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nano chemistry

Philippe Bertrand, Christophe Blanquart, Valérie Héroguez
Fast clearance, metabolism, and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects, despite displaying promising anti-tumor properties on tumor cells in vitro and in in vivo models of cancer. The specific delivery of anti-cancer drugs into the tumor should improve their clinical benefit by limiting systemic toxicity and by increasing the anti-tumor effect. This paper deals with the synthesis of the polymeric nanoparticle platform, which was produced by Ring-Opening Metathesis Polymerization (ROMP), able to release anti-cancer drugs in dispersion, such as histone deacetylase inhibitors, into mesothelioma tumors...
February 12, 2019: Biomolecules
Kunal Karan
Ion-containing perfluorinated polymers possess unique viscoelastic properties, excellent proton conductivity, and nano-phase-segregated structure all arising from the clustering of hydrophilic sulphonic acid groups within a matrix of hydrophobic fluorocarbons. When these ionomers are confined to nanothin films, a broad swathe of structural organization imparting a rich variety of surface, interfacial and bulk characteristics can be expected. However, our understanding of perfluorinated ionomer thin film behavior is still in a rudimentary stage with much of the focus on the hydration-related structure/properties pertinent to electrochemical applications...
February 12, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Denis Gebauer, Stephan E Wolf
"Non-classical" notions consider formation pathways of crystalline materials where larger species than monomeric chemical constituents, i.e., ions or single molecules, play crucial roles, which are not covered by the classical theories dating back to the 1870s and 1920s. Providing an outline of "non-classical" nucleation, we demonstrate that pre-nucleation clusters (PNCs) can lie on alternative pathways to phase separation, where the very event of demixing is not primarily based on the sizes of the species forming, as in the classical view, but their dynamics...
February 12, 2019: Journal of the American Chemical Society
Pengfei Tang, Lu Han, Pengfei Li, Zhanrong Jia, Kefeng Wang, Hongping Zhang, Hui Tan, Tailin Guo, Xiong Lu
Wound repair and tissue regeneration are complex processes that involves many physiological signals. Thus, it is a possible solution by employing novel wound dressings with potent biological activity and physiological signal response ability to accelerate wound healing. Herein, inspired by mussel chemistry, we developed a polydopamine-reduced GO (pGO)-incorporated chitosan (CS) and silk fibroin (SF) (pGO-CS/SF) scaffold with good mechanical, electroactive, and anti-oxidative properties as an efficient wound dressing...
February 4, 2019: ACS Applied Materials & Interfaces
Ramanathan Yegappan, Vignesh Selvaprithiviraj, Annapoorna Mohandas, Rangasamy Jayakumar
Crosslinking of polymeric network using nanoparticles by physical or chemical method to obtain hydrogel is an emerging approach. Herein, we synthesized Polydopamine (PDA) nanoparticles via oxidative self-polymerization of dopamine in water-ethanol mixture. Thiol-functionalized hyaluronic acid was developed using cysteamine and hyaluronic acid (HA-Cys) via 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide - N-hydroxysuccinimide (EDC-NHS) crosslinking chemistry. Developed HA-Cys conjugate was cross-linked using PDA nanoparticles via Michael-type addition reaction...
January 22, 2019: Colloids and Surfaces. B, Biointerfaces
Shinji Toyota, Eiji Tsurumaki
Saturn-like systems consisting of nanoscale rings and spheres are fascinating motifs in supramolecular chemistry. Several ring molecules are known to include spherical molecules at the center of the cavity via noncovalent attractive interactions. In this minireview, we generalize the molecular design, the structural features, and the supramolecular chemistry of such "nano-Saturns", which consist of monocyclic rings and fullerene spheres (mainly C60), on the basis of previous experimental and theoretical studies...
January 28, 2019: Chemistry: a European Journal
Shabnam Shaabani, Ruixue Xu, Maryam Ahmadianmoghaddam, Li Gao, Martin Stahorsky, Joe Olechno, Richard Ellson, Michael Kossenjans, Victoria Helan, Alexander Dömling
Automated, miniaturized and accelerated synthesis for efficient property optimization is a formidable challenge for chemistry in the 21st century as it helps to reduce resources and waste and can deliver products in shorter time frames. Here, we used for the first-time acoustic droplet ejection (ADE) technology and fast quality control to screen efficiency of synthetic reactions on a nanomole scale in an automated and miniaturized fashion. The interrupted Fischer indole combined with Ugi-type reactions yielded several attractive drug-like scaffolds...
