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https://read.qxmd.com/read/30771521/the-combination-of-mek-inhibitor-with-immunomodulatory-antibodies-targeting-pd-1-and-pd-l1-results-in-prolonged-survival-in-kras-p53-driven-lung-cancer
#1
Jong Woo Lee, Yu Zhang, Kyung Jin Eoh, Roshan Sharma, Miguel F Sanmamed, Jenny Wu, Justin Choi, Hee Sun Park, Akiko Iwasaki, Edward Kaftan, Lieping Chen, Vali Papadimitrakopoulou, Roy S Herbst, Ja Seok Koo
PURPOSE: To characterize the tumor-infiltrating immune cells population in Kras/p53-driven lung tumors and to evaluate the combinatorial anti-tumor effect with MEK inhibitor (MEKi), trametinib, and immunomodulatory monoclonal antibodies (mAbs) targeting either programmed cell death protein-1 (PD-1) or programmed cell death protein ligand 1 (PD-L1) in vivo. EXPERIMENTAL DESIGN: Trp53FloxFlox ;KrasG12D/+ ;Rosa26LSL-Luciferase/LSL-Luciferase (PKL) genetically engineered mice were utilized to develop autochthonous lung tumors with intratracheal delivery of adenoviral Cre recombinase...
February 13, 2019: Journal of Thoracic Oncology
https://read.qxmd.com/read/30771344/gynecologic-cancer-in-hiv-positive-women-a-systematic-review-and-meta-analysis
#2
REVIEW
Anna Jo Bodurtha Smith, Sanskriti Varma, Anne F Rositch, Kimberly L Levinson
OBJECTIVE: While there is a significant body of literature on cervical cancer in HIV-positive women, little is known about other gynecologic cancers in this population. The objective of this systematic review and meta-analysis is to describe the incidence, presentation, treatment, and outcomes for HIV-positive women with non-AIDS-defining gynecologic cancers. DATA SOURCE: We searched Medline, Embase, ClinicalTrials.gov, and the Cochrane Central Registry of Controlled trials for English-language studies published from 2000 to May 1, 2017...
February 13, 2019: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/30770946/-biomechanical-modeling-and-the-relevance-for-total-hip-arthroplasty
#3
REVIEW
J Eschweiler, F Migliorini, H Siebers, M Tingart, B Rath
BACKGROUND: Providing the hip with an endoprosthesis is one of the most common orthopedic interventions in Germany. The long-term success of such a procedure depends on the consideration of the loads due to muscle and joint forces in the planning and operative care. Patient-specific information of forces acting in vivo is not available to the surgeon in clinical routine today. This is where biomechanical modeling comes in. PROCEDURES: A field of activity of biomechanical modeling is the development of methods and procedures for the precise analysis and simulation of endoprosthetic supplies...
February 15, 2019: Der Orthopäde
https://read.qxmd.com/read/30770737/the-health-and-economic-effects-of-light-rail-lines-design-methods-and-protocol-for-a-natural-experiment
#4
Lawrence D Frank, Jennifer L Kuntz, James E Chapman, Eric H Fox, John F Dickerson, Richard T Meenan, Brian E Saelens, Deborah R Young, Janne Boone-Heinonen, Stephen P Fortmann
BACKGROUND: The health impacts of community design have been studied extensively over the past two decades. In particular, public transportation use is associated with more walking between transit stops and shops, work, home and other destinations. Change in transit access has been linked with physical activity and obesity but seldom to health outcomes and associated costs, especially within a causal framework. Health related fiscal impacts of transit investment should be a key consideration in major transit investment decisions...
February 15, 2019: BMC Public Health
https://read.qxmd.com/read/30770314/outcomes-of-ulnar-nerve-anterior-transmuscular-transposition-and-significance-of-ulnar-nerve-instability-in-cubital-tunnel-syndrome
#5
Lisa M Frantz, Jessica M Adams, G Stephen Granberry, Sarah M Johnson, Bernard F Hearon
BACKGROUND: We investigated the experience of a single surgeon with ulnar nerve anterior transmuscular transposition with the patient in the lateral decubitus position for cubital tunnel syndrome. METHODS: The medical records of all patients who underwent primary or revision ulnar nerve anterior transmuscular transposition were screened to define a cohort of 156 patients (162 limbs) for further study of demographic and disease-specific data and retrospective assessment of short-term outcomes...
