since October 2011 to March 2013. NGF levels were determinated in follicular fluid (FF) and serum sample using enzyme immunoassay ELISA kit for NGF...
November 2013: Gynecological Endocrinology
Danuta Michalska, Kinga Jaguszewska, Joanna Liss, Kamila Kitowska, Agata Mirecka, Krzysztof Łukaszuk
BACKGROUND: Preimplantation genetic diagnosis (PGD) remains nowadays a valid alternative for couples at high-risk of having a child with a genetic disease and for women older than 37-40 years with the high risk of chromosomal aneuploidies in the embryos. However the use of PGD for high penetrance recessive, dominant and X-liked disorders occurring in early life is documented, debate exists regarding its appropriateness in lower penetrance and late-onset cancer susceptibility syndromes...
2013: Hereditary Cancer in Clinical Practice
Francesco M Fusi, Marina Ferrario, Chiara Bosisio, Mariangela Arnoldi, Laura Zanga
The aim of this article is to describe unexpected spontaneous pregnancies in poor responder patients with long-term infertility, when treated with dehydroepiandrosterone (DHEA) supplementation prior to in vitro fertilization (IVF). Our evaluation was carried out in two groups of women. The first group included 39 young women with <40 years, all treated with DHEA because of a previous poor response. The second group included 38 women over 40 years who received DHEA supplementation. Controls for latter group were 24 comparable women who had not been treated with DHEA before the first IVF cycle to evaluate the spontaneous pregnancy rate during preparation to IVF...
October 2013: Gynecological Endocrinology
Yavuz Emre Sukur, Tugba Altun, Lubna Pal
OBJECTIVE: To identify patient and cycle parameters that relate to spontaneous reduction in multiple pregnancies following in vitro fertilization (IVF) and embryo transfer (ET). STUDY DESIGN: A retrospective cohort study was conducted in an academic infertility center. All IVF cycles between January 2007 and June 2008 were evaluated and 69 infertile women were diagnosed with multiple gestation following IVF. Multiple pregnancy was diagnosed by transvaginal sonography at 6-7 weeks gestation following embryo transfer (ET)...
June 2012: European Journal of Obstetrics, Gynecology, and Reproductive Biology
K Mac Dougall, Y Beyene, R D Nachtigall
BACKGROUND: As ages at first birth have steadily risen in the industrial west over the last several decades, the phenomenon of 'delayed childbearing' has come under research scrutiny by demographers, medical specialists and social scientists. In this study, we specifically explore the perceived advantages and disadvantages of postponed conception as well as participants' retrospective opinions on the 'optimal age' for parenting. METHODS: To this end, we examined a cohort purposely chosen to epitomize delayed childbearing, i...
April 2012: Human Reproduction
Norbert Gleicher, Andrea Weghofer, David H Barad
BACKGROUND: Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances in women with diminished ovarian reserve (DOR), and to reduce miscarriage rates by 50-80%. Such an effect is mathematically inconceivable without beneficial effects on embryo ploidy. This study, therefore, assesses effects of DHEA on embryo aneuploidy. METHODS: In a 1:2, matched case control study 22 consecutive women with DOR, supplemented with DHEA, underwent preimplantation genetic screening (PGS) of embryos during in vitro fertilization (IVF) cycles...
November 10, 2010: Reproductive Biology and Endocrinology: RB&E
Hey-Joo Kang, Zhaohui Feng, Yvonne Sun, Gurinder Atwal, Maureen E Murphy, Timothy R Rebbeck, Zev Rosenwaks, Arnold J Levine, Wenwei Hu
The tumor suppressor protein p53 plays an important role in maternal reproduction in mice through transcriptional regulation of leukemia inhibitory factor (LIF), a cytokine crucial for blastocyst implantation. To determine whether these observations could be extended to humans, a list of single-nucleotide polymorphisms (SNPs) in the p53 pathway that can modify the function of p53 was assembled and used to study their impact on human fertility. The p53 allele encoding proline at codon 72 (P72) was found to be significantly enriched over the allele encoding arginine (R72) among in vitro fertilization (IVF) patients...
June 16, 2009: Proceedings of the National Academy of Sciences of the United States of America
D Hvidtjørn, J Grove, D Schendel, L A Schieve, E Ernst, J Olsen, P Thorsen
BACKGROUND: An increasing number of children are born after assisted conception and in surveillance programmes information on mode of conception is often achieved via maternal self-report. We assessed the validity of self-reported assisted conception in The Danish National Birth Cohort (DNBC), a prospective pregnancy cohort. Here, the term assisted conception refers to IVF, ICSI, ovulation induction and insemination. METHODS: We compared self-reported assisted conception in the DNBC to corresponding data from Danish national registers; the IVF Register and Danish Drug Prescription Register, providing method of conception in the entire population...
September 2009: Human Reproduction
K L Goa, A J Wagstaff
UNLABELLED: Follitropin alpha (recombinant human follicle-stimulating hormone; follitropin alfa) is a recombinant form of follicle-stimulating hormone (FSH), an endogenous gonadotrophin. Unlike FSH products derived from urine [menotropins (human menopausal gonadotrophins), urofollitropin and highly purified urofollitropin], follitropin alpha is readily available and shows batch-to-batch consistency. As well, it is free of luteinising hormone (LH) activity and contaminant urinary proteins and can be self-administered subcutaneously...
March 1998: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
I Bar-Hava, A Ferber, J Ashkenazi, R Orvieto, B Kaplan, J Bar, D Peleg, Z Ben-Rafael
Deteriorating oocyte quality is commonly believed to be the primary determinant of the decreased implantation potential in older women. We assessed the influence of age on embryo morphology in standard in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) modalities. All 6350 consecutive embryos (2990 IVF, 3360 ICSI) obtained in our Assisted Reproductive Technology Unit from January 1996 through June 1997 were included. High quality embryos were defined as those with equal-sized blastomeres and < 10% fragmentations and a cleavage rate of four cells on day 2 or eight cells on day 3 transfers...
December 1999: Gynecological Endocrinology
S Munné, C Magli, J Cohen, P Morton, S Sadowy, L Gianaroli, M Tucker, C Márquez, D Sable, A P Ferraretti, J B Massey, R Scott
usromosomal abnormalities are responsible for a great deal of embryo wastage, which is reflected, at least partially, in decreased implantation and increased miscarriage in older women. To address this problem the transfer of only chromosomally normal embryos previously selected by preimplantation genetic diagnosis (PGD) has been proposed. We designed a multi-centre in-vitro fertilization (IVF) study to compare controls and a test group that underwent embryo biopsy and PGD for aneuploidy. Patients were matched retrospectively, but blindly, for average maternal age, number of previous IVF cycles, duration of stimulation, oestradiol concentrations on day +1, and average mature follicles...
September 1999: Human Reproduction
A Dionyssiou-Asteriou, P Drakakis, D Loutradis
Inhibin (INH), oestradiol (E2) and progesterone (P) were measured in the follicular fluid (FF) of 22 patients 28-38 years old (Group A) and 11 patients 43-47 years old (Group B) who had received gonadotrophin stimulation in an in vitro fertilization and embryo transfer (IVF-ET) programme. The results indicated that INH, E2 and P levels were significantly lower and the E2/P ratio was higher in FF of Group B patients (older women) compared to those of Group A. There were six single pregnancies among patients of Group A...
September 1993: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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