January 21, 2019: Green Chemistry: An International Journal and Green Chemistry Resource: GC
Hussain Tinwala, Sarika Wairkar
Diamond nano-particles or nanodiamonds (NDs) are nano-scale carbon allotropes and exhibit characteristic mechanical and optical properties. Unlike other nanocarbon materials NDs are highly bio-compatible and comparatively safe which makes them the material of future interest in the field of medicine. NDs are synthesized by various techniques which includes detonation technique, chemical vapour deposition, high pressure high temperature etc. and followed by post-synthesis processing such as purification, surface modification and functionalization...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
Eyal Kurzbaum, Luba Iliasafov, Luba Kolik, Jeana Starosvetsky, Dragoljub Bilanovic, Monica Butnariu, Robert Armon
Bacteria attach themselves either reversibly or irreversibly onto practically any surface in aqueous and other environments in order to reproduce, while generating extracellular polymeric substances (EPS) as a supportive structure for biofilm formation. Surfaces with a potential to prevent cellular attachment and aggregation (biofilm) would be extremely useful in environmental, biotechnological, medical and industrial applications. The scientific community is currently focusing on the design of micro- and nano-scale textured surfaces with antibacterial and/or antifouling properties (e...
March 25, 2019: Science of the Total Environment
Junqiang Zhao, Dongyang Li, Hongrui Han, Jingjing Lin, Jing Yang, Qiqi Wang, Xia Feng, Ning Yang, Yiping Zhao, Li Chen
Inspired by mussel adhesion chemistry, a kind of hydrophilic poly(vinylidene fluoride) (PVDF) microfiltration membranes with underwater superoleophobicity was prepared using thiolated hyperbranched zwitterionic poly(sulfobetaine methacrylate) (HPS) as a nanoscale surface modifier. The HPS was first synthesized via RAFT copolymerization and followed by sulfonation reaction, and then coated onto dopamine (PD) adhesive PVDF membranes via thiol-mediated Michael addition reaction. The successful and uniform coating of HPS onto the membrane surface was demonstrated by X-ray photoelectron spectroscopy and energy dispersive X-ray detector...
January 24, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Tu C Le, Matthew Penna, David A Winkler, Irene Yarovsky
Preventing biological contamination (biofouling) is key to successful development of novel surface and nanoparticle-based technologies in the manufacturing industry and biomedicine. Protein adsorption is a crucial mediator of the interactions at the bio - nano -materials interface but is not well understood. Although general, empirical rules have been developed to guide the design of protein-resistant surface coatings, they are still largely qualitative. Herein we demonstrate that this knowledge gap can be addressed by using machine learning approaches to extract quantitative relationships between the material surface chemistry and the protein adsorption characteristics...
January 22, 2019: Scientific Reports
Wolfgang Junge
Cyanobacteria and plants carry out oxygenic photosynthesis. They use water to generate the atmospheric oxygen we breathe and carbon dioxide to produce the biomass serving as food, feed, fibre and fuel. This paper scans the emergence of structural and mechanistic understanding of oxygen evolution over the past 50 years. It reviews speculative concepts and the stepped insight provided by novel experimental and theoretical techniques. Driven by sunlight photosystem II oxidizes the catalyst of water oxidation, a hetero-metallic Mn4CaO5(H2O)4 cluster...
January 2019: Quarterly Reviews of Biophysics
Samuel R Peurifoy, Thomas J Sisto, Fay Ng, Michael L Steigerwald, Rongsheng Chen, Colin Nuckolls
This Account details key developments in dimensional control of contorted aromatics for organic electronics. Coronene, perylene, pyrene, and [4]helicene, which are fragments of graphene, can be contorted using facile synthetic chemistry into large nanoribbons and nano-architectures. In comparing contorted or higher-dimensional graphene architectures to planar or lower-dimensional species, the materials properties are reliably enhanced for the contorted aromatics. Examples of enhanced properties include optical absorptivity, conductivity, device photoconversion efficiency, and solubility...
January 21, 2019: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Mansi Mishra, Kavya Dashora, Ayushi Srivastava, Vinayak D Fasake, Ramineni Harsha Nag
To meet the challenges of food security in a sustainable way, technological intervention in agriculture is of prime importance. With the existing conventional technologies supporting high yield, better crop production and protection, the emphasis is now on use of nanotechnology. Exploring new applications of nanotechnology has gained momentum in recent years and has shown acceptance in sectors like food, medicine, chemistry etc. As compared to other sectors, the accepted role in agriculture can still be considered on the marginal side in terms of nanotechnology application...