February 13, 2019: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/30770122/prospective-outcome-analysis-following-tenodesis-of-the-long-head-of-the-biceps-tendon-along-with-locking-plate-osteosynthesis-for-proximal-humerus-fractures
#6
F Greve, M Beirer, M Zyskowski, M Crönlein, M Müller, S Pesch, S Felix, P Biberthaler, A Buchholz, C Kirchhoff
BACKGROUND: Fractures of the proximal humerus are often associated with lesions of the long head of the biceps (LHB) tendon. This often leads to prolonged shoulder pain. Hence, many surgeons decide to perform a tenodesis of the LHB tendon simultaneous to ORIF. The purpose of this study was to evaluate the postoperative outcome after interlocking plate fixation and biceps tenodesis for treating proximal humerus fractures. METHODS: 56 patients (38 females, 18 male) suffering from proximal humerus fractures who underwent surgery were retrospectively included...
February 10, 2019: Injury
https://read.qxmd.com/read/30768358/rcc2-a-regulator-of-the-rala-signaling-pathway-is-identified-as-a-novel-therapeutic-target-in-cisplatin-resistant-ovarian-cancer
#7
Shipeng Gong, Yongning Chen, Fanliang Meng, Yadi Zhang, Huan Wu, Chanyuan Li, Guangping Zhang
Currently, cisplatin (DDP) is the first-line chemotherapeutic agent used for treatment of ovarian cancer, but gradually acquired drug resistance minimizes its therapeutic outcomes. We aimed to identify crucial genes associated with DDP resistance in ovarian cancer and uncover potential mechanisms. Two sets of gene expression data were downloaded from Gene Expression Omnibus, and bioinformatics analysis was conducted. In our study, the differentially expressed genes between DDP-sensitive and DDP-resistant ovarian cancer were screened in GSE15709 and GSE51373 database, and chromosome condensation 2 regulator (RCC2) and nucleoporin 160 were identified as 2 genes that significantly up-regulated in DDP-resistant ovarian cancer cell lines compared with DDP-sensitive cell lines...
February 15, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30761539/validating-peritonsillar-abscess-drainage-rates-using-the-pediatric-hospital-information-system-data
#8
Allison G Chisholm, Benjamin D Little, Romaine F Johnson
OBJECTIVES: To evaluate the accuracy of the Children's Hospital Association's Pediatric Health Information System (PHIS) registry data in determining surgical drainage rates as compared to a chart review on the same cohort of children with diagnosis of peritonsillar abscess. STUDY DESIGN: Retrospective analysis. METHODS: Our analysis included 200 children, ages 2 to 17 years, treated for a peritonsillar abscess from 2011 to 2016. The primary outcome was to determine the sensitivity, specificity, predictive values, receiver operating characteristics (ROC), and likelihood ratios of surgical drainage rates comparing the PHIS database to manual chart review of the same patients...
February 13, 2019: Laryngoscope
https://read.qxmd.com/read/30761207/passion-for-exercise-passion-s-relationship-to-general-fitness-indicators-and-exercise-addiction
#9
Alexander T Bureau, Lindsey C Blom, Jocelyn Bolin, Paul Nagelkirk
Research into the Dualistic Model of Passion (DMP) has suggested that a harmonious passion for an activity is related to more positive outcomes (e.g., higher well-being and satisfaction with life), and an obsessive passion for an activity is related to negative and less adaptive outcomes (e.g., lower self-esteem and burnout; 37, 40, 43). The current study demonstrated differences between passion types (i.e., harmonious passion, obsessive passion, no passion) in terms of physical fitness, risk of exercise addiction, frequency of exercise, and perceptions of exercise...
2019: International Journal of Exercise Science
https://read.qxmd.com/read/30761037/health-outcomes-associated-with-internalizing-problems-in-early-childhood-and-adolescence
#10
Matthew R Jamnik, Lisabeth F DiLalla
Physical and mental health problems are becoming more common among the general population. Studies examining mental and physical health often indicate that mental illness early in life is associated with more detrimental health outcomes later. However, additional work is needed to better identity which psychological problems may contribute to poorer health outcomes. Given recent increases in childhood anxiety and depression specifically, it is beneficial to further investigate the relationship between internalizing problems, both early and later in life, and related health problems...