January 15, 2019: Ecotoxicology and Environmental Safety
Sally Yunsun Kim, Dipesh Khanal, Bill Kalionis, Wojciech Chrzanowski
Extracellular vesicles (EVs) are highly specialized nanoscale assemblies that deliver complex biological cargos to mediate intercellular communication. EVs are heterogeneous, and characterization of this heterogeneity is paramount to understanding EV biogenesis and activity, as well as to associating them with biological responses and pathologies. Traditional approaches to studying EV composition generally lack the resolution and/or sensitivity to characterize individual EVs, and therefore the assessment of EV heterogeneity has remained challenging...
February 2019: Nature Protocols
Elena Calatrava-Pérez, Jason M Delente, Sankarasekaran Shanmugaraju, Chris S Hawes, Clive D Williams, Thorfinnur Gunnlaugsson, Eoin M Scanlan
Herein we report the synthesis of fluorescent, glycosylated 4-amino-1,8-naphthalimide (Nap) 1, and the related 1,8-naphthalimides Tröger's bases (TBNap) 2 and 3, from 1,8-naphthalic anhydride precursors, the α-mannosides being introduced through the use of CuAAC mediated 'click' chemistry. We investigate the photophysical properties of these probes in buffered solution and demonstrate their ability to function as fluorescent probes for Concanavalin A (Con A) lectin. We show that both the Nap and TBNap structures self-assemble in solution...
January 10, 2019: Organic & Biomolecular Chemistry
Carlos Sánchez-Sánchez, José Ignacio Martinez, Nerea Ruiz Del Arbol, Pascal Ruffieux, Roman Fasel, María Francisca López, Pedro L de Andres, José Ángel Martín-Gago
The activation, hydrogenation, and covalent coupling of polycyclic aromatic hydrocarbons (PAHs) are processes of great importance in fields like chemistry, energy, biology, or health, among others. So far, they are based on the use of catalysts which drive and increase the efficiency of the thermally- or light-induced reaction. Here, we report on the catalyst-free covalent coupling of non-functionalized PAHs adsorbed on a relatively inert surface in presence of atomic hydrogen. The underlying mechanism has been characterized by high-resolution scanning tunnelling microscopy and rationalized by density functional theory calculations...
January 9, 2019: Journal of the American Chemical Society
Anees A Ansari, Aslam Khan, Joselito P Labis, Manawwer Alam, M Aslam Manthrammel, Maqusood Ahamed, Mohd Javed Akhtar, Ali Aldalbahi, Hamid Ghaithan
Mesoporous multi-layered silica-coated luminescent Y2 O3 :Eu nanoparticles (NPs) were prepared by a urea-based decomposition process, and their surfaces were gradually modified with nanoporous and mesoporous silica layers using modified sol-gel methods. The synthesized luminescent core-shell NPs were characterized thoroughly to investigate their structural, morphological, thermal, optical, photo luminescent properties and their surface chemistry. The morphology of the core NPs were nearly spherical in shape and were nano-sized grains...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
Govinda Mandal, Petr Vaňhara, Josef Havel
RATIONALE: Carbon-phosphides, are new and promising strategic materials with applications e.g. in optoelectronics. However, their chemistry and methods of synthesis are not completely understood, and only a limited number of C-P clusters have been detected up to now. Laser ablation synthesis (LAS) or laser desorption ionisation (LDI) has great potential to generate Cm Pn clusters in the gas phase and to act as the basis for the development of new technology. METHODS: The laser ablation synthesis (LAS) of carbon phosphides using mixtures of nano-carbon sources (graphene, nanodiamonds) with phosphorus allotropes (red, black, and phosphorene) was examined...
January 2, 2019: Rapid Communications in Mass Spectrometry: RCM
Rena Haruki, Hironori Kouno, Masanori Hosoyamada, Taku Ogawa, Nobuhiro Yanai, Nobuo Kimizuka
Molecular self-assembly is a powerful means to construct nanoscale materials with advanced photophysical properties. Although the protection of the photo-excited states from oxygen quenching is a critical issue, it still has been in an early phase of development. In this work, we demonstrate that a simple and typical molecular design for aqueous supramolecular assembly, modification of chromophoric unit with hydrophilic oligo(ethylene glycol) chains and hydrophobic alkyl chains, is effective to avoid oxygen quenching of triplet-triplet annihilation-based photon upconversion (TTA-UC)...
January 2, 2019: Chemistry, An Asian Journal
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