2019: Frontiers in Psychology
https://read.qxmd.com/read/30759225/changing-trends-in-international-versus-domestic-hcv-transmission-in-hiv-positive-msm-a-perspective-for-the-daa-scale-up-era
#11
Luisa Salazar-Vizcaya, Roger D Kouyos, Karin J Metzner, Kamila Caraballo Cortes, Jürg Böni, Cyril Shah, Jan Fehr, Dominique L Braun, Enos Bernasconi, Herbert A Mbunkah, Matthias Hoffmann, Niklaus Labhardt, Matthias Cavassini, Mathieu Rougemont, Huldrych F Günthard, Olivia Keiser, Andri Rauch
Background: Scale-up of direct-acting antiviral(DAA) therapy is expected to abate HCV incidence among HIV-positive men-who-have-sex-with-men(MSM). Treatment programs in neighbouring countries may influence each other's outcomes through international transmission. We aimed at classifying HCV infections in HIV-positive MSM as either domestically or internationally acquired, and at estimating how this classification changed over time. Methods: HCV subtype 1a (the most frequent subtype among MSM) genomes from 99 persons enrolled in the Swiss-HIV-Cohort-Study(SHCS) and diagnosed with replicating HCV infections between 1999 and 2016, were sequenced...
February 13, 2019: Journal of Infectious Diseases
https://read.qxmd.com/read/30759103/presence-persistence-and-effects-of-pre-treatment-hiv-1-drug-resistance-variants-detected-using-next-generation-sequencing-a-retrospective-longitudinal-study-from-rural-coastal-kenya
#12
Amin S Hassan, David F Bibby, Shalton M Mwaringa, Clara A Agutu, Kennedy K Ndirangu, Eduard J Sanders, Patricia A Cane, Jean L Mbisa, James A Berkley
BACKGROUND: The epidemiology of HIV-1 drug resistance (HIVDR) determined by Sanger capillary sequencing, has been widely studied. However, much less is known about HIVDR detected using next generation sequencing (NGS) methods. We aimed to determine the presence, persistence and effect of pre-treatment HIVDR variants detected using NGS in HIV-1 infected antiretroviral treatment (ART) naïve participants from rural Coastal Kenya. METHODS: In a retrospective longitudinal study, samples from HIV-1 infected participants collected prior [n = 2 time-points] and after [n = 1 time-point] ART initiation were considered...
2019: PloS One
https://read.qxmd.com/read/30759022/exercise-interventions-for-improving-objective-physical-function-in-end-stage-kidney-disease-patients-on-dialysis-a-systematic-review-and-meta-analysis
#13
Matthew J Clarkson, Paul N Bennett, Steve F Fraser, Stuart Anthony Warmington
BACKGROUND: Patients with end stage kidney disease on dialysis have increased mortality and reduced physical activity contributing to impaired physical function. While exercise programmes have demonstrated a positive effect on physiological outcomes such as cardiovascular function and strength, there is a reduced focus on physical function. The aim of this review was to determine whether exercise programmes improve objective measures of physical function indicative of activities of daily living for end stage kidney disease patients on dialysis...
February 13, 2019: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/30755844/clinical-presentation-management-and-prognosis-of-pseudogout-in-joint-arthroplasty-a-retrospective-cohort-study
#14
Merit P George, Floranne C Ernste, Aaron Tande, Douglas Osmon, Tad Mabry, Elie F Berbari
Introduction: Calcium pyrophosphate deposition disease (CPPD), or pseudogout, is rare in prosthetic joints, but can mimic prosthetic joint infection (PJI) according to case reports. The purpose of this case series is to describe the demographics, presentation, management, and outcomes of a cohort of these patients seen at our academic medical center. Methods: Patients with post-implant pseudogout, who were evaluated at our medical center between January 1, 2000 and June 30, 2016, were identified from our EHR...
2019: Journal of Bone and Joint Infection
https://read.qxmd.com/read/30747567/effects-of-a-twelve-week-tai-chi-intervention-in-patients-with-chronic-ankle-instability-a-randomized-controlled-trial
#15
David Cruz-Díaz, Kyung-Min Kim, Fidel Hita-Contreras, Marco Bergamin, Agustin Aibar-Almazán, Antonio Martínez-Amat
CONTEXT: Tai Chi is a physical activity modality which is widely practiced over the world. The effectiveness of Tai Chi on postural control and balance, has been described in older population but until recently there is no studies which includes patients with Chronic Ankle Instability (CAI). OBJECTIVES: The aim of the present study was to evaluate the effectiveness of 12 weeks of Tai Chi intervention on dynamic balance and self-reported instability in patients with CAI...
February 12, 2019: Journal of Sport Rehabilitation
https://read.qxmd.com/read/30746055/improving-neurocognitive-functioning-in-schizophrenia-by-addition-of-cognitive-remediation-therapy-to-a-standard-treatment-of-metacognitive-training
#16
Pasquale Caponnetto, Marilena Maglia, Roberta Auditore, Marta Bocchieri, Antonio Caruso, Jennifer DiPiazza, Riccardo Polosa
Cognitive dysfunctions are a common clinical feature of schizophrenia and represent important indicators of outcome among patients who are affected. Therefore, a randomized, controlled, monocentric, singleblind trial was carried out to compare two different rehabilitation strategies adopted for the restoration and recovery of cognitive functioning of residential patients with schizophrenia. A sample of 110 residential patients were selected and, during the experimental period, a group of 55 patients was treated with sets of domain-specific exercises (SRT+CRT), whereas an equal control group was treated with sets of nondomain- specific exercises (SRT+PBO) belonging to the Cogpack® software...
November 6, 2018: Mental Illness
https://read.qxmd.com/read/30745561/neurodevelopmental-and-behavioral-consequences-of-perinatal-exposure-to-the-hiv-drug-efavirenz-in-a-rodent-model
#17
Lisa Van de Wijer, Lidiane P Garcia, Sabrina I Hanswijk, Juliette Rando, Anthonieke Middelman, Rob Ter Heine, Quirijn de Mast, Gerard J M Martens, André J A M van der Ven, Sharon M Kolk, Arnt F A Schellekens, Judith R Homberg
Efavirenz is recommended as a preferred first-line drug for women of childbearing potential living with human immunodeficiency virus. Efavirenz is known for its central nervous system side effects, which are partly mediated by serotonergic actions. The neurotransmitter serotonin exerts neurotrophic effects during neurodevelopment and antenatal exposure to serotonergic agents has been linked to developmental delay. Although the teratogenic risks of efavirenz appear to be minimal, data on long-term developmental effects remain scarce...
February 11, 2019: Translational Psychiatry
https://read.qxmd.com/read/30745168/poh1-contributes-to-hyperactivation-of-tgf-%C3%AE-signaling-and-facilitates-hepatocellular-carcinoma-metastasis-through-deubiquitinating-tgf-%C3%AE-receptors-and-caveolin-1
#18
Boshi Wang, Xiaoli Xu, Zhaojuan Yang, Li Zhang, Yun Liu, Aihui Ma, Guiqin Xu, Ming Tang, Tiantian Jing, Lin Wu, Yongzhong Liu
BACKGROUND: Hyper-activation of TGF-β signaling is critically involved in progression of hepatocellular carcinoma (HCC). However, the events that contribute to the dysregulation of TGF-β pathway in HCC, especially at the post-translational level, are not well understood. METHODS: Associations of deubiquitinase POH1 with TGF-β signaling activity and the outcomes of HCC patients were examined by data mining of online HCC datasets, immunohistochemistry analyses using human HCC specimens, spearman correlation and survival analyses...
February 7, 2019: EBioMedicine
https://read.qxmd.com/read/30744299/-effects-of-short-term-intervention-of-walking-on-body-mass-index-waist-circumference-and-related-indicators-of-working-population
#19
Y C Li, Y F Zhao, X Z Yang, Z X Li, W Jiang
Objective: To quantify the effects of short-term walking intervention on body mass index (BMI), waist circumference, and related indicators of working population. Methods: The China Motivational Healthy Walking Program in 2016 recruited 29 224 individuals from 139 demonstration areas for comprehensive prevention and control of chronic and non-communicable diseases at the national level and 70 areas at the provincial level. All subjects volunteered to participate into this program. The intervention lasted 100 days from June to September 2016...
February 6, 2019: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://read.qxmd.com/read/30739625/efficacy-and-acceptability-of-psychosocial-interventions-in-asylum-seekers-and-refugees-systematic-review-and-meta-analysis
#20
G Turrini, M Purgato, C Acarturk, M Anttila, T Au, F Ballette, M Bird, K Carswell, R Churchill, P Cuijpers, J Hall, L J Hansen, M Kösters, T Lantta, M Nosè, G Ostuzzi, M Sijbrandij, F Tedeschi, M Valimaki, J Wancata, R White, M van Ommeren, C Barbui
AimsIn the past few years, there has been an unprecedented increase in the number of forcibly displaced migrants worldwide, of which a substantial proportion is refugees and asylum seekers. Refugees and asylum seekers may experience high levels of psychological distress, and show high rates of mental health conditions. It is therefore timely and particularly relevant to assess whether current evidence supports the provision of psychosocial interventions for this population. We conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) assessing the efficacy and acceptability of psychosocial interventions compared with control conditions (treatment as usual/no treatment, waiting list, psychological placebo) aimed at reducing mental health problems in distressed refugees and asylum seekers...
February 11, 2019: Epidemiology and Psychiatric Sciences
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